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Projects: LiSyM Core Infrastructure and Management (LiSyM-PD), LiSyM Pillar II: Chronic Liver Disease Progression (LiSyM-DP), LiSyM Pillar I: Early Metabolic Injury (LiSyM-EMI), LiSyM Pillar IV: Liver Function Diagnostics (LiSyM-LiFuDi), LiSyM Pillar III: Regeneration and Repair in Acute-on-Chronic Liver Failure (LiSyM-ACLF), LiSyM network, LiSyM Scientific Leadership Team (LiSyM-LT)
Institutions: University of Freiburg - Institute of Physics, LiSyM programme directorate

Projects: LiSyM Pillar II: Chronic Liver Disease Progression (LiSyM-DP), LiSyM Pillar I: Early Metabolic Injury (LiSyM-EMI), LiSyM Core Infrastructure and Management (LiSyM-PD), LiSyM network, LiSyM Scientific Leadership Team (LiSyM-LT), LiSyM Pillar IV: Liver Function Diagnostics (LiSyM-LiFuDi), Model Guided Pharmacotherapy In Chronic Liver Disease (LiSyM-MGP), Molecular Steatosis - Imaging & Modeling (LiSyM-MSIM), Multi-Scale Models for Personalized Liver Function Tests (LiSyM-MM-PLF), LiSyM Pillar III: Regeneration and Repair in Acute-on-Chronic Liver Failure (LiSyM-ACLF), The Hedgehog Signalling Pathway (LiSyM-JGMMS), LiSyM-Krebs Partnering
Institutions: LiSyM programme directorate
Projects: LiSyM Core Infrastructure and Management (LiSyM-PD), LiSyM network, LiSyM Scientific Leadership Team (LiSyM-LT), LiSyM-Krebs Partnering, LiSyM Pillar II: Chronic Liver Disease Progression (LiSyM-DP), LiSyM Pillar I: Early Metabolic Injury (LiSyM-EMI), LiSyM Pillar IV: Liver Function Diagnostics (LiSyM-LiFuDi), Model Guided Pharmacotherapy In Chronic Liver Disease (LiSyM-MGP), The Hedgehog Signalling Pathway (LiSyM-JGMMS), LiSyM Pillar III: Regeneration and Repair in Acute-on-Chronic Liver Failure (LiSyM-ACLF), Multi-Scale Models for Personalized Liver Function Tests (LiSyM-MM-PLF), Molecular Steatosis - Imaging & Modeling (LiSyM-MSIM)
Institutions: LiSyM programme directorate
Roles: Project Coordinator
Projects: LiSyM Core Infrastructure and Management (LiSyM-PD), LiSyM network, LiSyM-Krebs Partnering, LiSyM Pillar II: Chronic Liver Disease Progression (LiSyM-DP), LiSyM Pillar I: Early Metabolic Injury (LiSyM-EMI), LiSyM Pillar IV: Liver Function Diagnostics (LiSyM-LiFuDi), LiSyM Scientific Leadership Team (LiSyM-LT), Model Guided Pharmacotherapy In Chronic Liver Disease (LiSyM-MGP), The Hedgehog Signalling Pathway (LiSyM-JGMMS), LiSyM Pillar III: Regeneration and Repair in Acute-on-Chronic Liver Failure (LiSyM-ACLF), Multi-Scale Models for Personalized Liver Function Tests (LiSyM-MM-PLF), Molecular Steatosis - Imaging & Modeling (LiSyM-MSIM)
Institutions: University of Freiburg - Institute of Physics, LiSyM programme directorate
This generic project is intended to be a forum for all LiSyM partner and external stakeholders interested in participating in the BMBF initiative LiSyM-Krebs.
Programme: LiSyM-Krebs
Public web page: https://www.ptj.de/projektfoerderung/gesundheitsforschung/lisym-krebs
Organisms: Not specified
Disorders of the liver show up through changes in blood tests. These blood tests indicate markers for events taking place in the liver. Usually studies of liver tissue cannot be performed: as liver samples would need to be obtained through a liver biopsy, and this procedure is not without risk, therefore these samples are usually unavailable. Complex metabolism models based on existing and new scientific data can simulate changes in the liver caused by disease. They often reveal unknown relationships
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Programme: LiSyM: Liver Systems Medicine
Public web page: http://www.lisym.org/our-work/pillar-research/the-liver-is-very-patient
Start date: 1st Jan 2016
Organisms: Homo sapiens
Day-to-day science within the LiSyM is overseen and directed by the the LiSyM Scientific Leadership Team. This coordination team comprises the pillar coordinators and additional LiSyM members, and ensures smooth interaction between multi-skilled groups, often working in different institutions and across significant distances within Germany.
Programme: LiSyM: Liver Systems Medicine
Public web page: http://www.lisym.org/who-we-are
Organisms: Not specified
Dr. Ahmed Ghallab (TU University, Dortmund) deals with chronic liver damage caused by toxins. In addition, he investigates processes associated with cholestasis - when bile accumulates in the bile ducts. Ghallab has been able to explain basic mechanisms of acute cholestasis, using a method for intravital two-photon microscopy, which he developed.
Programme: LiSyM: Liver Systems Medicine
Public web page: http://www.lisym.org/our-work/junior-group/the-liver-protects-itself
Start date: 1st Jan 2016
Organisms: Homo sapiens, Mus musculus
Major infrastructure backbone of the whole LiSyM network. It comprises the core management tasks of the program directorate and the scientific project management, as well as the central data management. The data management concept relies on FAIRDOM (http://fair-dom.org) and uses the LiSyM SEEK platform as a major hub for exchanging data, models, SOPs and other information, as well as yellow pages for the projects with its corresponding members, institutions, events, presentations and publications.
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Programme: LiSyM: Liver Systems Medicine
Public web page: http://www.lisym.org/our-work/data-management
Start date: 1st Jan 2016
Organisms: Not specified