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Wet-tip versus dry-tip regimes of osmotically driven fluid flow

Early Metabolic Injury (LiSyM-EMI - Pillar I)

Abstract (Expand)

The secretion of osmolytes into a lumen and thereby caused osmotic water inflow can drive fluid flows in organs without a mechanical pump. Such fluids include saliva, sweat, pancreatic juice and bile. ...

Authors: Oleksandr Ostrenko, Jochen Hampe, Lutz Brusch

Date Published: 1st Dec 2019

Journal: Sci Rep

DOI: 10.1038/s41598-019-40853-7

Citation: Sci Rep 9(1) : 823

Created: 20th May 2019 at 15:27, Last updated: 20th May 2019 at 15:32

Hepatic CYP1A2 activity in liver tumors and the implications for preoperative volume-function analysis.

Liver Function Diagnostics (LiSyM-LiFuDi - Pillar IV)

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Abstract (Expand)

Dynamic liver function assessment by the (13)C-methacetin maximal liver function capacity (LiMAx) test reflects the overall hepatic CYP1A2 activity. One proven strategy for preoperative risk assessement ...

Authors: Tilo Wuensch, Niklas Heucke, J. Wizenty, J. Quint, B. Sinn, R. Arsenic, M. Jara, M. Kaffarnik, J. Pratschke, Martin Stockmann

Date Published: 14th Mar 2019

Journal: Am J Physiol Gastrointest Liver Physiol

PubMed ID: 30869529

Citation: Am J Physiol Gastrointest Liver Physiol. 2019 Mar 14. doi: 10.1152/ajpgi.00335.2018.

Created: 20th Apr 2019 at 13:06

Non-invasive structure-function assessment of the liver by 2D time-harmonic elastography and the dynamic Liver MAximum capacity (LiMAx) test.

Liver Function Diagnostics (LiSyM-LiFuDi - Pillar IV)

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Abstract (Expand)

BACKGROUND AND AIM: Accurate assessment of structural and functional characteristics of the liver could improve the diagnosis and the clinical management of patients with chronic liver diseases. However, ...

Authors: Niklas Heucke, Tilo Wuensch, J. Mohr, M. Kaffarnik, R. Arsenic, B. Sinn, T. Muller, J. Pratschke, Martin Stockmann, I. Sack, H. Tzschatzsch

Date Published: 13th Feb 2019

Journal: J Gastroenterol Hepatol

PubMed ID: 30756433

Citation: J Gastroenterol Hepatol. 2019 Feb 13. doi: 10.1111/jgh.14629.

Created: 20th Apr 2019 at 13:04

SECOND EXPOSURE TO ACETAMINOPHEN OVERDOSE IS ASSOCIATED WITH LIVER FIBROSIS IN MICE

Chronic Liver Disease Progression (LiSyM-DP - Pillar II), Regeneration and Repair in Acute-on-Chronic Liver Failure (LiSyM-ACLF - Pillar III), LiSyM network

Abstract (Expand)

Repeated administration of hepatotoxicants is usually accompanied by liver fibrosis. However, the difference in response as a result of repeated exposures of acetaminophen (APAP) compared to a single ...

Author: Seddik Hammad

Date Published: 6th Feb 2019

Journal: EXCLI

DOI: 10.17179/excli2018-1920

Citation:

Created: 12th Feb 2019 at 14:49

Evolutionary Distance Predicts Recurrence After Liver Transplantation in Multifocal Hepatocellular Carcinoma.

Early Metabolic Injury (LiSyM-EMI - Pillar I)

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Abstract (Expand)

BACKGROUND: Liver transplantation (LTx) is a potentially curative treatment option for hepatocellular carcinoma (HCC) in cirrhosis. However, patients, where HCC is already a systemic disease, LTx may ...

Authors: N. Heits, Mario Brosch, A. Herrmann, R. Behrens, C. Rocken, H. Schrem, A. Kaltenborn, J. Klempnauer, H. H. Kreipe, B. Reichert, C. Lenschow, C. Wilms, T. Vogel, H. Wolters, E. Wardelmann, D. Seehofer, S. Buch, S. Zeissig, S. Pannach, N. Raschzok, M. Dietel, W. von Schoenfels, S. Hinz, A. Teufel, M. Evert, A. Franke, Ann-Kristin Becker, F. Braun, Jochen Hampe, Clemens Schafmayer

Date Published: 12th Jul 2018

Journal: Transplantation

PubMed ID: 29994984

Citation: Transplantation. 2018 Oct;102(10):e424-e430. doi: 10.1097/TP.0000000000002356.

Created: 15th Jan 2019 at 12:21

Hepatic Smad7 overexpression causes severe iron overload in mice

Chronic Liver Disease Progression (LiSyM-DP - Pillar II), LiSyM network

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Abstract:

Not specified

Authors: Dilay Lai, Feng Teng, Seddik Hammad, Julia Werle, Thorsten Maas, Andreas Teufel, Martina U. Muckenthaler, Steven Dooley, Maja Vujić Spasić

Date Published: 1st Feb 2018

Journal: Blood

DOI: 10.1182/blood-2017-07-796797

Citation: Blood 131(5) : 581

Created: 14th Jan 2019 at 13:37, Last updated: 14th Jan 2019 at 13:37

Ethanol sensitizes hepatocytes for TGF-beta-triggered apoptosis.

Chronic Liver Disease Progression (LiSyM-DP - Pillar II), LiSyM network

Abstract (Expand)

Alcohol abuse is a global health problem causing a substantial fraction of chronic liver diseases. Abundant TGF-beta-a potent pro-fibrogenic cytokine-leads to disease progression. Our aim was to elucidate ...

Authors: H. Gaitantzi, C. Meyer, P. Rakoczy, M. Thomas, K. Wahl, F. Wandrer, H. Bantel, H. Alborzinia, S. Wolfl, S. Ehnert, A. Nussler, I. Bergheim, L. Ciuclan, M. Ebert, K. Breitkopf-Heinlein, Steven Dooley

Date Published: 21st Jan 2018

Journal: Cell Death Dis

PubMed ID: 29352207

Citation: Cell Death Dis. 2018 Jan 19;9(2):51. doi: 10.1038/s41419-017-0071-y.

Created: 14th Jan 2019 at 13:34

Inverse agonist of ERRgamma reduces cannabinoid receptor type 1-mediated induction of fibrinogen synthesis in mice with a high-fat diet-intoxicated liver.

Chronic Liver Disease Progression (LiSyM-DP - Pillar II), Regeneration and Repair in Acute-on-Chronic Liver Failure (LiSyM-ACLF - Pillar III), LiSyM network

Abstract (Expand)

Upon liver intoxication with malnutrition or high-fat diet feeding, fibrinogen is synthesized by hepatocytes and secreted into the blood in human and mouse. Its primary function is to occlude blood ...

Authors: Y. Zhang, D. K. Kim, Y. S. Jung, Y. H. Kim, Y. S. Lee, J. Kim, W. I. Jeong, I. K. Lee, S. J. Cho, Steven Dooley, C. H. Lee, H. S. Choi

Date Published: 19th Jul 2018

Journal: Arch Toxicol

PubMed ID: 30019168

Citation: Arch Toxicol. 2018 Sep;92(9):2885-2896. doi: 10.1007/s00204-018-2270-4. Epub 2018 Jul 17.

Created: 14th Jan 2019 at 13:28

MicroRNA-942 mediates hepatic stellate cell activation by regulating BAMBI expression in human liver fibrosis.

Chronic Liver Disease Progression (LiSyM-DP - Pillar II), Regeneration and Repair in Acute-on-Chronic Liver Failure (LiSyM-ACLF - Pillar III), LiSyM network

Abstract (Expand)

MicroRNA (miRNA)-mediated gene regulation contributes to liver pathophysiology, including hepatic stellate cell (HSC) activation and fibrosis progression. Here, we investigated the role of miR-942 in ...

Authors: L. Tao, D. Xue, D. Shen, W. Ma, J. Zhang, X. Wang, W. Zhang, L. Wu, K. Pan, Y. Yang, Z. C. Nwosu, Steven Dooley, E. Seki, C. Liu

Date Published: 12th Aug 2018

Journal: Arch Toxicol

PubMed ID: 30097701

Citation: Arch Toxicol. 2018 Sep;92(9):2935-2946. doi: 10.1007/s00204-018-2278-9. Epub 2018 Aug 10.

Created: 14th Jan 2019 at 13:27

Effect of alcohol on the interleukin 6-mediated inflammatory response in a new mouse model of acute-on-chronic liver injury

Chronic Liver Disease Progression (LiSyM-DP - Pillar II), Regeneration and Repair in Acute-on-Chronic Liver Failure (LiSyM-ACLF - Pillar III), LiSyM network

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Abstract:

Not specified

Authors: Ersin Karatayli, Rabea A. Hall, Susanne Weber, Steven Dooley, Frank Lammert

Date Published: 1st Feb 2019

Journal: Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease

DOI: 10.1016/j.bbadis.2018.11.008

Citation: Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease 1865(2) : 298

Created: 14th Jan 2019 at 13:21, Last updated: 14th Jan 2019 at 13:21

Tellurium notebooks-An environment for reproducible dynamical modeling in systems biology.

Multi-Scale Models for Personalized Liver Function Tests (LiSyM-MM-PLF)

Abstract (Expand)

The considerable difficulty encountered in reproducing the results of published dynamical models limits validation, exploration and reuse of this increasingly large biomedical research resource. To ...

Authors: J. K. Medley, K. Choi, Matthias König, L. Smith, S. Gu, J. Hellerstein, S. C. Sealfon, H. M. Sauro

Date Published: 16th Jun 2018

Journal: PLoS Comput Biol

PubMed ID: 29906293

Citation: PLoS Comput Biol. 2018 Jun 15;14(6):e1006220. doi: 10.1371/journal.pcbi.1006220. eCollection 2018 Jun.

Created: 9th Jan 2019 at 11:08

Tellurium: An extensible python-based modeling environment for systems and synthetic biology.

Multi-Scale Models for Personalized Liver Function Tests (LiSyM-MM-PLF)

Abstract (Expand)

Here we present Tellurium, a Python-based environment for model building, simulation, and analysis that facilitates reproducibility of models in systems and synthetic biology. Tellurium is a modular, ...

Authors: K. Choi, J. K. Medley, Matthias König, K. Stocking, L. Smith, S. Gu, H. M. Sauro

Date Published: 28th Jul 2018

Journal: Biosystems

PubMed ID: 30053414

Citation: Biosystems. 2018 Sep;171:74-79. doi: 10.1016/j.biosystems.2018.07.006. Epub 2018 Jul 25.

Created: 9th Jan 2019 at 11:06

Simulation Experiment Description Markup Language (SED-ML) Level 1 Version 3 (L1V3).

Multi-Scale Models for Personalized Liver Function Tests (LiSyM-MM-PLF)

Abstract (Expand)

The creation of computational simulation experiments to inform modern biological research poses challenges to reproduce, annotate, archive, and share such experiments. Efforts such as SBML or CellML ...

Authors: F. T. Bergmann, J. Cooper, Matthias König, I. Moraru, D. Nickerson, N. Le Novere, B. G. Olivier, S. Sahle, L. Smith, D. Waltemath

Date Published: 20th Mar 2018

Journal: J Integr Bioinform

PubMed ID: 29550789

Citation: J Integr Bioinform. 2018 Mar 19;15(1). pii: /j/jib.ahead-of-print/jib-2017-0086/jib-2017-0086.xml. doi: 10.1515/jib-2017-0086.

Created: 9th Jan 2019 at 11:03

Delta-Like Ligand 4 Modulates Liver Damage by Down-Regulating Chemokine Expression

Chronic Liver Disease Progression (LiSyM-DP - Pillar II)

Abstract:

Not specified

Authors: Zhe Shen, Yan Liu, Bedair Dewidar, Junhao Hu, Ogyi Park, Teng Feng, Chengfu Xu, Chaohui Yu, Qi Li, Christoph Meyer, Iryna Ilkavets, Alexandra Müller, Carolin Stump-Guthier, Stefan Munker, Roman Liebe, Vincent Zimmer, Frank Lammert, Peter R. Mertens, Hai Li, Peter ten Dijke, Hellmut G. Augustin, Jun Li, Bin Gao, Matthias P. Ebert, Steven Dooley, Youming Li, Hong-Lei Weng

Date Published: 1st Jul 2016

Journal: The American Journal of Pathology

DOI: 10.1016/j.ajpath.2016.03.010

Citation: The American Journal of Pathology 186(7) : 1874

Created: 3rd Feb 2018 at 17:32, Last updated: 8th Jan 2019 at 17:50

Liver cancer cell lines distinctly mimic the metabolic gene expression pattern of the corresponding human tumours.

Chronic Liver Disease Progression (LiSyM-DP - Pillar II), Regeneration and Repair in Acute-on-Chronic Liver Failure (LiSyM-ACLF - Pillar III), LiSyM network

Abstract (Expand)

BACKGROUND: Although metabolism is profoundly altered in human liver cancer, the extent to which experimental models, e.g. cell lines, mimic those alterations is unresolved. Here, we aimed to determine ...

Authors: Z. C. Nwosu, N. Battello, M. Rothley, W. Pioronska, B. Sitek, M. P. Ebert, Ute Hofmann, J. Sleeman, S. Wolfl, C. Meyer, D. A. Megger, Steven Dooley

Date Published: 5th Sep 2018

Journal: J Exp Clin Cancer Res

PubMed ID: 30176945

Citation: J Exp Clin Cancer Res. 2018 Sep 3;37(1):211. doi: 10.1186/s13046-018-0872-6.

Created: 8th Jan 2019 at 16:54

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