This comprises the whole LiSyM network
Programme: LiSyM: Liver Systems Medicine
SEEK ID: https://seek.lisym.org/projects/13
Public web page: http://www.lisym.org
Organisms: Rattus norvegicus, Rattus rattus, Mus musculus, Homo sapiens
FAIRDOM PALs: Max Lüdemann, Matthias König, Vincent Moser, Matthias Reichert, Lutz Brusch, Christian Hudert, Janine Koehncke, Madlen Matz-Soja
Project start date: 1st Jan 2016
Related items
- People (112)
- Programmes (1)
- Institutions (35)
- Investigations (0+3)
- Studies (0+3)
- Assays (0+8)
- Data files (12+17)
- Models (4)
- SOPs (1+2)
- Publications (64)
- Presentations (43+47)
- Events (55+3)
- Documents (1+16)
Projects: LiSyM Core Infrastructure and Management (LiSyM-PD), LiSyM Pillar II: Chronic Liver Disease Progression (LiSyM-DP), LiSyM Pillar I: Early Metabolic Injury (LiSyM-EMI), LiSyM Pillar IV: Liver Function Diagnostics (LiSyM-LiFuDi), LiSyM Pillar III: Regeneration and Repair in Acute-on-Chronic Liver Failure (LiSyM-ACLF), LiSyM network, LiSyM Scientific Leadership Team (LiSyM-LT)
Institutions: University of Freiburg - Institute of Physics, LiSyM programme directorate

Projects: LiSyM network, Forschungsnetzwerk LiSyM-Krebs, LiSyM Pillar II: Chronic Liver Disease Progression (LiSyM-DP), LiSyM Core Infrastructure and Management (LiSyM-PD), LiSyM Pillar III: Regeneration and Repair in Acute-on-Chronic Liver Failure (LiSyM-ACLF), DEEP-HCC network
Institutions: HITS gGmbH
Liver Systems Medicine : striving to develop non-invasive methods for diagnosing and treating NAFLD by combining mathematical modeling and biological research. LiSyM, is a multidisciplinary research network, in which molecular and cell biologists, clinical researchers, pharmacologists and experts in mathematical modeling examine the liver in its entirety. LiSyM research focuses on the metabolic liver disease non-alcoholic fatty liver disease (NAFLD), which includes non-alcoholic steatohepatitis ...
Projects: LiSyM Core Infrastructure and Management (LiSyM-PD), LiSyM Pillar I: Early Metabolic Injury (LiSyM-EMI), LiSyM Pillar II: Chronic Liver Disease Progression (LiSyM-DP), LiSyM Pillar III: Regeneration and Repair in Acute-on-Chronic Liver Failure (LiSyM-ACLF), LiSyM Pillar IV: Liver Function Diagnostics (LiSyM-LiFuDi), Model Guided Pharmacotherapy In Chronic Liver Disease (LiSyM-MGP), Molecular Steatosis - Imaging & Modeling (LiSyM-MSIM), The Hedgehog Signalling Pathway (LiSyM-JGMMS), Multi-Scale Models for Personalized Liver Function Tests (LiSyM-MM-PLF), LiSyM PALs, Project Management PTJ, LiSyM network, LiSyM Scientific Leadership Team (LiSyM-LT)
Web page: https://www.lisym.org/
Creator: Seddik Hammad
Submitter: Seddik Hammad
Investigations: No Investigations
Studies: No Studies
Assays: No Assays
Proteomic Quantification of the Metabolic Targets in Tumor vs Adjacent Normal Liver Tissues
Creator: Seddik Hammad
Submitter: Seddik Hammad
Investigations: No Investigations
Studies: No Studies
Assays: No Assays
Consistently Altered Metabolic Targets in Human Hepatocellular Carcinoma
Creator: Seddik Hammad
Submitter: Seddik Hammad
Investigations: No Investigations
Studies: No Studies
Assays: No Assays
Creator: Alain Becam
Submitter: Alain Becam
Investigations: No Investigations
Studies: No Studies
Assays: No Assays
Creator: Alain Becam
Submitter: Alain Becam
Investigations: No Investigations
Studies: No Studies
Assays: No Assays
Taken from https://github.com/Benchmarking-Initiative/Benchmark-Models See the github repository for license Import and execute the model in d2d
Creator: Jens Timmer
Submitter: Daniel Lill
Model type: Ordinary differential equations (ODE)
Model format: Matlab package
Environment: Not specified
Organism: Not specified
Investigations: No Investigations
Studies: No Studies
Assays: No Assays
Taken from https://github.com/Benchmarking-Initiative/Benchmark-Models License according to the github repository's license Import and execute with d2d
Creators: Jens Timmer, Lorenza D'Alessandro, S.Sobotta, A. Raue, J. Vanlier
Submitter: Daniel Lill
Model type: Ordinary differential equations (ODE)
Model format: Matlab package
Environment: Not specified
Organism: Not specified
Investigations: No Investigations
Studies: No Studies
Assays: No Assays
ODE model describes dynamics of IFNalpha-induced signaling in Huh7.5 cells for a time scale up to 32 hours after stimulation with IFNalpha. The model consists of an IFN receptor model, formation/degradation and cytoplasmic/nuclear shuttling of STAT1-homodimers, STAT1-STAT2-heterodimers and STAT1-STAT2-IRF9 (ISGF3) complexes. On top, formation of feedback proteins STAT1, STAT2, IRF9, USP18, SOCS1, SOCS3 and IRF2 and corresponding influences on IFNalpha signaling dynamics was incorporated. The model ...
Creators: Jens Timmer, Ursula Klingmüller, Daniel Seehofer, Marcus Rosenblatt, Krishna Kumar Tiwari, Frédérique Kok
Submitter: Olga Krebs
Model type: Ordinary differential equations (ODE)
Model format: SBML
Environment: Copasi
Organism: Not specified
Investigations: 1 hidden item
Studies: 1 hidden item
Assays: 1 hidden item
For the spatio-temporal dynamics of bile transport, bile canalicular dilation, mechanical stimulation and transduction of YAP signaling during liver regeneration see the open access publication and its appendix: Meyer et al. (2020) Bile canaliculi remodeling activates YAP via the actin cytoskeleton during liver regeneration. Molecular Systems Biology 16:e8985. https://doi.org/10.15252/msb.20198985
The model format is MorpheusML that can readily be loaded and run in the free and open source software ...
Creator: Lutz Brusch
Submitter: Lutz Brusch
Model type: Agent based modelling
Model format: MorpheusML
Environment: Morpheus
The purpose of this document is to define procedures to follow for exchanging the following items between collaboration partners within the LiSyM network: a) Exchanging samples of human origin obtained from a natural person (i.e. a patient or other human subject). b) Exchanging material derived from samples of human origin as defined in a). c) Exchanging associated data describing samples of human origin and derived material as defined in a) and b). d) Exchanging data derived from samples of human ...
Creators: Martin Golebiewski, Frank Lammert, Wolfgang Müller
Submitter: Martin Golebiewski
Investigations: No Investigations
Studies: No Studies
Assays: No Assays
Abstract
Authors: Lenka Belicova, Urska Repnik, Julien Delpierre, Elzbieta Gralinska, Sarah Seifert, José Ignacio Valenzuela, Hernán Andrés Morales-Navarrete, Christian Franke, Helin Räägel, Evgeniya Shcherbinina, Tatiana Prikazchikova, Victor Koteliansky, Martin Vingron, Yannis L. Kalaidzidis, Timofei Zatsepin, Marino Zerial
Date Published: 4th Oct 2021
Publication Type: Journal
Citation: Journal of Cell Biology 220(10),e202103003
Abstract
Authors: Nachiket Vartak, Dirk Drasdo, Fabian Geisler, Tohru Itoh, Ronald P.J. Oude Elferink, Stan F.J. van de Graaf, John Chiang, Verena Keitel, Michael Trauner, Peter Jansen, Jan G Hengstler
Date Published: 23rd Jun 2021
Publication Type: Journal
DOI: 10.1002/hep.32027
Citation: Hepatology,hep.32027
Abstract (Expand)
Authors: C. O. Schmidt, J. Darms, A. Shutsko, M. Lobe, R. Nagrani, B. Seifert, B. Lindstadt, M. Golebiewski, S. Koleva, T. Bender, C. R. Bauer, U. Sax, X. Hu, M. Lieser, V. Junker, S. Klopfenstein, A. Zeleke, D. Waltemath, I. Pigeot, J. Fluck
Date Published: 27th May 2021
Publication Type: Journal
PubMed ID: 34042687
Citation: Stud Health Technol Inform. 2021 May 27;281:794-798. doi: 10.3233/SHTI210284.
Abstract (Expand)
Authors: M. C. Reichert, C. Schneider, R. Greinert, M. Casper, F. Grunhage, A. Wienke, A. Zipprich, F. Lammert, C. Ripoll
Date Published: 1st Mar 2021
Publication Type: Journal
PubMed ID: 33641234
Citation: Liver Int. 2021 Jun;41(6):1370-1378. doi: 10.1111/liv.14842. Epub 2021 Mar 14.
Abstract
Authors: Leonard Schmiester, Yannik Schälte, Frank T. Bergmann, Tacio Camba, Erika Dudkin, Janine Egert, Fabian Fröhlich, Lara Fuhrmann, Adrian L. Hauber, Svenja Kemmer, Polina Lakrisenko, Carolin Loos, Simon Merkt, Wolfgang Müller, Dilan Pathirana, Elba Raimúndez, Lukas Refisch, Marcus Rosenblatt, Paul L. Stapor, Philipp Städter, Dantong Wang, Franz-Georg Wieland, Julio R. Banga, Jens Timmer, Alejandro F. Villaverde, Sven Sahle, Clemens Kreutz, Jan Hasenauer, Daniel Weindl
Date Published: 26th Jan 2021
Publication Type: Journal
DOI: 10.1371/journal.pcbi.1008646
Citation: PLoS Comput Biol 17(1):e1008646
Talk at the Jamboree 2021 about epigenomic map of human liver zonation and loss of zonation in end-stage liver disease
Creators: Mario Brosch, Jochen Hampe, Lutz Brusch, Marino Zerial, Clemens Schafmayer
Submitter: Mario Brosch
Jamboree presentation
Creators: Daniel Lill, Viktor Makarenko, Ursula Klingmüller, Jens Timmer
Submitter: Daniel Lill
Workshop from LiSyM retreat in January 2020. Additional slides devoted to Social Media for Academics. Developed by Peter Krinenberg from https://naturalscience.careers/
Creator: Olga Vvedenskaya
Submitter: Olga Vvedenskaya
We face a reproducibility crisis and computational science, with most published models neither being accessible nor reproducible. The Systems Biology Markup Language (SBML) is the de facto standard format for encoding pathway based models, which provides a means for exchanging process based models between researchers and tools. The talk gives an overview of SBML and SBML-based tools.
Creator: Matthias König
Submitter: Matthias König
ICSB is one of the largest international conferences on systems biology. Since the first conference in Tokyo in 2000, which was organized by Dr. Hiroaki Kitano, it has been held annually in different countries.
Country: United States
City: Hartford, Connecticut
SBMC 2020 was postponed to 10th - 12th of May 2021. Further information will follow soon.
Start Date: 10th May 2021
End Date: 12th May 2021
Event Website: https://sbmc2020.bioquant.uni-heidelberg.de
Country: Germany
City: Heidelberg
The "Computational Modeling in Biology" Network (COMBINE) is an initiative to coordinate the development of the various community standards and formats in systems biology, systems medicine, synthetic biology and related fields. COMBINE 2020 will be a workshop-style event with invited lectures, oral presentations and posters, but also reserving enough time for afternoon breakout sessions to discuss topics around data and model standardization and integration, as well as harmonization and further ...
Country: United States
City: virtual
The Computational Modeling in Biology Network (COMBINE) is an initiative to coordinate the development of the various community standards and formats in systems biology, synthetic biology and related fields. HARMONY is a codefest-type meeting, with a focus on development of the standards, interoperability and infrastructure. There are generally not many general discussions or oral presentations during HARMONY; instead, the time is devoted to allowing hands-on hacking and interaction between people ...
Start Date: 9th Mar 2020
End Date: 13th Mar 2020
Event Website: http://co.mbine.org/events/HARMONY_2020
Country: United Kingdom
City: Hinxton, Cambridge
e:Med brings together leading scientists and exceptional young researchers from all over Germany in the emerging field of Systems Medicine. Systems medicine uses interdisciplinary systems-oriented research on diseases to create a basis for understanding complex physiological and pathological processes for development of innovative personalized diagnosis, therapies, and preventive measures. Key to the appropriate analysis and possibly to the modelling of Big Data derived from information levels ...
Start Date: 8th Mar 2020
End Date: 10th Mar 2020
Event Website: http://www.sys-med.de/de/meeting/emed-kick-off-2020/
Country: Germany
City: Bonn
Poster for the PhD retreat in Hofgeismar - Svenja Kemmer
Creator: Svenja Kemmer
Submitter: Svenja Kemmer
Investigations: No Investigations
Studies: No Studies
Assays: No Assays