SEEK ID: https://seek.lisym.org/people/49
Location:
Germany
ORCID: Not specified
Joined: 23rd May 2017
Expertise: Not specified
Tools: Not specified
LiSyM Pillar I: Early Metabolic Injury (LiSyM-EMI) (Universitätsklinikum Dresden - Medizinische Klinik I, Bereich Gastroenterologie & Hepatologie) ; LiSyM network (Universitätsklinikum Dresden - Medizinische Klinik I, Bereich Gastroenterologie & Hepatologie) ; LiSyM-Krebs Partnering (Universitätsklinikum Dresden - Medizinische Klinik I, Bereich Gastroenterologie & Hepatologie)
Related items
- Programmes (2)
- Projects (3)
- Institutions (1)
- Investigations (1)
- Studies (1)
- Assays (6+2)
- Data files (117+1)
- SOPs (1)
- Publications (21)
- Presentations (2+2)
- Samples (114)
LiSyM-Krebs ist ein nationales Forschungsnetz zur Früherkennung und Prävention von Leberkrebs, das unter Verwendung des systemmedizinischen Forschungsansatzes die komplexen, dynamischen Prozesse der Krankheitsprogression analysiert, um ausgehend von den Erkenntnissen aus dem Forschungsnetz LiSyM die Entstehung von Leberkrebs besser zu verstehen, vorherzusagen und im besten Fall sogar zu verhindern. LiSyM-Krebs setzt die erfolgreichen Forschungsaktivitäten der BMBF-Vorgängerprogramme ...
Projects: LiSyM-Krebs Partnering, Forschungsnetzwerk LiSyM-Krebs, SMART-NAFLD, DEEP-HCC network, C-TIP-HCC network
Web page: https://www.lisym-cancer.org
Liver Systems Medicine : striving to develop non-invasive methods for diagnosing and treating NAFLD by combining mathematical modeling and biological research. LiSyM, is a multidisciplinary research network, in which molecular and cell biologists, clinical researchers, pharmacologists and experts in mathematical modeling examine the liver in its entirety. LiSyM research focuses on the metabolic liver disease non-alcoholic fatty liver disease (NAFLD), which includes non-alcoholic steatohepatitis ...
Projects: LiSyM Core Infrastructure and Management (LiSyM-PD), LiSyM Pillar I: Early Metabolic Injury (LiSyM-EMI), LiSyM Pillar II: Chronic Liver Disease Progression (LiSyM-DP), LiSyM Pillar III: Regeneration and Repair in Acute-on-Chronic Liver Failure (LiSyM-ACLF), LiSyM Pillar IV: Liver Function Diagnostics (LiSyM-LiFuDi), Model Guided Pharmacotherapy In Chronic Liver Disease (LiSyM-MGP), Molecular Steatosis - Imaging & Modeling (LiSyM-MSIM), The Hedgehog Signalling Pathway (LiSyM-JGMMS), Multi-Scale Models for Personalized Liver Function Tests (LiSyM-MM-PLF), LiSyM PALs, Project Management PTJ, LiSyM network, LiSyM Scientific Leadership Team (LiSyM-LT)
Web page: https://www.lisym.org/
This comprises the whole LiSyM network
Programme: LiSyM: Liver Systems Medicine
Public web page: http://www.lisym.org
Start date: 1st Jan 2016
Organisms: Rattus norvegicus, Rattus rattus, Mus musculus, Homo sapiens
This generic project is intended to be a forum for all LiSyM partner and external stakeholders interested in participating in the BMBF initiative LiSyM-Krebs.
Programme: LiSyM-Krebs - Systemmedizinisches Forschungsnetz zur Früherkennung und Prävention von Leberkrebs
Public web page: https://www.ptj.de/projektfoerderung/gesundheitsforschung/lisym-krebs
Organisms: Not specified
One of the tasks of the healthy liver is to store fat. Yet, at some stage, too much fat makes the liver sick. One critical time point occurs when a healthy fatty liver becomes inflamed and progresses to steatohepatitis, or NASH. LiSyM-Pillar I will identify what events lead to this transition. Does it occur in all parts of the liver? Which molecules indicate that it is taking place? Can the degeneration be stopped or undone - and if so, how?
Programme: LiSyM: Liver Systems Medicine
Public web page: http://www.lisym.org/our-work/pillar-research/zones-of-the-liver
Start date: 1st Jan 2016
Organisms: Mus musculus, Rattus rattus, Rattus norvegicus, Homo sapiens
To investigate the underlying molecular principles of metabolic and morphogenic zonation of the human liver lobule, we generated an integrated epigenetic map across three zones (pericentral, intermediate and periportal) by methylation and transcriptomic analysis of hepatocytes captured by laser micro-dissection. We observe a deep link between epigenetic zonation of human liver and a zonated expression of metabolic and morphogenic pathways: Key transcriptionally zonated enzymes in xenobiotic and ...
Submitter: Mario Brosch
Studies: Integrated epigenetic map across three hepatic zones (pericentral, inte...
Assays: DNA-methylation at binding sites of uniformly expressed transcription fa..., DNA-methylation at binding sites of uniformly expressed transcription fa..., DNA-methylation at binding sites of uniformly expressed transcription fa..., Transcriptomic analysis of hepatocytes ( hepatic zone: intermediate (IZ), Transcriptomic analysis of hepatocytes ( hepatic zone: periportal (PP), Transcriptomic analysis of hepatocytes ; hepatic zone: pericentral (CV)
Snapshots: No snapshots
The study comprises 19 human liver biopsy donors divided into the groups normal control (NC = 7012, 7173, 7194, 7279), healthy obese (HO = 6758, 6922, 7213, 7230, 7252), bland steatosis (STEA = 6967, 7137, 7172, 7181, 7251) and early NASH (EARLY = 6610, 7041, 7157, 7188, 7344).
Hepatocytes captured by laser microdissection were obtained from three hepatic zones (pericentral, intermediate and periportal) and subjected to reduced representation bisulfite sequencing and RNA-seq resulting in 114 ...
Submitter: Mario Brosch
Investigation: Epigenomic analysis of micro-dissected human liver
Assays: DNA-methylation at binding sites of uniformly expressed transcription fa..., DNA-methylation at binding sites of uniformly expressed transcription fa..., DNA-methylation at binding sites of uniformly expressed transcription fa..., Transcriptomic analysis of hepatocytes ( hepatic zone: intermediate (IZ), Transcriptomic analysis of hepatocytes ( hepatic zone: periportal (PP), Transcriptomic analysis of hepatocytes ; hepatic zone: pericentral (CV)
Snapshots: No snapshots
Transcriptomic analysis of hepatocytes captured by laser micro-dissection from hepatic zone: pericentral (CV)
Submitter: Mario Brosch
Assay type: RNA-seq Profiling
Technology type: Rna-seq
Investigation: Epigenomic analysis of micro-dissected human liver
Organisms: Homo sapiens
SOPs: SOP : liver tissue microdissection for RNA seq...
Data files: Human RNA-Seq data set GSM2819677 stored in..., Human RNA-Seq data set GSM2819678 stored in..., Human RNA-Seq data set GSM2819679 stored in..., Human RNA-Seq data set GSM2819680 stored in..., Human RNA-Seq data set GSM2819681 stored in..., Human RNA-Seq data set GSM2819682 stored in..., Human RNA-Seq data set GSM2819683 stored in..., Human RNA-Seq data set GSM2819684 stored in..., Human RNA-Seq data set GSM2819685 stored in..., Human RNA-Seq data set GSM2819686 stored in..., Human RNA-Seq data set GSM2819687 stored in..., Human RNA-Seq data set GSM2819688 stored in..., Human RNA-Seq data set GSM2819689 stored in..., Human RNA-Seq data set GSM2819690 stored in..., Human RNA-Seq data set GSM2819691 stored in..., Human RNA-Seq data set GSM2819692 stored in..., Human RNA-Seq data set GSM2819693 stored in..., Human RNA-Seq data set GSM2819694 stored in..., Human RNA-Seq data set GSM2819695 stored in...
Snapshots: No snapshots
DNA-methylation at binding sites of uniformly expressed transcription factors in human hepatocytes ; hepatic zone: pericentral (CV)
Submitter: Mario Brosch
Assay type: Methylation Profiling
Technology type: Technology Type
Investigation: Epigenomic analysis of micro-dissected human liver
Organisms: Homo sapiens
SOPs: No SOPs
Data files: Human DNA methylation data set GSM2819627 sto..., Human DNA methylation data set GSM2819634 ..., Human DNA methylation data set GSM2819636 ..., Human DNA methylation data set GSM2819638 ..., Human DNA methylation data set GSM2819621 stor..., Human DNA methylation data set GSM2819622 stor..., Human DNA methylation data set GSM2819623 stor..., Human DNA methylation data set GSM2819629 s..., Human DNA methylation data set GSM2819630 s..., Human DNA methylation data set GSM2819631 s..., Human DNA methylation data set GSM2819632 s..., Human DNA methylation data set GSM2819633 s..., Human DNA methylation data set GSM2819635 s..., Human DNA methylation data set GSM2819637 s..., Human DNA methylation data set GSM2819624 stor..., Human DNA methylation data set GSM2819625 store..., Human DNA methylation data set GSM2819626 store..., Human DNA methylation data set GSM2819628 store..., HumanDNA methylation data set GSM2819620 st...
Snapshots: No snapshots
Transcriptomic analysis of hepatocytes captured by laser micro-dissection from hepatic zone: intermediate (IZ)
Submitter: Mario Brosch
Assay type: RNA-seq Profiling
Technology type: Rna-seq
Investigation: Epigenomic analysis of micro-dissected human liver
Organisms: Homo sapiens
SOPs: SOP : liver tissue microdissection for RNA seq...
Data files: Human RNA-Seq data set GSM2819696 stored in..., Human RNA-Seq data set GSM2819697 stored in..., Human RNA-Seq data set GSM2819698 stored in..., Human RNA-Seq data set GSM2819699 stored in..., Human RNA-Seq data set GSM2819700 stored in..., Human RNA-Seq data set GSM2819701 stored in..., Human RNA-Seq data set GSM2819702 stored in..., Human RNA-Seq data set GSM2819703 stored in..., Human RNA-Seq data set GSM2819704 stored in..., Human RNA-Seq data set GSM2819705 stored in..., Human RNA-Seq data set GSM2819706 stored in..., Human RNA-Seq data set GSM2819707 stored in..., Human RNA-Seq data set GSM2819708 stored in..., Human RNA-Seq data set GSM2819709 stored in..., Human RNA-Seq data set GSM2819710 stored in..., Human RNA-Seq data set GSM2819711 stored in..., Human RNA-Seq data set GSM2819712 stored in..., Human RNA-Seq data set GSM2819713 stored in..., Human RNA-Seq data set GSM2819714 stored in ...
Snapshots: No snapshots
Transcriptomic analysis of hepatocytes captured by laser micro-dissection from hepatic zone: periportal (PP)
Submitter: Mario Brosch
Assay type: RNA-seq Profiling
Technology type: Rna-seq
Investigation: Epigenomic analysis of micro-dissected human liver
Organisms: Homo sapiens
SOPs: SOP : liver tissue microdissection for RNA seq...
Data files: Human RNA-Seq data set GSM2819715 stored in..., Human RNA-Seq data set GSM2819716 stored in..., Human RNA-Seq data set GSM2819717 stored in..., Human RNA-Seq data set GSM2819718 stored in..., Human RNA-Seq data set GSM2819719 stored in..., Human RNA-Seq data set GSM2819720 stored in..., Human RNA-Seq data set GSM2819721 stored in..., Human RNA-Seq data set GSM2819722 stored in..., Human RNA-Seq data set GSM2819723 stored in..., Human RNA-Seq data set GSM2819724 stored in..., Human RNA-Seq data set GSM2819725 stored in..., Human RNA-Seq data set GSM2819726 stored in..., Human RNA-Seq data set GSM2819727 stored in..., Human RNA-Seq data set GSM2819728 stored in..., Human RNA-Seq data set GSM2819729 stored in..., Human RNA-Seq data set GSM2819730 stored in..., Human RNA-Seq data set GSM2819731 stored in..., Human RNA-Seq data set GSM2819732 stored in..., Human RNA-Seq data set GSM2819733 stored in...
Snapshots: No snapshots
DNA-methylation at binding sites of uniformly expressed transcription factors in human hepatocytes ; hepatic zone: intermediate (IZ)
Submitter: Olga Krebs
Assay type: Methylation Profiling
Technology type: Technology Type
Investigation: Epigenomic analysis of micro-dissected human liver
Organisms: Homo sapiens
SOPs: No SOPs
Data files: Human DNA methylation data set GSM2819639 ..., Human DNA methylation data set GSM2819641 ..., Human DNA methylation data set GSM2819642 ..., Human DNA methylation data set GSM2819643 ..., Human DNA methylation data set GSM2819647 ..., Human DNA methylation data set GSM2819640 s..., Human DNA methylation data set GSM2819644 s..., Human DNA methylation data set GSM2819645 s..., Human DNA methylation data set GSM2819646 s..., Human DNA methylation data set GSM2819648 s..., Human DNA methylation data set GSM2819650 s..., Human DNA methylation data set GSM2819651 s..., Human DNA methylation data set GSM2819652 s..., Human DNA methylation data set GSM2819653 s..., Human DNA methylation data set GSM2819654 s..., Human DNA methylation data set GSM2819655 s..., Human DNA methylation data set GSM2819656 s..., Human DNA methylation data set GSM2819657 s..., HumanDNA methylation data set GSM2819649 st...
Snapshots: No snapshots
Human RNA-Seq data set GSM2819712 stored in NCBI (GEO)
Creator: Mario Brosch
Submitter: Mario Brosch
Human RNA-Seq data set GSM2819698 stored in NCBI (GEO)
liver tissue sample : 6922_IZ_RNA
Creator: Mario Brosch
Submitter: Mario Brosch
Human RNA-Seq data set GSM2819714 stored in NCBI (GEO)
Creator: Mario Brosch
Submitter: Mario Brosch
Human RNA-Seq data set GSM2819713 stored in NCBI (GEO)
Creator: Mario Brosch
Submitter: Mario Brosch
Human RNA-Seq data set GSM2819711 stored in NCBI (GEO)
Creator: Mario Brosch
Submitter: Mario Brosch
Abstract (Expand)
Authors: Olga Vvedenskaya, Tim Daniel Rose, Oskar Knittelfelder, Alessandra Palladini, Judith Andrea Heidrun Wodke, Kai Schumann, Jacobo Miranda Ackerman, Yuting Wang, Canan Has, Mario Brosch, Veera Raghavan Thangapandi, Stephan Buch, Thomas Züllig, Jürgen Hartler, Harald C. Köfeler, Christoph Röcken, Ünal Coskun, Edda Klipp, Witigo von Schoenfels, Justus Gross, Clemens Schafmayer, Jochen Hampe, Josch Konstantin Pauling, Andrej Shevchenko
Date Published: 1st Aug 2021
Publication Type: Journal
DOI: 10.1016/j.jlr.2021.100104
Citation: Journal of Lipid Research:100104
Abstract (Expand)
Authors: V. R. Thangapandi, O. Knittelfelder, M. Brosch, E. Patsenker, O. Vvedenskaya, S. Buch, S. Hinz, A. Hendricks, M. Nati, A. Herrmann, D. R. Rekhade, T. Berg, M. Matz-Soja, K. Huse, E. Klipp, J. K. Pauling, J. A. Wodke, J. Miranda Ackerman, M. V. Bonin, E. Aigner, C. Datz, W. von Schonfels, S. Nehring, S. Zeissig, C. Rocken, A. Dahl, T. Chavakis, F. Stickel, A. Shevchenko, C. Schafmayer, J. Hampe, P. Subramanian
Date Published: 26th Jun 2020
Publication Type: Journal
PubMed ID: 32591434
Citation: Gut. 2020 Jun 26. pii: gutjnl-2020-320853. doi: 10.1136/gutjnl-2020-320853.
Abstract (Expand)
Authors: H. Innes, S. Buch, S. Hutchinson, I. N. Guha, J. R. Morling, E. Barnes, W. Irving, E. Forrest, V. Pedergnan, D. Goldberg, E. Aspinall, S. Barclay, P. Hayes, J. Dillon, H. D. Nischalke, P. Lutz, U. Spengler, J. Fischer, T. Berg, M. Brosch, F. Eyer, C. Datz, S. Mueller, T. Peccerella, P. Deltenre, A. Marot, M. Soyka, A. McQuillin, M. Y. Morgan, J. Hampe, F. Stickel
Date Published: 16th Jun 2020
Publication Type: Journal
PubMed ID: 32561361
Citation: Gastroenterology. 2020 Jun 16. pii: S0016-5085(20)34767-3. doi: 10.1053/j.gastro.2020.06.014.
Abstract (Expand)
Authors: F. Segovia-Miranda, H. Morales-Navarrete, M. Kucken, V. Moser, S. Seifert, U. Repnik, F. Rost, M. Brosch, A. Hendricks, S. Hinz, C. Rocken, D. Lutjohann, Y. Kalaidzidis, C. Schafmayer, L. Brusch, J. Hampe, M. Zerial
Date Published: 2nd Dec 2019
Publication Type: Not specified
PubMed ID: 31792455
Citation: Nat Med. 2019 Dec 2. pii: 10.1038/s41591-019-0660-7. doi: 10.1038/s41591-019-0660-7.
Abstract (Expand)
Authors: Erik Kolbe, Susanne Aleithe, Christiane Rennert, Luise Spormann, Fritzi Ott, David Meierhofer, Robert Gajowski, Claus Stöpel, Stefan Hoehme, Michael Kücken, Lutz Brusch, Michael Seifert, Witigo von Schoenfels, Clemens Schafmayer, Mario Brosch, Ute Hofmann, Georg Damm, Daniel Seehofer, Jochen Hampe, Rolf Gebhardt, Madlen Matz-Soja
Date Published: 1st Dec 2019
Publication Type: Not specified
DOI: 10.1016/j.celrep.2019.11.104
Citation: Cell Reports 29(13) : 4553
Talk at the Jamboree 2021 about epigenomic map of human liver zonation and loss of zonation in end-stage liver disease
Creators: Mario Brosch, Jochen Hampe, Lutz Brusch, Marino Zerial, Clemens Schafmayer
Submitter: Mario Brosch