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- University of Freiburg - Institute of Physics
Web page: http://www.mathphys.uni-freiburg.de/physik/
Country: Germany
City: 79104 Freiburg im Breisgau
Address:
Hermann-Herder Str. 3
Related items
Projects: LiSyM Core Infrastructure and Management (LiSyM-PD), Chronic Liver Disease Progression (LiSyM-DP - Pillar II), Early Metabolic Injury (LiSyM-EMI - Pillar I), Liver Function Diagnostics (LiSyM-LiFuDi - Pillar IV), Model Guided Pharmacotherapy In Chronic Liver Disease (LiSyM-MGP), Molecular Steatosis - Imaging & Modeling (LiSyM-MSIM), Multi-Scale Models for Personalized Liver Function Tests (LiSyM-MM-PLF), Regeneration and Repair in Acute-on-Chronic Liver Failure (LiSyM-ACLF - Pillar III), The Hedgehog Signalling Pathway (LiSyM-JGMMS), LiSyM network, LiSyM Scientific Leadership Team
Institutions: University of Freiburg - Institute of Physics, LiSyM programme directorate

PhD student
Timmer group
Institute of Physics University of Freiburg
Hermann-Herder-Straße 3, 79104 Freiburg, Germany
phone +49 761 203 7710
svenja.kemmer ät fdm.uni-freiburg.de
Projects: LiSyM network
Institutions: University of Freiburg - Institute of Physics
The incidence of this life-threatening acute-on-chronic liver failure (ACLF) is increasing, and early detection and cure are urgent clinical needs. Pillar III applies a Systems Medicine approach to identify the critical mechanisms of acute-on-chronic liver failure (ACLF) and to foster liver regeneration and repair.
Public web page: Not specified
Organisms: Not specified
Data (breath tests scores, imaging data from MRE, histopathological characterization and proteomics data of liver biopsies) will be acquired from two different groups of patients to be used in computer-assisted diagnostic tools for early detection and comprehensive evaluation of altered liver functions.
Public web page: Not specified
Organisms: Not specified
Non-alcoholic fatty liver disease (NAFLD) is the most common chronic liver disease worldwide. LiSyM-EMI looks into the transition from steatosis to non-alcoholic steatohepatitis (NASH) as the disease-defining moment in NAFLD. A systems analysis of these early disease events will be performed to elucidate the molecular mechanisms that trigger disease establishment.
Public web page: Not specified
Organisms: Mus musculus, Rattus rattus, Rattus norvegicus
Chronic liver diseases (CLD) progression leads to cirrhosis, often cancer, and ultimately to organ failure and death. Because of the complexity of this scenario, a Systems Medicine approach is chosen to develop strategies to better characterize progression and resolution of fibrosis. Pillar II aims to define key molecular mechanisms and structural changes in tissue architecture during the progression of CLD by visualizing and quantifying at a cellular level, tissue and organ scale.
Public web page: Not specified
Organisms: Mus musculus, Rattus rattus, Rattus norvegicus
This comprises the whole LiSyM network
Public web page: http://www.lisym.org
Organisms: Rattus norvegicus, Rattus rattus, Mus musculus, Homo sapiens