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LiSyM PALs (Saarland University Hospital - Department of Medicine II) ; Regeneration and Repair in Acute-on-Chronic Liver Failure (LiSyM-ACLF - Pillar III) (Saarland University Hospital - Department of Medicine II) ; LiSyM network (Saarland University Hospital - Department of Medicine II) ; Chronic Liver Disease Progression (LiSyM-DP - Pillar II) (Saarland University Hospital - Department of Medicine II)
The incidence of this life-threatening acute-on-chronic liver failure (ACLF) is increasing, and early detection and cure are urgent clinical needs. Pillar III applies a Systems Medicine approach to identify the critical mechanisms of acute-on-chronic liver failure (ACLF) and to foster liver regeneration and repair.
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Chronic liver diseases (CLD) progression leads to cirrhosis, often cancer, and ultimately to organ failure and death. Because of the complexity of this scenario, a Systems Medicine approach is chosen to develop strategies to better characterize progression and resolution of fibrosis. Pillar II aims to define key molecular mechanisms and structural changes in tissue architecture during the progression of CLD by visualizing and quantifying at a cellular level, tissue and organ scale.
Date Published: 1st Feb 2019
Journal: Clin Transl Gastroenterol
PubMed ID: 30702490
Citation: Clin Transl Gastroenterol. 2019 Jan;10(1):e00002. doi: 10.14309/ctg.0000000000000002.
Date Published: 19th May 2017
PubMed ID: 28520105
Citation: Hepatology. 2017 May 18. doi: 10.1002/hep.29268.