Projects

Chronic liver diseases (CLD) progression leads to cirrhosis, often cancer, and ultimately to organ failure and death. Because of the complexity of this scenario, a Systems Medicine approach is chosen to develop strategies to better characterize progression and resolution of fibrosis. Pillar II aims to define key molecular mechanisms and structural changes in tissue architecture during the progression of CLD by visualizing and quantifying at a cellular level, tissue and organ scale.

Public web page: Not specified

Non-alcoholic fatty liver disease (NAFLD) is the most common chronic liver disease worldwide. LiSyM-EMI looks into the transition from steatosis to non-alcoholic steatohepatitis (NASH) as the disease-defining moment in NAFLD. A systems analysis of these early disease events will be performed to elucidate the molecular mechanisms that trigger disease establishment.

Public web page: Not specified

Major infrastructure backbone of the whole LiSyM network. It comprises the core management tasks of the program directorate and the scientific project management, as well as the central data management. The data management concept relies on FAIRDOM (http://fair-dom.org) and uses the LiSyM SEEK platform as a major hub for exchanging data, models, SOPs and other information, as well as yellow pages for the projects with its corresponding members, institutions, events, presentations and publications.
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Public web page: Not specified

This comprises the whole LiSyM network

This is a generic project that comprises all LiSyM data management PALs and associated FAIRDOM PALs, as well as the LiSyM data management team.

Public web page: Not specified

Day-to-day science within the LiSyM is overseen and directed by the the LiSyM Scientific Leadership Team. This coordination team comprises the pillar coordinators and additional LiSyM members, and ensures smooth interaction between multi-skilled groups, often working in different institutions and across significant distances within Germany.

Data (breath tests scores, imaging data from MRE, histopathological characterization and proteomics data of liver biopsies) will be acquired from two different groups of patients to be used in computer-assisted diagnostic tools for early detection and comprehensive evaluation of altered liver functions.

Public web page: Not specified

Approach:
– Systems modeling of hepatic metabolism in liver diseases
– Control mechanisms of liver regeneration

Public web page: Not specified

Lipid droplet accumulation is the primary cellular phenotype that is interpreted as fat deposition at organ level in steatosis. The goal of this project is to establish a model that bridges molecular lipogenic stimuli with compromised liver functions.
Approach:
– Functional imaging of hepatic transport mechanisms
– Systems modeling of lipid droplet formation

Public web page: Not specified

Multiscale model of human galactose metabolism - from single hepatocytes to individual liver function.

Public web page: https://livermetabolism.com

No description specified

Public web page: Not specified

The incidence of this life-threatening acute-on-chronic liver failure (ACLF) is increasing, and early detection and cure are urgent clinical needs. Pillar III applies a Systems Medicine approach to identify the critical mechanisms of acute-on-chronic liver failure (ACLF) and to foster liver regeneration and repair.

Public web page: Not specified

Identification of key processes leading to non-alcoholic fatty liver disease (NAFLD) and its progression to non-alcoholic steato-hepatitis (NASH): Based on the finding within the Virtual Liver Network that the Hedgehog signalling pathway is a core player in the regulation of liver lipid metabolism, this project aims to characterize and model the central role of Hedgehog signalling during the transition from benign steatosis to NAFLD and NASH using patient data and large data sets from various
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Public web page: Not specified

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