Study about Smad complexes in liver-derived cells
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In this study we identify most relevant Smad complexes in liver-derived cells, the contribution of the Smad complexes on target gene expression, and the role of Smad abundance and Smad2 phosphorylation in hepatocellular carcinoma
SEEK ID: http://localhost:3000/studies/58
Investigation of the Smad Protein Complex Formation and Its Link toGeneExpression
Projects: LiSyM network
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Created: 28th Mar 2023 at 13:48
Last updated: 22nd May 2023 at 13:42
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Projects: LiSyM PALs, LiSyM network, LiSyM Pillar I: Early Metabolic Injury (LiSyM-EMI), LiSyM Pillar II: Chronic Liver Disease Progression (LiSyM-DP), LiSyM Pillar IV: Liver Function Diagnostics (LiSyM-LiFuDi), LiSyM Core Infrastructure and Management (LiSyM-PD), Molecular Steatosis - Imaging & Modeling (LiSyM-MSIM), Multi-Scale Models for Personalized Liver Function Tests (LiSyM-MM-PLF), The Hedgehog Signalling Pathway (LiSyM-JGMMS), Forschungsnetzwerk LiSyM-Krebs, SMART-NAFLD, DEEP-HCC network, C-TIP-HCC network, Default Project
Institutions: HITS gGmbH
https://orcid.org/0000-0003-3540-0402
I am a researcher at the Scientific Databases and Visualization Group at Heidelberg Institute for Theoretical Studies (HITS) , one of the developers of SabioRK - System for the Analysis of Biochemical Pathways - Reaction Kinetics (http://sabiork.h-its.org/) . I am working on design and maintenance of the information systems to store, query and analyse systems biology data; definition and implementation of methods for the integration of data from multiple sources. In SySMO-DB project ...
Projects: LiSyM Pillar II: Chronic Liver Disease Progression (LiSyM-DP), LiSyM Pillar III: Regeneration and Repair in Acute-on-Chronic Liver Failure (LiSyM-ACLF), LiSyM network, LiSyM-Krebs Partnering, Forschungsnetzwerk LiSyM-Krebs, SMART-NAFLD, C-TIP-HCC network
Institutions: University of Freiburg - Institute of Physics
https://orcid.org/0000-0003-4517-1383
This comprises the whole LiSyM network
Public web page: http://www.lisym.org
Start date: 1st Jan 2016
Upon stimulation of cells with transforming growth factorb(TGF-b),Smad proteins form trimeric complexes and activate a broad spectrum of target genes. It remains unresolved which of the possible Smad complexes are formed in cellular contexts and how these contribute to gene expression. Combining quantitative mass spectrometry with a computational selection strategy, we investigate Smad complexes in the mouse hepatoma cell line Hepa1-6.
Submitter: Olga Krebs
Submitter: Olga Krebs
Biological problem addressed: Signal Induction
Investigation: Investigation of the Smad Protein Complex Forma...
