LiSyM Pillar II: Chronic Liver Disease Progression (LiSyM-DP) (Universitätsklinikum Düsseldorf - Klinik für Gastroenterologie, Hepatologie und Infektiologie) ; LiSyM Pillar III: Regeneration and Repair in Acute-on-Chronic Liver Failure (LiSyM-ACLF) (Universitätsklinikum Düsseldorf - Klinik für Gastroenterologie, Hepatologie und Infektiologie) ; LiSyM network (Universitätsklinikum Düsseldorf - Klinik für Gastroenterologie, Hepatologie und Infektiologie)
In one in five people with NAFLD, the functioning liver cells, the hepatocytes, are replaced by connective tissue. Eventually this fibrosis becomes irreversible. In this state the liver is like a ‘scar that never heals’. Through it, the liver loses many of its vital functions.
LiSyM-Pillar II wants to know more about which factors promote fibrosis and the conditions under which fibrosis becomes irreversible How can fibrosis be diagnosed as early as possible? Researchers in the pillar are also
In chronic diseases, at some point the liver can suddenly stop functioning. This is called acute-on-chronic liver failure, or ACLF. This is the leading cause of death in liver patients and is often provoked by the use of transcription or freely available drugs or alcohol abuse. For this condition we need an effective treatment quickly.
LiSyM-Pillar III researches the factors that contribute significantly to ACLF. What exactly happens then? Are there any early signs that would enable ACLF to be