C-TIP-HCC network

Overview
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**C-TIP-HCC **- Mechanism-based Multiscale Model to Dissect the Tipping Point from Liver Cirrhosis to Hepatocellular Carcinoma

The ultimate goal of the C-TIP-HCC is a „mechanistic multiscale model to describe dynamic changes in regenerative nodes across a tipping point (TIP) towards development in patients with cirrhosis to facilitate early monitoring and intervention“ and facilitate intervention“. To achieve this, we will conduct in-depth studies on cirrhotic regenerative nodes.

Programme: LiSyM-Krebs - Systemmedizinisches Forschungsnetz zur Früherkennung und Prävention von Leberkrebs

SEEK ID: https://seek.lisym.org/projects/19

Public web page: Not specified

Organisms: Homo sapiens, Mus musculus

FAIRDOM PALs: No PALs for this Project

Project created: 1st Dec 2021

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Ina Biermayer

Projects: LiSyM network, LiSyM Pillar III: Regeneration and Repair in Acute-on-Chronic Liver Failure (LiSyM-ACLF), SMART-NAFLD, Forschungsnetzwerk LiSyM-Krebs, DEEP-HCC network, C-TIP-HCC network

Institutions: Deutsches Krebsforschungszentrum, HITS gGmbH

Roles: PhD Student, Postdoc

Expertise: Molecular Biology, Primary human hepatocytes, Systems Biology, wet lab, Signal transduction, Proteomics

Tools: Cell and tissue culture, Cell Isolation, Isolation and cultivation of mouse hepatocyte, Molecular Biology

Program management team LiSyM-Cancer (project and communications manager)

Former PhD student in LiSyM, at DKFZ Heidelberg in the group of Ursula Klingmüller

(née Schmitt)

Johannes Bode

Steven Dooley

Projects: LiSyM Pillar II: Chronic Liver Disease Progression (LiSyM-DP), LiSyM Pillar III: Regeneration and Repair in Acute-on-Chronic Liver Failure (LiSyM-ACLF), LiSyM network, LiSyM-Krebs Partnering, Forschungsnetzwerk LiSyM-Krebs, C-TIP-HCC network, SMART-NAFLD

Institutions: Molecular Hepatology - Dept of Medicine II - Medical Faculty Mannheim - Heidelberg University

Dirk Drasdo

Projects: LiSyM Pillar II: Chronic Liver Disease Progression (LiSyM-DP), LiSyM network, LiSyM Pillar III: Regeneration and Repair in Acute-on-Chronic Liver Failure (LiSyM-ACLF), LiSyM Scientific Leadership Team (LiSyM-LT), LiSyM-Krebs Partnering, Forschungsnetzwerk LiSyM-Krebs, C-TIP-HCC network

Institutions: INRIA (French National Institute for Research in Computer Science and Control), Leibniz-Institut für Arbeitsforschung (IfADo)

Susan Eckerle

Projects: Forschungsnetzwerk LiSyM-Krebs, C-TIP-HCC network, DEEP-HCC network, LiSyM network, LiSyM Core Infrastructure and Management (LiSyM-PD), SMART-NAFLD

Institutions: HITS gGmbH, Molecular Hepatology - Dept of Medicine II - Medical Faculty Mannheim - Heidelberg University

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LiSyM-Krebs - Systemmedizinisches Forschungsnetz zur Früherkennung und Prävention von Leberkrebs

LiSyM-Krebs ist ein nationales Forschungsnetz zur Früherkennung und Prävention von Leberkrebs, das unter Verwendung des systemmedizinischen Forschungsansatzes die komplexen, dynamischen Prozesse der Krankheitsprogression analysiert, um ausgehend von den Erkenntnissen aus dem Forschungsnetz LiSyM die Entstehung von Leberkrebs besser zu verstehen, vorherzusagen und im besten Fall sogar zu verhindern. LiSyM-Krebs setzt die erfolgreichen Forschungsaktivitäten der BMBF-Vorgängerprogramme ...

Projects: LiSyM-Krebs Partnering, Forschungsnetzwerk LiSyM-Krebs, SMART-NAFLD, DEEP-HCC network, C-TIP-HCC network

Web page: https://www.lisym-cancer.org

Deutsches Krebsforschungszentrum

Country: Germany

City: 69120 Heidelberg

Web page: http://www.dkfz.de

Heidelberg University - Institute for Computational Biomedicine

Country: Germany

City: Heidelberg

Web page: Not specified

HITS gGmbH

Country: Germany

City: 69118 Heidelberg

Web page: https://www.h-its.org/

INRIA (French National Institute for Research in Computer Science and Control)

Country: France

City: Paris

Web page: https://www.inria.fr/en

Leibniz-Institut für Arbeitsforschung (IfADo)

Country: Germany

City: 44139 Dortmund

Web page: http://www.ifado.de/

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Meeting minutes

Forschungsnetzwerk LiSyM-Krebs, SMART-NAFLD, DEEP-HCC network, C-TIP-HCC network

Documents submitted to BMBF

Submitter: Olga Krebs

Investigation: 1 hidden item

Assays: Meeting minutes 2021, Meeting minutes 2022

Snapshots: No snapshots

Created: 8th Feb 2021 at 09:17

Documents submitted to BMBF

Forschungsnetzwerk LiSyM-Krebs, SMART-NAFLD, DEEP-HCC network, C-TIP-HCC network

Documents submitted to BMBF

Submitter: Olga Krebs

Investigation: 1 hidden item

Assays: Project deliverables 2021, Project deliverables 2022, Project proposals

Snapshots: No snapshots

Created: 8th Feb 2021 at 09:16

2 hidden items

Project proposals

Forschungsnetzwerk LiSyM-Krebs, SMART-NAFLD, DEEP-HCC network, C-TIP-HCC network

Project proposals

Submitter: Olga Krebs

Biological problem addressed: Model Analysis Type

Investigation: 1 hidden item

Study: Documents submitted to BMBF

Organisms: No organisms

Models: No Models

SOPs: No SOPs

Data files: No Data files

Snapshots: No snapshots

Created: 8th Feb 2021 at 09:20, Last updated: 8th Feb 2021 at 09:21

Meeting minutes 2021

Forschungsnetzwerk LiSyM-Krebs, SMART-NAFLD, DEEP-HCC network, C-TIP-HCC network

Meeting minutes 2021

Submitter: Olga Krebs

Biological problem addressed: Model Analysis Type

Investigation: 1 hidden item

Study: Meeting minutes

Organisms: No organisms

Models: No Models

SOPs: No SOPs

Data files: No Data files

Snapshots: No snapshots

Created: 8th Feb 2021 at 09:25

Meeting minutes 2022

Forschungsnetzwerk LiSyM-Krebs, SMART-NAFLD, DEEP-HCC network, C-TIP-HCC network

Meeting minutes 2022

Submitter: Olga Krebs

Biological problem addressed: Model Analysis Type

Investigation: 1 hidden item

Study: Meeting minutes

Organisms: No organisms

Models: No Models

SOPs: No SOPs

Data files: No Data files

Snapshots: No snapshots

Created: 8th Feb 2021 at 09:25

Project deliverables 2021

Forschungsnetzwerk LiSyM-Krebs, SMART-NAFLD, DEEP-HCC network, C-TIP-HCC network

Project deliverables 2021

Submitter: Olga Krebs

Biological problem addressed: Model Analysis Type

Investigation: 1 hidden item

Study: Documents submitted to BMBF

Organisms: No organisms

Models: No Models

SOPs: No SOPs

Data files: No Data files

Snapshots: No snapshots

Created: 8th Feb 2021 at 09:26

Project deliverables 2022

Forschungsnetzwerk LiSyM-Krebs, SMART-NAFLD, DEEP-HCC network, C-TIP-HCC network

Project deliverables 2022

Submitter: Olga Krebs

Biological problem addressed: Model Analysis Type

Investigation: 1 hidden item

Study: Documents submitted to BMBF

Organisms: No organisms

Models: No Models

SOPs: No SOPs

Data files: No Data files

Snapshots: No snapshots

Created: 8th Feb 2021 at 09:26

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3 hidden items

Tumour cells can escape antiproliferative pressure by interferon-β through immunoediting of interferon receptor expression

Forschungsnetzwerk LiSyM-Krebs, SMART-NAFLD, C-TIP-HCC network

Abstract (Expand)

Abstract Type I interferons (IFNs) play a central role not only in innate immunity against viral infection, but also in the antitumour response. Apart from indirect immune-modulatory and anti-angiogenic …

Authors: Felix Hiebinger, Aiste Kudulyte, Huanting Chi, Sebastian Burbano de Lara, Barbara Helm, Hendrik Welsch, Viet Loan Dao Thi, Ursula Klingmüller, Marco Binder

Date Published: 24th Aug 2023

Publication Type: Journal

DOI: 10.21203/rs.3.rs-3276415/v1

Citation: [Preprint]

Created: 6th Sep 2023 at 15:39, Last updated: 6th Sep 2023 at 15:40

TGF-β1 inhibits cholesterol metabolism in hepatocytes to facilitate cell death, EMT and signals for HSC activation.

Forschungsnetzwerk LiSyM-Krebs, C-TIP-HCC network

Abstract (Expand)

Objective: Transforming growth factor-β1 (TGF-β1) plays important roles in chronic liver diseases, including metabolic dysfunction-associated steatotic liver disease (MASLD), which involves various …

Authors: Sai Wang, Frederik Link, Mei Han, Roman Liebe, Ye Yao, Seddik Hammad, Anne Dropmann, Roohi Chaudhary, Anastasia Asimakopoulos, Marinela Krizanac, Ralf Weiskirchen, Yoav I Henis, Marcelo Ehrlich, Matthias Ebert, Steven Dooley

Date Published: 15th Aug 2023

Publication Type: Journal

DOI: 10.1101/2023.08.14.552900

Citation: biorxiv;2023.08.14.552900v1,[Preprint]

Created: 16th Aug 2023 at 07:43, Last updated: 16th Aug 2023 at 07:43

Hepatokine‐based identification of fibrotic NASH and improved risk stratification in a multicentre cohort of NAFLD patients

Forschungsnetzwerk LiSyM-Krebs, C-TIP-HCC network

Abstract (Expand)

Abstract Background and Aims The presence of significant liver fibrosis associated with non‐alcoholic steatohepatitis (NASH) is regarded as the major prognostic factor in non‐alcoholic fatty liver …

Authors: Martin Franck, Katharina John, Sherin Al Aoua, Monika Rau, Andreas Geier, Jörn M. Schattenberg, Heiner Wedemeyer, Klaus Schulze‐Osthoff, Heike Bantel

Date Published: 3rd Aug 2023

Publication Type: Journal

DOI: 10.1111/liv.15686

Citation: Liver International,liv.15686

Created: 7th Aug 2023 at 07:55, Last updated: 7th Aug 2023 at 07:56

An integrative experimental and computational twin modeling approach to understand clonal dynamics in the normal liver

Forschungsnetzwerk LiSyM-Krebs, C-TIP-HCC network

Abstract

Not specified

Authors: Dirk Drasdo, Jieling Zhao

Date Published: 1st Aug 2023

Publication Type: Journal

DOI: 10.1016/j.jhep.2023.05.016

Citation: Journal of Hepatology 79(2):273-276

Created: 24th Jul 2023 at 07:19, Last updated: 24th Jul 2023 at 07:20

Tolerance of repeated toxic injuries of murine livers is associated with steatosis and inflammation

LiSyM Pillar II: Chronic Liver Disease Progression (LiSyM-DP), LiSyM network, C-TIP-HCC network

(Show All)

Abstract (Expand)

Abstract The human liver has a remarkable capacity to regenerate and thus compensate over decades for fibrosis caused by toxic chemicals, drugs, alcohol, or malnutrition. To date, no protective mechanisms …

Authors: Seddik Hammad, Christoph Ogris, Amnah Othman, Pia Erdoesi, Wolfgang Schmidt-Heck, Ina Biermayer, Barbara Helm, Yan Gao, Weronika Piorońska, Christian H. Holland, Lorenza A. D’Alessandro, Carolina de la Torre, Carsten Sticht, Sherin Al Aoua, Fabian J. Theis, Heike Bantel, Matthias P. Ebert, Ursula Klingmüller, Jan G. Hengstler, Steven Dooley, Nikola S. Mueller

Date Published: 1st Jul 2023

Publication Type: Journal

DOI: 10.1038/s41419-023-05855-4

Citation: Cell Death Dis 14(7),414

Created: 12th Jul 2023 at 13:09, Last updated: 2nd Aug 2023 at 13:10

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LiSyM Cancer Young Scientists Retreat (YSR)

Young Scientists Retreat (YSR) will take place from September 7th to 9th in Hofgeismar (close to Kassel) (https://tagungsstaette-hofgeismar.de/). Participation is mandatory for all PhD students, MD students and Postdocs in SMART-NAFLD, C-TIP-HCC and DEEP-HCC