Program management team LiSyM-Cancer (project and communications manager)
Former PhD student in LiSyM, at DKFZ Heidelberg in the group of Ursula Klingmüller
(née Schmitt)
SEEK ID: https://seek.lisym.org/people/115
Location: Germany
ORCID: Not specified
Joined: 29th Nov 2018
Related items
- Programmes (2)
- Projects (6)
- Institutions (2)
- Investigations (0+1)
- Studies (1+3)
- Assays (0+7)
- Data files (0+3)
- SOPs (2+2)
- Publications (44)
- Presentations (0+14)
- Documents (7+121)
LiSyM-Krebs ist ein nationales Forschungsnetz zur Früherkennung und Prävention von Leberkrebs, das unter Verwendung des systemmedizinischen Forschungsansatzes die komplexen, dynamischen Prozesse der Krankheitsprogression analysiert, um ausgehend von den Erkenntnissen aus dem Forschungsnetz LiSyM die Entstehung von Leberkrebs besser zu verstehen, vorherzusagen und im besten Fall sogar zu verhindern. LiSyM-Krebs setzt die erfolgreichen Forschungsaktivitäten der BMBF-Vorgängerprogramme ...
Projects: LiSyM-Krebs Partnering, Forschungsnetzwerk LiSyM-Krebs, SMART-NAFLD, DEEP-HCC network, C-TIP-HCC network
Web page: https://www.lisym-cancer.org
Liver Systems Medicine : striving to develop non-invasive methods for diagnosing and treating NAFLD by combining mathematical modeling and biological research. LiSyM, is a multidisciplinary research network, in which molecular and cell biologists, clinical researchers, pharmacologists and experts in mathematical modeling examine the liver in its entirety. LiSyM research focuses on the metabolic liver disease non-alcoholic fatty liver disease (NAFLD), which includes non-alcoholic steatohepatitis ...
Projects: LiSyM Core Infrastructure and Management (LiSyM-PD), LiSyM Pillar I: Early Metabolic Injury (LiSyM-EMI), LiSyM Pillar II: Chronic Liver Disease Progression (LiSyM-DP), LiSyM Pillar III: Regeneration and Repair in Acute-on-Chronic Liver Failure (LiSyM-ACLF), LiSyM Pillar IV: Liver Function Diagnostics (LiSyM-LiFuDi), Model Guided Pharmacotherapy In Chronic Liver Disease (LiSyM-MGP), Molecular Steatosis - Imaging & Modeling (LiSyM-MSIM), The Hedgehog Signalling Pathway (LiSyM-JGMMS), Multi-Scale Models for Personalized Liver Function Tests (LiSyM-MM-PLF), LiSyM PALs, Project Management PTJ, LiSyM network, LiSyM Scientific Leadership Team (LiSyM-LT)
Web page: https://www.lisym.org/
Forschungsnetzwerk zur Früherkennung und Prävention- LiSyM-Krebs
Ein Netzwerk von Klinikern, Wissenschaftlern und Datenmanagern hat sich zur Aufgabe gemacht, Methoden zu entwickeln, um Patienten mit einem hohen Risiko für ein Leberkarzinom frühzeitig, in Vorstadien der Tumorentwicklung, identifizieren zu können. Gemeinsam bilden sie das „Systemmedizinische Forschungsnetzwerk zur Früherkennung und Prävention von Leberkrebs“, LiSym-Krebs, das vom Bundesministerium für Bildung und Forschung ...
Programme: LiSyM-Krebs - Systemmedizinisches Forschungsnetz zur Früherkennung und Prävention von Leberkrebs
Public web page: Not specified
Organisms: Homo sapiens, Mus musculus, Rattus norvegicus, Rattus rattus
SMART-NAFLD : A Systems Medicine Approach to Early Detection and Prevention of Hepatocellular Carcinoma in Non-Alcoholic Fatty Liver Disease
The massive increase in obesity is leading to an alarming rise in non-alcoholic liver disease (NAFLD). This development will lead to a dramatic increase in liver diseases such as hepatocellular carcinoma (HCC). A particular challenge is that NAFLD-associated HCCs, for reasons still unknown, not only occur in association with advanced liver fibrosis/cirrhosis, ...
Programme: LiSyM-Krebs - Systemmedizinisches Forschungsnetz zur Früherkennung und Prävention von Leberkrebs
Public web page: Not specified
Organisms: Mus musculus, Homo sapiens
DEEP-HCC - Detailed Analysis of the Spatial Organization of the Development of Hepatocellular Carcinoma
Programme: LiSyM-Krebs - Systemmedizinisches Forschungsnetz zur Früherkennung und Prävention von Leberkrebs
Public web page: Not specified
Organisms: Homo sapiens, Mus musculus
C-TIP-HCC- Mechanism-based Multiscale Model to Dissect the Tipping Point from Liver Cirrhosis to Hepatocellular Carcinoma
The ultimate goal of the C-TIP-HCC is a „mechanistic multiscale model to describe dynamic changes in regenerative nodes across a tipping point (TIP) towards development in patients with cirrhosis to facilitate early monitoring and intervention“ and facilitate intervention“. To achieve this, we will conduct in-depth studies on cirrhotic regenerative nodes.
Programme: LiSyM-Krebs - Systemmedizinisches Forschungsnetz zur Früherkennung und Prävention von Leberkrebs
Public web page: Not specified
Organisms: Homo sapiens, Mus musculus
This comprises the whole LiSyM network
Programme: LiSyM: Liver Systems Medicine
Public web page: http://www.lisym.org
Start date: 1st Jan 2016
Organisms: Rattus norvegicus, Rattus rattus, Mus musculus, Homo sapiens
In this study, we characterize Western diet-induced phenotypic changes in murine 392 hepatocytes and employ dynamic pathway modelling to resolve the underlying molecular 393 mechanisms resulting in altered intracellular signal transduction and enhanced proliferation 394 of WD hepatocytes.
Snapshots: No snapshots
SOP Western diat mouse housing and feeding
Creator: Ina Biermayer
Submitter: Olga Krebs
Investigations: 1 hidden item
Studies: Proteomic alterations in Western Diet (WD) hepa...
Assays: 2 hidden items
Isolation of primary mouse hepatocytes
Creators: Ina Biermayer, Ursula Klingmüller
Submitter: Olga Krebs
Investigations: 1 hidden item
Studies: Proteomic alterations in Western Diet (WD) hepa...
Assays: 2 hidden items
Abstract (Expand)
Authors: Sophia Müller-Dott, Eric J. Jaehnig, Khoi Pham Munchic, Wen Jiang, Tomer M. Yaron-Barir, Sara R. Savage, Martin Garrido-Rodriguez, Jared L. Johnson, Alessandro Lussana, Evangelia Petsalaki, Jonathan T. Lei, Aurélien Dugourd, Karsten Krug, Lewis C. Cantley, D. R. Mani, Bing Zhang, Julio Saez-Rodriguez
Date Published: 2nd Jul 2024
Publication Type: Journal
DOI: 10.1101/2024.06.27.601117
Citation: biorxiv;2024.06.27.601117v1,[Preprint]
Abstract (Expand)
Authors: Valentin Blank, Thomas Karlas, Ulf Anderegg, Johannes Wiegand, Josi Arnold, Linnaeus Bundalian, Gabriela‐Diana Le Duc, Christiane Körner, Thomas Ebert, Anja Saalbach
Date Published: 4th May 2024
Publication Type: Journal
DOI: 10.1111/liv.15956
Citation: Liver International,liv.15956
Abstract (Expand)
Authors: Barbara Helm, Pauline Hansen, Li Lai, Luisa Schwarzmüller, Simone M. Clas, Annika Richter, Max Ruwolt, Fan Liu, Dario Frey, Lorenza A. D’Alessandro, Wolf-Dieter Lehmann, Marcel Schilling, Dominic Helm, Dorothea Fiedler, Ursula Klingmüller
Date Published: 21st Feb 2024
Publication Type: Journal
DOI: 10.1101/2024.02.19.580971
Citation:
All authors
Abstract (Expand)
Authors: Sebastian Burbano De Lara, Svenja Kemmer, Ina Biermayer, Svenja Feiler, Artyom Vlasov, Lorenza A D’Alessandro, Barbara Helm, Christina Mölders, Yannik Dieter, Ahmed Ghallab, Jan G Hengstler, Christiane Körner, Madlen Matz-Soja, Christina Götz, Georg Damm, Katrin Hoffmann, Daniel Seehofer, Thomas Berg, Marcel Schilling, Jens Timmer, Ursula Klingmüller
Date Published: 12th Jan 2024
Publication Type: Journal
DOI: 10.1038/s44320-023-00007-4
Citation: Mol Syst Biol
Abstract (Expand)
Authors: Felix Hiebinger, Aiste Kudulyte, Huanting Chi, Sebastian Burbano De Lara, Doroteja Ilic, Barbara Helm, Hendrik Welsch, Viet Loan Dao Thi, Ursula Klingmüller, Marco Binder
Date Published: 1st Dec 2023
Publication Type: Journal
DOI: 10.1186/s12935-023-03150-y
Citation: Cancer Cell Int 23(1),315
Creators: Ina Biermayer, Susan Eckerle
Submitter: Maja Rey
Investigations: No Investigations
Studies: No Studies
Assays: No Assays
Creators: Ina Biermayer, Susan Eckerle
Submitter: Maja Rey
Investigations: No Investigations
Studies: No Studies
Assays: No Assays
Group picture from Lisym-Cancer Status Seminar 2023
Creators: Olga Krebs, Ina Biermayer, Susan Eckerle
Submitter: Olga Krebs
Investigations: No Investigations
Studies: No Studies
Assays: No Assays
Creators: Ursula Klingmüller, Ina Biermayer, Susan Eckerle
Submitter: Ursula Klingmüller
Investigations: No Investigations
Studies: No Studies
Assays: No Assays
Agenda for LiSyM-Cancer status seminar 2022
Creators: Olga Krebs, Wolfgang Müller, Ursula Klingmüller, Ina Biermayer
Submitter: Olga Krebs
Investigations: No Investigations
Studies: No Studies
Assays: No Assays