Forschungsnetzwerk LiSyM-Krebs
OverviewForschungsnetzwerk zur Früherkennung und Prävention- LiSyM-Krebs
Ein Netzwerk von Klinikern, Wissenschaftlern und Datenmanagern hat sich zur Aufgabe gemacht, Methoden zu entwickeln, um Patienten mit einem hohen Risiko für ein Leberkarzinom frühzeitig, in Vorstadien der Tumorentwicklung, identifizieren zu können. Gemeinsam bilden sie das „Systemmedizinische Forschungsnetzwerk zur Früherkennung und Prävention von Leberkrebs“, LiSym-Krebs, das vom Bundesministerium für Bildung und Forschung (BMBF) in den kommenden drei Jahren mit circa 10 Mio. Euro gefördert wird.
LiSyM-Krebs besteht aus den drei Forschungsverbünden : C-TIP-HCC, SMART-NAFLD und DEEP-HCC.
Programme: LiSyM-Krebs - Systemmedizinisches Forschungsnetz zur Früherkennung und Prävention von Leberkrebs
SEEK ID: https://seek.lisym.org/projects/16
Public web page: Not specified
Organisms: Homo sapiens, Mus musculus, Rattus norvegicus, Rattus rattus
FAIRDOM PALs: No PALs for this Project
Project created: 15th Jan 2021
Related items
https://orcid.org/0000-0002-3016-7026
: inactive since 2024-01-01
Projects: LiSyM network, Forschungsnetzwerk LiSyM-Krebs, LiSyM Pillar II: Chronic Liver Disease Progression (LiSyM-DP), LiSyM Core Infrastructure and Management (LiSyM-PD), LiSyM Pillar III: Regeneration and Repair in Acute-on-Chronic Liver Failure (LiSyM-ACLF), DEEP-HCC network
Institutions: HITS gGmbH
LiSyM-Krebs ist ein nationales Forschungsnetz zur Früherkennung und Prävention von Leberkrebs, das unter Verwendung des systemmedizinischen Forschungsansatzes die komplexen, dynamischen Prozesse der Krankheitsprogression analysiert, um ausgehend von den Erkenntnissen aus dem Forschungsnetz LiSyM die Entstehung von Leberkrebs besser zu verstehen, vorherzusagen und im besten Fall sogar zu verhindern. LiSyM-Krebs setzt die erfolgreichen Forschungsaktivitäten der BMBF-Vorgängerprogramme ...
Projects: LiSyM-Krebs Partnering, Forschungsnetzwerk LiSyM-Krebs, SMART-NAFLD, DEEP-HCC network, C-TIP-HCC network
Web page: https://www.lisym-cancer.org
Country: 
Germany
City: 69120 Heidelberg
Web page: https://www.dkfz.de/en/tumor-metabolismus-microenvironment/index.php
Submitter: Olga Krebs
Studies: GENOMICS/TRANSCRIPTOMICS, METABOLOMICS, OTHER OMICS DATA, PROTEOMICS
Assays: DNA sequence data, RNA sequence data, Western blot
OTHER OMICS DATA
Submitter: Olga Krebs
Investigation: LiSyM-Cancer project data for integration into...
Assays: No Assays
METABOLOMICS
Submitter: Olga Krebs
Investigation: LiSyM-Cancer project data for integration into...
Assays: No Assays
PROTEOMICS
Submitter: Olga Krebs
Investigation: LiSyM-Cancer project data for integration into...
Assays: Western blot
GENOMICS/TRANSCRIPTOMICS
Submitter: Olga Krebs
Investigation: LiSyM-Cancer project data for integration into...
Assays: DNA sequence data, RNA sequence data
In this study, we characterize Western diet-induced phenotypic changes in murine 392 hepatocytes and employ dynamic pathway modelling to resolve the underlying molecular 393 mechanisms resulting in altered intracellular signal transduction and enhanced proliferation 394 of WD hepatocytes.
Project proposals
Submitter: Olga Krebs
Biological problem addressed: Model Analysis Type
Investigation: 1 hidden item
Study: Documents submitted to BMBF
Meeting minutes 2021
Submitter: Olga Krebs
Biological problem addressed: Model Analysis Type
Investigation: 1 hidden item
Study: Meeting minutes
Meeting minutes 2022
Submitter: Olga Krebs
Biological problem addressed: Model Analysis Type
Investigation: 1 hidden item
Study: Meeting minutes
Project deliverables 2021
Submitter: Olga Krebs
Biological problem addressed: Model Analysis Type
Investigation: 1 hidden item
Study: Documents submitted to BMBF
Project deliverables 2022
Submitter: Olga Krebs
Biological problem addressed: Model Analysis Type
Investigation: 1 hidden item
Study: Documents submitted to BMBF
Raw data of RNA-seq analysis of primary murine hepatocytes treated with Hh modulating compounds
Creators: None
Submitter: Fritzi Ott
Creator: Andreas Weidemann
Submitter: Andreas Weidemann
Model type: Stoichiometric model
Model format: SBML
Environment: Copasi
Download
This protocol details the RNAseq sample preparation starting with mRNA and ending with quality control of finished libraries. This protocol was used specifically for virus mRNA samples related to ORFeome lab group.
Creators: Olga Krebs, Marcia Sanders (marcia_sanders@unc.edu), Anne Beall (aebeall@email.unc.edu
Submitter: Olga Krebs
SOP Western diat mouse housing and feeding
Creator: Ina Biermayer
Submitter: Olga Krebs
Isolation of primary mouse hepatocytes
Creators: Ina Biermayer, Ursula Klingmüller
Submitter: Olga Krebs
Abstract (Expand)
Authors: Barbara Helm, Pauline Hansen, Li Lai, Luisa Schwarzmüller, Simone M. Clas, Annika Richter, Max Ruwolt, Fan Liu, Dario Frey, Lorenza A. D’Alessandro, Wolf-Dieter Lehmann, Marcel Schilling, Dominic Helm, Dorothea Fiedler, Ursula Klingmüller
Date Published: 21st Feb 2024
Publication Type: Journal
Abstract (Expand)
Authors: Sebastian Burbano de Lara, Svenja Kemmer, Ina Biermayer, Svenja Feiler, Artyom Vlasov, Lorenza A D’Alessandro, Barbara Helm, Christina Mölders, Yannik Dieter, Ahmed Ghallab, Jan G Hengstler, Christiane Körner, Madlen Matz-Soja, Christina Götz, Georg Damm, Katrin Hoffmann, Daniel Seehofer, Thomas Berg, Marcel Schilling, Jens Timmer, Ursula Klingmüller
Date Published: 12th Jan 2024
Publication Type: Journal
Abstract (Expand)
Authors: Felix Hiebinger, Aiste Kudulyte, Huanting Chi, Sebastian Burbano De Lara, Doroteja Ilic, Barbara Helm, Hendrik Welsch, Viet Loan Dao Thi, Ursula Klingmüller, Marco Binder
Date Published: 1st Dec 2023
Publication Type: Journal
Abstract (Expand)
Authors: Sophia Müller-Dott, Eirini Tsirvouli, Miguel Vazquez, Ricardo O Ramirez Flores, Pau Badia-i-Mompel, Robin Fallegger, Dénes Türei, Astrid Lægreid, Julio Saez-Rodriguez
Date Published: 10th Nov 2023
Publication Type: Journal
Abstract (Expand)
Authors: E. Alamoudi, Y. Schalte, R. Muller, J. Starruss, N. Bundgaard, F. Graw, L. Brusch, J. Hasenauer
Date Published: 1st Nov 2023
Publication Type: Journal
The “Computational Modeling in Biology” Network (COMBINE) is an initiative to coordinate the development of the various community standards and formats in systems biology and related fields. COMBINE 2024 is a workshop-style event with oral presentations, breakout sessions and tutorials. The three meeting days will include talks about the COMBINE standards and associated or related standardization efforts, presentations of tools using these standards, breakout sessions for detailed discussions as ...
Start Date: 1st Sep 2024 (1st Sep 2024 (Europe/Berlin))
End Date: 3rd Sep 2024 (3rd Sep 2024 (Europe/Berlin))
Event Website: https://co.mbine.org/author/combine-2024/
Country: Germany
City: Stuttgart
The “Computational Modeling in Biology” Network (COMBINE) is an initiative to coordinate the development of the various community standards and formats in systems biology, synthetic biology and related fields. HARMONY is a codefest-type meeting, with a focus on development of the standards, interoperability and infrastructure. There are generally not many general discussions or oral presentations during HARMONY; instead, the time is devoted to allowing hands-on hacking and interaction between ...
Start Date: 8th Apr 2024 (8th Apr 2024 (Europe/London))
End Date: 11th Apr 2024 (11th Apr 2024 (Europe/London))
Event Website: https://co.mbine.org/author/harmony-2024/
Country: 
United Kingdom
City: London
Just over 30 years ago, the cellular Potts model (CPM) was introduced to explain experimental observations of spontaneous cell sorting in embryonic tissue cultures. In the years since, the CPM evolved into a powerful model framework for simulating a wide range of physical and biological processes – from foam physics to tissue development, cancer growth, angiogenesis, plant development, evolution, immune responses, and cell migration. Having just celebrated the 30th birthday of the CPM, now is a ...
Start Date: 18th Dec 2023 (18th Dec 2023 (Europe/Amsterdam))
End Date: 22nd Dec 2023 (22nd Dec 2023 (Europe/Amsterdam))
Event Website: https://www.lorentzcenter.nl/simulating-tissue-dynamics-with-cellular-potts-models.html
Country: 
Netherlands
City: Leiden
The “Computational Modeling in Biology” Network (COMBINE) is an initiative to coordinate the development of the various community standards and formats in systems biology and related fields. COMBINE 2023 is a workshop-style event with oral presentations, breakout sessions and tutorials. The three meeting days will include talks about the COMBINE standards and associated or related standardization efforts, presentations of tools using these standards, breakout sessions for detailed discussions as ...
Start Date: 5th Oct 2023 (5th Oct 2023 (America/New_York))
End Date: 7th Oct 2023 (7th Oct 2023 (America/New_York))
Event Website: https://co.mbine.org/author/combine-2023/
Country: 
United States
City: Farmington, CT
The Computational Modeling in Biology Network (COMBINE) is an initiative to coordinate the development of the various community standards and formats in systems biology, synthetic biology and related fields. HARMONY is a codefest-type meeting, with a focus on development of the standards, interoperability and infrastructure. There are generally not many general discussions or oral presentations during HARMONY; instead, the time is devoted to allowing hands-on hacking and interaction between people ...
Start Date: 24th Apr 2023
End Date: 27th Apr 2023
Event Website: https://co.mbine.org/author/harmony-2023/
Country: United States
City: Seattle
Creators: Ina Biermayer, Susan Eckerle
Submitter: Maja Rey
Creators: Ina Biermayer, Susan Eckerle
Submitter: Maja Rey
Workshop #1 LiSym status seminar March 2023, Dresden “Towards concordant multiomics of liver”
Creators: Andrej Shevchenko, Ursula Klingmüller
Submitter: Olga Krebs
Group picture from Lisym-Cancer Status Seminar 2023
Creators: Olga Krebs, Ina Biermayer, Susan Eckerle
Submitter: Olga Krebs
Creators: Ursula Klingmüller, Ina Biermayer, Susan Eckerle
Submitter: Ursula Klingmüller
External Link