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Disorders of the liver show up through changes in blood tests. These blood tests indicate markers for events taking place in the liver. Usually studies of liver tissue cannot be performed: as liver samples would need to be obtained through a liver biopsy, and this procedure is not without risk, therefore these samples are usually unavailable. Complex metabolism models based on existing and new scientific data can simulate changes in the liver caused by disease. They often reveal unknown relationships
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Programme: LiSyM: Liver Systems Medicine
Public web page: http://www.lisym.org/our-work/pillar-research/the-liver-is-very-patient
Start date: 1st Jan 2016
Organisms: Homo sapiens
LiSyM-Krebs
Programme: LiSyM-Krebs
Public web page: Not specified
Organisms: Homo sapiens
Dr. Ahmed Ghallab (TU University, Dortmund) deals with chronic liver damage caused by toxins. In addition, he investigates processes associated with cholestasis - when bile accumulates in the bile ducts. Ghallab has been able to explain basic mechanisms of acute cholestasis, using a method for intravital two-photon microscopy, which he developed.
Programme: LiSyM: Liver Systems Medicine
Public web page: http://www.lisym.org/our-work/junior-group/the-liver-protects-itself
Start date: 1st Jan 2016
Organisms: Homo sapiens, Mus musculus
One of the tasks of the healthy liver is to store fat. Yet, at some stage, too much fat makes the liver sick. One critical time point occurs when a healthy fatty liver becomes inflamed and progresses to steatohepatitis, or NASH.
LiSyM-Pillar I will identify what events lead to this transition. Does it occur in all parts of the liver? Which molecules indicate that it is taking place? Can the degeneration be stopped or undone - and if so, how?
Programme: LiSyM: Liver Systems Medicine
Public web page: http://www.lisym.org/our-work/pillar-research/zones-of-the-liver
Start date: 1st Jan 2016
Organisms: Mus musculus, Rattus rattus, Rattus norvegicus, Homo sapiens
In one in five people with NAFLD, the functioning liver cells, the hepatocytes, are replaced by connective tissue. Eventually this fibrosis becomes irreversible. In this state the liver is like a ‘scar that never heals’. Through it, the liver loses many of its vital functions.
LiSyM-Pillar II wants to know more about which factors promote fibrosis and the conditions under which fibrosis becomes irreversible How can fibrosis be diagnosed as early as possible? Researchers in the pillar are also
...
Programme: LiSyM: Liver Systems Medicine
Public web page: http://www.lisym.org/our-work/pillar-research
Start date: 1st Jan 2016
Organisms: Mus musculus, Rattus rattus, Rattus norvegicus, Homo sapiens
Data digitized from publication.
Jeppesen1996 Description
Submitter: Matthias König
Assay type: /assay_types?uri=http%3A%2F%2Fwww.mygrid.org.uk%2Fontology%2FJERMOntology%23metabolomics
Technology type: /technology_types?uri=http%3A%2F%2Fwww.mygrid.org.uk%2Fontology%2FJERMOntology%23metabolomics
Snapshots: No snapshots
Investigation: Caffeine investigation
Study: PKDB Caffeine Study
Organisms: Homo sapiens
SOPs: No SOPs
Data files: CSV (Jeppesen1996), PNG (Jeppesen1996)
Data digitized from publication.
Magnusson2008 Description
Submitter: Matthias König
Assay type: /assay_types?uri=http%3A%2F%2Fwww.mygrid.org.uk%2Fontology%2FJERMOntology%23metabolomics
Technology type: /technology_types?uri=http%3A%2F%2Fwww.mygrid.org.uk%2Fontology%2FJERMOntology%23metabolomics
Snapshots: No snapshots
Investigation: Caffeine investigation
Study: PKDB Caffeine Study
Organisms: Homo sapiens
SOPs: No SOPs
Data files: CSV (Magnusson2008), PNG (Magnusson2008)
Data digitized from publication.
Kaplan1997 Description
Submitter: Matthias König
Assay type: /assay_types?uri=http%3A%2F%2Fwww.mygrid.org.uk%2Fontology%2FJERMOntology%23metabolomics
Technology type: /technology_types?uri=http%3A%2F%2Fwww.mygrid.org.uk%2Fontology%2FJERMOntology%23metabolomics
Snapshots: No snapshots
Investigation: Caffeine investigation
Study: PKDB Caffeine Study
Organisms: Homo sapiens
SOPs: No SOPs
Data files: CSV (Kaplan1997), PNG (Kaplan1997)
Data digitized from publication.
Tanaka2014 Description
Submitter: Matthias König
Assay type: /assay_types?uri=http%3A%2F%2Fwww.mygrid.org.uk%2Fontology%2FJERMOntology%23metabolomics
Technology type: /technology_types?uri=http%3A%2F%2Fwww.mygrid.org.uk%2Fontology%2FJERMOntology%23metabolomics
Snapshots: No snapshots
Investigation: Caffeine investigation
Study: PKDB Caffeine Study
Organisms: Homo sapiens
SOPs: No SOPs
Data files: CSV (Tanaka2014), PNG (Tanaka2014)
Data digitized from publication.
Blanchard1983a Description
Submitter: Matthias König
Assay type: /assay_types?uri=http%3A%2F%2Fwww.mygrid.org.uk%2Fontology%2FJERMOntology%23metabolomics
Technology type: /technology_types?uri=http%3A%2F%2Fwww.mygrid.org.uk%2Fontology%2FJERMOntology%23metabolomics
Snapshots: No snapshots
Investigation: Caffeine investigation
Study: PKDB Caffeine Study
Organisms: Homo sapiens
SOPs: No SOPs
Data files: CSV (Blanchard1983a), PNG (Blanchard1983a)
Code for the bile flow model in Segovia-Miranda et al.: Three-dimensional spatially resolved geometrical and functional models of human liver tissue reveal new aspects of NAFLD progression (https://www.nature.com/articles/s41591-019-0660-7)
See the README file in the link for details installing and running the code.
Creators: Michael Kücken, Lutz Brusch
Submitter: Michael Kücken
Model type: Ordinary differential equations (ODE)
Model format: Not specified
Environment: Not specified
Organism: Homo sapiens
Investigations: No Investigations
Studies: No Studies
Modelling analyses: No Modelling analyses
Abstract (Expand)
Authors: F. Segovia-Miranda, H. Morales-Navarrete, M. Kucken, V. Moser, S. Seifert, U. Repnik, F. Rost, M. Brosch, A. Hendricks, S. Hinz, C. Rocken, D. Lutjohann, Y. Kalaidzidis, C. Schafmayer, L. Brusch, J. Hampe, M. Zerial
Date Published: 2nd Dec 2019
Publication Type: Not specified
PubMed ID: 31792455
Citation: Nat Med. 2019 Dec 2. pii: 10.1038/s41591-019-0660-7. doi: 10.1038/s41591-019-0660-7.