Liver Regeneration from CCl4
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In the experimental paradigm of CCl₄ intoxication of mice, hepatocytes around the central vein (located in the center of an idealized hexagonal liver lobule) are dying and are subsequently replaced by new hepatocytes, largely through activation of proliferation in the remaining hepatocytes.

Alignment of daughter hepatocytes along the orientation of the closest sinusoid, a process which is named hepatocyte-sinusoid alignment (HSA), was proposed by Höhme et al. (https://doi.org/10.1073/pnas.0909374107) as necessary mechanism to restore the layered tissue microarchitecture.

Originally, Höhme et al. employed a center-based model. Here, the model is encoded in the standardized language MorpheusML. Using the same processes and parameter values wherever possible, the published results are reproduced quantitatively by a cellular Potts model (CPM).

The detailed quantitative comparison is presented under https://identifiers.org/morpheus/M9147.

SEEK ID: https://seek.lisym.org/models/19?version=1

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