SEEK ID: https://seek.lisym.org/people/21
Location:
Germany
ORCID:
https://orcid.org/0000-0003-0137-5106
Joined: 28th Apr 2017
LiSyM Pillar I: Early Metabolic Injury (LiSyM-EMI) (Zentrum für Informationsdienste und Hochleistungsrechnen (ZIH), Technische Universität Dresden) ; LiSyM PALs (Zentrum für Informationsdienste und Hochleistungsrechnen (ZIH), Technische Universität Dresden) ; LiSyM network (Zentrum für Informationsdienste und Hochleistungsrechnen (ZIH), Technische Universität Dresden) ; LiSyM-Krebs Partnering (Zentrum für Informationsdienste und Hochleistungsrechnen (ZIH), Technische Universität Dresden) ; Forschungsnetzwerk LiSyM-Krebs (Zentrum für Informationsdienste und Hochleistungsrechnen (ZIH), Technische Universität Dresden) ; DEEP-HCC network (Zentrum für Informationsdienste und Hochleistungsrechnen (ZIH), Technische Universität Dresden)
Related items
- Programmes (2)
- Projects (6)
- Institutions (1)
- Investigations (0+1)
- Studies (0+1)
- Assays (0+1)
- Models (7)
- Publications (15)
- Presentations (2+5)
- Events (2)
- Documents (0+2)
LiSyM-Krebs ist ein nationales Forschungsnetz zur Früherkennung und Prävention von Leberkrebs, das unter Verwendung des systemmedizinischen Forschungsansatzes die komplexen, dynamischen Prozesse der Krankheitsprogression analysiert, um ausgehend von den Erkenntnissen aus dem Forschungsnetz LiSyM die Entstehung von Leberkrebs besser zu verstehen, vorherzusagen und im besten Fall sogar zu verhindern. LiSyM-Krebs setzt die erfolgreichen Forschungsaktivitäten der BMBF-Vorgängerprogramme ...
Projects: LiSyM-Krebs Partnering, Forschungsnetzwerk LiSyM-Krebs, SMART-NAFLD, DEEP-HCC network, C-TIP-HCC network
Web page: https://www.lisym-cancer.org
Liver Systems Medicine : striving to develop non-invasive methods for diagnosing and treating NAFLD by combining mathematical modeling and biological research. LiSyM, is a multidisciplinary research network, in which molecular and cell biologists, clinical researchers, pharmacologists and experts in mathematical modeling examine the liver in its entirety. LiSyM research focuses on the metabolic liver disease non-alcoholic fatty liver disease (NAFLD), which includes non-alcoholic steatohepatitis ...
Projects: LiSyM Core Infrastructure and Management (LiSyM-PD), LiSyM Pillar I: Early Metabolic Injury (LiSyM-EMI), LiSyM Pillar II: Chronic Liver Disease Progression (LiSyM-DP), LiSyM Pillar III: Regeneration and Repair in Acute-on-Chronic Liver Failure (LiSyM-ACLF), LiSyM Pillar IV: Liver Function Diagnostics (LiSyM-LiFuDi), Model Guided Pharmacotherapy In Chronic Liver Disease (LiSyM-MGP), Molecular Steatosis - Imaging & Modeling (LiSyM-MSIM), The Hedgehog Signalling Pathway (LiSyM-JGMMS), Multi-Scale Models for Personalized Liver Function Tests (LiSyM-MM-PLF), LiSyM PALs, Project Management PTJ, LiSyM network, LiSyM Scientific Leadership Team (LiSyM-LT)
Web page: https://www.lisym.org/
This comprises the whole LiSyM network
Programme: LiSyM: Liver Systems Medicine
Public web page: http://www.lisym.org
Start date: 1st Jan 2016
Organisms: Rattus norvegicus, Rattus rattus, Mus musculus, Homo sapiens
DEEP-HCC - Detailed Analysis of the Spatial Organization of the Development of Hepatocellular Carcinoma
Programme: LiSyM-Krebs - Systemmedizinisches Forschungsnetz zur Früherkennung und Prävention von Leberkrebs
Public web page: Not specified
Organisms: Homo sapiens, Mus musculus
Forschungsnetzwerk zur Früherkennung und Prävention- LiSyM-Krebs
Ein Netzwerk von Klinikern, Wissenschaftlern und Datenmanagern hat sich zur Aufgabe gemacht, Methoden zu entwickeln, um Patienten mit einem hohen Risiko für ein Leberkarzinom frühzeitig, in Vorstadien der Tumorentwicklung, identifizieren zu können. Gemeinsam bilden sie das „Systemmedizinische Forschungsnetzwerk zur Früherkennung und Prävention von Leberkrebs“, LiSym-Krebs, das vom Bundesministerium für Bildung und Forschung ...
Programme: LiSyM-Krebs - Systemmedizinisches Forschungsnetz zur Früherkennung und Prävention von Leberkrebs
Public web page: Not specified
Organisms: Homo sapiens
This generic project is intended to be a forum for all LiSyM partner and external stakeholders interested in participating in the BMBF initiative LiSyM-Krebs.
Programme: LiSyM-Krebs - Systemmedizinisches Forschungsnetz zur Früherkennung und Prävention von Leberkrebs
Public web page: https://www.ptj.de/projektfoerderung/gesundheitsforschung/lisym-krebs
Organisms: Not specified
This is a generic project that comprises all LiSyM data management PALs and associated FAIRDOM PALs, as well as the LiSyM data management team. Olga Maja Alain
Programme: LiSyM: Liver Systems Medicine
Public web page: Not specified
Organisms: Not specified
This model was used in the Modeling Workshop at the 2nd LiSyM-Cancer Status Seminar.
Creator: Lutz Brusch
Submitter: Lutz Brusch
Model type: Agent based modelling
Model format: MorpheusML
Environment: Morpheus
Organism: Not specified
Investigations: No Investigations
Studies: No Studies
Assays: No Assays
The model is adapted from A.P. Kupinski, I. Raabe, M. Michel, D. Ail, L. Brusch, T. Weidemann, C. Bökel (2013) Phosphorylation of the Smo tail is controlled by membrane localization and is dispensable for clustering, J. Cell Sci., 126, 20, 4684-4697 https://doi.org/10.1242/jcs.128926
The model format is MorpheusML that can readily be loaded and run in Morpheus: https://morpheus.gitlab.io
Creator: Lutz Brusch
Submitter: Lutz Brusch
Model type: Ordinary differential equations (ODE)
Model format: MorpheusML
Environment: Morpheus
Organism: Not specified
Investigations: No Investigations
Studies: No Studies
Assays: No Assays
Model for the interaction of Wnt and Hh as published in Kolbe et al.: Mutual Zonated Interactions of Wnt and Hh Signaling Are Orchestrating the Metabolism of the Adult Liver in Mice and Human, Cell Reports, 29,4553,
Creators: Michael Kücken, Lutz Brusch
Submitters: Lutz Brusch, Michael Kücken
Model type: Partial differential equations (PDE)
Model format: MorpheusML
Environment: Morpheus
For the spatio-temporal dynamics of bile transport, bile canalicular dilation, mechanical stimulation and transduction of YAP signaling during liver regeneration see the open access publication and its appendix: Meyer et al. (2020) Bile canaliculi remodeling activates YAP via the actin cytoskeleton during liver regeneration. Molecular Systems Biology 16:e8985. https://doi.org/10.15252/msb.20198985
The model format is MorpheusML that can readily be loaded and run in the free and open source software ...
Creator: Lutz Brusch
Submitter: Lutz Brusch
Model type: Agent based modelling
Model format: MorpheusML
Environment: Morpheus
Morpheus is the modelling and simulation framework for multicellular systems biology developed at Technische Universität Dresden. Manual, examples and binaries for Windows, Linux, MacOS at: https://morpheus.gitlab.io Open source code at: https://gitlab.com/morpheus.lab/morpheus
Creators: Lutz Brusch, Jörn Starruß, Walter de Back, Andreas Deutsch
Submitter: Lutz Brusch
Model type: Agent based modelling
Model format: MorpheusML
Environment: Morpheus
Organism: Not specified
Investigations: No Investigations
Studies: No Studies
Assays: No Assays
Abstract (Expand)
Authors: Paula Heinke, Fabian Rost, Julian Rode, Palina Trus, Irina Simonova, Enikő Lázár, Joshua Feddema, Thilo Welsch, Kanar Alkass, Mehran Salehpour, Andrea Zimmermann, Daniel Seehofer, Göran Possnert, Georg Damm, Henrik Druid, Lutz Brusch, Olaf Bergmann
Date Published: 1st Jun 2022
Publication Type: Journal
DOI: 10.1016/j.cels.2022.05.001
Citation: Cell Systems 13(6):499-507.e12
Abstract (Expand)
Authors: A. Scholich, S. Syga, H. Morales-Navarrete, F. Segovia-Miranda, H. Nonaka, K. Meyer, W. de Back, L. Brusch, Y. Kalaidzidis, M. Zerial, F. Julicher, B. M. Friedrich
Date Published: 11th Dec 2020
Publication Type: Journal
PubMed ID: 33301446
Citation: PLoS Comput Biol. 2020 Dec 10;16(12):e1008412. doi: 10.1371/journal.pcbi.1008412. eCollection 2020 Dec.
Abstract (Expand)
Authors: Paula Heinke, Fabian Rost, Julian Rode, Thilo Welsch, Kanar Alkass, Joshua Feddema, Mehran Salehpour, Göran Possnert, Henrik Druid, Lutz Brusch, Olaf Bergmann
Date Published: 7th Aug 2020
Publication Type: Unpublished
DOI: 10.1101/2020.08.07.230086
Citation: biorxiv;2020.08.07.230086v1,[Preprint]
Abstract (Expand)
Authors: Andre Scholich, Simon Syga, Hernan Morales-Navarrete, Fabian Segovia Miranda, Hidenori Nonaka, Kirstin Meyer, Walter de Back, Lutz Brusch, Yannis Kalaidzidis, Marino Zerial, Frank Julicher, Benjamin M. Friedrich
Date Published: 22nd Apr 2020
Publication Type: Not specified
Citation: arXiv:1904.08886 [q-bio.TO]
Abstract (Expand)
Authors: K. Meyer, H. Morales-Navarrete, S. Seifert, M. Wilsch-Braeuninger, U. Dahmen, E. M. Tanaka, L. Brusch, Y. Kalaidzidis, M. Zerial
Date Published: 25th Feb 2020
Publication Type: Journal
PubMed ID: 32090478
Citation: Mol Syst Biol. 2020 Feb;16(2):e8985. doi: 10.15252/msb.20198985.
Talk at the Jamboree 2021 about epigenomic map of human liver zonation and loss of zonation in end-stage liver disease
Creators: Mario Brosch, Jochen Hampe, Lutz Brusch, Marino Zerial, Clemens Schafmayer
Submitter: Mario Brosch
Computational modeling and simulation become increasingly important for Systems Medicine. A number of corresponding software tools have been developed but require scientists to encode their models in an imperative programming language. Morpheus [1,2], on the other hand, is an extensible open-source software framework that is entirely based on declarative modeling. It uses the domain-specific language MorpheusML to define multicellular models through a user-friendly GUI and has since proven ...
Creators: Lutz Brusch, Michael Kücken
Submitter: Lutz Brusch
The “Computational Modeling in Biology” Network (COMBINE) is an initiative to coordinate the development of the various community standards and formats in systems biology and related fields. COMBINE 2022 will be a workshop-style event with oral presentations, breakout sessions and tutorials. The three meeting days will include talks about the COMBINE standards and associated or related standardization efforts, presentations of tools using these standards, breakout sessions for detailed discussions ...
Start Date: 6th Oct 2022
End Date: 8th Oct 2022
Event Website: https://co.mbine.org/author/combine-2022/
Country: Germany
City: Berlin
This workshop is a satellite meeting to the LiSyM Young Scientist Retreat. It takes place just before the retreat and is organised by Matthias König (Junior Group), Michael Kücken and Lutz Brusch (Pillar I). The aim of this additional workshop for the modelers is to demonstrate and discuss the wider applicability, but also the limitations of the mathematical and computational methods and software used and even (co-)developed within LiSyM and to exchange them among LiSyM groups. These methods and ...
Start Date: 28th Jan 2020
End Date: 29th Jan 2020
Event Website: https://event.zih.tu-dresden.de/events/view/46
Country: Germany
City: Hofgeismar