City: 40225 Düsseldorf
Tools: Cytometry and fluorescent microscopy, Mouse surgery, Cell and tissue culture, RNA analysis, confocal microscopy, rtPCR, Milliplex analysis, Isolation and cultivation of mouse hepatocyte, Immunohistochemistry, qPCR, Preparation and differentiation of bone marrow derived macrophages, Mouse experiments in vivo (LPS PHx MCMV), Molecular Biology, Laser scan microscopy
I received my diploma in biology in 2001 from the Heinrich-Heine-University in Duesseldorf and the Dr. rer. nat. (Ph.D.) degree in 2006 from the University of Hohenheim in Germany. The practical part of my Ph.D. thesis had been realized at the clinic for gastroenterology, hepatology and infectiology at the university hospital in Duesseldorf. After my Ph.D. I focussed my studies on LPS-, PHx- and CMV-induced MAP-kinase-regulated intra- or intercellular signal transduction and immune cell recruitment
Roles: Project Coordinator
The incidence of this life-threatening acute-on-chronic liver failure (ACLF) is increasing, and early detection and cure are urgent clinical needs. Pillar III applies a Systems Medicine approach to identify the critical mechanisms of acute-on-chronic liver failure (ACLF) and to foster liver regeneration and repair.
Public web page: Not specified
Organisms: Not specified
Chronic liver diseases (CLD) progression leads to cirrhosis, often cancer, and ultimately to organ failure and death. Because of the complexity of this scenario, a Systems Medicine approach is chosen to develop strategies to better characterize progression and resolution of fibrosis. Pillar II aims to define key molecular mechanisms and structural changes in tissue architecture during the progression of CLD by visualizing and quantifying at a cellular level, tissue and organ scale.