Investigations
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Submitter
Olga Krebs1
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LiSyM network1
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LiSyM: Liver Systems Medicine 1
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Investigation visible to you, out of a total of 4
Upon stimulation of cells with transforming growth factorb(TGF-b),Smad proteins form trimeric complexes and activate a broad spectrum of target genes. It remains unresolved which of the possible Smad complexes are formed in cellular contexts and how these contribute to gene expression. Combining quantitative mass spectrometry with a computational selection strategy, we investigate Smad complexes in the mouse hepatoma cell line Hepa1-6.
Submitter: Olga Krebs
