Martin Golebiewski
Data management and standardization expert for systems biology and systems medicine, responsible for the data management user requirements and user contacts within the German LiSyM network (Liver Systems Medicine: http://lisym.org/) and associated to the FAIRDOM team.
Involved in different standardization initiatives and committees, i.e. COMBINE (http://co.mbine.org), ISO/TC 276 Biotechnology (https://www.iso.org/committee/4514241.html), European COST action CHARME (http://www.cost-charme.eu) and others.
SEEK ID: https://seek.lisym.org/people/3
Location:
Germany
Expertise: Data Management, Databases, Biochemistry, Bioinformatics, Systems Biology, Standards
Tools: kinetic modelling, Databases, Mathematical Modelling, Ontologies, Workflows
https://orcid.org/0000-0002-8683-7084 
Project roles
Project administrator
- LiSyM Core Infrastructure and Management (LiSyM-PD)
- LiSyM Pillar I: Early Metabolic Injury (LiSyM-EMI)
- LiSyM Pillar II: Chronic Liver Disease Progression (LiSyM-DP)
- LiSyM Pillar III: Regeneration and Repair in Acute-on-Chronic Liver Failure (LiSyM-ACLF)
- LiSyM Pillar IV: Liver Function Diagnostics (LiSyM-LiFuDi)
- Model Guided Pharmacotherapy In Chronic Liver Disease (LiSyM-MGP)
- Molecular Steatosis - Imaging & Modeling (LiSyM-MSIM)
- The Hedgehog Signalling Pathway (LiSyM-JGMMS)
- Multi-Scale Models for Personalized Liver Function Tests (LiSyM-MM-PLF)
- LiSyM PALs
- LiSyM network
- LiSyM-Krebs Partnering
Asset housekeeper
- LiSyM PALs
- LiSyM Pillar III: Regeneration and Repair in Acute-on-Chronic Liver Failure (LiSyM-ACLF)
- LiSyM Pillar II: Chronic Liver Disease Progression (LiSyM-DP)
- LiSyM Pillar I: Early Metabolic Injury (LiSyM-EMI)
- LiSyM Core Infrastructure and Management (LiSyM-PD)
- LiSyM Pillar IV: Liver Function Diagnostics (LiSyM-LiFuDi)
- The Hedgehog Signalling Pathway (LiSyM-JGMMS)
- LiSyM network
- LiSyM-Krebs Partnering
Their tagsLiSyM Core Infrastructure and Management (LiSyM-PD) (HITS gGmbH) ; LiSyM Pillar I: Early Metabolic Injury (LiSyM-EMI) (HITS gGmbH) ; LiSyM Pillar II: Chronic Liver Disease Progression (LiSyM-DP) (HITS gGmbH) ; LiSyM Pillar III: Regeneration and Repair in Acute-on-Chronic Liver Failure (LiSyM-ACLF) (HITS gGmbH) ; LiSyM Pillar IV: Liver Function Diagnostics (LiSyM-LiFuDi) (HITS gGmbH) ; Model Guided Pharmacotherapy In Chronic Liver Disease (LiSyM-MGP) (HITS gGmbH) ; Molecular Steatosis - Imaging & Modeling (LiSyM-MSIM) (HITS gGmbH) ; The Hedgehog Signalling Pathway (LiSyM-JGMMS) (HITS gGmbH) ; Multi-Scale Models for Personalized Liver Function Tests (LiSyM-MM-PLF) (HITS gGmbH) ; LiSyM PALs (HITS gGmbH) ; LiSyM network (HITS gGmbH) ; LiSyM-Krebs Partnering (HITS gGmbH)
Related items
Disorders of the liver show up through changes in blood tests. These blood tests indicate markers for events taking place in the liver. Usually studies of liver tissue cannot be performed: as liver samples would need to be obtained through a liver biopsy, and this procedure is not without risk, therefore these samples are usually unavailable. Complex metabolism models based on existing and new scientific data can simulate changes in the liver caused by disease. They often reveal unknown relationships
...
Public web page: http://www.lisym.org/our-work/pillar-research/the-liver-is-very-patient
Start date: 1st Jan 2016
In chronic diseases, at some point the liver can suddenly stop functioning. This is called acute-on-chronic liver failure, or ACLF. This is the leading cause of death in liver patients and is often provoked by the use of transcription or freely available drugs or alcohol abuse. For this condition we need an effective treatment quickly.
LiSyM-Pillar III researches the factors that contribute significantly to ACLF. What exactly happens then? Are there any early signs that would enable ACLF to be
...
Public web page: http://www.lisym.org/our-work/pillar-research
Start date: 1st Jan 2016
In one in five people with NAFLD, the functioning liver cells, the hepatocytes, are replaced by connective tissue. Eventually this fibrosis becomes irreversible. In this state the liver is like a ‘scar that never heals’. Through it, the liver loses many of its vital functions.
LiSyM-Pillar II wants to know more about which factors promote fibrosis and the conditions under which fibrosis becomes irreversible How can fibrosis be diagnosed as early as possible? Researchers in the pillar are also
...
Public web page: http://www.lisym.org/our-work/pillar-research
Start date: 1st Jan 2016
One of the tasks of the healthy liver is to store fat. Yet, at some stage, too much fat makes the liver sick. One critical time point occurs when a healthy fatty liver becomes inflamed and progresses to steatohepatitis, or NASH.
LiSyM-Pillar I will identify what events lead to this transition. Does it occur in all parts of the liver? Which molecules indicate that it is taking place? Can the degeneration be stopped or undone - and if so, how?
Public web page: http://www.lisym.org/our-work/pillar-research/zones-of-the-liver
Start date: 1st Jan 2016
Dr. Ahmed Ghallab (TU University, Dortmund) deals with chronic liver damage caused by toxins. In addition, he investigates processes associated with cholestasis - when bile accumulates in the bile ducts. Ghallab has been able to explain basic mechanisms of acute cholestasis, using a method for intravital two-photon microscopy, which he developed.
Public web page: http://www.lisym.org/our-work/junior-group/the-liver-protects-itself
Start date: 1st Jan 2016
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The purpose of this document is to define procedures to follow for exchanging the following items between collaboration partners within the LiSyM network:
a) Exchanging samples of human origin obtained from a natural person (i.e. a patient or other human subject).
b) Exchanging material derived from samples of human origin as defined in a).
c) Exchanging associated data describing samples of human origin and derived material as defined in a) and b).
d) Exchanging data derived from samples of human
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Creators: Martin Golebiewski, Frank Lammert, Wolfgang Müller
Submitter: Martin Golebiewski
This SOP - Standard Operating Procedure for Sample Collection and Preservation of Blood and
Endometrial Tissue were developed at NIH University of California San Francisco Human Endometrial Tissue and DNA Bank
by Elizabeth Sheldonand, Ramsey A McIntire
Creators: Olga Krebs, Martin Golebiewski, Elizabeth Sheldonand, Ramsey A McIntire
Submitter: Olga Krebs
Abstract (Expand)
Authors: Dagmar Waltemath, Martin Golebiewski, Michael L Blinov, Padraig Gleeson, Henning Hermjakob, Michael Hucka, Esther Thea Inau, Sarah M Keating, Matthias König, Olga Krebs, Rahuman S Malik-Sheriff, David Nickerson, Ernst Oberortner, Herbert M Sauro, Falk Schreiber, Lucian Smith, Melanie I Stefan, Ulrike Wittig, Chris J Myers
Date Published: 29th Jun 2020
Publication Type: Journal
Abstract (Expand)
Authors: Falk Schreiber, Björn Sommer, Tobias Czauderna, Martin Golebiewski, Thomas E. Gorochowski, Michael Hucka, Sarah M. Keating, Matthias König, Chris Myers, David Nickerson, Dagmar Waltemath
Date Published: 29th Jun 2020
Publication Type: Journal
Abstract (Expand)
Authors: Maxwell L. Neal, John H. Gennari, Dagmar Waltemath, David P. Nickerson, Matthias König
Date Published: 25th Jun 2020
Publication Type: Journal
Abstract (Expand)
Authors: N. J. Stanford, M. Scharm, P. D. Dobson, M. Golebiewski, M. Hucka, V. B. Kothamachu, D. Nickerson, S. Owen, J. Pahle, U. Wittig, D. Waltemath, C. Goble, P. Mendes, J. Snoep
Date Published: 12th Oct 2019
Publication Type: Not specified
Abstract (Expand)
Authors: Falk Schreiber, Björn Sommer, Gary D. Bader, Padraig Gleeson, Martin Golebiewski, Michael Hucka, Sarah M. Keating, Matthias König, Chris Myers, David Nickerson, Dagmar Waltemath
Date Published: 26th Jun 2019
Publication Type: Not specified
Poster presentation at SBMC 2018 (Bremen)
Creators: Martin Golebiewski, Olga Krebs, Hadas Leonov, Wolfgang Müller, Stuart Owen, Maja Rey, Natalie Stanford, Andreas Weidemann, Ulrike Wittig, Katy Wolstencroft, Jacky L. Snoep, Carole Goble
Submitter: Martin Golebiewski
LiSyM/de.NBI/ERASysAPP Tutorial: How to Share FAIR — The FAIRDOM Data and Model Management Practice
Introduction into SABIO-RK
Creator: Maja Rey
Submitter: Martin Golebiewski
LiSyM/de.NBI/ERASysAPP Tutorial: How to Share FAIR — The FAIRDOM Data and Model Management Practice
Hands-on tasks
Creator: Maja Rey
Submitter: Martin Golebiewski
LiSyM/de.NBI/ERASysAPP Tutorial: How to Share FAIR — The FAIRDOM Data and Model Management Practice
Hands-on slides
Creator: Maja Rey
Submitter: Martin Golebiewski
LiSyM/de.NBI/ERASysAPP Tutorial: How to Share FAIR — The FAIRDOM Data and Model Management Practice
Introduction slides
Creator: Martin Golebiewski
Submitter: Martin Golebiewski
ICSB is one of the largest international conferences on systems biology. Since the first conference in Tokyo in 2000, which was organized by Dr. Hiroaki Kitano, it has been held annually in different countries.
Country: 
United States
City: Hartford, Connecticut
SBMC 2020 was postponed to 10th - 12th of May 2021. Further information will follow soon.
Start Date: 10th May 2021
End Date: 12th May 2021
Event Website: https://sbmc2020.bioquant.uni-heidelberg.de
Country: Germany
City: Heidelberg
The "Computational Modeling in Biology" Network (COMBINE) is an initiative to coordinate the development of the various community standards and formats in systems biology, systems medicine, synthetic biology and related fields. COMBINE 2020 will be a workshop-style event with invited lectures, oral presentations and posters, but also reserving enough time for afternoon breakout sessions to discuss topics around data and model standardization and integration, as well as harmonization and further
...
Country: United States
City: virtual
The Computational Modeling in Biology Network (COMBINE) is an initiative to coordinate the development of the various community standards and formats in systems biology, synthetic biology and related fields. HARMONY is a codefest-type meeting, with a focus on development of the standards, interoperability and infrastructure. There are generally not many general discussions or oral presentations during HARMONY; instead, the time is devoted to allowing hands-on hacking and interaction between people
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Start Date: 9th Mar 2020
End Date: 13th Mar 2020
Event Website: http://co.mbine.org/events/HARMONY_2020
Country: 
United Kingdom
City: Hinxton, Cambridge
e:Med brings together leading scientists and exceptional young researchers from all over Germany in the emerging field of Systems Medicine. Systems medicine uses interdisciplinary systems-oriented research on diseases to create a basis for understanding complex physiological and pathological processes for development of innovative personalized diagnosis, therapies, and preventive measures. Key to the appropriate analysis and possibly to the modelling of Big Data derived from information levels
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Start Date: 8th Mar 2020
End Date: 10th Mar 2020
Event Website: http://www.sys-med.de/de/meeting/emed-kick-off-2020/
Country: Germany
City: Bonn
