SEEK ID: https://seek.lisym.org/people/36
Location:
Germany
Expertise: Animal experimentalist, Imaging and image analysis, Omics
Tools: Animal facility, Microarray analysis, confocal microscopy, Metabolomics
ORCID: Not specified
LiSyM Pillar II: Chronic Liver Disease Progression (LiSyM-DP) (Molecular Hepatology - Dept of Medicine II - Medical Faculty Mannheim - Heidelberg University) ; LiSyM Pillar III: Regeneration and Repair in Acute-on-Chronic Liver Failure (LiSyM-ACLF) (Molecular Hepatology - Dept of Medicine II - Medical Faculty Mannheim - Heidelberg University)
LiSyM network (Molecular Hepatology - Dept of Medicine II - Medical Faculty Mannheim - Heidelberg University) ; LiSyM PALs (Molecular Hepatology - Dept of Medicine II - Medical Faculty Mannheim - Heidelberg University) ; LiSyM-Krebs Partnering (Molecular Hepatology - Dept of Medicine II - Medical Faculty Mannheim - Heidelberg University)
Related items
- Programmes (2)
- Projects (5)
- Institutions (1)
- Investigations (1+1)
- Studies (1+2)
- Assays (1+5)
- Data files (29+16)
- Publications (55)
- Presentations (24+7)
LiSyM-Krebs ist ein nationales Forschungsnetz zur Früherkennung und Prävention von Leberkrebs, das unter Verwendung des systemmedizinischen Forschungsansatzes die komplexen, dynamischen Prozesse der Krankheitsprogression analysiert, um ausgehend von den Erkenntnissen aus dem Forschungsnetz LiSyM die Entstehung von Leberkrebs besser zu verstehen, vorherzusagen und im besten Fall sogar zu verhindern. LiSyM-Krebs setzt die erfolgreichen Forschungsaktivitäten der BMBF-Vorgängerprogramme ...
Projects: LiSyM-Krebs Partnering, Forschungsnetzwerk LiSyM-Krebs, SMART-NAFLD, DEEP-HCC network, C-TIP-HCC network
Web page: Not specified
Liver Systems Medicine : striving to develop non-invasive methods for diagnosing and treating NAFLD by combining mathematical modeling and biological research. LiSyM, is a multidisciplinary research network, in which molecular and cell biologists, clinical researchers, pharmacologists and experts in mathematical modeling examine the liver in its entirety. LiSyM research focuses on the metabolic liver disease non-alcoholic fatty liver disease (NAFLD), which includes non-alcoholic steatohepatitis ...
Projects: LiSyM Core Infrastructure and Management (LiSyM-PD), LiSyM Pillar I: Early Metabolic Injury (LiSyM-EMI), LiSyM Pillar II: Chronic Liver Disease Progression (LiSyM-DP), LiSyM Pillar III: Regeneration and Repair in Acute-on-Chronic Liver Failure (LiSyM-ACLF), LiSyM Pillar IV: Liver Function Diagnostics (LiSyM-LiFuDi), Model Guided Pharmacotherapy In Chronic Liver Disease (LiSyM-MGP), Molecular Steatosis - Imaging & Modeling (LiSyM-MSIM), The Hedgehog Signalling Pathway (LiSyM-JGMMS), Multi-Scale Models for Personalized Liver Function Tests (LiSyM-MM-PLF), LiSyM PALs, Project Management PTJ, LiSyM network, LiSyM Scientific Leadership Team (LiSyM-LT)
Web page: https://www.lisym.org/
In one in five people with NAFLD, the functioning liver cells, the hepatocytes, are replaced by connective tissue. Eventually this fibrosis becomes irreversible. In this state the liver is like a ‘scar that never heals’. Through it, the liver loses many of its vital functions. LiSyM-Pillar II wants to know more about which factors promote fibrosis and the conditions under which fibrosis becomes irreversible How can fibrosis be diagnosed as early as possible? Researchers in the pillar are also ...
Programme: LiSyM: Liver Systems Medicine
Public web page: http://www.lisym.org/our-work/pillar-research
Start date: 1st Jan 2016
Organisms: Mus musculus, Rattus rattus, Rattus norvegicus, Homo sapiens
In chronic diseases, at some point the liver can suddenly stop functioning. This is called acute-on-chronic liver failure, or ACLF. This is the leading cause of death in liver patients and is often provoked by the use of transcription or freely available drugs or alcohol abuse. For this condition we need an effective treatment quickly. LiSyM-Pillar III researches the factors that contribute significantly to ACLF. What exactly happens then? Are there any early signs that would enable ACLF to be ...
Programme: LiSyM: Liver Systems Medicine
Public web page: http://www.lisym.org/our-work/pillar-research
Start date: 1st Jan 2016
Organisms: Homo sapiens, Mus musculus, Rattus norvegicus, Rattus rattus
This comprises the whole LiSyM network
Programme: LiSyM: Liver Systems Medicine
Public web page: http://www.lisym.org
Start date: 1st Jan 2016
Organisms: Rattus norvegicus, Rattus rattus, Mus musculus, Homo sapiens
This generic project is intended to be a forum for all LiSyM partner and external stakeholders interested in participating in the BMBF initiative LiSyM-Krebs.
Programme: LiSyM-Krebs - Systemmedizinisches Forschungsnetz zur Früherkennung und Prävention von Leberkrebs
Public web page: https://www.ptj.de/projektfoerderung/gesundheitsforschung/lisym-krebs
Organisms: Not specified
This is a generic project that comprises all LiSyM data management PALs and associated FAIRDOM PALs, as well as the LiSyM data management team.
Programme: LiSyM: Liver Systems Medicine
Public web page: Not specified
Organisms: Not specified
Pillar II dooley
Snapshots: No snapshots
Snapshots: No snapshots
Submitter: Seddik Hammad
Assay type: Proteomics
Technology type: FACS
Investigation: Julia/Yan
Study: CCl4 Treatment in mice
Organisms: Mus musculus
SOPs: Sample Collection and Preservation of Blood and...
Data files: Movies for quantification, SAC mice RNA microarray, Supp MM 1, Supp fig 3, Supp fig1, Supp fig2, Supplemental Table 1:, Supplemental Table 2, Supplmentary Materials, Methods, Figures and Ta... and 1 hidden item
Snapshots: No snapshots
Creator: Seddik Hammad
Submitter: Seddik Hammad
Investigations: No Investigations
Studies: No Studies
Assays: No Assays
Proteomic Quantification of the Metabolic Targets in Tumor vs Adjacent Normal Liver Tissues
Creator: Seddik Hammad
Submitter: Seddik Hammad
Investigations: No Investigations
Studies: No Studies
Assays: No Assays
Consistently Altered Metabolic Targets in Human Hepatocellular Carcinoma
Creator: Seddik Hammad
Submitter: Seddik Hammad
Investigations: No Investigations
Studies: No Studies
Assays: No Assays
Creator: Seddik Hammad
Submitter: Seddik Hammad
Investigations: No Investigations
Studies: No Studies
Assays: No Assays
Creator: Seddik Hammad
Submitter: Seddik Hammad
Investigations: No Investigations
Studies: No Studies
Assays: No Assays
Abstract
Authors: Silvia Colucci, Sandro Altamura, Oriana Marques, Anne Dropmann, Natalie K. Horvat, Katja Müdder, Seddik Hammad, Steven Dooley, Martina U. Muckenthaler
Date Published: 13th May 2021
Publication Type: Journal
DOI: 10.1002/hep.31900
Citation: Hepatology,hep.31900
Abstract
Authors: P Erdoesi, E Karatayli, F Lammert, S Dooley, S Hammad
Date Published: 2021
Publication Type: Proceedings
Citation: 37. Jahrestagung der Deutschen Arbeitsgemeinschaft zum Studium der Leber,Georg Thieme Verlag KG
Abstract
Authors: Kamalakannan Radhakrishnan, Yong-Hoon Kim, Yoon Seok Jung, Jina Kim, Don-Kyu Kim, Sung Jin Cho, In-Kyu Lee, Steven Dooley, Chul-Ho Lee, Hueng-Sik Choi
Date Published: 1st Oct 2020
Publication Type: Journal
DOI: 10.3390/ijms21197148
Citation: IJMS 21(19):7148
Abstract
Authors: Fatma El-Zahraa Ammar Mohamed, Seddik Hammad, Tu Vinh Luong, Bedair Dewidar, Rajai Al-Jehani, Nathan Davies, Steven Dooley, Rajiv Jalan
Date Published: 1st Aug 2020
Publication Type: Journal
DOI: 10.1016/j.prp.2020.152980
Citation: Pathology - Research and Practice 216(8):152980
Abstract (Expand)
Authors: F. E. A. Mohamed, S. Hammad, T. V. Luong, B. Dewidar, R. Al-Jehani, N. Davies, S. Dooley, R. Jalan
Date Published: 25th Jul 2020
Publication Type: Journal
PubMed ID: 32703481
Citation: Pathol Res Pract. 2020 Aug;216(8):152980. doi: 10.1016/j.prp.2020.152980. Epub 2020 May 19.