Publications

Abstract (Expand)

Dynamic liver function assessment by the (13)C-methacetin maximal liver function capacity (LiMAx) test reflects the overall hepatic CYP1A2 activity. One proven strategy for preoperative risk assessement ...

Authors: Tilo Wuensch, Niklas Heucke, J. Wizenty, J. Quint, B. Sinn, R. Arsenic, M. Jara, M. Kaffarnik, J. Pratschke, Martin Stockmann

Date Published: 14th Mar 2019

Journal: Am J Physiol Gastrointest Liver Physiol

Abstract (Expand)

BACKGROUND AND AIM: Accurate assessment of structural and functional characteristics of the liver could improve the diagnosis and the clinical management of patients with chronic liver diseases. However, ...

Authors: Niklas Heucke, Tilo Wuensch, J. Mohr, M. Kaffarnik, R. Arsenic, B. Sinn, T. Muller, J. Pratschke, Martin Stockmann, I. Sack, H. Tzschatzsch

Date Published: 13th Feb 2019

Journal: J Gastroenterol Hepatol

Abstract (Expand)

Repeated administration of hepatotoxicants is usually accompanied by liver fibrosis. However, the difference in response as a result of repeated exposures of acetaminophen (APAP) compared to a single ...

Author: Seddik Hammad

Date Published: 6th Feb 2019

Journal: EXCLI

Abstract (Expand)

BACKGROUND: Liver transplantation (LTx) is a potentially curative treatment option for hepatocellular carcinoma (HCC) in cirrhosis. However, patients, where HCC is already a systemic disease, LTx may ...

Authors: N. Heits, Mario Brosch, A. Herrmann, R. Behrens, C. Rocken, H. Schrem, A. Kaltenborn, J. Klempnauer, H. H. Kreipe, B. Reichert, C. Lenschow, C. Wilms, T. Vogel, H. Wolters, E. Wardelmann, D. Seehofer, S. Buch, S. Zeissig, S. Pannach, N. Raschzok, M. Dietel, W. von Schoenfels, S. Hinz, A. Teufel, M. Evert, A. Franke, Ann-Kristin Becker, F. Braun, Jochen Hampe, Clemens Schafmayer

Date Published: 12th Jul 2018

Journal: Transplantation

Abstract:

Not specified

Authors: Dilay Lai, Feng Teng, Seddik Hammad, Julia Werle, Thorsten Maas, Andreas Teufel, Martina U. Muckenthaler, Steven Dooley, Maja Vujić Spasić

Date Published: 1st Feb 2018

Journal: Blood

Abstract (Expand)

Alcohol abuse is a global health problem causing a substantial fraction of chronic liver diseases. Abundant TGF-beta-a potent pro-fibrogenic cytokine-leads to disease progression. Our aim was to elucidate ...

Authors: H. Gaitantzi, C. Meyer, P. Rakoczy, M. Thomas, K. Wahl, F. Wandrer, H. Bantel, H. Alborzinia, S. Wolfl, S. Ehnert, A. Nussler, I. Bergheim, L. Ciuclan, M. Ebert, K. Breitkopf-Heinlein, Steven Dooley

Date Published: 21st Jan 2018

Journal: Cell Death Dis

Abstract (Expand)

Upon liver intoxication with malnutrition or high-fat diet feeding, fibrinogen is synthesized by hepatocytes and secreted into the blood in human and mouse. Its primary function is to occlude blood ...

Authors: Y. Zhang, D. K. Kim, Y. S. Jung, Y. H. Kim, Y. S. Lee, J. Kim, W. I. Jeong, I. K. Lee, S. J. Cho, Steven Dooley, C. H. Lee, H. S. Choi

Date Published: 19th Jul 2018

Journal: Arch Toxicol

Abstract (Expand)

MicroRNA (miRNA)-mediated gene regulation contributes to liver pathophysiology, including hepatic stellate cell (HSC) activation and fibrosis progression. Here, we investigated the role of miR-942 in ...

Authors: L. Tao, D. Xue, D. Shen, W. Ma, J. Zhang, X. Wang, W. Zhang, L. Wu, K. Pan, Y. Yang, Z. C. Nwosu, Steven Dooley, E. Seki, C. Liu

Date Published: 12th Aug 2018

Journal: Arch Toxicol

Abstract:

Not specified

Authors: Ersin Karatayli, Rabea A. Hall, Susanne Weber, Steven Dooley, Frank Lammert

Date Published: 1st Feb 2019

Journal: Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease

Abstract (Expand)

The considerable difficulty encountered in reproducing the results of published dynamical models limits validation, exploration and reuse of this increasingly large biomedical research resource. To ...

Authors: J. K. Medley, K. Choi, Matthias König, L. Smith, S. Gu, J. Hellerstein, S. C. Sealfon, H. M. Sauro

Date Published: 16th Jun 2018

Journal: PLoS Comput Biol

Abstract (Expand)

Here we present Tellurium, a Python-based environment for model building, simulation, and analysis that facilitates reproducibility of models in systems and synthetic biology. Tellurium is a modular, ...

Authors: K. Choi, J. K. Medley, Matthias König, K. Stocking, L. Smith, S. Gu, H. M. Sauro

Date Published: 28th Jul 2018

Journal: Biosystems

Abstract (Expand)

The creation of computational simulation experiments to inform modern biological research poses challenges to reproduce, annotate, archive, and share such experiments. Efforts such as SBML or CellML ...

Authors: F. T. Bergmann, J. Cooper, Matthias König, I. Moraru, D. Nickerson, N. Le Novere, B. G. Olivier, S. Sahle, L. Smith, D. Waltemath

Date Published: 20th Mar 2018

Journal: J Integr Bioinform

Abstract:

Not specified

Authors: Zhe Shen, Yan Liu, Bedair Dewidar, Junhao Hu, Ogyi Park, Teng Feng, Chengfu Xu, Chaohui Yu, Qi Li, Christoph Meyer, Iryna Ilkavets, Alexandra Müller, Carolin Stump-Guthier, Stefan Munker, Roman Liebe, Vincent Zimmer, Frank Lammert, Peter R. Mertens, Hai Li, Peter ten Dijke, Hellmut G. Augustin, Jun Li, Bin Gao, Matthias P. Ebert, Steven Dooley, Youming Li, Hong-Lei Weng

Date Published: 1st Jul 2016

Journal: The American Journal of Pathology

Abstract (Expand)

BACKGROUND: Although metabolism is profoundly altered in human liver cancer, the extent to which experimental models, e.g. cell lines, mimic those alterations is unresolved. Here, we aimed to determine ...

Authors: Z. C. Nwosu, N. Battello, M. Rothley, W. Pioronska, B. Sitek, M. P. Ebert, Ute Hofmann, J. Sleeman, S. Wolfl, C. Meyer, D. A. Megger, Steven Dooley

Date Published: 5th Sep 2018

Journal: J Exp Clin Cancer Res

Abstract (Expand)

Neurotoxic bilirubin is the end product of heme catabolism in mammals. Bilirubin is solely conjugated by uridine diphospho-glucuronosyltransferase 1A1, which is a membrane-bound enzyme that catalyzes ...

Authors: Ryoichi Fujiwara, Mathias Haag, Elke Schaeffeler, Anne T. Nies, Ulrich M. Zanger, Matthias Schwab

Date Published: 1st Apr 2018

Journal: Hepatology

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