Chronic Liver Disease Progression (LiSyM-DP - Pillar II) (Molecular Hepatology - Dept of Medicine II - Medical Faculty Mannheim - Heidelberg University) ; Regeneration and Repair in Acute-on-Chronic Liver Failure (LiSyM-ACLF - Pillar III) (Molecular Hepatology - Dept of Medicine II - Medical Faculty Mannheim - Heidelberg University) ; LiSyM network (Molecular Hepatology - Dept of Medicine II - Medical Faculty Mannheim - Heidelberg University)
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The incidence of this life-threatening acute-on-chronic liver failure (ACLF) is increasing, and early detection and cure are urgent clinical needs. Pillar III applies a Systems Medicine approach to identify the critical mechanisms of acute-on-chronic liver failure (ACLF) and to foster liver regeneration and repair.
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Chronic liver diseases (CLD) progression leads to cirrhosis, often cancer, and ultimately to organ failure and death. Because of the complexity of this scenario, a Systems Medicine approach is chosen to develop strategies to better characterize progression and resolution of fibrosis. Pillar II aims to define key molecular mechanisms and structural changes in tissue architecture during the progression of CLD by visualizing and quantifying at a cellular level, tissue and organ scale.
Date Published: 20th Jul 2019
Journal: Mol Med Rep
PubMed ID: 31322255
Citation: Mol Med Rep. 2019 Sep;20(3):2743-2753. doi: 10.3892/mmr.2019.10508. Epub 2019 Jul 19.
Authors: B. Dewidar, C. Meyer, Steven Dooley, A. N. Meindl-Beinker
Date Published: 11th Nov 2019
PubMed ID: 31718044
Citation: Cells. 2019 Nov 11;8(11). pii: cells8111419. doi: 10.3390/cells8111419.
Authors: W. Fan, T. Liu, W. Chen, Seddik Hammad, T. Longerich, Y. Fu, N. Li, Y. He, C. Liu, Y. Zhang, Q. Lian, Jieling Zhao, C. Yan, L. Li, C. Yi, Z. Ling, L. Ma, Jieling Zhao, H. Xu, P. Wang, M. Cong, H. You, Z. Liu, Y. Wang, J. Chen, D. Li, L. Hui, Steven Dooley, J. Hou, J. Jia, B. Sun
Date Published: 27th Jul 2019
PubMed ID: 31362006
Citation: Gastroenterology. 2019 Jul 27. pii: S0016-5085(19)41133-5. doi: 10.1053/j.gastro.2019.07.036.
Poster presented at Hünfeld Retreat 2018
Contributor: Lars Ole Schwen