Liver Regeneration from CCl4
Version 1

In the experimental paradigm of CCl4 intoxication of mice, hepatocytes around the central vein (located in the center of an idealized hexagonal liver lobule) are dying and are subsequently replaced by new hepatocytes, largely through activation of proliferation in the remaining hepatocytes.

Alignment of daughter hepatocytes along the orientation of the closest sinusoid, a process which is named hepatocyte-sinusoid alignment (HSA), was proposed by Höhme et al. (https://doi.org/10.1073/pnas.0909374107) as necessary mechanism to restore the layered tissue microarchitecture.

Originally, Höhme et al. employed a center-based model. Here, the model is encoded in the standardized language MorpheusML. Using the same processes and parameter values wherever possible, the published results are reproduced quantitatively by a cellular Potts model (CPM).

The detailed quantitative comparison is presented under https://identifiers.org/morpheus/M9147.

SEEK ID: https://seek.lisym.org/models/19?version=1

1 item (and an image) are associated with this Model:
  • Liver-Regeneration-MorpheusML.xml (XML document - 27.9 KB) Download

Organism: Mus musculus

Model type: Agent based modelling

Model format: MorpheusML

Execution or visualisation environment: Morpheus

Model image: (Click on the image to zoom) (Original)

help Creators and Submitter
Activity

Views: 94   Downloads: 4

Created: 14th Jun 2024 at 08:06

Last updated: 14th Jun 2024 at 08:06

Version History

Version 1 (earliest) Created 14th Jun 2024 at 08:06 by Diego Jahn

No revision comments

Powered by
(v.1.15.2)
Copyright © 2008 - 2024 The University of Manchester and HITS gGmbH