This comprises the whole LiSyM network
SEEK ID: https://seek.lisym.org/projects/13
Public web page: http://www.lisym.org
- People (109)
- Institutions (34)
- Investigations (0+1)
- Studies (0+1)
- Data files (7+13)
- Models (1)
- SOPs (1)
- Publications (38)
- Presentations (40+46)
- Events (54+2)
- Documents (1+12)
Projects: LiSyM Core Infrastructure and Management (LiSyM-PD), Chronic Liver Disease Progression (LiSyM-DP - Pillar II), Early Metabolic Injury (LiSyM-EMI - Pillar I), Liver Function Diagnostics (LiSyM-LiFuDi - Pillar IV), Model Guided Pharmacotherapy In Chronic Liver Disease (LiSyM-MGP), Molecular Steatosis - Imaging & Modeling (LiSyM-MSIM), Multi-Scale Models for Personalized Liver Function Tests (LiSyM-MM-PLF), Regeneration and Repair in Acute-on-Chronic Liver Failure (LiSyM-ACLF - Pillar III), The Hedgehog Signalling Pathway (LiSyM-JGMMS), LiSyM network, LiSyM Scientific Leadership Teamhttps://orcid.org/0000-0002-1003-1682
For the spatio-temporal dynamics of bile transport, bile canalicular dilation, mechanical stimulation and transduction of YAP signaling during liver regeneration see the open access publication and its appendix:
Meyer et al. (2020) Bile canaliculi remodeling activates YAP via the actin cytoskeleton during liver regeneration. Molecular Systems Biology 16:e8985. https://doi.org/10.15252/msb.20198985
The model format is MorpheusML that can readily be loaded and run in the free and open source software
Creator: Lutz Brusch
Contributor: Lutz Brusch
Model type: Agent based modelling
Model format: MorpheusML
Organism: Mus musculus
Investigations: No Investigations
Studies: No Studies
Modelling analyses: No Modelling analyses
The purpose of this document is to define procedures to follow for exchanging the following items between collaboration partners within the LiSyM network:
a) Exchanging samples of human origin obtained from a natural person (i.e. a patient or other human subject).
b) Exchanging material derived from samples of human origin as defined in a).
c) Exchanging associated data describing samples of human origin and derived material as defined in a) and b).
d) Exchanging data derived from samples of human
Investigations: No Investigations
Studies: No Studies
Assays: No Assays
Authors: Christian Holland, Jovan Tanevski, Javier Perales-Patón, Jan Gleixner, Manu P. Kumar, Elisabetta Mereu, Brian A. Joughin, Oliver Stegle, Douglas A. Lauffenburger, Holger Heyn, Bence Szalai, Julio Saez-Rodriguez
Date Published: 1st Dec 2020
Journal: Genome Biol
Citation: Genome Biol 21(1) : e120
Authors: Christian Holland, Bence Szalai, Julio Saez-Rodriguez
Date Published: 1st Sep 2019
Journal: Biochimica et Biophysica Acta (BBA) - Gene Regulatory Mechanisms
Citation: Biochimica et Biophysica Acta (BBA) - Gene Regulatory Mechanisms : 194431
Authors: N. J. Stanford, M. Scharm, P. D. Dobson, Martin Golebiewski, M. Hucka, V. B. Kothamachu, D. Nickerson, S. Owen, J. Pahle, U. Wittig, D. Waltemath, C. Goble, P. Mendes, J. Snoep
Date Published: 12th Oct 2019
Journal: Methods Mol Biol
PubMed ID: 31602618
Citation: Methods Mol Biol. 2019;2049:285-314. doi: 10.1007/978-1-4939-9736-7_17.
Authors: Fabian Segovia Miranda, H. Morales-Navarrete, Michael Kücken, Vincent Moser, S. Seifert, U. Repnik, Fabian Rost, Mario Brosch, A. Hendricks, S. Hinz, C. Rocken, D. Lutjohann, Y. Kalaidzidis, Clemens Schafmayer, Lutz Brusch, Jochen Hampe, Marino Zerial
Date Published: 2nd Dec 2019
Journal: Nat Med
PubMed ID: 31792455
Citation: Nat Med. 2019 Dec 2. pii: 10.1038/s41591-019-0660-7. doi: 10.1038/s41591-019-0660-7.
We face a reproducibility crisis and computational science, with most published models neither being accessible nor reproducible.
The Systems Biology Markup Language (SBML) is the de facto standard format for encoding pathway based models, which provides a means for exchanging process based models between researchers and tools.
The talk gives an overview of SBML and SBML-based tools.
Creator: Matthias König
Contributor: Matthias König
The Computational Modeling in Biology Network (COMBINE) is an initiative to coordinate the development of the various community standards and formats in systems biology, synthetic biology and related fields. HARMONY is a codefest-type meeting, with a focus on development of the standards, interoperability and infrastructure. There are generally not many general discussions or oral presentations during HARMONY; instead, the time is devoted to allowing hands-on hacking and interaction between people
60 Poster boards will be prepared for your poster presentation. Please register your poster in the following link:
Start Date: 4th Mar 2020
End Date: 5th Mar 2020
Event Website: Not specified
Venue : Evangelische Tagungsstätte Hofgeismar, Kassel-Wilhelmshöhe
This young scientist retreat is being organized by the Junior Group Leaders, Madlen Matz-Soja, Matthias König, Ahmed Ghallab and Nachiket Vartak.
This workshop is a satellite meeting to the LiSyM Young Scientist Retreat. It takes place just before the retreat and is organised by Matthias König (Junior Group), Michael Kücken and Lutz Brusch (Pillar I).
The aim of this additional workshop for the modelers is to demonstrate and discuss the wider applicability, but also the limitations of the mathematical and computational methods and software used and even (co-)developed within LiSyM and to exchange them among LiSyM groups. These methods and
e:Med brings together leading scientists and exceptional young researchers from all over Germany in the emerging field of Systems Medicine. Systems medicine uses interdisciplinary systems-oriented research on diseases to create a basis for understanding complex physiological and pathological processes for development of innovative personalized diagnosis, therapies, and preventive measures. Key to the appropriate analysis and possibly to the modelling of Big Data derived from information levels
Start Date: 8th Mar 2020
End Date: 10th Mar 2020
Event Website: http://www.sys-med.de/de/meeting/emed-kick-off-2020/