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mouse <Mus musculus>
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Non-alcoholic fatty liver disease (NAFLD) is the most common chronic liver disease worldwide. LiSyM-EMI looks into the transition from steatosis to non-alcoholic steatohepatitis (NASH) as the disease-defining moment in NAFLD. A systems analysis of these early disease events will be performed to elucidate the molecular mechanisms that trigger disease establishment.
Chronic liver diseases (CLD) progression leads to cirrhosis, often cancer, and ultimately to organ failure and death. Because of the complexity of this scenario, a Systems Medicine approach is chosen to develop strategies to better characterize progression and resolution of fibrosis. Pillar II aims to define key molecular mechanisms and structural changes in tissue architecture during the progression of CLD by visualizing and quantifying at a cellular level, tissue and organ scale.
Identification of key processes leading to non-alcoholic fatty liver disease (NAFLD) and its progression to non-alcoholic steato-hepatitis (NASH): Based on the finding within the Virtual Liver Network that the Hedgehog signalling pathway is a core player in the regulation of liver lipid metabolism, this project aims to characterize and model the central role of Hedgehog signalling during the transition from benign steatosis to NAFLD and NASH using patient data and large data sets from various