Studies

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17 Studies visible to you, out of a total of 44

OTHER OMICS DATA

Submitter: Olga Krebs

Investigation: LiSyM-Cancer project data for integration into...

Assays: No Assays

METABOLOMICS

Submitter: Olga Krebs

Investigation: LiSyM-Cancer project data for integration into...

Assays: No Assays

TRANSCRIPTOMICS

Submitter: Olga Krebs

Investigation: LiSyM-Cancer project data for integration into...

Assays: No Assays

PROTEOMICS

GENOMICS/TRANSCRIPTOMICS

In this study, we characterize Western diet-induced phenotypic changes in murine 392 hepatocytes and employ dynamic pathway modelling to resolve the underlying molecular 393 mechanisms resulting in altered intracellular signal transduction and enhanced proliferation 394 of WD hepatocytes.

Submitter: Olga Krebs

Investigation: 1 hidden item

Assays: No Assays

In this study we identify most relevant Smad complexes in liver-derived cells, the contribution of the Smad complexes on target gene expression, and the role of Smad abundance and Smad2 phosphorylation in hepatocellular carcinoma

The study comprises 19 human liver biopsy donors divided into the groups normal control (NC = 7012, 7173, 7194, 7279), healthy obese (HO = 6758, 6922, 7213, 7230, 7252), bland steatosis (STEA = 6967, 7137, 7172, 7181, 7251) and early NASH (EARLY = 6610, 7041, 7157, 7188, 7344).

Hepatocytes captured by laser microdissection were obtained from three hepatic zones (pericentral, intermediate and periportal) and subjected to reduced representation bisulfite sequencing and RNA-seq resulting in 114 ...

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In this study, we investigated human LMs in tissue sections as well as isolated from human liver tissues which were characterized both in suspension and in adherent cultures to find out whether the inflammatory state of primary human LMs corresponds to patients and disease characteristics and whather it is possible to maintain the macrophage pattern in suspension as well as in adherent cultures with just a few limitations. (CCA: cholangiocarcinoma, CRLM: colorectal liver metastasis, FNH: focal ...

Documents submitted to BMBF

Submitter: Olga Krebs

Investigation: 1 hidden item

Assays: Meeting minutes 2021, Meeting minutes 2022

Documents submitted to BMBF

Submitter: Olga Krebs

Investigation: 1 hidden item

Assays: Project deliverables 2021, Project deliverables 2022, Project proposals

A multitude of pharmacokinetics studies have been published. However, due to the lack of an open database, pharmacokinetics data, as well as the corresponding meta-information, have been difficult to access. We present PK-DB (https://develop.pk-db.com), an open database for pharmacokinetics information from clinical trials including pre-clinical research. PK-DB provides curated information on (i) characteristics of studied patient cohorts and subjects (e.g. age, bodyweight, smoking status); (ii) ...

Submitter: Matthias König

Investigation: Stratification and Personalization of Computati...

Assays: No Assays

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