In the experimental paradigm of CCl4 intoxication of mice, hepatocytes around the central vein (located in the center of an idealized hexagonal liver lobule) are dying and are subsequently replaced by new hepatocytes, largely through activation of proliferation in the remaining hepatocytes.
Alignment of daughter hepatocytes along the orientation of the closest sinusoid, a process which is named hepatocyte-sinusoid alignment (HSA), was proposed by Höhme et al. (https://doi.org/10.1073/pnas.0909374107) as necessary mechanism to restore the layered tissue microarchitecture.
Originally, Höhme et al. employed a center-based model. Here, the model is encoded in the standardized language MorpheusML. Using the same processes and parameter values wherever possible, the published results are reproduced quantitatively by a cellular Potts model (CPM).
The detailed quantitative comparison is presented under https://identifiers.org/morpheus/M9147.
SEEK ID: https://seek.lisym.org/models/19?version=1
1 item (and an image) are associated with this Model:Organism: Mus musculus
Model type: Agent based modelling
Model format: MorpheusML
Execution or visualisation environment: Morpheus
Model image: (Click on the image to zoom) (Original)
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Created: 14th Jun 2024 at 08:06
Last updated: 14th Jun 2024 at 08:06
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Version 1 (earliest) Created 14th Jun 2024 at 08:06 by Diego Jahn
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