PhD student at Joint Research Center for Computational Biomedicine (JRC-COMBINE)
Chronic liver diseases (CLD) progression leads to cirrhosis, often cancer, and ultimately to organ failure and death. Because of the complexity of this scenario, a Systems Medicine approach is chosen to develop strategies to better characterize progression and resolution of fibrosis. Pillar II aims to define key molecular mechanisms and structural changes in tissue architecture during the progression of CLD by visualizing and quantifying at a cellular level, tissue and organ scale.
GitHub repository that contains all analyses scripts to reproduce the results reported in "Transfer of regulatory knowledge from human to mouse for functional genomics analysis"
Investigations: No Investigations
Studies: No Studies
Assays: No Assays
Authors: Christian Holland, Jovan Tanevski, Javier Perales-Patón, Jan Gleixner, Manu P. Kumar, Elisabetta Mereu, Brian A. Joughin, Oliver Stegle, Douglas A. Lauffenburger, Holger Heyn, Bence Szalai, Julio Saez-Rodriguez
Date Published: 1st Dec 2020
Journal: Genome Biol
Citation: Genome Biol 21(1) : e120
Authors: Christian Holland, Bence Szalai, Julio Saez-Rodriguez
Date Published: 1st Sep 2019
Journal: Biochimica et Biophysica Acta (BBA) - Gene Regulatory Mechanisms
Citation: Biochimica et Biophysica Acta (BBA) - Gene Regulatory Mechanisms : 194431
Authors: Ahmed Ghallab, Maiju Myllys, Christian Holland, Ayham Zaza, Walaa Murad, Reham Hassan, Yasser A Ahmed, Tahany Abbas, Eman Abdelrahim, Annika Schneider, Madlen Matz-Soja, Joerg Reinders, Rolf Gebhardt, Theresa Hildegard Wirtz, Maximilian Hatting, Dirk Drasdo, Julio Saez-Rodriguez, Christian Trautwein, Jan Hengstler
Date Published: 1st Dec 2019
Citation: Cells 8(12):1556 2019
Authors: Luz Garcia-Alonso, Christian Holland, Mahmoud M. Ibrahim, Denes Turei, Julio Saez-Rodriguez
Date Published: 1st Aug 2019
Journal: Genome Res.
Citation: Genome Res. 29(8) : 1363