Group leader of the junior group: The Hedgehog Signalling Pathway (LiSyM-JGMMS)
SEEK ID: https://seek.lisym.org/people/26
Location: Germany
ORCID: Not specified
Joined: 2nd May 2017
Related items
- Programmes (2)
- Projects (8)
- Institutions (2)
- Investigations (2+1)
- Studies (0+1)
- Assays (1+1)
- Data files (12+10)
- SOPs (0+2)
- Publications (18)
- Presentations (8+9)
LiSyM-Krebs ist ein nationales Forschungsnetz zur Früherkennung und Prävention von Leberkrebs, das unter Verwendung des systemmedizinischen Forschungsansatzes die komplexen, dynamischen Prozesse der Krankheitsprogression analysiert, um ausgehend von den Erkenntnissen aus dem Forschungsnetz LiSyM die Entstehung von Leberkrebs besser zu verstehen, vorherzusagen und im besten Fall sogar zu verhindern. LiSyM-Krebs setzt die erfolgreichen Forschungsaktivitäten der BMBF-Vorgängerprogramme ...
Projects: LiSyM-Krebs Partnering, Forschungsnetzwerk LiSyM-Krebs, SMART-NAFLD, DEEP-HCC network, C-TIP-HCC network
Web page: https://www.lisym-cancer.org
Liver Systems Medicine : striving to develop non-invasive methods for diagnosing and treating NAFLD by combining mathematical modeling and biological research. LiSyM, is a multidisciplinary research network, in which molecular and cell biologists, clinical researchers, pharmacologists and experts in mathematical modeling examine the liver in its entirety. LiSyM research focuses on the metabolic liver disease non-alcoholic fatty liver disease (NAFLD), which includes non-alcoholic steatohepatitis ...
Projects: LiSyM Core Infrastructure and Management (LiSyM-PD), LiSyM Pillar I: Early Metabolic Injury (LiSyM-EMI), LiSyM Pillar II: Chronic Liver Disease Progression (LiSyM-DP), LiSyM Pillar III: Regeneration and Repair in Acute-on-Chronic Liver Failure (LiSyM-ACLF), LiSyM Pillar IV: Liver Function Diagnostics (LiSyM-LiFuDi), Model Guided Pharmacotherapy In Chronic Liver Disease (LiSyM-MGP), Molecular Steatosis - Imaging & Modeling (LiSyM-MSIM), The Hedgehog Signalling Pathway (LiSyM-JGMMS), Multi-Scale Models for Personalized Liver Function Tests (LiSyM-MM-PLF), LiSyM PALs, Project Management PTJ, LiSyM network, LiSyM Scientific Leadership Team (LiSyM-LT)
Web page: https://www.lisym.org/
Forschungsnetzwerk zur Früherkennung und Prävention- LiSyM-Krebs
Ein Netzwerk von Klinikern, Wissenschaftlern und Datenmanagern hat sich zur Aufgabe gemacht, Methoden zu entwickeln, um Patienten mit einem hohen Risiko für ein Leberkarzinom frühzeitig, in Vorstadien der Tumorentwicklung, identifizieren zu können. Gemeinsam bilden sie das „Systemmedizinische Forschungsnetzwerk zur Früherkennung und Prävention von Leberkrebs“, LiSym-Krebs, das vom Bundesministerium für Bildung und Forschung ...
Programme: LiSyM-Krebs - Systemmedizinisches Forschungsnetz zur Früherkennung und Prävention von Leberkrebs
Public web page: Not specified
Organisms: Homo sapiens, Mus musculus, Rattus norvegicus, Rattus rattus
SMART-NAFLD : A Systems Medicine Approach to Early Detection and Prevention of Hepatocellular Carcinoma in Non-Alcoholic Fatty Liver Disease
The massive increase in obesity is leading to an alarming rise in non-alcoholic liver disease (NAFLD). This development will lead to a dramatic increase in liver diseases such as hepatocellular carcinoma (HCC). A particular challenge is that NAFLD-associated HCCs, for reasons still unknown, not only occur in association with advanced liver fibrosis/cirrhosis, ...
Programme: LiSyM-Krebs - Systemmedizinisches Forschungsnetz zur Früherkennung und Prävention von Leberkrebs
Public web page: Not specified
Organisms: Mus musculus, Homo sapiens
DEEP-HCC - Detailed Analysis of the Spatial Organization of the Development of Hepatocellular Carcinoma
Programme: LiSyM-Krebs - Systemmedizinisches Forschungsnetz zur Früherkennung und Prävention von Leberkrebs
Public web page: Not specified
Organisms: Homo sapiens, Mus musculus
This comprises the whole LiSyM network
Programme: LiSyM: Liver Systems Medicine
Public web page: http://www.lisym.org
Start date: 1st Jan 2016
Organisms: Rattus norvegicus, Rattus rattus, Mus musculus, Homo sapiens
Dr. Madlen Matz-Soja (University of Leipzig) investigates the importance of a control mechanism - the hedgehog signaling pathway - for fatty liver disease. She has shown that the signaling pathway directs how liver cells in NAFLD accumulate fat. Hedgehog also affects sex hormones in the liver. Therefore, Matz-Soya hopes to clarify why women and men suffer from cirrhosis and liver cancer with varying degrees of frequency.
Programme: LiSyM: Liver Systems Medicine
Public web page: http://www.lisym.org/our-work/junior-group/hedgehog-influences
Start date: 1st Jan 2016
Organisms: Homo sapiens, Mus musculus
Country: Germany
City: 04103 Leipzig
Web page: http://biochemie.medizin.uni-leipzig.de/bch_cms/index.php
To investigate the underlying molecular principles of metabolic and morphogenic zonation of the human liver lobule, we generated an integrated epigenetic map across three zones (pericentral, intermediate and periportal) by methylation and transcriptomic analysis of hepatocytes captured by laser micro-dissection. We observe a deep link between epigenetic zonation of human liver and a zonated expression of metabolic and morphogenic pathways: Key transcriptionally zonated enzymes in xenobiotic and ...
Submitter: Mario Brosch
Studies: Integrated epigenetic map across three hepatic zones (pericentral, inte...
Assays: DNA-methylation at binding sites of uniformly expressed transcription fa..., DNA-methylation at binding sites of uniformly expressed transcription fa..., DNA-methylation at binding sites of uniformly expressed transcription fa..., Transcriptomic analysis of hepatocytes ( hepatic zone: intermediate (IZ), Transcriptomic analysis of hepatocytes ( hepatic zone: periportal (PP), Transcriptomic analysis of hepatocytes ; hepatic zone: pericentral (CV)
Snapshots: No snapshots
Liver macrophages (LMs) play a central role in acute and chronic liver pathologies. In our study, we sought to gain further insight into the role of LMs in different liver pathologies and into their characteristics after isolation from liver tissue. Here we will characterize LMs in human liver tissue sections using immunohistochemistry and bioinformatic image analysis. We investigate liver tissues characterized by antiinflammatory LMs which show a homogeneous distribution and increased cell numbers ...
Submitter: Martin Golebiewski
Studies: In vivo and in vitro characterization of primary human macrophages and t...
Assays: Characterization of liver macrophages (LMs) in human liver tissue sections
Snapshots: No snapshots
DNA-methylation at binding sites of uniformly expressed transcription factors in human hepatocytes ; hepatic zone: intermediate (IZ)
Submitter: Olga Krebs
Assay type: Methylation Profiling
Technology type: Technology Type
Investigation: Epigenomic analysis of micro-dissected human liver
Organisms: Homo sapiens
SOPs: No SOPs
Data files: Human DNA methylation data set GSM2819639 ..., Human DNA methylation data set GSM2819641 ..., Human DNA methylation data set GSM2819642 ..., Human DNA methylation data set GSM2819643 ..., Human DNA methylation data set GSM2819647 ..., Human DNA methylation data set GSM2819640 s..., Human DNA methylation data set GSM2819644 s..., Human DNA methylation data set GSM2819645 s..., Human DNA methylation data set GSM2819646 s..., Human DNA methylation data set GSM2819648 s..., Human DNA methylation data set GSM2819650 s..., Human DNA methylation data set GSM2819651 s..., Human DNA methylation data set GSM2819652 s..., Human DNA methylation data set GSM2819653 s..., Human DNA methylation data set GSM2819654 s..., Human DNA methylation data set GSM2819655 s..., Human DNA methylation data set GSM2819656 s..., Human DNA methylation data set GSM2819657 s..., HumanDNA methylation data set GSM2819649 st...
Snapshots: No snapshots
Creator: Madlen Matz-Soja
Submitter: Madlen Matz-Soja
Investigations: No Investigations
Studies: No Studies
Assays: No Assays
Creator: Madlen Matz-Soja
Submitter: Madlen Matz-Soja
Investigations: No Investigations
Studies: No Studies
Assays: No Assays
Metabolic capacities of the Intermediate zone
Creator: Madlen Matz-Soja
Submitter: Madlen Matz-Soja
Investigations: 1 hidden item
Studies: 1 hidden item
Assays: 1 hidden item
LFQ intensities of the model protein subset with imputed missing values highlighted in yellow.
Creator: Madlen Matz-Soja
Submitter: Madlen Matz-Soja
Investigations: 1 hidden item
Studies: 1 hidden item
Assays: 1 hidden item
List of proteins that are significantly higher abundant in the portal zone (sheet 1: from the subset of model proteins, sheet 3: from whole proteome) or in the central zone (sheet 2: from the subset of model proteins, sheet 4: from whole proteome).
Creator: Madlen Matz-Soja
Submitter: Madlen Matz-Soja
Investigations: 1 hidden item
Studies: 1 hidden item
Assays: 1 hidden item
All authors
Abstract (Expand)
Authors: Sebastian Burbano De Lara, Svenja Kemmer, Ina Biermayer, Svenja Feiler, Artyom Vlasov, Lorenza A D’Alessandro, Barbara Helm, Christina Mölders, Yannik Dieter, Ahmed Ghallab, Jan G Hengstler, Christiane Körner, Madlen Matz-Soja, Christina Götz, Georg Damm, Katrin Hoffmann, Daniel Seehofer, Thomas Berg, Marcel Schilling, Jens Timmer, Ursula Klingmüller
Date Published: 12th Jan 2024
Publication Type: Journal
DOI: 10.1038/s44320-023-00007-4
Citation: Mol Syst Biol
Abstract (Expand)
Authors: F. Ott, C. Korner, K. Werner, M. Gericke, I. Liebscher, D. Lobsien, S. Radrezza, A. Shevchenko, U. Hofmann, J. Kratzsch, R. Gebhardt, T. Berg, M. Matz-Soja
Date Published: 18th May 2022
Publication Type: Journal
PubMed ID: 35626717
Citation: Cells. 2022 May 18;11(10):1680. doi: 10.3390/cells11101680.
Abstract (Expand)
Authors: Fritzi Ott, Christiane Körner, Kim Werner, Martin Gericke, Ines Liebscher, Donald Lobsien, Silvia Radrezza, Andrej Shevchenko, Ute Hofmann, Jürgen Kratzsch, Rolf Gebhardt, Thomas Berg, Madlen Matz-Soja
Date Published: 1st May 2022
Publication Type: Journal
Citation: Cells 11(10):1680
Abstract (Expand)
Authors: Andrea Zimmermann, René Hänsel, Kilian Gemünden, Victoria Kegel-Hübner, Jonas Babel, Hendrik Bläker, Madlen Matz-Soja, Daniel Seehofer, Georg Damm
Date Published: 1st Apr 2021
Publication Type: Journal
DOI: 10.3390/biomedicines9040406
Citation: Biomedicines 9(4):406
Abstract (Expand)
Authors: K. B. Cokan, Z. Urlep, G. Lorbek, M. Matz-Soja, C. Skubic, M. Perse, J. Jeruc, P. Juvan, T. Rezen, D. Rozman
Date Published: 9th Nov 2020
Publication Type: Journal
PubMed ID: 33182326
Citation: Cancers (Basel). 2020 Nov 9;12(11). pii: cancers12113302. doi: 10.3390/cancers12113302.