LiSyM (Liver Systems Medicine) represents a research network of German centers and institutions, brought together by a 20 Million Euro funding program of the German Government, in which mathematicians, modelers, pharmacologists, molecular biologists and clinical scientists work together to develop a Systems Medicine approach to study early and advanced liver disease.
The aim of this unique research program is to acquire and use new experimental data and data from existing data bases to build computational models that facilitate decision making at the patient's bedsite and to predict the actions of new medicines in the treatment of metabolic liver disease.
Latest additions
Correction to: Meeting report from the fourth meeting of the Computational Modeling in Biology Network (COMBINE).
Publication - added 7 days ago- Focused scores enable reliable discrimination of small differences in steatosis.
Publication - added 25 days ago 
Zonated Quantification of Steatosis for Pharmacokinetics Simulations
Presentation - added about 1 month ago- Liver cancer cell lines distinctly mimic the metabolic gene expression pattern of the corresponding human tumours.
Publication - added about 1 month ago - Digitoxin metabolism by rat liver microsomes.
Publication - added about 1 month ago - Bile micro-infarcts in cholestasis are initiated by rupture of the apical hepatocyte membrane and cause shunting of bile to sinusoidal blood
Publication - added 2 months ago - Spatio-temporal visualization of the distribution of acetaminophen as well as its metabolites and adducts in mouse livers by MALDI MSI
Publication - added 2 months ago - Along the porto-central axis – Zone specific isolation of primary hepatocyte and its integration into a metabolic model
Presentation - added 2 months ago
Latest downloads
- The emerging field of morphogens in the adult liver of mice and human – a deep insight into distribution, interaction and regulation
Presentation - downloaded about 2 hours ago - FAIRDOM tutorial workshop SBMC2018 Bremen - Introduction into SABIO-RK
Presentation - downloaded about 3 hours ago 
LiSyM Evaluation Pillar III Hengstler
Presentation - downloaded about 4 hours ago
SOP FACS analysis of Macrophage population in healthy and fatty liver
SOP - downloaded about 4 hours ago- SOP RNA Isolation from healthy and fatty liver
SOP - downloaded about 4 hours ago 
SAC mice RNA microarray
Data file - downloaded about 5 hours ago
Patient biopsy sample type
Sample type - downloaded about 6 hours ago- Sample Collection and Preservation of Blood and Endometrial Tissue
SOP - downloaded about 6 hours ago
