LiSyM Pillar III: Regeneration and Repair in Acute-on-Chronic Liver Failure (LiSyM-ACLF)
OverviewIn chronic diseases, at some point the liver can suddenly stop functioning. This is called acute-on-chronic liver failure, or ACLF. This is the leading cause of death in liver patients and is often provoked by the use of transcription or freely available drugs or alcohol abuse. For this condition we need an effective treatment quickly. LiSyM-Pillar III researches the factors that contribute significantly to ACLF. What exactly happens then? Are there any early signs that would enable ACLF to be prevented? Can the liver be repaired or regenerated after ACLF?
Programme: LiSyM: Liver Systems Medicine
SEEK ID: https://seek.lisym.org/projects/5
Public web page: http://www.lisym.org/our-work/pillar-research
Organisms: Homo sapiens, Mus musculus, Rattus norvegicus, Rattus rattus
FAIRDOM PALs: Matthias Reichert, Max Lüdemann, Seddik Hammad, Daniel Lill, Annika Schneider
Project start date: 1st Jan 2016
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Projects: LiSyM Core Infrastructure and Management (LiSyM-PD), LiSyM Pillar II: Chronic Liver Disease Progression (LiSyM-DP), LiSyM Pillar I: Early Metabolic Injury (LiSyM-EMI), LiSyM Pillar IV: Liver Function Diagnostics (LiSyM-LiFuDi), LiSyM Pillar III: Regeneration and Repair in Acute-on-Chronic Liver Failure (LiSyM-ACLF), LiSyM network, LiSyM Scientific Leadership Team (LiSyM-LT)
Institutions: University of Freiburg - Institute of Physics, LiSyM programme directorate
https://orcid.org/0000-0002-1003-1682
Projects: LiSyM network, Forschungsnetzwerk LiSyM-Krebs, LiSyM Pillar II: Chronic Liver Disease Progression (LiSyM-DP), LiSyM Core Infrastructure and Management (LiSyM-PD), LiSyM Pillar III: Regeneration and Repair in Acute-on-Chronic Liver Failure (LiSyM-ACLF), DEEP-HCC network
Institutions: HITS gGmbH
Projects: LiSyM network, LiSyM Pillar III: Regeneration and Repair in Acute-on-Chronic Liver Failure (LiSyM-ACLF), SMART-NAFLD, Forschungsnetzwerk LiSyM-Krebs, DEEP-HCC network, C-TIP-HCC network
Institutions: German Cancer Research Center (DKFZ), Division of Systems Biology of Signal Transduction, HITS gGmbH
Program management team LiSyM-Cancer (project and communications manager)
Former PhD student in LiSyM, at DKFZ Heidelberg in the group of Ursula Klingmüller
(née Schmitt)
Liver Systems Medicine : striving to develop non-invasive methods for diagnosing and treating NAFLD by combining mathematical modeling and biological research. LiSyM, is a multidisciplinary research network, in which molecular and cell biologists, clinical researchers, pharmacologists and experts in mathematical modeling examine the liver in its entirety. LiSyM research focuses on the metabolic liver disease non-alcoholic fatty liver disease (NAFLD), which includes non-alcoholic steatohepatitis ...
Projects: LiSyM Core Infrastructure and Management (LiSyM-PD), LiSyM Pillar I: Early Metabolic Injury (LiSyM-EMI), LiSyM Pillar II: Chronic Liver Disease Progression (LiSyM-DP), LiSyM Pillar III: Regeneration and Repair in Acute-on-Chronic Liver Failure (LiSyM-ACLF), LiSyM Pillar IV: Liver Function Diagnostics (LiSyM-LiFuDi), Model Guided Pharmacotherapy In Chronic Liver Disease (LiSyM-MGP), Molecular Steatosis - Imaging & Modeling (LiSyM-MSIM), The Hedgehog Signalling Pathway (LiSyM-JGMMS), Multi-Scale Models for Personalized Liver Function Tests (LiSyM-MM-PLF), LiSyM PALs, Project Management PTJ, LiSyM network, LiSyM Scientific Leadership Team (LiSyM-LT)
Web page: https://www.lisym.org/
Country: 
Germany
City: 69120 Heidelberg
Web page: https://www.klinikum.uni-heidelberg.de/Willkommen.574.0.html
Country: Germany
City: 69120 Heidelberg
Web page: https://www.klinikum.uni-heidelberg.de/Willkommen.100293.0.html
Submitter: Martin Golebiewski
Studies: OpenBIS E520, OpenBIS E521, OpenBIS E522
Assays: OpenBIS 01_SCC_11928, OpenBIS 01_SCC_11934, OpenBIS 01_SCC_11976, OpenBIS 02_T_11979, OpenBIS 03_FACS_11972, OpenBIS 03_FACS_11974, OpenBIS 03_FACS_12091, OpenBIS 03_FACS_12099, OpenBIS 03_FACS_12101, OpenBIS 03_FACS_12102, OpenBIS FILES, OpenBIS FILES, OpenBIS FILES, OpenBIS FILES
Submitter: Alain Becam
Investigation: LiSyM Pillar III: Regeneration and Repair in Ac...
Assays: OpenBIS FILES
Submitter: Alain Becam
Investigation: LiSyM Pillar III: Regeneration and Repair in Ac...
Assays: OpenBIS FILES
Submitter: Alain Becam
Investigation: LiSyM Pillar III: Regeneration and Repair in Ac...
Assays: OpenBIS FILES
Automatically generated assay to host openbis files that are linked to the original OpenBIS experiment. Its content and linked data files will be updated by the system if automatic synchronization was selected.
Submitter: Alain Becam
Assay type: Experimental Assay Type
Technology type: Technology Type
Investigation: LiSyM Pillar III: Regeneration and Repair in Ac...
Study: OpenBIS E522
Automatically generated assay to host openbis files that are linked to the original OpenBIS experiment. Its content and linked data files will be updated by the system if automatic synchronization was selected.
Submitter: Alain Becam
Assay type: Experimental Assay Type
Technology type: Technology Type
Investigation: LiSyM Pillar III: Regeneration and Repair in Ac...
Study: OpenBIS E521
Automatically generated assay to host openbis files that are linked to the original OpenBIS experiment. Its content and linked data files will be updated by the system if automatic synchronization was selected.
Submitter: Alain Becam
Assay type: Experimental Assay Type
Technology type: Technology Type
Investigation: LiSyM Pillar III: Regeneration and Repair in Ac...
Study: OpenBIS E520
Automatically generated assay to host openbis files that are linked to the original OpenBIS experiment. Its content and linked data files will be updated by the system if automatic synchronization was selected.
Submitter: Alain Becam
Assay type: Experimental Assay Type
Technology type: Technology Type
Investigation: LiSyM Pillar III: Regeneration and Repair in Ac...
Study: 1 hidden item
Submitter: Alain Becam
Assay type: Experimental Assay Type
Technology type: Technology Type
Investigation: LiSyM Pillar III: Regeneration and Repair in Ac...
Study: 1 hidden item
Creators: None
Submitter: Alain Becam
DownloadCreators: None
Submitter: Alain Becam
Creators: None
Submitter: Alain Becam
Creators: None
Submitter: Alain Becam
Creators: None
Submitter: Alain Becam
Creator: Sonja Kleeschulte
Submitter: Sonja Kleeschulte
Non-parenchymal liver cells are isolated and staining for FACS analysis
Creator: Sonja Kleeschulte
Submitter: Sonja Kleeschulte
Macrophage staining in paraffin-embedded tissue
Creator: Sonja Kleeschulte
Submitter: Sonja Kleeschulte
Abstract (Expand)
Authors: Stephanie D. Wolf, Christian Ehlting, Sophia Müller-Dott, Gereon Poschmann, Patrick Petzsch, Tobias Lautwein, Sai Wang, Barbara Helm, Marcel Schilling, Julio Saez-Rodriguez, Mihael Vucur, Kai Stühler, Karl Köhrer, Frank Tacke, Steven Dooley, Ursula Klingmüller, Tom Luedde, Johannes G. Bode
Date Published: 2023
Publication Type: Journal
Abstract
Authors: Rilu Feng, Kejia Kan, Carsten Sticht, Yujia Li, Shanshan Wang, Hui Liu, Chen Shao, Stefan Munker, Hanno Niess, Sai Wang, Christoph Meyer, Roman Liebe, Matthias P. Ebert, Steven Dooley, Huiguo Ding, Honglei Weng
Date Published: 1st Dec 2022
Publication Type: Journal
Abstract (Expand)
Authors: Sai Wang, Rilu Feng, Shan Shan Wang, Hui Liu, Chen Shao, Yujia Li, Frederik Link, Stefan Munker, Roman Liebe, Christoph Meyer, Elke Burgermeister, Matthias Ebert, Steven Dooley, Huiguo Ding, Honglei Weng
Date Published: 20th Apr 2022
Publication Type: Journal
Abstract
Authors: Tao Lin, Shanshan Wang, Stefan Munker, Kyounghwa Jung, Ricardo U. Macías‐Rodríguez, Astrid Ruiz‐Margáin, Robert Schierwagen, Hui Liu, Chen Shao, Chunlei Fan, Rilu Feng, Xiaodong Yuan, Sai Wang, Franziska Wandrer, Christoph Meyer, Ralf Wimmer, Roman Liebe, Jens Kroll, Long Zhang, Tobias Schiergens, Peter ten Dijke, Andreas Teufel, Alexander Marx, Peter R. Mertens, Hua Wang, Matthias P.A. Ebert, Heike Bantel, Enrico De Toni, Jonel Trebicka, Steven Dooley, Donghun Shin, Huiguo Ding, Hong‐Lei Weng
Date Published: 1st Feb 2022
Publication Type: Journal
Abstract
Authors: Sai Wang, Rilu Feng, Shanshan Wang, Hui Liu, Chen Shao, Yujia Li, Link Frederik, Stefan Munker, Roman Liebe, Christoph Meyer, Elke Burgermeister, Matthias Ebert, Steven Dooley, Huiguo Ding, Honglei Weng
Date Published: 2022
Publication Type: Journal
The meeting will provide a great opportunity for discussion between modellers, experimentalists and clinicians and to organize and harmonize our future work within the LiSyM network on the grassroot level.
Start Date: 20th Nov 2017
End Date: 22nd Nov 2017
Event Website: Not specified
Country: Germany
City: Hünfeld
This summit will cover both the basic and translational / clinical aspects of NAFLD, with a specific focus on novel drug target and prognostic signature development.
Key sessions include all crucial pathophysiological aspects currently known to affect development and progression of NAFLD, such as "lipid metabolism and lipotoxicity" and "insulin resistance, insulin and hormonal signaling". Furthermore, oxidative stress, ER stress, and mitochondrial dysfunction will be addressed. On the second day, ...
Start Date: 9th Nov 2017
End Date: 11th Nov 2017
Event Website: https://events.easl.eu/EventPortal/Information/EventInformation.aspx?EventInformationPageCode=HOME&EventCode=nafld2017
Country: 
Italy
City: Rome
ICSB continues to be the flagship conference of the International Society for Systems Biology (ISSB). The conference will cover a variety of themes from Fundamental Biological Sciences, Network Analysis, to Metabolic Engineering and Cancer Biology. The conference will also include a variety of engaging plenary lectures, parallel sessions, poster sessions, and interactive networking opportunities.
Abstract submission deadline: May 13th, 2017
Country: 
United States
City: Blacksburg, Virginia
The International Conference on Systems Biology of Human Disease (SBHD) is a transatlantic event and communication platform for scientific exchange that takes place alternately between the United States and Germany.
SBHD 2017 is continuing a conference series launched by Peter Sorger and colleagues from Harvard Medical School in 2008. The conference focus is on mammalian systems biology, particularly on its application to human disease and therapy.
Start Date: 5th Jul 2017
End Date: 7th Jul 2017
Event Website: http://www.sbhd-conference.org/2017/index.php
Country: Germany
City: Heidelberg
This event is a jointly organized Data Management PALs Meeting that involves PALs from the German LiSyM (Liver Systems Medicine) network and from the ERASysAPP (ERA-Net for Systems Biology Applications) initiative. PALs (Project Area Liaisons) are the front line experts of the data management teams of these projects. They act as data management advocates and help gathering user requirements and testing potential data management solutions. An important part of the meeting will be to gather the ...
Country: Germany
City: 36088 Hünfeld bei Fulda
Poster for the PhD retreat in Hofgeismar - Svenja Kemmer
Creator: Svenja Kemmer
Submitter: Svenja Kemmer
Non-alcoholic fatty liver disease and nonalcoholic steatohepatitis can lead to advanced liver disease. Both conditions are becoming increasingly prevalent as the epidemics of obesity and diabetes continue to increase. A mathematical model was built to understand how the disease burden associated with nonalcoholic fatty liver disease and nonalcoholic steatohepatitis will change over time. Results suggest increasing cases of advanced liver disease and liver-related mortality in the coming years.
Creators: None
Submitter: Ina Biermayer
