I am a researcher at the Scientific Databases and Visualization Group at Heidelberg Institute for Theoretical Studies (HITS) , one of the developers of SabioRK - System for the Analysis of Biochemical Pathways - Reaction Kinetics (http://sabiork.h-its.org/) . I am working on design and maintenance of the information systems to store, query and analyse systems biology data; definition and implementation of methods for the integration of data from multiple sources. In SySMO-DB project (http://www.sysmo-db.org) I was responsible for metadata design (SEEK), conceptual and logical modelling of experimental data (JERM), now our team continue this work as FAIRDOM project (http://fair-dom.org/).
SEEK ID: https://seek.lisym.org/people/8
Location:
Germany
Expertise: big data, Systems Biology, Genetics, wet lab
Tools: SEEK, openBis, Protege, Copasi, JWS online RightFiled
ORCID: Not specified




Project roles
Project administrator
- LiSyM network
- LiSyM Pillar I: Early Metabolic Injury (LiSyM-EMI)
- LiSyM Pillar III: Regeneration and Repair in Acute-on-Chronic Liver Failure (LiSyM-ACLF)
- LiSyM Pillar II: Chronic Liver Disease Progression (LiSyM-DP)
- LiSyM PALs
- LiSyM Core Infrastructure and Management (LiSyM-PD)
- LiSyM Pillar IV: Liver Function Diagnostics (LiSyM-LiFuDi)
- LiSyM-Krebs Partnering
- Molecular Steatosis - Imaging & Modeling (LiSyM-MSIM)
- Forschungsnetzwerk LiSyM-Krebs
- SMART-NAFLD
- DEEP-HCC network
- C-TIP-HCC network
Asset housekeeper
- LiSyM network
- LiSyM Pillar I: Early Metabolic Injury (LiSyM-EMI)
- LiSyM Pillar III: Regeneration and Repair in Acute-on-Chronic Liver Failure (LiSyM-ACLF)
- LiSyM Pillar II: Chronic Liver Disease Progression (LiSyM-DP)
- LiSyM PALs
- LiSyM Pillar IV: Liver Function Diagnostics (LiSyM-LiFuDi)
- LiSyM-Krebs Partnering
LiSyM PALs (HITS gGmbH) ; LiSyM network (HITS gGmbH) ; LiSyM Pillar I: Early Metabolic Injury (LiSyM-EMI) (HITS gGmbH) ; LiSyM Pillar III: Regeneration and Repair in Acute-on-Chronic Liver Failure (LiSyM-ACLF) (HITS gGmbH) ; LiSyM Pillar II: Chronic Liver Disease Progression (LiSyM-DP) (HITS gGmbH) ; LiSyM Pillar IV: Liver Function Diagnostics (LiSyM-LiFuDi) (HITS gGmbH) ; LiSyM Core Infrastructure and Management (LiSyM-PD) (HITS gGmbH) ; LiSyM-Krebs Partnering (HITS gGmbH) ; Molecular Steatosis - Imaging & Modeling (LiSyM-MSIM) (HITS gGmbH) ; Multi-Scale Models for Personalized Liver Function Tests (LiSyM-MM-PLF) (HITS gGmbH) ; The Hedgehog Signalling Pathway (LiSyM-JGMMS) (HITS gGmbH) ; Forschungsnetzwerk LiSyM-Krebs (HITS gGmbH) ; SMART-NAFLD (HITS gGmbH) ; DEEP-HCC network (HITS gGmbH) ; C-TIP-HCC network (HITS gGmbH)
Related items
- Programmes (2)
- Projects (15)
- Institutions (1)
- Investigations (0+2)
- Studies (2+4)
- Assays (9+8)
- Data files (0+3)
- Models (1)
- SOPs (1)
- Publications (2)
- Presentations (1+1)
- Events (1+1)
- Documents (2+8)
- Samples (0+20)
LiSyM-Krebs ist ein nationales Forschungsnetz zur Früherkennung und Prävention von Leberkrebs, das unter Verwendung des systemmedizinischen Forschungsansatzes die komplexen, dynamischen Prozesse der Krankheitsprogression analysiert, um ausgehend von den Erkenntnissen aus dem Forschungsnetz LiSyM die Entstehung von Leberkrebs besser zu verstehen, vorherzusagen und im besten Fall sogar zu verhindern. LiSyM-Krebs setzt die erfolgreichen Forschungsaktivitäten der BMBF-Vorgängerprogramme ...
Projects: LiSyM-Krebs Partnering, Forschungsnetzwerk LiSyM-Krebs, SMART-NAFLD, DEEP-HCC network, C-TIP-HCC network
Web page: Not specified
Liver Systems Medicine : striving to develop non-invasive methods for diagnosing and treating NAFLD by combining mathematical modeling and biological research. LiSyM, is a multidisciplinary research network, in which molecular and cell biologists, clinical researchers, pharmacologists and experts in mathematical modeling examine the liver in its entirety. LiSyM research focuses on the metabolic liver disease non-alcoholic fatty liver disease (NAFLD), which includes non-alcoholic steatohepatitis ...
Projects: LiSyM Core Infrastructure and Management (LiSyM-PD), LiSyM Pillar I: Early Metabolic Injury (LiSyM-EMI), LiSyM Pillar II: Chronic Liver Disease Progression (LiSyM-DP), LiSyM Pillar III: Regeneration and Repair in Acute-on-Chronic Liver Failure (LiSyM-ACLF), LiSyM Pillar IV: Liver Function Diagnostics (LiSyM-LiFuDi), Model Guided Pharmacotherapy In Chronic Liver Disease (LiSyM-MGP), Molecular Steatosis - Imaging & Modeling (LiSyM-MSIM), The Hedgehog Signalling Pathway (LiSyM-JGMMS), Multi-Scale Models for Personalized Liver Function Tests (LiSyM-MM-PLF), LiSyM PALs, Project Management PTJ, LiSyM network, LiSyM Scientific Leadership Team (LiSyM-LT)
Web page: https://www.lisym.org/
One of the tasks of the healthy liver is to store fat. Yet, at some stage, too much fat makes the liver sick. One critical time point occurs when a healthy fatty liver becomes inflamed and progresses to steatohepatitis, or NASH. LiSyM-Pillar I will identify what events lead to this transition. Does it occur in all parts of the liver? Which molecules indicate that it is taking place? Can the degeneration be stopped or undone - and if so, how?
Programme: LiSyM: Liver Systems Medicine
Public web page: http://www.lisym.org/our-work/pillar-research/zones-of-the-liver
Start date: 1st Jan 2016
Organisms: Mus musculus, Rattus rattus, Rattus norvegicus, Homo sapiens
Forschungsnetzwerk zur Früherkennung und Prävention- LiSyM-Krebs
Ein Netzwerk von Klinikern, Wissenschaftlern und Datenmanagern hat sich zur Aufgabe gemacht, Methoden zu entwickeln, um Patienten mit einem hohen Risiko für ein Leberkarzinom frühzeitig, in Vorstadien der Tumorentwicklung, identifizieren zu können. Gemeinsam bilden sie das „Systemmedizinische Forschungsnetzwerk zur Früherkennung und Prävention von Leberkrebs“, LiSym-Krebs, das vom Bundesministerium für Bildung und Forschung ...
Programme: LiSyM-Krebs - Systemmedizinisches Forschungsnetz zur Früherkennung und Prävention von Leberkrebs
Public web page: Not specified
Organisms: Homo sapiens
In one in five people with NAFLD, the functioning liver cells, the hepatocytes, are replaced by connective tissue. Eventually this fibrosis becomes irreversible. In this state the liver is like a ‘scar that never heals’. Through it, the liver loses many of its vital functions. LiSyM-Pillar II wants to know more about which factors promote fibrosis and the conditions under which fibrosis becomes irreversible How can fibrosis be diagnosed as early as possible? Researchers in the pillar are also ...
Programme: LiSyM: Liver Systems Medicine
Public web page: http://www.lisym.org/our-work/pillar-research
Start date: 1st Jan 2016
Organisms: Mus musculus, Rattus rattus, Rattus norvegicus, Homo sapiens
In chronic diseases, at some point the liver can suddenly stop functioning. This is called acute-on-chronic liver failure, or ACLF. This is the leading cause of death in liver patients and is often provoked by the use of transcription or freely available drugs or alcohol abuse. For this condition we need an effective treatment quickly. LiSyM-Pillar III researches the factors that contribute significantly to ACLF. What exactly happens then? Are there any early signs that would enable ACLF to be ...
Programme: LiSyM: Liver Systems Medicine
Public web page: http://www.lisym.org/our-work/pillar-research
Start date: 1st Jan 2016
Organisms: Homo sapiens, Mus musculus, Rattus norvegicus, Rattus rattus
DEEP-HCC - Detailed Analysis of the Spatial Organization of the Development of Hepatocellular Carcinoma
Programme: LiSyM-Krebs - Systemmedizinisches Forschungsnetz zur Früherkennung und Prävention von Leberkrebs
Public web page: Not specified
Organisms: Homo sapiens, Mus musculus
Documents submitted to BMBF
Submitter: Olga Krebs
Investigation: 1 hidden item
Assays: Meeting minutes 2021, Meeting minutes 2022
Snapshots: No snapshots
Documents submitted to BMBF
Submitter: Olga Krebs
Investigation: 1 hidden item
Assays: Project deliverables 2021, Project deliverables 2022, Project proposals
Snapshots: No snapshots
DNA-methylation at binding sites of uniformly expressed transcription factors in human hepatocytes ; hepatic zone: intermediate (IZ)
Submitter: Olga Krebs
Assay type: Methylation Profiling
Technology type: Technology Type
Investigation: Epigenomic analysis of micro-dissected human liver
Organisms: Homo sapiens
SOPs: No SOPs
Data files: Human DNA methylation data set GSM2819639 ..., Human DNA methylation data set GSM2819641 ..., Human DNA methylation data set GSM2819642 ..., Human DNA methylation data set GSM2819643 ..., Human DNA methylation data set GSM2819647 ..., Human DNA methylation data set GSM2819640 s..., Human DNA methylation data set GSM2819644 s..., Human DNA methylation data set GSM2819645 s..., Human DNA methylation data set GSM2819646 s..., Human DNA methylation data set GSM2819648 s..., Human DNA methylation data set GSM2819650 s..., Human DNA methylation data set GSM2819651 s..., Human DNA methylation data set GSM2819652 s..., Human DNA methylation data set GSM2819653 s..., Human DNA methylation data set GSM2819654 s..., Human DNA methylation data set GSM2819655 s..., Human DNA methylation data set GSM2819656 s..., Human DNA methylation data set GSM2819657 s..., HumanDNA methylation data set GSM2819649 st...
Snapshots: No snapshots
DMPlaning 2022
Submitter: Olga Krebs
Biological problem addressed: Model Analysis Type
Investigation: 1 hidden item
Study: 1 hidden item
Organisms: No organisms
Models: No Models
SOPs: No SOPs
Data files: No Data files
Snapshots: No snapshots
DMPlaning 2021
Submitter: Olga Krebs
Biological problem addressed: Model Analysis Type
Investigation: 1 hidden item
Study: 1 hidden item
Organisms: No organisms
Models: No Models
SOPs: No SOPs
Data files: No Data files
Snapshots: No snapshots
DNA-methylation at binding sites of uniformly expressed transcription factors in human hepatocytes ; periportal (PP)
Submitter: Olga Krebs
Assay type: Methylation Profiling
Technology type: Technology Type
Investigation: Epigenomic analysis of micro-dissected human liver
Organisms: Homo sapiens
SOPs: No SOPs
Data files: Human DNA methylation data set GSM2819660 ..., Human DNA methylation data set GSM2819663 ..., Human DNA methylation data set GSM2819662 ..., Human DNA methylation data set GSM2819659 ..., Human DNA methylation data set GSM2819661 ..., Human DNA methylation data set GSM2819670 ..., Human DNA methylation data set GSM2819671 ..., Human DNA methylation data set GSM2819672 ..., Human DNA methylation data set GSM2819673 ..., Human DNA methylation data set GSM2819675 ..., Human DNA methylation data set GSM2819676 ..., Human DNA methylation data set GSM2819658 s..., Human DNA methylation data set GSM2819664 s..., Human DNA methylation data set GSM2819665 s..., Human DNA methylation data set GSM2819666 s..., Human DNA methylation data set GSM2819667 s..., Human DNA methylation data set GSM2819668 s..., Human DNA methylation data set GSM2819669 s..., Human DNA methylation data set GSM2819674 s...
Snapshots: No snapshots
Project deliverables 2022
Submitter: Olga Krebs
Biological problem addressed: Model Analysis Type
Investigation: 1 hidden item
Study: Documents submitted to BMBF
Organisms: No organisms
Models: No Models
SOPs: No SOPs
Data files: No Data files
Snapshots: No snapshots
ODE model describes dynamics of IFNalpha-induced signaling in Huh7.5 cells for a time scale up to 32 hours after stimulation with IFNalpha. The model consists of an IFN receptor model, formation/degradation and cytoplasmic/nuclear shuttling of STAT1-homodimers, STAT1-STAT2-heterodimers and STAT1-STAT2-IRF9 (ISGF3) complexes. On top, formation of feedback proteins STAT1, STAT2, IRF9, USP18, SOCS1, SOCS3 and IRF2 and corresponding influences on IFNalpha signaling dynamics was incorporated. The model ...
Creators: Jens Timmer, Ursula Klingmüller, Daniel Seehofer, Marcus Rosenblatt, Krishna Kumar Tiwari, Frédérique Kok
Submitter: Olga Krebs
Model type: Ordinary differential equations (ODE)
Model format: SBML
Environment: Copasi
Organism: Not specified
Investigations: 1 hidden item
Studies: 1 hidden item
Assays: 1 hidden item
This SOP - Standard Operating Procedure for Sample Collection and Preservation of Blood and Endometrial Tissue were developed at NIH University of California San Francisco Human Endometrial Tissue and DNA Bank by Elizabeth Sheldonand, Ramsey A McIntire
Creators: Olga Krebs, Martin Golebiewski, Elizabeth Sheldonand, Ramsey A McIntire
Submitter: Olga Krebs
Investigations: Julia/Yan and 1 hidden item
Studies: CCl4 Treatment in mice and 1 hidden item
Assays: Metabolic CCl4 and 1 hidden item
Abstract (Expand)
Authors: Dagmar Waltemath, Martin Golebiewski, Michael L Blinov, Padraig Gleeson, Henning Hermjakob, Michael Hucka, Esther Thea Inau, Sarah M Keating, Matthias König, Olga Krebs, Rahuman S Malik-Sheriff, David Nickerson, Ernst Oberortner, Herbert M Sauro, Falk Schreiber, Lucian Smith, Melanie I Stefan, Ulrike Wittig, Chris J Myers
Date Published: 29th Jun 2020
Publication Type: Journal
Citation: Journal of Integrative Bioinformatics 17(2-3)
Abstract (Expand)
Authors: K. Wolstencroft, O. Krebs, J. L. Snoep, N. J. Stanford, F. Bacall, M. Golebiewski, R. Kuzyakiv, Q. Nguyen, S. Owen, S. Soiland-Reyes, J. Straszewski, D. D. van Niekerk, A. R. Williams, L. Malmstrom, B. Rinn, W. Muller, C. Goble
Date Published: 3rd Dec 2016
Publication Type: Not specified
PubMed ID: 27899646
Citation: Nucleic Acids Res. 2017 Jan 4;45(D1):D404-D407. doi: 10.1093/nar/gkw1032. Epub 2016 Nov 28.
Poster presentation at SBMC 2018 (Bremen)
Creators: Martin Golebiewski, Olga Krebs, Hadas Leonov, Wolfgang Müller, Stuart Owen, Maja Rey, Natalie Stanford, Andreas Weidemann, Ulrike Wittig, Katy Wolstencroft, Jacky L. Snoep, Carole Goble
Submitter: Martin Golebiewski
Kickoff Meeting SMART- NAFLD 1.12.2021 - 2.12.2021
Heidelberg, Bioquant 7th Floor Greenier Room
Start Date: 1st Dec 2021
End Date: 2nd Dec 2021
Event Website: Not specified
Country: Germany
City: Heidelberg
Agenda for LiSyM-Cancer status seminar 2022
Creators: Olga Krebs, Susan Eckerle, Wolfgang Müller, Ursula Klingmüller, Ina Biermayer
Submitter: Olga Krebs
Investigations: No Investigations
Studies: No Studies
Assays: No Assays
Agenda Kickoff Meeting SMART-NAFLD 1-2 december 2021 in Heidelberg
Creators: Ursula Klingmüller, Ina Biermayer
Submitter: Olga Krebs
Investigations: No Investigations
Studies: No Studies
Assays: No Assays