Investigation of the Smad Protein Complex Formation and Its Link toGeneExpression

Upon stimulation of cells with transforming growth factorb(TGF-b),Smad proteins form trimeric complexes and activate a broad spectrum of target genes. It remains unresolved which of the possible Smad complexes are formed in cellular contexts and how these contribute to gene expression. Combining quantitative mass spectrometry with a computational selection strategy, we investigate Smad complexes in the mouse hepatoma cell line Hepa1-6.

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Philippe Lucarelli

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Created: 28th Mar 2023 at 13:46

Last updated: 22nd May 2023 at 13:39

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