DEEP-HCC network

Overview

Overview
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DEEP-HCC - Detailed Analysis of the Spatial Organization of the Development of Hepatocellular Carcinoma

Programme: LiSyM-Krebs - Systemmedizinisches Forschungsnetz zur Früherkennung und Prävention von Leberkrebs

SEEK ID: https://seek.lisym.org/projects/18

Public web page: Not specified

Organisms: Homo sapiens, Mus musculus

FAIRDOM PALs: No PALs for this Project

Project created: 1st Dec 2021

Related items

Alain Becam

Projects: LiSyM network, Forschungsnetzwerk LiSyM-Krebs, LiSyM Pillar II: Chronic Liver Disease Progression (LiSyM-DP), LiSyM Core Infrastructure and Management (LiSyM-PD), LiSyM Pillar III: Regeneration and Repair in Acute-on-Chronic Liver Failure (LiSyM-ACLF), DEEP-HCC network

Institutions: HITS gGmbH

Thomas Berg

Projects: LiSyM-Krebs Partnering, SMART-NAFLD, DEEP-HCC network

Institutions: Universitätsklinikum Leipzig - Klinik und Poliklinik für Gastroenterologie, Sektion Hepatologie, Universität Leipzig - Sächsischer Inkubator für Klinische Translation (SIKT)

Nikolaus Berndt

Projects: LiSyM-Krebs Partnering, LiSyM network, LiSyM Pillar IV: Liver Function Diagnostics (LiSyM-LiFuDi), Forschungsnetzwerk LiSyM-Krebs, DEEP-HCC network

Institutions: Charité - Universitätsmedizin Berlin, Institute of Biochemistry, Computational Systems Biochemistry Group

Ina Biermayer

Projects: LiSyM network, LiSyM Pillar III: Regeneration and Repair in Acute-on-Chronic Liver Failure (LiSyM-ACLF), SMART-NAFLD, Forschungsnetzwerk LiSyM-Krebs, DEEP-HCC network, C-TIP-HCC network

Institutions: Deutsches Krebsforschungszentrum, HITS gGmbH

Roles: PhD Student, Postdoc

Expertise: Molecular Biology, Primary human hepatocytes, Systems Biology, wet lab, Signal transduction, Proteomics

Tools: Cell and tissue culture, Cell Isolation, Isolation and cultivation of mouse hepatocyte, Molecular Biology

Program management team LiSyM-Cancer (project and communications manager)

Former PhD student in LiSyM, at DKFZ Heidelberg in the group of Ursula Klingmüller

(née Schmitt)

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LiSyM-Krebs - Systemmedizinisches Forschungsnetz zur Früherkennung und Prävention von Leberkrebs

LiSyM-Krebs ist ein nationales Forschungsnetz zur Früherkennung und Prävention von Leberkrebs, das unter Verwendung des systemmedizinischen Forschungsansatzes die komplexen, dynamischen Prozesse der Krankheitsprogression analysiert, um ausgehend von den Erkenntnissen aus dem Forschungsnetz LiSyM die Entstehung von Leberkrebs besser zu verstehen, vorherzusagen und im besten Fall sogar zu verhindern. LiSyM-Krebs setzt die erfolgreichen Forschungsaktivitäten der BMBF-Vorgängerprogramme ...

Projects: LiSyM-Krebs Partnering, Forschungsnetzwerk LiSyM-Krebs, SMART-NAFLD, DEEP-HCC network, C-TIP-HCC network

Web page: https://www.lisym-cancer.org

Charité - Universitätsmedizin Berlin, Institute of Biochemistry, Computational Systems Biochemistry Group

Country: Germany

City: 10117 Berlin

Web page: https://biochemie.charite.de/

Helmholtz-Zentrum Dresden-Rossendorf

Country: Germany

City: Dresden

Web page: https://www.hzdr.de

HITS gGmbH

Country: Germany

City: 69118 Heidelberg

Web page: https://www.h-its.org/

Max Planck Institute of Molecular Cell Biology and Genetics

Country: Germany

City: 01307 Dresden

Web page: https://mpi-cbg.de

Universität Leipzig - Sächsischer Inkubator für Klinische Translation (SIKT)

Country: Germany

City: Leipzig

Web page: https://sikt.uni-leipzig.de/

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1 hidden item

Meeting minutes

Forschungsnetzwerk LiSyM-Krebs, SMART-NAFLD, DEEP-HCC network, C-TIP-HCC network

Documents submitted to BMBF

Submitter: Olga Krebs

Investigation: 1 hidden item

Assays: Meeting minutes 2021, Meeting minutes 2022

Snapshots: No snapshots

Created: 8th Feb 2021 at 09:17

Documents submitted to BMBF

Forschungsnetzwerk LiSyM-Krebs, SMART-NAFLD, DEEP-HCC network, C-TIP-HCC network

Documents submitted to BMBF

Submitter: Olga Krebs

Investigation: 1 hidden item

Assays: Project deliverables 2021, Project deliverables 2022, Project proposals

Snapshots: No snapshots

Created: 8th Feb 2021 at 09:16

1 hidden item

Project proposals

Forschungsnetzwerk LiSyM-Krebs, SMART-NAFLD, DEEP-HCC network, C-TIP-HCC network

Project proposals

Submitter: Olga Krebs

Biological problem addressed: Model Analysis Type

Investigation: 1 hidden item

Study: Documents submitted to BMBF

Organisms: No organisms

Models: No Models

SOPs: No SOPs

Data files: No Data files

Snapshots: No snapshots

Created: 8th Feb 2021 at 09:20, Last updated: 8th Feb 2021 at 09:21

Meeting minutes 2021

Forschungsnetzwerk LiSyM-Krebs, SMART-NAFLD, DEEP-HCC network, C-TIP-HCC network

Meeting minutes 2021

Submitter: Olga Krebs

Biological problem addressed: Model Analysis Type

Investigation: 1 hidden item

Study: Meeting minutes

Organisms: No organisms

Models: No Models

SOPs: No SOPs

Data files: No Data files

Snapshots: No snapshots

Created: 8th Feb 2021 at 09:25

Meeting minutes 2022

Forschungsnetzwerk LiSyM-Krebs, SMART-NAFLD, DEEP-HCC network, C-TIP-HCC network

Meeting minutes 2022

Submitter: Olga Krebs

Biological problem addressed: Model Analysis Type

Investigation: 1 hidden item

Study: Meeting minutes

Organisms: No organisms

Models: No Models

SOPs: No SOPs

Data files: No Data files

Snapshots: No snapshots

Created: 8th Feb 2021 at 09:25

Project deliverables 2021

Forschungsnetzwerk LiSyM-Krebs, SMART-NAFLD, DEEP-HCC network, C-TIP-HCC network

Project deliverables 2021

Submitter: Olga Krebs

Biological problem addressed: Model Analysis Type

Investigation: 1 hidden item

Study: Documents submitted to BMBF

Organisms: No organisms

Models: No Models

SOPs: No SOPs

Data files: No Data files

Snapshots: No snapshots

Created: 8th Feb 2021 at 09:26

Project deliverables 2022

Forschungsnetzwerk LiSyM-Krebs, SMART-NAFLD, DEEP-HCC network, C-TIP-HCC network

Project deliverables 2022

Submitter: Olga Krebs

Biological problem addressed: Model Analysis Type

Investigation: 1 hidden item

Study: Documents submitted to BMBF

Organisms: No organisms

Models: No Models

SOPs: No SOPs

Data files: No Data files

Snapshots: No snapshots

Created: 8th Feb 2021 at 09:26

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Hepatocyte polarity model

DEEP-HCC network

This model was used in the Modeling Workshop at the 2nd LiSyM-Cancer Status Seminar.

Creator: Lutz Brusch

Submitter: Lutz Brusch

Model type: Agent based modelling

Model format: MorpheusML

Environment: Morpheus

Organism: Not specified

Investigations: No Investigations

Studies: No Studies

Assays: No Assays

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Created: 28th Mar 2023 at 22:52, Last updated: 28th Mar 2023 at 22:52

Synthesis and In Vitro Biological Evaluation of p-Carborane-Based Di-tert-butylphenol Analogs

DEEP-HCC network

Abstract (Expand)

Targeting inflammatory mediators and related signaling pathways may offer a rational strategy for the treatment of cancer. The incorporation of metabolically stable, sterically demanding, and hydrophobic …

Authors: Sebastian Braun, Sanja Jelača, Markus Laube, Sven George, Bettina Hofmann, Peter Lönnecke, Dieter Steinhilber, Jens Pietzsch, Sanja Mijatović, Danijela Maksimović-Ivanić, Evamarie Hey-Hawkins

Date Published: 1st Jun 2023

Publication Type: Journal

DOI: 10.3390/molecules28114547

Citation: Molecules 28(11):4547

Created: 7th Jun 2023 at 12:03, Last updated: 7th Jun 2023 at 12:05

Isonimesulide and Its Carborane Analogues as Isoform‐Selective COX Inhibitors and Antitumor Agents

DEEP-HCC network

Abstract (Expand)

Nonsteroidal anti-inflammatory drugs (NSAIDs) are the most widely used therapeutics against pain, fever, and inflammation; additionally, antitumor properties are reported. NSAIDs reduce the synthesis …

Authors: Liridona Useini, Teodora Komazec, Markus Laube, Peter Lönnecke, Jonas Schädlich, Sanja Mijatović, Danijela Maksimović‐Ivanić, Jens Pietzsch, Evamarie Hey‐Hawkins

Date Published: 24th May 2023

Publication Type: Journal

DOI: 10.1002/adtp.202300117

Citation: Advanced Therapeutics,2300117

Created: 7th Jun 2023 at 12:09, Last updated: 7th Jun 2023 at 12:10

Hepatocyte apical bulkheads provide a mechanical means to oppose bile pressure

Forschungsnetzwerk LiSyM-Krebs, DEEP-HCC network

Abstract (Expand)

Hepatocytes grow their apical surfaces anisotropically to generate a 3D network of bile canaliculi (BC). BC elongation is ensured by apical bulkheads, membrane extensions that traverse the lumen and …

Authors: Maarten P. Bebelman, Matthew J. Bovyn, Carlotta M. Mayer, Julien Delpierre, Ronald Naumann, Nuno P. Martins, Alf Honigmann, Yannis Kalaidzidis, Pierre A. Haas, Marino Zerial

Date Published: 3rd Apr 2023

Publication Type: Journal

DOI: 10.1083/jcb.202208002

Citation: Journal of Cell Biology 222(4),e202208002

Created: 8th Feb 2023 at 18:16, Last updated: 8th Feb 2023 at 18:16

Shell engineering in soft alginate‐based capsules for culturing liver spheroids

DEEP-HCC network

Abstract (Expand)

Functional interaction between cancer cells and the surrounding microenvironment is still not sufficiently understood, which motivates the tremendous interest for the development of numerous in vitro …

Authors: Xuan Peng, Željko Janićijević, Sandy Lemm, Markus Laube, Jens Pietzsch, Michael Bachmann, Larysa Baraban

Date Published: 27th Mar 2023

Publication Type: Journal

DOI: 10.1002/biot.202200365

Citation: Biotechnology Journal,2200365

Created: 3rd Apr 2023 at 10:46, Last updated: 3rd Apr 2023 at 11:27

Solid-Phase Parallel Synthesis of Dual Histone Deacetylase-Cyclooxygenase Inhibitors

Forschungsnetzwerk LiSyM-Krebs, DEEP-HCC network

Abstract (Expand)

Multi-target drugs (MTDs) are emerging alternatives to combination therapies. Since both histone deacetylases (HDACs) and cyclooxygenase-2 (COX-2) are known to be overexpressed in several cancer types, …

Authors: Luisa M. Bachmann, Maria Hanl, Felix Feller, Laura Sinatra, Andrea Schöler, Jens Pietzsch, Markus Laube, Finn K. Hansen

Date Published: 1st Feb 2023

Publication Type: Journal

DOI: 10.3390/molecules28031061

Citation: Molecules 28(3):1061

Created: 26th Jan 2023 at 08:09, Last updated: 26th Jan 2023 at 08:10

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LiSyM Cancer Young Scientists Retreat (YSR)

Young Scientists Retreat (YSR) will take place from September 7th to 9th in Hofgeismar (close to Kassel) (https://tagungsstaette-hofgeismar.de/). Participation is mandatory for all PhD students, MD students and Postdocs in SMART-NAFLD, C-TIP-HCC and DEEP-HCC