IFNalpha-induced signaling in Huh7.5 cells
Version 2

ODE model describes dynamics of IFNalpha-induced signaling in Huh7.5 cells for a time scale up to 32 hours after stimulation with IFNalpha. The model consists of an IFN receptor model, formation/degradation and cytoplasmic/nuclear shuttling of STAT1-homodimers, STAT1-STAT2-heterodimers and STAT1-STAT2-IRF9 (ISGF3) complexes. On top, formation of feedback proteins STAT1, STAT2, IRF9, USP18, SOCS1, SOCS3 and IRF2 and corresponding influences on IFNalpha signaling dynamics was incorporated. The model was calibrated by dose response and time course measurements over 32 hours as well as time courses for USP18 inhibition and overexpression experiments. As a special focus, the model is able to describe dose-dependent sensitization and desensitization of IFNalpha signaling in form of double treatment experiments at 0h and 24h.

Version 1 contains local file in SBML format Version 2 is a registered link to Biomodels database

SEEK ID: https://seek.lisym.org/models/11?version=2

2 items (and an image) are associated with this Model:
  • MODEL2005110001 (Binary file - Unknown) Download
  • Kok2020.xml (XML document - 272 KB) Download

Organism: Not specified

Model type: Ordinary differential equations (ODE)

Model format: SBML

Execution or visualisation environment: Copasi

Model image: (Click on the image to zoom) (Original)

help Creators and Submitter

Views: 259   Downloads: 17

Created: 6th May 2021 at 20:52

Last updated: 7th May 2021 at 05:51

Last used: 5th Dec 2022 at 13:07

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Version History

Version 2 (latest) Created 7th May 2021 at 05:48 by Olga Krebs

Model in BioModels database MODEL2005110001

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