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Web page: https://www.h-its.org/
Country: Germany
City: 69118 Heidelberg
Address:
Schloss-Wolfsbrunnenweg 35
Related items
Projects: LiSyM Core Infrastructure and Management (LiSyM-PD), LiSyM Pillar I: Early Metabolic Injury (LiSyM-EMI), LiSyM Pillar II: Chronic Liver Disease Progression (LiSyM-DP), LiSyM Pillar III: Regeneration and Repair in Acute-on-Chronic Liver Failure (LiSyM-ACLF), LiSyM Pillar IV: Liver Function Diagnostics (LiSyM-LiFuDi), Model Guided Pharmacotherapy In Chronic Liver Disease (LiSyM-MGP), Molecular Steatosis - Imaging & Modeling (LiSyM-MSIM), The Hedgehog Signalling Pathway (LiSyM-JGMMS), Multi-Scale Models for Personalized Liver Function Tests (LiSyM-MM-PLF), LiSyM PALs, LiSyM network, LiSyM-Krebs Partnering
Institutions: HITS gGmbH

Expertise: Data Management, Databases, Biochemistry, Bioinformatics, Systems Biology, Standards
Tools: kinetic modelling, Databases, Mathematical Modelling, Ontologies, Workflows
Data management and standardization expert for systems biology and systems medicine, responsible for the data management user requirements and user contacts within the German LiSyM network (Liver Systems Medicine: http://lisym.org/) and associated to the FAIRDOM team.
Involved in different standardization initiatives and committees, i.e. COMBINE (http://co.mbine.org), ISO/TC 276 Biotechnology (https://www.iso.org/committee/4514241.html), European COST action CHARME (http://www.cost-charme.eu) and
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Projects: LiSyM Core Infrastructure and Management (LiSyM-PD), LiSyM network, LiSyM PALs, LiSyM Pillar II: Chronic Liver Disease Progression (LiSyM-DP), LiSyM Pillar I: Early Metabolic Injury (LiSyM-EMI), LiSyM Pillar IV: Liver Function Diagnostics (LiSyM-LiFuDi), LiSyM Pillar III: Regeneration and Repair in Acute-on-Chronic Liver Failure (LiSyM-ACLF)
Institutions: HITS gGmbH
Projects: LiSyM PALs, LiSyM network, LiSyM Pillar I: Early Metabolic Injury (LiSyM-EMI), LiSyM Pillar III: Regeneration and Repair in Acute-on-Chronic Liver Failure (LiSyM-ACLF), LiSyM Pillar II: Chronic Liver Disease Progression (LiSyM-DP), LiSyM Pillar IV: Liver Function Diagnostics (LiSyM-LiFuDi), LiSyM Core Infrastructure and Management (LiSyM-PD), LiSyM-Krebs Partnering, Molecular Steatosis - Imaging & Modeling (LiSyM-MSIM), Multi-Scale Models for Personalized Liver Function Tests (LiSyM-MM-PLF), The Hedgehog Signalling Pathway (LiSyM-JGMMS), LiSyM-Krebs
Institutions: HITS gGmbH
Expertise: big data, Systems Biology, Genetics, wet lab
Tools: SEEK, openBis, Protege, Copasi, JWS online RightFiled
I am a researcher at the Scientific Databases and Visualization Group at Heidelberg Institute for Theoretical Studies (HITS) , one of the developers of SabioRK - System for the Analysis of Biochemical Pathways - Reaction Kinetics (http://sabiork.h-its.org/) . I am working on design and maintenance of the information systems to store, query and analyse systems biology data; definition and implementation of methods for the integration of data from multiple sources. In SySMO-DB project
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Projects: LiSyM PALs, LiSyM network, LiSyM Core Infrastructure and Management (LiSyM-PD)
Institutions: HITS gGmbH
Expertise: computational biology, Data Management, Bioinformatics
Tools: Databases, Python, Ruby on Rails, Molecular Dynamics Simulations, Javascript
Projects: LiSyM Core Infrastructure and Management (LiSyM-PD)
Institutions: HITS gGmbH
LiSyM-Krebs
Programme: LiSyM-Krebs
Public web page: Not specified
Organisms: Homo sapiens
Day-to-day science within the LiSyM is overseen and directed by the the LiSyM Scientific Leadership Team. This coordination team comprises the pillar coordinators and additional LiSyM members, and ensures smooth interaction between multi-skilled groups, often working in different institutions and across significant distances within Germany.
Programme: LiSyM: Liver Systems Medicine
Public web page: http://www.lisym.org/who-we-are
Organisms: Not specified
Dr. Ahmed Ghallab (TU University, Dortmund) deals with chronic liver damage caused by toxins. In addition, he investigates processes associated with cholestasis - when bile accumulates in the bile ducts. Ghallab has been able to explain basic mechanisms of acute cholestasis, using a method for intravital two-photon microscopy, which he developed.
Programme: LiSyM: Liver Systems Medicine
Public web page: http://www.lisym.org/our-work/junior-group/the-liver-protects-itself
Start date: 1st Jan 2016
Organisms: Homo sapiens, Mus musculus
Major infrastructure backbone of the whole LiSyM network. It comprises the core management tasks of the program directorate and the scientific project management, as well as the central data management. The data management concept relies on FAIRDOM (http://fair-dom.org) and uses the LiSyM SEEK platform as a major hub for exchanging data, models, SOPs and other information, as well as yellow pages for the projects with its corresponding members, institutions, events, presentations and publications.
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Programme: LiSyM: Liver Systems Medicine
Public web page: http://www.lisym.org/our-work/data-management
Start date: 1st Jan 2016
Organisms: Not specified
One of the tasks of the healthy liver is to store fat. Yet, at some stage, too much fat makes the liver sick. One critical time point occurs when a healthy fatty liver becomes inflamed and progresses to steatohepatitis, or NASH.
LiSyM-Pillar I will identify what events lead to this transition. Does it occur in all parts of the liver? Which molecules indicate that it is taking place? Can the degeneration be stopped or undone - and if so, how?
Programme: LiSyM: Liver Systems Medicine
Public web page: http://www.lisym.org/our-work/pillar-research/zones-of-the-liver
Start date: 1st Jan 2016
Organisms: Mus musculus, Rattus rattus, Rattus norvegicus, Homo sapiens