Chronic Liver Disease Progression (LiSyM-DP - Pillar II) (University of Freiburg - Institute of Physics) ; LiSyM network (University of Freiburg - Institute of Physics) ; Regeneration and Repair in Acute-on-Chronic Liver Failure (LiSyM-ACLF - Pillar III) (University of Freiburg - Institute of Physics)
The incidence of this life-threatening acute-on-chronic liver failure (ACLF) is increasing, and early detection and cure are urgent clinical needs. Pillar III applies a Systems Medicine approach to identify the critical mechanisms of acute-on-chronic liver failure (ACLF) and to foster liver regeneration and repair.
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Organisms: Not specified
Chronic liver diseases (CLD) progression leads to cirrhosis, often cancer, and ultimately to organ failure and death. Because of the complexity of this scenario, a Systems Medicine approach is chosen to develop strategies to better characterize progression and resolution of fibrosis. Pillar II aims to define key molecular mechanisms and structural changes in tissue architecture during the progression of CLD by visualizing and quantifying at a cellular level, tissue and organ scale.
Date Published: 1st Jun 2019
Journal: NPJ Syst Biol Appl
PubMed ID: 31149348
Citation: NPJ Syst Biol Appl. 2019 May 23;5:19. doi: 10.1038/s41540-019-0096-1. eCollection 2019.
Date Published: 3rd Jun 2019
Journal: PLoS ONE
Citation: PLoS ONE 14(6) : e0217837