ODE model describes dynamics of IFNalpha-induced signaling in Huh7.5 cells for a time scale up to 32 hours after stimulation with IFNalpha. The model consists of an IFN receptor model, formation/degradation and cytoplasmic/nuclear shuttling of STAT1-homodimers, STAT1-STAT2-heterodimers and STAT1-STAT2-IRF9 (ISGF3) complexes. On top, formation of feedback proteins STAT1, STAT2, IRF9, USP18, SOCS1, SOCS3 and IRF2 and corresponding influences on IFNalpha signaling dynamics was incorporated. The model was calibrated by dose response and time course measurements over 32 hours as well as time courses for USP18 inhibition and overexpression experiments. The model is able to describe dose-dependent sensitization and desensitization of IFNalpha signaling in form of double treatment experiments at 0h and 24h.
Version 1 contains local file in SBML format Version 2 is a registered link to Biomodels database
SEEK ID: https://seek.lisym.org/models/11?version=2
2 items (and an image) are associated with this Model:Organism: Not specified
Model type: Ordinary differential equations (ODE)
Model format: SBML
Execution or visualisation environment: Copasi
Model image: (Click on the image to zoom) (Original)
Creators
Additional credit
Marcus Rosenblatt, Krishna Kumar Tiwari, Frédérique Kok
Submitter
Views: 766 Downloads: 49
Created: 6th May 2021 at 20:52
Last updated: 28th Dec 2023 at 08:58
None
Version History
Version 2 (latest) Created 7th May 2021 at 05:48 by Olga Krebs
Model in BioModels database MODEL2005110001