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In one in five people with NAFLD, the functioning liver cells, the hepatocytes, are replaced by connective tissue. Eventually this fibrosis becomes irreversible. In this state the liver is like a ‘scar that never heals’. Through it, the liver loses many of its vital functions.
LiSyM-Pillar II wants to know more about which factors promote fibrosis and the conditions under which fibrosis becomes irreversible How can fibrosis be diagnosed as early as possible? Researchers in the pillar are also developing anti-fibrotic drugs, but these are not yet available.
Programme: LiSyM: Liver Systems Medicine
SEEK ID: https://seek.lisym.org/projects/4
Public web page: http://www.lisym.org/our-work/pillar-research
Organisms: Mus musculus, Rattus rattus, Rattus norvegicus, Homo sapiens
FAIRDOM PALs: Janine Koehncke, Annika Schneider, Daniel Lill, Seddik Hammad, Matthias Reichert
Project start date: 1st Jan 2016
Related items
- People (46)
- Institutions (14)
- Investigations (2+1)
- Studies (1+3)
- Assays (1+5)
- Data files (12+38)
- SOPs (3)
- Publications (55)
- Presentations (30+24)
- Events (5+2)
- Documents (0+6)
Projects: LiSyM Core Infrastructure and Management (LiSyM-PD), LiSyM Pillar II: Chronic Liver Disease Progression (LiSyM-DP), LiSyM Pillar I: Early Metabolic Injury (LiSyM-EMI), LiSyM Pillar IV: Liver Function Diagnostics (LiSyM-LiFuDi), LiSyM Pillar III: Regeneration and Repair in Acute-on-Chronic Liver Failure (LiSyM-ACLF), LiSyM network, LiSyM Scientific Leadership Team (LiSyM-LT)
Institutions: University of Freiburg - Institute of Physics, LiSyM programme directorate

Projects: LiSyM Pillar II: Chronic Liver Disease Progression (LiSyM-DP), LiSyM Pillar III: Regeneration and Repair in Acute-on-Chronic Liver Failure (LiSyM-ACLF), LiSyM network, LiSyM-Krebs Partnering, LiSyM-Krebs
Institutions: Universitätsklinikum Düsseldorf - Klinik für Gastroenterologie, Hepatologie und Infektiologie
Roles: Project Coordinator
Expertise: Liver injury and regeneration, Inflammation, Jak/STAT pathway, Hepatocytes, Imaging and image analysis, non parenchymal cells
Tools: Immunohistochemistry, Isolation and cultivation of mouse hepatocyte, Isolation purification and separation, Molecular Biology, Mouse surgery, Cell and tissue culture, confocal microscopy
Person responsible: Seddik Hammad
Snapshots: No snapshots
Investigation: Julia/Yan
Assays: Metabolic CCl4
Investigation: Julia/Yan
Study: CCl4 Treatment in mice
Organisms: Mus musculus
SOPs: Sample Collection and Preservation of Blood and...
Data files: Movies for quantification, SAC mice RNA microarray and 1 hidden item
GitHub repository containing the analysis code
Creator: Christian Holland
Submitter: Christian Holland
Investigations: No Investigations
Studies: No Studies
Assays: No Assays
GitHub repository that contains all analyses scripts to reproduce the results reported in "Transfer of regulatory knowledge from human to mouse for functional genomics analysis"
Creator: Christian Holland
Submitter: Christian Holland
Investigations: No Investigations
Studies: No Studies
Assays: No Assays
Creators: None
Submitter: Seddik Hammad
Investigations: No Investigations
Studies: No Studies
Assays: No Assays
Creators: None
Submitter: Seddik Hammad
Investigations: No Investigations
Studies: No Studies
Assays: No Assays
Creator: Sonja Kleeschulte
Submitter: Sonja Kleeschulte
Investigations: No Investigations
Studies: No Studies
Assays: No Assays
Non-parenchymal liver cells are isolated and staining for FACS analysis
Creator: Sonja Kleeschulte
Submitter: Sonja Kleeschulte
Investigations: No Investigations
Studies: No Studies
Assays: No Assays
Macrophage staining in paraffin-embedded tissue
Creator: Sonja Kleeschulte
Submitter: Sonja Kleeschulte
Investigations: No Investigations
Studies: No Studies
Assays: No Assays
Abstract (Expand)
Authors: D. Heinrichs, E. F. Brandt, P. Fischer, Janine Koehncke, Theresa H. Wirtz, N. Guldiken, S. Djudjaj, P. Boor, D.Kroy, R. Weiskirchen, Richard Bucala, H.E. Wasmuth, P. Strnad, Christian Trautwein, J. Bernhagen, M. L. Berres
Date Published: 28th Jan 2021
Publication Type: Journal
Citation:
Abstract (Expand)
Authors: Christian H. Holland, Jovan Tanevski, Javier Perales-Patón, Jan Gleixner, Manu P. Kumar, Elisabetta Mereu, Brian A. Joughin, Oliver Stegle, Douglas A. Lauffenburger, Holger Heyn, Bence Szalai, Julio Saez-Rodriguez
Date Published: 1st Dec 2020
Publication Type: Journal
DOI: 10.1186/s13059-020-1949-z
Citation: Genome Biol 21(1),36
Abstract
Authors: Theresa H. Wirtz, Philipp A. Reuken, Christian Jansen, Petra Fischer, Irina Bergmann, Christina Backhaus, Christoph Emontzpohl, Johanna Reißing, Elisa F. Brandt, M. Teresa Koenen, Kai M. Schneider, Robert Schierwagen, Maximilian J. Brol, Johannes Chang, Henning W. Zimmermann, Nilay Köse-Vogel, Thomas Eggermann, Ingo Kurth, Christian Stoppe, Richard Bucala, Jürgen Bernhagen, Michael Praktiknjo, Andreas Stallmach, Christian Trautwein, Jonel Trebicka, Tony Bruns, Marie-Luise Berres
Date Published: 1st Dec 2020
Publication Type: Journal
DOI: 10.1016/j.jhepr.2020.100221
Citation: JHEP Reports:100221
Abstract (Expand)
Authors: N. Boissier, D. Drasdo, I. E. Vignon-Clementel
Date Published: 29th Nov 2020
Publication Type: Journal
PubMed ID: 33249746
Citation: Int J Numer Method Biomed Eng. 2020 Nov 29:e3422. doi: 10.1002/cnm.3422.
Abstract
Authors: Kamalakannan Radhakrishnan, Yong-Hoon Kim, Yoon Seok Jung, Jina Kim, Don-Kyu Kim, Sung Jin Cho, In-Kyu Lee, Steven Dooley, Chul-Ho Lee, Hueng-Sik Choi
Date Published: 1st Oct 2020
Publication Type: Journal
DOI: 10.3390/ijms21197148
Citation: IJMS 21(19):7148
The meeting will provide a great opportunity for discussion between modellers, experimentalists and clinicians and to organize and harmonize our future work within the LiSyM network on the grassroot level.
Start Date: 20th Nov 2017
End Date: 22nd Nov 2017
Event Website: Not specified
Country: Germany
City: Hünfeld
This summit will cover both the basic and translational / clinical aspects of NAFLD, with a specific focus on novel drug target and prognostic signature development.
Key sessions include all crucial pathophysiological aspects currently known to affect development and progression of NAFLD, such as "lipid metabolism and lipotoxicity" and "insulin resistance, insulin and hormonal signaling". Furthermore, oxidative stress, ER stress, and mitochondrial dysfunction will be addressed. On the second day,
...
Start Date: 9th Nov 2017
End Date: 11th Nov 2017
Event Website: https://events.easl.eu/EventPortal/Information/EventInformation.aspx?EventInformationPageCode=HOME&EventCode=nafld2017
Country: Italy
City: Rome
ICSB continues to be the flagship conference of the International Society for Systems Biology (ISSB). The conference will cover a variety of themes from Fundamental Biological Sciences, Network Analysis, to Metabolic Engineering and Cancer Biology. The conference will also include a variety of engaging plenary lectures, parallel sessions, poster sessions, and interactive networking opportunities.
Abstract submission deadline: May 13th, 2017
Country: United States
City: Blacksburg, Virginia
The International Conference on Systems Biology of Human Disease (SBHD) is a transatlantic event and communication platform for scientific exchange that takes place alternately between the United States and Germany.
SBHD 2017 is continuing a conference series launched by Peter Sorger and colleagues from Harvard Medical School in 2008. The conference focus is on mammalian systems biology, particularly on its application to human disease and therapy.
Start Date: 5th Jul 2017
End Date: 7th Jul 2017
Event Website: http://www.sbhd-conference.org/2017/index.php
Country: Germany
City: Heidelberg
This event is a jointly organized Data Management PALs Meeting that involves PALs from the German LiSyM (Liver Systems Medicine) network and from the ERASysAPP (ERA-Net for Systems Biology Applications) initiative. PALs (Project Area Liaisons) are the front line experts of the data management teams of these projects. They act as data management advocates and help gathering user requirements and testing potential data management solutions. An important part of the meeting will be to gather the
...
Country: Germany
City: 36088 Hünfeld bei Fulda