Projects: LiSyM Pillar II: Chronic Liver Disease Progression (LiSyM-DP), LiSyM Pillar III: Regeneration and Repair in Acute-on-Chronic Liver Failure (LiSyM-ACLF), LiSyM network, LiSyM-Krebs Partnering, Forschungsnetzwerk LiSyM-Krebs, C-TIP-HCC network
Institutions: Universitätsklinikum Düsseldorf - Klinik für Gastroenterologie, Hepatologie und Infektiologie
Expertise: Liver injury and regeneration, Inflammation, Jak/STAT pathway, Hepatocytes, Imaging and image analysis, non parenchymal cells
Tools: Immunohistochemistry, Isolation and cultivation of mouse hepatocyte, Isolation purification and separation, Molecular Biology, Mouse surgery, Cell and tissue culture, confocal microscopy
Projects: LiSyM Pillar II: Chronic Liver Disease Progression (LiSyM-DP), LiSyM Pillar III: Regeneration and Repair in Acute-on-Chronic Liver Failure (LiSyM-ACLF), LiSyM network
Institutions: Universitätsklinikum Düsseldorf - Klinik für Gastroenterologie, Hepatologie und Infektiologie
https://orcid.org/0000-0003-0103-1856Expertise: Biochemistry, Hepatocytes, Inflammation, Liver injury and regeneration, MAP kinases, Macrophages, Jak/STAT pathway, RNA stability, Molecular Biology, wet lab, non parenchymal cells
Tools: Milliplex analysis, qPCR, Molecular Biology, Laser scan microscopy, Immunohistochemistry, Cell and tissue culture, confocal microscopy, Mouse surgery, RNA analysis, rtPCR, Cytometry and fluorescent microscopy, Mouse experiments in vivo, Isolation of primary cells (hepatocytes and non-parenchymal cells)
I received my diploma in biology in 2001 from the Heinrich-Heine-University in Duesseldorf and the Dr. rer. nat. (Ph.D.) degree in 2006 from the University of Hohenheim in Germany. The practical part of my Ph.D. thesis had been realized at the clinic for gastroenterology, hepatology and infectiology at the university hospital in Duesseldorf. After my Ph.D. I focussed my studies on MAP-kinase-regulated cytokine/chemokine expression in response to bacterial or viral pathogens with a main issue on ...
The model studies the influence of hepatocyte–sinusoid alignment (HSA), i.e. the orientation of the division plane such that daughter hepatocytes align with nearby sinusoids, on the shape of tumor nodules in liver lobules. It employs the structure of the model ‘Liver Regeneration from CCl4’ (https://seek.lisym.org/models/19).
Originally, Höhme et al. (https://doi.org/10.1007/s11538-017-0375-1) employed a center-based model. Here, the model is encoded in the standardized language MorpheusML. ...
Creators: Diego Jahn, Michael Kücken, Lutz Brusch
Submitter: Diego Jahn
Model type: Agent based modelling
Model format: MorpheusML
Environment: Morpheus
In the experimental paradigm of CCl4 intoxication of mice, hepatocytes around the central vein (located in the center of an idealized hexagonal liver lobule) are dying and are subsequently replaced by new hepatocytes, largely through activation of proliferation in the remaining hepatocytes.
Alignment of daughter hepatocytes along the orientation of the closest sinusoid, a process which is named hepatocyte-sinusoid alignment (HSA), was proposed by Höhme et al. (https://doi.org/10.1073/pnas.0909374107) ...
Creators: Diego Jahn, Michael Kücken, Lutz Brusch
Submitter: Diego Jahn
Model type: Agent based modelling
Model format: MorpheusML
Environment: Morpheus
SOP Western diet mouse housing and feeding
Creator: Ina Biermayer
Submitter: Olga Krebs
Investigations: 1 hidden item
Studies: Proteomic alterations in Western Diet (WD) hepa...
Assays: 2 hidden items
Abstract (Expand)
Authors: Rilu Feng, Chenhao Tong, Tao Lin, Hui Liu, Chen Shao, Yujia Li, Carsten Sticht, Kejia Kan, Xiaofeng Li, Rui Liu, Sai Wang, Shanshan Wang, Stefan Munker, Hanno Niess, Christoph Meyer, Roman Liebe, Matthias P. Ebert, Steven Dooley, Hua Wang, Huiguo Ding, Hong-Lei Weng
Date Published: 1st Oct 2023
Publication Type: Journal
DOI: 10.1016/j.ajpath.2023.09.009
Citation: The American Journal of Pathology,S0002944023003656
Abstract (Expand)
Authors: C. Mayer, S. Nehring, M. Kucken, U. Repnik, S. Seifert, A. Sljukic, J. Delpierre, H. Morales-Navarrete, S. Hinz, M. Brosch, B. Chung, T. Karlsen, M. Huch, Y. Kalaidzidis, L. Brusch, J. Hampe, C. Schafmayer, M. Zerial
Date Published: 31st Jul 2023
Publication Type: Journal
PubMed ID: 37522754
Citation: EMBO Rep. 2023 Jul 31:e57181. doi: 10.15252/embr.202357181.
Abstract (Expand)
Authors: Paula Heinke, Fabian Rost, Julian Rode, Palina Trus, Irina Simonova, Enikő Lázár, Joshua Feddema, Thilo Welsch, Kanar Alkass, Mehran Salehpour, Andrea Zimmermann, Daniel Seehofer, Göran Possnert, Georg Damm, Henrik Druid, Lutz Brusch, Olaf Bergmann
Date Published: 1st Jun 2022
Publication Type: Journal
DOI: 10.1016/j.cels.2022.05.001
Citation: Cell Systems 13(6):499-507.e12