LiSyM-Krebs ist ein nationales Forschungsnetz zur Früherkennung und Prävention von Leberkrebs, das unter Verwendung des systemmedizinischen Forschungsansatzes die komplexen, dynamischen Prozesse der Krankheitsprogression analysiert, um ausgehend von den Erkenntnissen aus dem Forschungsnetz LiSyM die Entstehung von Leberkrebs besser zu verstehen, vorherzusagen und im besten Fall sogar zu verhindern. LiSyM-Krebs setzt die erfolgreichen Forschungsaktivitäten der BMBF-Vorgängerprogramme HepatoSys / HepatoSys II, Die Virtuelle Leber und vor allem LiSyM fort. Diese haben einen wichtigen Beitrag zur Aufklärung verschiedener physiologischer Prozesse der gesunden und kranken Leber wie Verfettung, Entzündung und Regeneration geleistet. Mit Hilfe des systembiologischen und -medizinischen Forschungsansatzes konnten die Forschungsverbünde sogenannte Multiskalen-Modelle zur Beschreibung der Leberprozesse aufstellen. Die dort gewonnenen Erkenntnisse fließen nun in die Umsetzung der Ziele des Forschungsnetzes LiSyM-Krebs ein. Das neue Netzwerk hat am 1. Juli 2021 seine Arbeit aufgenommen. Es besteht aus interdisziplinären Kooperationen aus den Bereichen Medizin, Informatik, mathematischer Modellierung und Molekularbiologie, die in drei Verbundvorhaben organisiert sind. Die Forschungsgruppen untersuchen klinisch-relevante Fragestellungen und Ziele. Mit Hilfe sogenannter Multiskalen-Ansätzen versuchen sie, den kritischen „Kipp-Punkt“ am Übergang von einer Fettlebererkrankung zum Lebertumor zu identifizieren. Zum anderen wollen sie die Diagnose früher Leberkrebsstadien verbessern. Darüber hinaus haben sie sich das Ziel gesetzt, verlässliche, nicht-invasive Verfahren zur Diagnose sowie individualisierte Therapiemöglichkeiten zu entwickeln. Neben den Forschungsverbünden fördert das BMBF ein eigenes Programm-Management zur Steuerung des Netzwerks sowie ein zentrales Daten-Management.
LiSyM-Krebs ist ein nationales Forschungsnetz zur Früherkennung und Prävention von Leberkrebs, das unter Verwendung des systemmedizinischen Forschungsansatzes die komplexen, dynamischen Prozesse der Krankheitsprogression analysiert, um ausgehend von den Erkenntnissen aus dem Forschungsnetz LiSyM die Entstehung von Leberkrebs besser zu verstehen, vorherzusagen und im besten Fall sogar zu verhindern.
Web page: https://www.lisym-cancer.org
Funding details:Related items
- People (178)
- Projects (5)
- Institutions (61)
- Investigations (3+4)
- Studies (8+4)
- Assays (13+13)
- Data files (12+8)
- Models (4)
- SOPs (6+10)
- Publications (80)
- Presentations (2+64)
- Events (10+7)
- Documents (9+18)
- Samples (0+4)
Projects: SMART-NAFLD, Forschungsnetzwerk LiSyM-Krebs
Institutions: Augsburg University, Institute of Computer Science
Projects: LiSyM-Krebs Partnering
Institutions: Roche Pharma AG
Program management team LiSyM-Cancer (project and communications manager)
Former PhD student in LiSyM, at DKFZ Heidelberg in the group of Ursula Klingmüller
(née Schmitt)
Forschungsnetzwerk zur Früherkennung und Prävention- LiSyM-Krebs
Ein Netzwerk von Klinikern, Wissenschaftlern und Datenmanagern hat sich zur Aufgabe gemacht, Methoden zu entwickeln, um Patienten mit einem hohen Risiko für ein Leberkarzinom frühzeitig, in Vorstadien der Tumorentwicklung, identifizieren zu können. Gemeinsam bilden sie das „Systemmedizinische Forschungsnetzwerk zur Früherkennung und Prävention von Leberkrebs“, LiSym-Krebs, das vom Bundesministerium für Bildung und Forschung ...
Programme: LiSyM-Krebs - Systemmedizinisches Forschungsnetz zur Früherkennung und Prävention von Leberkrebs
Public web page: Not specified
Organisms: Homo sapiens, Mus musculus, Rattus norvegicus, Rattus rattus
SMART-NAFLD : A Systems Medicine Approach to Early Detection and Prevention of Hepatocellular Carcinoma in Non-Alcoholic Fatty Liver Disease
The massive increase in obesity is leading to an alarming rise in non-alcoholic liver disease (NAFLD). This development will lead to a dramatic increase in liver diseases such as hepatocellular carcinoma (HCC). A particular challenge is that NAFLD-associated HCCs, for reasons still unknown, not only occur in association with advanced liver fibrosis/cirrhosis, ...
Programme: LiSyM-Krebs - Systemmedizinisches Forschungsnetz zur Früherkennung und Prävention von Leberkrebs
Public web page: Not specified
Organisms: Mus musculus, Homo sapiens
DEEP-HCC - Detailed Analysis of the Spatial Organization of the Development of Hepatocellular Carcinoma
Programme: LiSyM-Krebs - Systemmedizinisches Forschungsnetz zur Früherkennung und Prävention von Leberkrebs
Public web page: Not specified
Organisms: Homo sapiens, Mus musculus
C-TIP-HCC- Mechanism-based Multiscale Model to Dissect the Tipping Point from Liver Cirrhosis to Hepatocellular Carcinoma
The ultimate goal of the C-TIP-HCC is a „mechanistic multiscale model to describe dynamic changes in regenerative nodes across a tipping point (TIP) towards development in patients with cirrhosis to facilitate early monitoring and intervention“ and facilitate intervention“. To achieve this, we will conduct in-depth studies on cirrhotic regenerative nodes.
Programme: LiSyM-Krebs - Systemmedizinisches Forschungsnetz zur Früherkennung und Prävention von Leberkrebs
Public web page: Not specified
Organisms: Homo sapiens, Mus musculus
This generic project is intended to be a forum for all LiSyM partner and external stakeholders interested in participating in the BMBF initiative LiSyM-Krebs.
Programme: LiSyM-Krebs - Systemmedizinisches Forschungsnetz zur Früherkennung und Prävention von Leberkrebs
Public web page: https://www.ptj.de/projektfoerderung/gesundheitsforschung/lisym-krebs
Organisms: Not specified
Country: Germany
City: 86159 Augsburg
Web page: https://www.uni-augsburg.de/en/fakultaet/fai/informatik/
Country: Germany
City: 69120 Heidelberg
Web page: https://www.dkfz.de/en/applied-bioinformatics/index.php
Due to increasing incidence and high mortality rates, hepatocellular carcinoma (HCC) is an important health problem worldwide. However, its etiopathology and development are poorly understood. While liver metabolism is organized in spatially specific zones, little is known how the zonation is associated with the onset and propagation of liver diseases. To this end, we applied laser capture microdissection (LCM) technique to excise histologically specific features of liver tissues, healthy and ...
Snapshots: No snapshots
Macrophages play an important role in maintaining liver homeostasis and regeneration. Here we investigate how different macrophage populations of the liver differ in terms of their activation state and which other liver cell populations may play a role in regulating the same.
Submitter: Stephanie Wolf
Studies: Study changes in gene expression and in the activation state of macropha...
Assays: Hepatocytes induces properties of wound healing type and regulatory macr..., Transcriptomics : RNA Microarray, Transcriptomics: RNA-seq of coding RNA from single cells
Snapshots: No snapshots
LiSyM-Cancer project data for integration into public repositories based on
Submitter: Olga Krebs
Studies: GENOMICS/TRANSCRIPTOMICS, METABOLOMICS, OTHER OMICS DATA, Several proteomics experimental data
Assays: DNA sequence data, RNA sequence data, Western blot
Snapshots: No snapshots
Reverse transcription PCR, flow cytometry, transcriptome, proteome, secretome, single cell analysis, and immunohistochemical methods were used to study changes in gene expression as well as the activation state of macrophages in vitro and in vivo under homeostatic conditions and after partial hepatectomy.
Submitter: Stephanie Wolf
Investigation: Hepatocytes reprogram liver macrophages involvi...
Assays: Hepatocytes induces properties of wound healing type and regulatory macr..., Transcriptomics : RNA Microarray, Transcriptomics: RNA-seq of coding RNA from single cells
Snapshots: No snapshots
Several proteomics experimental data
Submitter: Olga Krebs
Investigation: LiSyM-Cancer project data for integration into...
Assays: Western blot
Snapshots: No snapshots
OTHER OMICS DATA
Submitter: Olga Krebs
Investigation: LiSyM-Cancer project data for integration into...
Assays: No Assays
Snapshots: No snapshots
METABOLOMICS
Submitter: Olga Krebs
Investigation: LiSyM-Cancer project data for integration into...
Assays: No Assays
Snapshots: No snapshots
GENOMICS/TRANSCRIPTOMICS
Submitter: Olga Krebs
Investigation: LiSyM-Cancer project data for integration into...
Assays: DNA sequence data, RNA sequence data
Snapshots: No snapshots
In this study, we characterize Western diet-induced phenotypic changes in murine 392 hepatocytes and employ dynamic pathway modelling to resolve the underlying molecular 393 mechanisms resulting in altered intracellular signal transduction and enhanced proliferation 394 of WD hepatocytes.
Snapshots: No snapshots
Documents submitted to BMBF
Submitter: Olga Krebs
Investigation: 1 hidden item
Assays: Meeting minutes 2021, Meeting minutes 2022
Snapshots: No snapshots
Documents submitted to BMBF
Submitter: Olga Krebs
Investigation: 1 hidden item
Assays: Project deliverables 2021, Project deliverables 2022, Project proposals
Snapshots: No snapshots
Project proposals
Submitter: Olga Krebs
Biological problem addressed: Model Analysis Type
Investigation: 1 hidden item
Study: Documents submitted to BMBF
Organisms: No organisms
Models: No Models
SOPs: No SOPs
Data files: No Data files
Snapshots: No snapshots
Meeting minutes 2021
Submitter: Olga Krebs
Biological problem addressed: Model Analysis Type
Investigation: 1 hidden item
Study: Meeting minutes
Organisms: No organisms
Models: No Models
SOPs: No SOPs
Data files: No Data files
Snapshots: No snapshots
Meeting minutes 2022
Submitter: Olga Krebs
Biological problem addressed: Model Analysis Type
Investigation: 1 hidden item
Study: Meeting minutes
Organisms: No organisms
Models: No Models
SOPs: No SOPs
Data files: No Data files
Snapshots: No snapshots
Project deliverables 2021
Submitter: Olga Krebs
Biological problem addressed: Model Analysis Type
Investigation: 1 hidden item
Study: Documents submitted to BMBF
Organisms: No organisms
Models: No Models
SOPs: No SOPs
Data files: No Data files
Snapshots: No snapshots
Project deliverables 2022
Submitter: Olga Krebs
Biological problem addressed: Model Analysis Type
Investigation: 1 hidden item
Study: Documents submitted to BMBF
Organisms: No organisms
Models: No Models
SOPs: No SOPs
Data files: No Data files
Snapshots: No snapshots
DMPlaning 2021
Submitter: Olga Krebs
Biological problem addressed: Model Analysis Type
Investigation: 1 hidden item
Study: 1 hidden item
Organisms: No organisms
Models: No Models
SOPs: No SOPs
Data files: No Data files
Snapshots: No snapshots
DMPlaning 2022
Submitter: Olga Krebs
Biological problem addressed: Model Analysis Type
Investigation: 1 hidden item
Study: 1 hidden item
Organisms: No organisms
Models: No Models
SOPs: No SOPs
Data files: No Data files
Snapshots: No snapshots
The liver comprises the body´s largest pool of macrophages constituting approximately 80 % of all sessile tissue macrophages of the body. After liver damage monocyte-derived macrophages are recruited into the liver and were here affected by a micro milieu which is considerably influenced by hepatocytes. Up to now the complex network that determines the differentiation and function of liver macrophages and the impact of the intercellular communication between macrophages and the other parenchymal ...
Submitter: Stephanie Wolf
Assay type: Shotgun proteomics
Technology type: LTQ Orbitrap Elite
Investigation: Hepatocytes reprogram liver macrophages involvi...
Organisms: Mus musculus
SOPs: SOP: Mice hepatocytes isolation and co-cultivat... and 1 hidden item
Data files: Shotgun proteomics data at PRIDE
Snapshots: No snapshots
We describe a distinct macrophage population, whose presence in the liver during homoeostasis depends on recruitment signals mediated by the chemokine receptor CCR2. The identified polarization state of this population closely resembles that induced in co-culture experiments, where hepatocytes are reducing the availability of TGFb to macrophages. Accordingly, disruption of TGFb signal transduction in macrophages phenocopies the influence of hepatocytes on macrophage polarization.
Submitter: Stephanie Wolf
Assay type: Transcriptomics
Technology type: Technology Type
Investigation: Hepatocytes reprogram liver macrophages involvi...
Organisms: No organisms
SOPs: SOP: Mice hepatocytes isolation and co-cultivat...
Data files: Sequence data at ENA, The single-cell RNA sequencing data (ArrayExpress)
Snapshots: No snapshots
Transcriptomics: the RNA expression of primary hepatocytes and BMDM (Bone Marrow–Derived acrophages) were analysed in 4 different conditions (mono- vs. co-culture, hepatocytes and macrophages) with 5 replicas each to detect the impact of hepatocytes on macrophages and vice versa.
Submitter: Stephanie Wolf
Assay type: Experimental Assay Type
Technology type: Technology Type
Investigation: Hepatocytes reprogram liver macrophages involvi...
Organisms: No organisms
SOPs: SOP: Mice hepatocytes isolation and co-cultivat...
Data files: GEO data set, The single-cell RNA sequencing data (ArrayExpress)
Snapshots: No snapshots
Creator: Sophia Müller-Dott
Submitter: Sophia Müller-Dott
Investigations: No Investigations
Studies: No Studies
Assays: No Assays
Creator: Sophia Müller-Dott
Submitter: Sophia Müller-Dott
Investigations: No Investigations
Studies: No Studies
Assays: No Assays
Hepatocyte-controlled availability of activated TGFb reprograms macrophage polarization affecting liver injury and regeneration
Creator: Stephanie Wolf
Submitter: Olga Krebs
Creator: Seddik Hammad
Submitter: Seddik Hammad
Investigations: No Investigations
Studies: No Studies
Assays: No Assays
Raw data of proteomic analysis of primary murine hepatocytes treated with Hedgehog-modulating compounds
Manuscript: "Impact of Hedgehog Modulators on Signaling Pathways in Primary Murine and Human Hepatocytes in vitro: Insights into Liver Metabolism" Journal Name: Archives of Toxicology Author Names: Fritzi Ott, Christiane Körner, Knut Krohn, Janett Fischer, Georg Damm, Daniel Seehofer, Thomas Berg, Madlen Matz-Soja Corresponding author: Madlen Matz-Soja (madlen.matz-soja@medizin.uni-leipzig.de) ...
Creator: Fritzi Ott
Submitter: Fritzi Ott
Investigations: No Investigations
Studies: No Studies
Assays: No Assays
Raw data of RNA-seq analysis of primary murine hepatocytes treated with Hh modulating compounds
Manuscript: "Impact of Hedgehog Modulators on Signaling Pathways in Primary Murine and Human Hepatocytes in vitro: Insights into Liver Metabolism" Journal Name: Archives of Toxicology Author Names: Fritzi Ott, Christiane Körner, Knut Krohn, Janett Fischer, Georg Damm, Daniel Seehofer, Thomas Berg, Madlen Matz-Soja Corresponding author: Madlen Matz-Soja (madlen.matz-soja@medizin.uni-leipzig.de)
Creators: None
Submitter: Fritzi Ott
Investigations: No Investigations
Studies: No Studies
Assays: No Assays
Supplementary Tables 1-7 of the Manuscript: "Multiomics and kinetic modeling reveal dominance of 12-hour rhythms in global liver metabolism"
for table headings please refer to Supplementary Material
Creator: Fritzi Ott
Submitter: Fritzi Ott
Investigations: No Investigations
Studies: No Studies
Assays: No Assays
Data deposited on the European Bioinformatics Insititute (EBI) database under accession number E-MTAB- 11727 (https://www.ebi.ac.uk/arrayexpress/experiments/ E-MTAB-11727)
Hepatocyte-controlled availability of activated TGFb reprograms macrophage polarization affecting liver injury and regeneration.
Samples in SEEK (ArrayExpress-compliant sample type https://seek.lisym.org/sample_types/21)
Creator: Stephanie Wolf
Submitter: Stephanie Wolf
Hepatocytes and macrophages from mono and co-culture were harvested and prepared for mass spectrometric analysis , samples were shortly separated in a polyacrylamide gel, silver-stained, reduced, alkylated and digested with trypsin.
Creators: None
Submitter: Stephanie Wolf
GEO data set
Creators: None
Submitter: Stephanie Wolf
Investigations: Hepatocytes reprogram liver macrophages involvi...
Studies: Study changes in gene expression and in the act...
Assays: Transcriptomics : RNA Microarray
The model studies the influence of hepatocyte–sinusoid alignment (HSA), i.e. the orientation of the division plane such that daughter hepatocytes align with nearby sinusoids, on the shape of tumor nodules in liver lobules. It employs the structure of the model ‘Liver Regeneration from CCl4’ (https://seek.lisym.org/models/19).
Originally, Höhme et al. (https://doi.org/10.1007/s11538-017-0375-1) employed a center-based model. Here, the model is encoded in the standardized language MorpheusML. ...
Creators: Diego Jahn, Michael Kücken, Lutz Brusch
Submitter: Diego Jahn
Model type: Agent based modelling
Model format: MorpheusML
Environment: Morpheus
In the experimental paradigm of CCl4 intoxication of mice, hepatocytes around the central vein (located in the center of an idealized hexagonal liver lobule) are dying and are subsequently replaced by new hepatocytes, largely through activation of proliferation in the remaining hepatocytes.
Alignment of daughter hepatocytes along the orientation of the closest sinusoid, a process which is named hepatocyte-sinusoid alignment (HSA), was proposed by Höhme et al. (https://doi.org/10.1073/pnas.0909374107) ...
Creators: Diego Jahn, Michael Kücken, Lutz Brusch
Submitter: Diego Jahn
Model type: Agent based modelling
Model format: MorpheusML
Environment: Morpheus
Creator: Andreas Weidemann
Submitter: Andreas Weidemann
Model type: Stoichiometric model
Model format: SBML
Environment: Copasi
Organism: Not specified
Investigations: No Investigations
Studies: No Studies
Assays: No Assays
This model was used in the Modeling Workshop at the 2nd LiSyM-Cancer Status Seminar.
Creator: Lutz Brusch
Submitter: Lutz Brusch
Model type: Agent based modelling
Model format: MorpheusML
Environment: Morpheus
Organism: Not specified
Investigations: No Investigations
Studies: No Studies
Assays: No Assays
SOP Western diet mouse housing and feeding
Creator: Ina Biermayer
Submitter: Olga Krebs
Investigations: 1 hidden item
Studies: Proteomic alterations in Western Diet (WD) hepa...
Assays: 2 hidden items
Empty SOP template based on nature protocol format and reqiremeents
Creator: Olga Krebs
Submitter: Olga Krebs
Investigations: LiSyM-Cancer project data for integration into...
Studies: METABOLOMICS, Several proteomics experimental data
Assays: Western blot and 1 hidden item
Liver is the major site for glycogen storage. Glycogen content can be significantly altered upon disruption of glucose homeostasis in metabolic syndromes, such as diabetes.
Glycogen content can be determined by an acid-hydrolysis method . Basically, glucose, the hydrolysis product of glycogen, is converted into glucose-6- phosphate (G-6-P) by hexokinase in the presence of ATP.
With the supply of NADP, G-6-P is further converted into 6-phosphogluconic acid by G-6-P dehydrogenase (G-6-PDH), while ...
Creator: Olga Krebs
Submitter: Olga Krebs
Investigations: LiSyM-Cancer project data for integration into...
Studies: METABOLOMICS
Assays: 1 hidden item
SOP: Mice hepatocytes isolation and co-cultivation with BMDM
Creator: Stephanie Wolf
Submitter: Stephanie Wolf
This protocol details the RNAseq sample preparation starting with mRNA and ending with quality control of finished libraries. This protocol was used specifically for virus mRNA samples related to ORFeome lab group.
Creators: Olga Krebs, Marcia Sanders (marcia_sanders@unc.edu), Anne Beall (aebeall@email.unc.edu
Submitter: Olga Krebs
Investigations: LiSyM-Cancer project data for integration into...
Studies: GENOMICS/TRANSCRIPTOMICS
Assays: RNA sequence data
Isolation of primary mouse hepatocytes
Creators: Ina Biermayer, Ursula Klingmüller
Submitter: Olga Krebs
Investigations: 1 hidden item
Studies: Proteomic alterations in Western Diet (WD) hepa...
Assays: 2 hidden items
Abstract (Expand)
Authors: A. Dropmann, S. Alex, K. Schorn, C. Tong, T. Caccamo, P. Godoy, I. Ilkavets, R. Liebe, D. Gonzalez, J. G. Hengstler, A. Piiper, L. Quagliata, M. S. Matter, O. Waidmann, F. Finkelmeier, T. Feng, T. S. Weiss, N. Rahbari, E. Birgin, E. Rasbach, S. Roessler, K. Breuhahn, M. Toth, M. P. Ebert, S. Dooley, S. Hammad, N. M. Meindl-Beinker
Date Published: 5th Nov 2024
Publication Type: Journal
PubMed ID: 39033550
Citation: Biochem Biophys Res Commun. 2024 Nov 5;732:150409. doi: 10.1016/j.bbrc.2024.150409. Epub 2024 Jul 16.
Abstract (Expand)
Authors: W. Gu, V. de Ledinghen, C. Aube, A. Krag, C. Strassburg, L. Castera, J. Dumortier, M. Friedrich-Rust, S. Pol, I. Grgurevic, Y. Zeleke, M. Praktiknjo, R. Schierwagen, S. Klein, S. Francque, H. Gottfriedova, I. Sporea, P. Schindler, F. Rennebaum, M. J. Brol, M. Schulz, F. E. Uschner, J. Fischer, C. Margini, W. Wang, A. Delamarre, J. Best, A. Canbay, D. J. M. Bauer, B. Simbrunner, G. Semmler, T. Reiberger, J. Boursier, D. N. Rasmussen, V. Vilgrain, A. Guibal, S. Zeuzem, C. Vassord, L. Vonghia, R. Senkerikova, A. Popescu, A. Berzigotti, W. Laleman, M. Thiele, C. Jansen, J. Trebicka
Date Published: 22nd Oct 2024
Publication Type: Journal
PubMed ID: 39437136
Citation: NEJM Evid. 2024 Nov;3(11):EVIDoa2400062. doi: 10.1056/EVIDoa2400062. Epub 2024 Oct 22.
Abstract (Expand)
Authors: C. Zheng, S. Li, H. Lyu, C. Chen, J. Mueller, A. Dropmann, S. Hammad, S. Dooley, S. He, S. Mueller
Date Published: 9th Sep 2024
Publication Type: Journal
PubMed ID: 39247515
Citation: Hepat Med. 2024 Sep 3;16:65-77. doi: 10.2147/HMER.S469990. eCollection 2024.
Abstract (Expand)
Authors: S. Wang, F. Link, S. Munker, W. Wang, R. Feng, R. Liebe, Y. Li, Y. Yao, H. Liu, C. Shao, M. P. A. Ebert, H. Ding, S. Dooley, H. L. Weng, S. S. Wang
Date Published: 1st Aug 2024
Publication Type: Journal
PubMed ID: 39023343
Citation: Hepatol Commun. 2024 Jul 18;8(8):e0483. doi: 10.1097/HC9.0000000000000483. eCollection 2024 Aug 1.
Abstract (Expand)
Authors: C. Schmithals, B. Kakoschky, D. Denk, M. von Harten, J. H. Klug, E. Hintermann, A. Dropmann, E. Hamza, A. C. Jacomin, J. U. Marquardt, S. Zeuzem, P. Schirmacher, E. Herrmann, U. Christen, T. J. Vogl, O. Waidmann, S. Dooley, F. Finkelmeier, A. Piiper
Date Published: 13th Jul 2024
Publication Type: Journal
PubMed ID: 38889481
Citation: EBioMedicine. 2024 Jul;105:105178. doi: 10.1016/j.ebiom.2024.105178. Epub 2024 Jun 17.
Abstract (Expand)
Authors: Sophia Müller-Dott, Eric J. Jaehnig, Khoi Pham Munchic, Wen Jiang, Tomer M. Yaron-Barir, Sara R. Savage, Martin Garrido-Rodriguez, Jared L. Johnson, Alessandro Lussana, Evangelia Petsalaki, Jonathan T. Lei, Aurélien Dugourd, Karsten Krug, Lewis C. Cantley, D. R. Mani, Bing Zhang, Julio Saez-Rodriguez
Date Published: 2nd Jul 2024
Publication Type: Journal
DOI: 10.1101/2024.06.27.601117
Citation: biorxiv;2024.06.27.601117v1,[Preprint]
Abstract (Expand)
Authors: Valentin Blank, Thomas Karlas, Ulf Anderegg, Johannes Wiegand, Josi Arnold, Linnaeus Bundalian, Gabriela‐Diana Le Duc, Christiane Körner, Thomas Ebert, Anja Saalbach
Date Published: 4th May 2024
Publication Type: Journal
DOI: 10.1111/liv.15956
Citation: Liver International,liv.15956
Abstract
Authors: Yoon Seok Jung, Kamalakannan Radhakrishnan, Seddik Hammad, Sebastian Müller, Johannes Müller, Jung-Ran Noh, Jina kim, In-Kyu Lee, Sung Jin Cho, Don-Kyu Kim, Yong-Hoon Kim, Chul-Ho Lee, Steven Dooley, Hueng-Sik Choi
Date Published: 1st Mar 2024
Publication Type: Journal
DOI: 10.1016/j.redox.2024.103107
Citation: Redox Biology:103107
Abstract (Expand)
Authors: Barbara Helm, Pauline Hansen, Li Lai, Luisa Schwarzmüller, Simone M. Clas, Annika Richter, Max Ruwolt, Fan Liu, Dario Frey, Lorenza A. D’Alessandro, Wolf-Dieter Lehmann, Marcel Schilling, Dominic Helm, Dorothea Fiedler, Ursula Klingmüller
Date Published: 21st Feb 2024
Publication Type: Journal
DOI: 10.1101/2024.02.19.580971
Citation:
Abstract (Expand)
Authors: J. Zhao, A. Ghallab, R. Hassan, S. Dooley, J. G. Hengstler, D. Drasdo
Date Published: 16th Feb 2024
Publication Type: Journal
PubMed ID: 38371522
Citation: iScience. 2023 Sep 28;27(2):108077. doi: 10.1016/j.isci.2023.108077. eCollection 2024 Feb 16.
As a member of LiSyM-Cancer you already have a “profile” in LiSyM SEEK, i.e. your name and mail address is known to the system. You now have to register or in other words create a user name and a password. Download and watch the the short tutorial on how this works.
Creator: Maja Rey
Submitter: Maja Rey
The “Computational Modeling in Biology” Network (COMBINE) is an initiative to coordinate the development of the various community standards and formats in systems biology and related fields. COMBINE 2024 is a workshop-style event with oral presentations, breakout sessions and tutorials. The three meeting days will include talks about the COMBINE standards and associated or related standardization efforts, presentations of tools using these standards, breakout sessions for detailed discussions as ...
Start Date: 1st Sep 2024 (1st Sep 2024 (Europe/Berlin))
End Date: 3rd Sep 2024 (3rd Sep 2024 (Europe/Berlin))
Event Website: https://co.mbine.org/author/combine-2024/
Country: Germany
City: Stuttgart
Sessions:
- From single cell analysis to clinical application
- Mechanistic modeling at the cellular scale proposing intervention strategies
- Tissue scale modeling and organ communication in systems medicine
- AI contributions to systems medicine - Diagnosis and therapy monitoring
- The future of systems biology
Start Date: 13th May 2024 (13th May 2024 (Etc/UTC))
End Date: 15th May 2024 (15th May 2024 (Etc/UTC))
Event Website: https://www.lisym-cancer.org/sbmc2024
Country: Germany
City: 04109 Leipzig
The “Computational Modeling in Biology” Network (COMBINE) is an initiative to coordinate the development of the various community standards and formats in systems biology, synthetic biology and related fields. HARMONY is a codefest-type meeting, with a focus on development of the standards, interoperability and infrastructure. There are generally not many general discussions or oral presentations during HARMONY; instead, the time is devoted to allowing hands-on hacking and interaction between ...
Start Date: 8th Apr 2024 (8th Apr 2024 (Europe/London))
End Date: 11th Apr 2024 (11th Apr 2024 (Europe/London))
Event Website: https://co.mbine.org/author/harmony-2024/
Country: United Kingdom
City: London
Just over 30 years ago, the cellular Potts model (CPM) was introduced to explain experimental observations of spontaneous cell sorting in embryonic tissue cultures. In the years since, the CPM evolved into a powerful model framework for simulating a wide range of physical and biological processes – from foam physics to tissue development, cancer growth, angiogenesis, plant development, evolution, immune responses, and cell migration. Having just celebrated the 30th birthday of the CPM, now is a ...
Start Date: 18th Dec 2023 (18th Dec 2023 (Europe/Amsterdam))
End Date: 22nd Dec 2023 (22nd Dec 2023 (Europe/Amsterdam))
Event Website: https://www.lorentzcenter.nl/simulating-tissue-dynamics-with-cellular-potts-models.html
Country: Netherlands
City: Leiden
The “Computational Modeling in Biology” Network (COMBINE) is an initiative to coordinate the development of the various community standards and formats in systems biology and related fields. COMBINE 2023 is a workshop-style event with oral presentations, breakout sessions and tutorials. The three meeting days will include talks about the COMBINE standards and associated or related standardization efforts, presentations of tools using these standards, breakout sessions for detailed discussions as ...
Start Date: 5th Oct 2023 (5th Oct 2023 (America/New_York))
End Date: 7th Oct 2023 (7th Oct 2023 (America/New_York))
Event Website: https://co.mbine.org/author/combine-2023/
Country: United States
City: Farmington, CT
The Computational Modeling in Biology Network (COMBINE) is an initiative to coordinate the development of the various community standards and formats in systems biology, synthetic biology and related fields. HARMONY is a codefest-type meeting, with a focus on development of the standards, interoperability and infrastructure. There are generally not many general discussions or oral presentations during HARMONY; instead, the time is devoted to allowing hands-on hacking and interaction between people ...
Start Date: 24th Apr 2023
End Date: 27th Apr 2023
Event Website: https://co.mbine.org/author/harmony-2023/
Country: United States
City: Seattle
The “Computational Modeling in Biology” Network (COMBINE) is an initiative to coordinate the development of the various community standards and formats in systems biology and related fields. COMBINE 2022 will be a workshop-style event with oral presentations, breakout sessions and tutorials. The three meeting days will include talks about the COMBINE standards and associated or related standardization efforts, presentations of tools using these standards, breakout sessions for detailed discussions ...
Start Date: 6th Oct 2022
End Date: 8th Oct 2022
Event Website: https://co.mbine.org/author/combine-2022/
Country: Germany
City: Berlin
Young Scientists Retreat (YSR) will take place from September 7th to 9th in Hofgeismar (close to Kassel) (https://tagungsstaette-hofgeismar.de/). Participation is mandatory for all PhD students, MD students and Postdocs in SMART-NAFLD, C-TIP-HCC and DEEP-HCC
Start Date: 7th Sep 2022
End Date: 9th Sep 2022
Event Website: Not specified
Country: Germany
City: Not specified
Kickoff Meeting SMART- NAFLD 1.12.2021 - 2.12.2021
Heidelberg, Bioquant 7th Floor Greenier Room
Start Date: 1st Dec 2021
End Date: 2nd Dec 2021
Event Website: Not specified
Country: Germany
City: Heidelberg
SBMC 2020 was postponed to 10th - 12th of May 2021. Further information will follow soon.
Start Date: 10th May 2021
End Date: 12th May 2021
Event Website: https://sbmc2020.bioquant.uni-heidelberg.de
Country: Germany
City: Heidelberg
Creators: Ina Biermayer, Susan Eckerle
Submitter: Maja Rey
Investigations: No Investigations
Studies: No Studies
Assays: No Assays
Creators: Ina Biermayer, Susan Eckerle
Submitter: Maja Rey
Investigations: No Investigations
Studies: No Studies
Assays: No Assays
Workshop #1 LiSym status seminar March 2023, Dresden “Towards concordant multiomics of liver”
Creators: Andrej Shevchenko, Ursula Klingmüller
Submitter: Olga Krebs
Investigations: No Investigations
Studies: No Studies
Assays: No Assays
Group picture from Lisym-Cancer Status Seminar 2023
Creators: Olga Krebs, Ina Biermayer, Susan Eckerle
Submitter: Olga Krebs
Investigations: No Investigations
Studies: No Studies
Assays: No Assays
Creators: Ursula Klingmüller, Ina Biermayer, Susan Eckerle
Submitter: Ursula Klingmüller
Investigations: No Investigations
Studies: No Studies
Assays: No Assays
Creator: Olga Krebs
Submitter: Olga Krebs
Investigations: No Investigations
Studies: No Studies
Assays: No Assays
Agreement on the Use of Personal Data during LiSyM-Cancer Young Scientists Retreat Date: 07.09. -09.09.2022 Place: Ev. Tagungsstätte Hofgeismar
Creator: Olga Krebs
Submitter: Olga Krebs
Investigations: No Investigations
Studies: No Studies
Assays: No Assays
Agenda for LiSyM-Cancer status seminar 2022
Creators: Olga Krebs, Wolfgang Müller, Ursula Klingmüller, Ina Biermayer
Submitter: Olga Krebs
Investigations: No Investigations
Studies: No Studies
Assays: No Assays
Agenda Kickoff Meeting SMART-NAFLD 1-2 december 2021 in Heidelberg
Creators: Ursula Klingmüller, Ina Biermayer
Submitter: Olga Krebs
Investigations: No Investigations
Studies: No Studies
Assays: No Assays