SMART-NAFLD : A Systems Medicine Approach to Early Detection and Prevention of Hepatocellular Carcinoma in Non-Alcoholic Fatty Liver Disease
The massive increase in obesity is leading to an alarming rise in non-alcoholic liver disease (NAFLD). This development will lead to a dramatic increase in liver diseases such as hepatocellular carcinoma (HCC). A particular challenge is that NAFLD-associated HCCs, for reasons still unknown, not only occur in association with advanced liver fibrosis/cirrhosis, but one third of NAFLD-associated HCCs arise in non-cirrhotic liver tissue. As a result, the tumour is often not detected until it is in a late, incurable state. Innovative strategies for early detection of NAFLD patients at high risk of HCC are urgently needed. To address this clinical challenge, the interdisciplinary team consisting of physicians, clinical scientists, cell biologists, systems biologists, and physics and bioinformatics theorists in SMART-NAFLD is taking an integrative systems medicine approach. By providing longitudinal serum samples, imaging diagnostics with multiparametric MRI, tissue samples and primary hepatocytes used by the project partners for quantitative mass spectrometry, metabolic analyses and the use of artificial intelligence, a classifier will be developed that allows early detection of NAFLD patients at particularly high risk for HCC. The established tissue model of hepatic steatosis will be further developed into a multiclade model. By combining the results from serum and image data in combination with trained CNNS (artificial intelligence), the classification of patients is to be carried out, which can predict an early prognosis with regard to the dynamics of the disease progression to HCC and estimate the liver regeneration potential. The aim is to support decisions in the clinic and to contribute to the prevention of HCC development.
Programme: LiSyM-Krebs - Systemmedizinisches Forschungsnetz zur Früherkennung und Prävention von Leberkrebs
SEEK ID: https://seek.lisym.org/projects/17
Public web page: Not specified
Organisms: Mus musculus, Homo sapiens
FAIRDOM PALs: No PALs for this Project
Project created: 1st Dec 2021
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Projects: LiSyM network, LiSyM Pillar III: Regeneration and Repair in Acute-on-Chronic Liver Failure (LiSyM-ACLF), SMART-NAFLD, Forschungsnetzwerk LiSyM-Krebs, DEEP-HCC network, C-TIP-HCC network
Institutions: Deutsches Krebsforschungszentrum, HITS gGmbH
Roles: PhD Student, Postdoc
née Schmitt
Projects: LiSyM-Krebs Partnering, The Hedgehog Signalling Pathway (LiSyM-JGMMS), SMART-NAFLD, DEEP-HCC network
Institutions: Universität Leipzig - Sächsischer Inkubator für Klinische Translation (SIKT)

Roles: Postdoc
Expertise: Primary human hepatocytes, liver models, Steatosis, NPCs
Tools: Biobanking, Cell Isolation, REIMS
The clinical department of Prof. Dr. med Daniel Seehofer performs more than 200 surgical interventions on the liver annually. Therefore, the group has access to a broad variety of liver tissues as well as corresponding patient, clinical laboratory and characterization data. I lead the experimental work group which has a longstandind expertise in the isolation, characterization and application of primary human liver and hepatoma cells. These cells as well as data generated from established liver ...
Projects: LiSyM Pillar II: Chronic Liver Disease Progression (LiSyM-DP), LiSyM Pillar III: Regeneration and Repair in Acute-on-Chronic Liver Failure (LiSyM-ACLF), LiSyM network, LiSyM-Krebs Partnering, Forschungsnetzwerk LiSyM-Krebs, C-TIP-HCC network, SMART-NAFLD
Institutions: Molecular Hepatology - Dept of Medicine II - Medical Faculty Mannheim - Heidelberg University
Projects: LiSyM Pillar I: Early Metabolic Injury (LiSyM-EMI), LiSyM network, LiSyM-Krebs Partnering, Forschungsnetzwerk LiSyM-Krebs, SMART-NAFLD, C-TIP-HCC network
Institutions: Universität Leipzig - Institute for Computer Science (Bioinformatics), Dr. Margarete Fischer-Bosch-Institut für Klinische Pharmakologie
LiSyM-Krebs ist ein nationales Forschungsnetz zur Früherkennung und Prävention von Leberkrebs, das unter Verwendung des systemmedizinischen Forschungsansatzes die komplexen, dynamischen Prozesse der Krankheitsprogression analysiert, um ausgehend von den Erkenntnissen aus dem Forschungsnetz LiSyM die Entstehung von Leberkrebs besser zu verstehen, vorherzusagen und im besten Fall sogar zu verhindern. LiSyM-Krebs setzt die erfolgreichen Forschungsaktivitäten der BMBF-Vorgängerprogramme ...
Projects: LiSyM-Krebs Partnering, Forschungsnetzwerk LiSyM-Krebs, SMART-NAFLD, DEEP-HCC network, C-TIP-HCC network
Web page: https://www.lisym-cancer.org
Country: Germany
City: 69120 Heidelberg
Web page: https://www.klinikum.uni-heidelberg.de/Willkommen.100293.0.html
Documents submitted to BMBF
Submitter: Olga Krebs
Investigation: 1 hidden item
Assays: Meeting minutes 2021, Meeting minutes 2022
Snapshots: No snapshots
Documents submitted to BMBF
Submitter: Olga Krebs
Investigation: 1 hidden item
Assays: Project deliverables 2021, Project deliverables 2022, Project proposals
Snapshots: No snapshots
Project proposals
Submitter: Olga Krebs
Biological problem addressed: Model Analysis Type
Investigation: 1 hidden item
Study: Documents submitted to BMBF
Organisms: No organisms
Models: No Models
SOPs: No SOPs
Data files: No Data files
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Meeting minutes 2021
Submitter: Olga Krebs
Biological problem addressed: Model Analysis Type
Investigation: 1 hidden item
Study: Meeting minutes
Organisms: No organisms
Models: No Models
SOPs: No SOPs
Data files: No Data files
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Meeting minutes 2022
Submitter: Olga Krebs
Biological problem addressed: Model Analysis Type
Investigation: 1 hidden item
Study: Meeting minutes
Organisms: No organisms
Models: No Models
SOPs: No SOPs
Data files: No Data files
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Project deliverables 2021
Submitter: Olga Krebs
Biological problem addressed: Model Analysis Type
Investigation: 1 hidden item
Study: Documents submitted to BMBF
Organisms: No organisms
Models: No Models
SOPs: No SOPs
Data files: No Data files
Snapshots: No snapshots
Project deliverables 2022
Submitter: Olga Krebs
Biological problem addressed: Model Analysis Type
Investigation: 1 hidden item
Study: Documents submitted to BMBF
Organisms: No organisms
Models: No Models
SOPs: No SOPs
Data files: No Data files
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Abstract (Expand)
Authors: S. Heming, P. Hansen, A. Vlasov, F. Schworer, S. Schaumann, P. Frolovaite, W. D. Lehmann, J. Timmer, M. Schilling, B. Helm, U. Klingmuller
Date Published: 26th Jan 2023
Publication Type: Journal
PubMed ID: 36699356
Citation: Bioinform Adv. 2022 Jan 17;2(1):vbac004. doi: 10.1093/bioadv/vbac004. eCollection 2022.
Abstract (Expand)
Authors: L. Seidemann, S. Prinz, J. C. Scherbel, C. Gotz, D. Seehofer, G. Damm
Date Published: 20th Jan 2023
Publication Type: Journal
PubMed ID: 36660192
Citation: EXCLI J. 2023 Jan 4;22:12-34. doi: 10.17179/excli2022-5459. eCollection 2023.
Abstract (Expand)
Authors: A. Friebel, T. Johann, D. Drasdo, S. Hoehme
Date Published: 30th Sep 2022
Publication Type: Journal
PubMed ID: 35976110
Citation: Bioinformatics. 2022 Sep 30;38(19):4622-4628. doi: 10.1093/bioinformatics/btac547.
Abstract (Expand)
Authors: S. Chakraborty, G. Andrieux, P. Kastl, L. Adlung, S. Altamura, M. E. Boehm, L. E. Schwarzmuller, Y. Abdullah, M. C. Wagner, B. Helm, H. J. Grone, W. D. Lehmann, M. Boerries, H. Busch, M. U. Muckenthaler, M. Schilling, U. Klingmuller
Date Published: 20th Sep 2022
Publication Type: Journal
PubMed ID: 36130519
Citation: Cell Rep. 2022 Sep 20;40(12):111360. doi: 10.1016/j.celrep.2022.111360.
Abstract (Expand)
Authors: Lorenza A. D’Alessandro, Ursula Klingmüller, Marcel Schilling
Date Published: 30th Jun 2022
Publication Type: Journal
DOI: 10.1042/BCJ20210548
Citation: Biochemical Journal 479(12):1361-1374
Young Scientists Retreat (YSR) will take place from September 7th to 9th in Hofgeismar (close to Kassel) (https://tagungsstaette-hofgeismar.de/). Participation is mandatory for all PhD students, MD students and Postdocs in SMART-NAFLD, C-TIP-HCC and DEEP-HCC
Start Date: 7th Sep 2022
End Date: 9th Sep 2022
Event Website: Not specified
Country: Germany
City: Not specified
Kickoff Meeting SMART- NAFLD 1.12.2021 - 2.12.2021
Heidelberg, Bioquant 7th Floor Greenier Room
Start Date: 1st Dec 2021
End Date: 2nd Dec 2021
Event Website: Not specified
Country: Germany
City: Heidelberg
Creator: Olga Krebs
Submitter: Olga Krebs
Investigations: No Investigations
Studies: No Studies
Assays: No Assays
Agreement on the Use of Personal Data during LiSyM-Cancer Young Scientists Retreat Date: 07.09. -09.09.2022 Place: Ev. Tagungsstätte Hofgeismar
Creator: Olga Krebs
Submitter: Olga Krebs
Investigations: No Investigations
Studies: No Studies
Assays: No Assays
Agenda for LiSyM-Cancer status seminar 2022
Creators: Olga Krebs, Wolfgang Müller, Ursula Klingmüller, Ina Biermayer
Submitter: Olga Krebs
Investigations: No Investigations
Studies: No Studies
Assays: No Assays
Agenda Kickoff Meeting SMART-NAFLD 1-2 december 2021 in Heidelberg
Creators: Ursula Klingmüller, Ina Biermayer
Submitter: Olga Krebs
Investigations: No Investigations
Studies: No Studies
Assays: No Assays