Early Metabolic Injury (LiSyM-EMI - Pillar I)
OverviewNon-alcoholic fatty liver disease (NAFLD) is the most common chronic liver disease worldwide. LiSyM-EMI looks into the transition from steatosis to non-alcoholic steatohepatitis (NASH) as the disease-defining moment in NAFLD. A systems analysis of these early disease events will be performed to elucidate the molecular mechanisms that trigger disease establishment.
SEEK ID: https://seek.lisym.org/projects/3
Public web page: Not specified
Organisms: Mus musculus, Rattus rattus, Rattus norvegicus
FAIRDOM PALs: Vincent Moser, Lutz Brusch, Annika Schneider, Mario Brosch, Josch Pauling
Project created: 21st Feb 2017
Related items
https://orcid.org/0000-0003-0137-5106
Projects: Chronic Liver Disease Progression (LiSyM-DP - Pillar II), Early Metabolic Injury (LiSyM-EMI - Pillar I), LiSyM Core Infrastructure and Management (LiSyM-PD), LiSyM network, LiSyM Scientific Leadership Team, Liver Function Diagnostics (LiSyM-LiFuDi - Pillar IV), Model Guided Pharmacotherapy In Chronic Liver Disease (LiSyM-MGP), Molecular Steatosis - Imaging & Modeling (LiSyM-MSIM), Multi-Scale Models for Personalized Liver Function Tests (LiSyM-MM-PLF), Project Management PTJ, Regeneration and Repair in Acute-on-Chronic Liver Failure (LiSyM-ACLF - Pillar III), The Hedgehog Signalling Pathway (LiSyM-JGMMS)
Institutions: LiSyM programme directorate
Country: 
Germany
City: 79104 Freiburg im Breisgau
Country: Germany
City: 17475 Greifswald
Web page: http://www2.medizin.uni-greifswald.de/bioinformatik/
Snapshots: No snapshots
BACKGROUND & AIMS: Nonalcoholic fatty liver disease (NAFLD) is the most common chronic liver disorder in industrialized countries. Mouse models of NAFLD have been used in studies of pathogenesis and treatment, and have certain features of the human disease. We performed a systematic transcriptome-wide analysis of liver tissues from patients at different stages of NAFLD progression (ranging from healthy obese individuals to those with steatosis), as well as rodent models of NAFLD, to identify
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Creators: Mario Brosch, Jochen Hampe, Clemens Schafmayer, Witigo Von Schönfels
Contributor: Mario Brosch
BACKGROUND & AIMS: Nonalcoholic fatty liver disease (NAFLD) is the most common chronic liver disorder in industrialized countries. Mouse models of NAFLD have been used in studies of pathogenesis and treatment, and have certain features of the human disease. We performed a systematic transcriptome-wide analysis of liver tissues from patients at different stages of NAFLD progression (ranging from healthy obese individuals to those with steatosis), as well as rodent models of NAFLD, to identify
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Creators: Mario Brosch, Jochen Hampe, Clemens Schafmayer, Witigo Von Schönfels
Contributor: Mario Brosch
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Morpheus is the modelling and simulation framework for multicellular systems biology developed at Technische Universität Dresden.
Manual, examples and binaries for Windows, Linux, MacOS at: https://imc.zih.tu-dresden.de/wiki/morpheus
Open source code at: https://gitlab.com/morpheus.lab/morpheus
Creators: Lutz Brusch, Jörn Starruß, Walter de Back, Andreas Deutsch
Contributor: Lutz Brusch
Model type: Agent based modelling
Model format: MorpheusML
Environment: Morpheus
The model is adapted from A.P. Kupinski, I. Raabe, M. Michel, D. Ail, L. Brusch, T. Weidemann, C. Bökel (2013) Phosphorylation of the Smo tail is controlled by membrane localization and is dispensable for clustering, J. Cell Sci., 126, 20, 4684-4697 doi: 10.1242/jcs.128926
The model format is MorpheusML that can readily be loaded and run in Morpheus: https://imc.zih.tu-dresden.de//wiki/morpheus
Creator: Lutz Brusch
Contributor: Lutz Brusch
Model type: Ordinary differential equations (ODE)
Model format: MorpheusML
Environment: Morpheus
This model describes a core process during endocytosis. Intracellular vesicles called early endosomes contain the endocytosed cargo, e.g. signaling components like growth factors and RTKs, pathogens like viruses and nutrients like iron in transferrin. Early endosomes form an interacting pool of thousands of vesicles and jointly constitute the sorting and transport machinery in the endocytic pathway. Together with the cargo, membrane components travel to other compartments of the pathway which
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Creator: Lutz Brusch
Contributor: Lutz Brusch
Model type: Partial differential equations (PDE)
Model format: SBML
Environment: AUTO2000
Abstract (Expand)
Authors: C. Franke, U. Repnik, S. Segeletz, N. Brouilly, Y. Kalaidzidis, J. M. Verbavatz, Marino Zerial
Date Published: 17th Jun 2019
Journal: Traffic
Abstract (Expand)
Authors: H. Morales-Navarrete, H. Nonaka, A. Scholich, F. Segovia-Miranda, W. de Back, K. Meyer, R. L. Bogorad, V. Koteliansky, Lutz Brusch, Y. Kalaidzidis, F. Julicher, B. M. Friedrich, Marino Zerial
Date Published: 17th Jun 2019
Journal: Elife
Abstract (Expand)
Authors: Oleksandr Ostrenko, Jochen Hampe, Lutz Brusch
Date Published: 1st Dec 2019
Journal: Sci Rep
Abstract (Expand)
Authors: N. Heits, Mario Brosch, A. Herrmann, R. Behrens, C. Rocken, H. Schrem, A. Kaltenborn, J. Klempnauer, H. H. Kreipe, B. Reichert, C. Lenschow, C. Wilms, T. Vogel, H. Wolters, E. Wardelmann, D. Seehofer, S. Buch, S. Zeissig, S. Pannach, N. Raschzok, M. Dietel, W. von Schoenfels, S. Hinz, A. Teufel, M. Evert, A. Franke, Ann-Kristin Becker, F. Braun, Jochen Hampe, Clemens Schafmayer
Date Published: 12th Jul 2018
Journal: Transplantation
Abstract (Expand)
Authors: Ryoichi Fujiwara, Mathias Haag, Elke Schaeffeler, Anne T. Nies, Ulrich M. Zanger, Matthias Schwab
Date Published: 1st Apr 2018
Journal: Hepatology
Shotgun lipidomics of microdissected periportal and pericentral zones; Characterization of NAFLD in Human Liver Biopsies by Shotgun Lipidomics
Creators: Oskar Knittelfelder, Olga Vvedenskaya
Contributor: Oskar Knittelfelder
The meeting will provide a great opportunity for discussion between modellers, experimentalists and clinicians and to organize and harmonize our future work within the LiSyM network on the grassroot level.
Start Date: 20th Nov 2017
End Date: 22nd Nov 2017
Event Website: Not specified
Country: Germany
City: Hünfeld
The International Conference on Systems Biology of Human Disease (SBHD) is a transatlantic event and communication platform for scientific exchange that takes place alternately between the United States and Germany.
SBHD 2017 is continuing a conference series launched by Peter Sorger and colleagues from Harvard Medical School in 2008. The conference focus is on mammalian systems biology, particularly on its application to human disease and therapy.
Start Date: 5th Jul 2017
End Date: 7th Jul 2017
Event Website: http://www.sbhd-conference.org/2017/index.php
Country: Germany
City: Heidelberg
This summit will cover both the basic and translational / clinical aspects of NAFLD, with a specific focus on novel drug target and prognostic signature development.
Key sessions include all crucial pathophysiological aspects currently known to affect development and progression of NAFLD, such as "lipid metabolism and lipotoxicity" and "insulin resistance, insulin and hormonal signaling". Furthermore, oxidative stress, ER stress, and mitochondrial dysfunction will be addressed. On the second day,
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Start Date: 9th Nov 2017
End Date: 11th Nov 2017
Event Website: https://events.easl.eu/EventPortal/Information/EventInformation.aspx?EventInformationPageCode=HOME&EventCode=nafld2017
Country: 
Italy
City: Rome
ICSB continues to be the flagship conference of the International Society for Systems Biology (ISSB). The conference will cover a variety of themes from Fundamental Biological Sciences, Network Analysis, to Metabolic Engineering and Cancer Biology. The conference will also include a variety of engaging plenary lectures, parallel sessions, poster sessions, and interactive networking opportunities.
Abstract submission deadline: May 13th, 2017
Country: 
United States
City: Blacksburg, Virginia
This event is a jointly organized Data Management PALs Meeting that involves PALs from the German LiSyM (Liver Systems Medicine) network and from the ERASysAPP (ERA-Net for Systems Biology Applications) initiative. PALs (Project Area Liaisons) are the front line experts of the data management teams of these projects. They act as data management advocates and help gathering user requirements and testing potential data management solutions. An important part of the meeting will be to gather the
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Country: Germany
City: 36088 Hünfeld bei Fulda
