Abstract (Expand)

Repeated administration of hepatotoxicants is usually accompanied by liver fibrosis. However, the difference in response as a result of repeated exposures of acetaminophen (APAP) compared to a single ...

Author: Seddik Hammad

Date Published: 6th Feb 2019

Journal: EXCLI

Abstract (Expand)

BACKGROUND: Liver transplantation (LTx) is a potentially curative treatment option for hepatocellular carcinoma (HCC) in cirrhosis. However, patients, where HCC is already a systemic disease, LTx may ...

Authors: Mario Brosch, Ann-Kristin Becker, Jochen Hampe, Clemens Schafmayer, Heits N.,Herrmann A.,Behrens R.,Rocken C.,Schrem H.,Kaltenborn A.,Klempnauer J.,Kreipe H. H.,Reichert B.,Lenschow C.,Wilms C.,Vogel T.,Wolters H.,Wardelmann E.,Seehofer D.,Buch S.,Zeissig S.,Pannach S.,Raschzok N.,Dietel M.,von Schoenfels W.,Hinz S.,Teufel A.,Evert M.,Franke A.,Braun F.

Date Published: 12th Jul 2018

Journal: Transplantation


Not specified

Authors: Seddik Hammad, Julia Werle, Steven Dooley, Lai Dilay,Teng Feng,Maas Thorsten,Teufel Andreas,Muckenthaler Martina U.,Vujić Spasić Maja

Date Published: 1st Feb 2018

Journal: Blood

Abstract (Expand)

Alcohol abuse is a global health problem causing a substantial fraction of chronic liver diseases. Abundant TGF-beta-a potent pro-fibrogenic cytokine-leads to disease progression. Our aim was to elucidate ...

Authors: Steven Dooley, Gaitantzi H.,Meyer C.,Rakoczy P.,Thomas M.,Wahl K.,Wandrer F.,Bantel H.,Alborzinia H.,Wolfl S.,Ehnert S.,Nussler A.,Bergheim I.,Ciuclan L.,Ebert M.,Breitkopf-Heinlein K.

Date Published: 21st Jan 2018

Journal: Cell Death Dis

Abstract (Expand)

Upon liver intoxication with malnutrition or high-fat diet feeding, fibrinogen is synthesized by hepatocytes and secreted into the blood in human and mouse. Its primary function is to occlude blood ...

Authors: Steven Dooley, Zhang Y.,Kim D. K.,Jung Y. S.,Kim Y. H.,Lee Y. S.,Kim J.,Jeong W. I.,Lee I. K.,Cho S. J.,Lee C. H.,Choi H. S.

Date Published: 19th Jul 2018

Journal: Arch Toxicol

Abstract (Expand)

MicroRNA (miRNA)-mediated gene regulation contributes to liver pathophysiology, including hepatic stellate cell (HSC) activation and fibrosis progression. Here, we investigated the role of miR-942 in ...

Authors: Steven Dooley, Tao L.,Xue D.,Shen D.,Ma W.,Zhang J.,Wang X.,Zhang W.,Wu L.,Pan K.,Yang Y.,Nwosu Z. C.,Seki E.,Liu C.

Date Published: 12th Aug 2018

Journal: Arch Toxicol


Not specified

Authors: Ersin Karatayli, Susanne Weber, Steven Dooley, Frank Lammert, Hall Rabea A.

Date Published: 1st Feb 2019

Journal: Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease

Abstract (Expand)

The considerable difficulty encountered in reproducing the results of published dynamical models limits validation, exploration and reuse of this increasingly large biomedical research resource. To ...

Authors: Matthias König, Medley J. K.,Choi K.,Smith L.,Gu S.,Hellerstein J.,Sealfon S. C.,Sauro H. M.

Date Published: 16th Jun 2018

Journal: PLoS Comput Biol

Abstract (Expand)

Here we present Tellurium, a Python-based environment for model building, simulation, and analysis that facilitates reproducibility of models in systems and synthetic biology. Tellurium is a modular, ...

Authors: Matthias König, Choi K.,Medley J. K.,Stocking K.,Smith L.,Gu S.,Sauro H. M.

Date Published: 28th Jul 2018

Journal: Biosystems

Abstract (Expand)

The creation of computational simulation experiments to inform modern biological research poses challenges to reproduce, annotate, archive, and share such experiments. Efforts such as SBML or CellML ...

Authors: Matthias König, Bergmann F. T.,Cooper J.,Moraru I.,Nickerson D.,Le Novere N.,Olivier B. G.,Sahle S.,Smith L.,Waltemath D.

Date Published: 20th Mar 2018

Journal: J Integr Bioinform


Not specified

Authors: Frank Lammert, Steven Dooley, Shen Zhe,Liu Yan,Dewidar Bedair,Hu Junhao,Park Ogyi,Feng Teng,Xu Chengfu,Yu Chaohui,Li Qi,Meyer Christoph,Ilkavets Iryna,Müller Alexandra,Stump-Guthier Carolin,Munker Stefan,Liebe Roman,Zimmer Vincent,Mertens Peter R.,Li Hai,ten Dijke Peter,Augustin Hellmut G.,Li Jun,Gao Bin,Ebert Matthias P.,Li Youming,Weng Hong-Lei

Date Published: 1st Jul 2016

Journal: The American Journal of Pathology

Abstract (Expand)

BACKGROUND: Although metabolism is profoundly altered in human liver cancer, the extent to which experimental models, e.g. cell lines, mimic those alterations is unresolved. Here, we aimed to determine ...

Authors: Ute Hofmann, Steven Dooley, Nwosu Z. C.,Battello N.,Rothley M.,Pioronska W.,Sitek B.,Ebert M. P.,Sleeman J.,Wolfl S.,Meyer C.,Megger D. A.

Date Published: 5th Sep 2018

Journal: J Exp Clin Cancer Res

Abstract (Expand)

Neurotoxic bilirubin is the end product of heme catabolism in mammals. Bilirubin is solely conjugated by uridine diphospho-glucuronosyltransferase 1A1, which is a membrane-bound enzyme that catalyzes ...

Authors: Matthias Schwab, Fujiwara Ryoichi,Haag Mathias,Schaeffeler Elke,Nies Anne T.,Zanger Ulrich M.

Date Published: 1st Apr 2018

Journal: Hepatology

Abstract (Expand)

In this review we develop the argument that cholestatic liver diseases, particularly primary biliary cholangitis and primary sclerosing cholangitis (PSC), evolve over time with anatomically an ascending ...

Authors: Peter Jansen, Ahmed Ghallab, Nachiket Vartak, Frank Lammert, Jochen Hampe, Jan Hengstler, Reif R.

Date Published: 17th Feb 2017

Journal: Hepatology

Abstract (Expand)

Dynamic polarisation of tumour cells is essential for metastasis. While the role of polarisation during dedifferentiation and migration is well established, polarisation of metastasising tumour cells ...

Authors: Amruta Damle Vartak, Nachiket Vartak, Lorentzen A.,Becker P. F.,Kosla J.,Saini M.,Weidele K.,Ronchi P.,Klein C.,Wolf M. J.,Geist F.,Seubert B.,Ringelhan M.,Mihic-Probst D.,Esser K.,Roblek M.,Kuehne F.,Bianco G.,O'Connor T.,Muller Q.,Schuck K.,Lange S.,Hartmann D.,Spaich S.,Gross O.,Utikal J.,Haferkamp S.,Sprick M. R.,Hapfelmeier A.,Huser N.,Protzer U.,Trumpp A.,Saur D.,Klein C. A.,Polzer B.,Borsig L.,Heikenwalder M.

Date Published: 2nd Mar 2018

Journal: Nat Commun

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