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<pre>The proposed ODE model describes dynamics of IFNalpha-induced signaling in Huh7.5 cells for a time scale up to 32 hours after stimulation with IFNalpha. The model consists of an IFN receptor model, formation/degradation and cytoplasmic/nuclear shuttling of STAT1-homodimers, STAT1-STAT2-heterodimers and STAT1-STAT2-IRF9 (ISGF3) complexes. On top, formation of feedback proteins STAT1, STAT2, IRF9, USP18, SOCS1, SOCS3 and IRF2 and corresponding influences on IFNalpha signaling dynamics was incorporated. The model was calibrated by dose response and time course measurements over 32 hours as well as time courses for USP18 inhibition and overexpression experiments. As a special focus, the model is able to describe dose-dependent sensitization and desensitization of IFNalpha signaling in form of double treatment experiments at 0h and 24h.</pre>
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<lambda>
<bvar>
<ci> OccGAS_ISREbs </ci>
</bvar>
<bvar>
<ci> synthSTAT2mRNA </ci>
</bvar>
<apply>
<times/>
<ci> synthSTAT2mRNA </ci>
<ci> OccGAS_ISREbs </ci>
</apply>
</lambda>
</math>
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</COPASI>
</annotation>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<lambda>
<bvar>
<ci> OccGAS_ISREbs </ci>
</bvar>
<bvar>
<ci> kmIRF9 </ci>
</bvar>
<bvar>
<ci> synthIRF9mRNA </ci>
</bvar>
<apply>
<divide/>
<apply>
<times/>
<ci> synthIRF9mRNA </ci>
<ci> OccGAS_ISREbs </ci>
</apply>
<apply>
<plus/>
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</apply>
</apply>
</lambda>
</math>
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</COPASI>
</annotation>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<lambda>
<bvar>
<ci> OccGAS_ISREbs </ci>
</bvar>
<bvar>
<ci> synthIRF2mRNA </ci>
</bvar>
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<times/>
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<ci> OccGAS_ISREbs </ci>
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</lambda>
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<math xmlns="http://www.w3.org/1998/Math/MathML">
<lambda>
<bvar>
<ci> OccGAS_ISREbs </ci>
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</bvar>
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<times/>
<ci> synthUSP18mRNA </ci>
<ci> OccGAS_ISREbs </ci>
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</lambda>
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<math xmlns="http://www.w3.org/1998/Math/MathML">
<lambda>
<bvar>
<ci> OccGAS_ISREbs </ci>
</bvar>
<bvar>
<ci> synthSOCS1mRNA </ci>
</bvar>
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<times/>
<ci> synthSOCS1mRNA </ci>
<ci> OccGAS_ISREbs </ci>
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</lambda>
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</rdf:Description>
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</annotation>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<lambda>
<bvar>
<ci> IRF2 </ci>
</bvar>
<bvar>
<ci> SOCS1mRNA </ci>
</bvar>
<bvar>
<ci> hlSOCS1mRNA </ci>
</bvar>
<apply>
<times/>
<ci> hlSOCS1mRNA </ci>
<ci> SOCS1mRNA </ci>
<apply>
<plus/>
<cn> 1 </cn>
<ci> IRF2 </ci>
</apply>
</apply>
</lambda>
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</rdf:Description>
</dcterms:created>
</rdf:Description>
</rdf:RDF>
</COPASI>
</annotation>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<lambda>
<bvar>
<ci> OccGASbs </ci>
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<bvar>
<ci> synthSOCS3mRNA </ci>
</bvar>
<apply>
<times/>
<ci> synthSOCS3mRNA </ci>
<ci> OccGASbs </ci>
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</lambda>
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<COPASI xmlns="http://www.copasi.org/static/sbml">
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<rdf:Description>
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</dcterms:created>
</rdf:Description>
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</COPASI>
</annotation>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<lambda>
<bvar>
<ci> STAT1mRNA </ci>
</bvar>
<bvar>
<ci> kmsynthSTAT1 </ci>
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<bvar>
<ci> synthSTAT1 </ci>
</bvar>
<apply>
<divide/>
<apply>
<times/>
<ci> synthSTAT1 </ci>
<ci> STAT1mRNA </ci>
</apply>
<apply>
<plus/>
<ci> kmsynthSTAT1 </ci>
<ci> STAT1mRNA </ci>
</apply>
</apply>
</lambda>
</math>
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<COPASI xmlns="http://www.copasi.org/static/sbml">
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</rdf:Description>
</dcterms:created>
</rdf:Description>
</rdf:RDF>
</COPASI>
</annotation>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<lambda>
<bvar>
<ci> STAT2mRNA </ci>
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<bvar>
<ci> synthSTAT2 </ci>
</bvar>
<apply>
<times/>
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<ci> STAT2mRNA </ci>
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</rdf:RDF>
</COPASI>
</annotation>
<math xmlns="http://www.w3.org/1998/Math/MathML">
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<bvar>
<ci> IRF9mRNA </ci>
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<ci> synthIRF9 </ci>
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<times/>
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<ci> IRF9mRNA </ci>
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<ci> synthUSP18 </ci>
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<times/>
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<ci> USP18mRNA </ci>
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</COPASI>
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<math xmlns="http://www.w3.org/1998/Math/MathML">
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<ci> synthSOCS1 </ci>
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<times/>
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<ci> SOCS1mRNA </ci>
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</lambda>
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<rdf:li rdf:resource="http://identifiers.org/uniprot/O15524"/>
</rdf:Bag>
</bqbiol:isVersionOf>
</rdf:Description>
</rdf:RDF>
<COPASI xmlns="http://www.copasi.org/static/sbml">
<rdf:RDF xmlns:CopasiMT="http://www.copasi.org/RDF/MiriamTerms#" xmlns:bqmodel="http://biomodels.net/model-qualifiers/" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#">
<rdf:Description rdf:about="#COPASI42">
<bqmodel:isInstanceOf rdf:resource="urn:miriam:ncit:C80450"/>
<dcterms:created>
<rdf:Description>
<dcterms:W3CDTF>2019-04-16T08:57:26Z</dcterms:W3CDTF>
</rdf:Description>
</dcterms:created>
<CopasiMT:isVersionOf rdf:resource="urn:miriam:uniprot:O15524"/>
</rdf:Description>
</rdf:RDF>
</COPASI>
</annotation>
</species>
</listOfSpecies>
<listOfParameters>
<parameter constant="false" id="IRF2_mRNA_log10" metaid="COPASI43" name="IRF2_mRNA_log10" value="-0.0334828235532081">
<annotation>
<COPASI xmlns="http://www.copasi.org/static/sbml">
<rdf:RDF xmlns:dcterms="http://purl.org/dc/terms/" xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#">
<rdf:Description rdf:about="#COPASI43">
<dcterms:created>
<rdf:Description>
<dcterms:W3CDTF>2020-08-17T14:00:27Z</dcterms:W3CDTF>
</rdf:Description>
</dcterms:created>
</rdf:Description>
</rdf:RDF>
</COPASI>
</annotation>
</parameter>
<parameter constant="false" id="IRF9_mRNA_log10" metaid="COPASI44" name="IRF9_mRNA_log10" value="-0.0651986582534633">
<annotation>
<COPASI xmlns="http://www.copasi.org/static/sbml">
<rdf:RDF xmlns:dcterms="http://purl.org/dc/terms/" xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#">
<rdf:Description rdf:about="#COPASI44">
<dcterms:created>
<rdf:Description>
<dcterms:W3CDTF>2020-08-17T14:05:13Z</dcterms:W3CDTF>
</rdf:Description>
</dcterms:created>
</rdf:Description>
</rdf:RDF>
</COPASI>
</annotation>
</parameter>
<parameter constant="false" id="STAT1mRNA_log10" metaid="COPASI45" name="STAT1mRNA_log10" value="0.00518051250378031">
<annotation>
<COPASI xmlns="http://www.copasi.org/static/sbml">
<rdf:RDF xmlns:dcterms="http://purl.org/dc/terms/" xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#">
<rdf:Description rdf:about="#COPASI45">
<dcterms:created>
<rdf:Description>
<dcterms:W3CDTF>2020-08-17T14:07:20Z</dcterms:W3CDTF>
</rdf:Description>
</dcterms:created>
</rdf:Description>
</rdf:RDF>
</COPASI>
</annotation>
</parameter>
<parameter constant="false" id="STAT2mRNA_log10" metaid="COPASI46" name="STAT2mRNA_log10" value="-0.0727323191891184">
<annotation>
<COPASI xmlns="http://www.copasi.org/static/sbml">
<rdf:RDF xmlns:dcterms="http://purl.org/dc/terms/" xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#">
<rdf:Description rdf:about="#COPASI46">
<dcterms:created>
<rdf:Description>
<dcterms:W3CDTF>2020-08-17T14:07:20Z</dcterms:W3CDTF>
</rdf:Description>
</dcterms:created>
</rdf:Description>
</rdf:RDF>
</COPASI>
</annotation>
</parameter>
<parameter constant="false" id="USP18mRNA_log10" metaid="COPASI47" name="USP18mRNA_log10" value="-0.150150804394742">
<annotation>
<COPASI xmlns="http://www.copasi.org/static/sbml">
<rdf:RDF xmlns:dcterms="http://purl.org/dc/terms/" xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#">
<rdf:Description rdf:about="#COPASI47">
<dcterms:created>
<rdf:Description>
<dcterms:W3CDTF>2020-08-17T14:07:21Z</dcterms:W3CDTF>
</rdf:Description>
</dcterms:created>
</rdf:Description>
</rdf:RDF>
</COPASI>
</annotation>
</parameter>
<parameter constant="false" id="SOCS1mRNA_log10" metaid="COPASI48" name="SOCS1mRNA_log10" value="-0.0816550710377251">
<annotation>
<COPASI xmlns="http://www.copasi.org/static/sbml">
<rdf:RDF xmlns:dcterms="http://purl.org/dc/terms/" xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#">
<rdf:Description rdf:about="#COPASI48">
<dcterms:created>
<rdf:Description>
<dcterms:W3CDTF>2020-08-17T14:07:21Z</dcterms:W3CDTF>
</rdf:Description>
</dcterms:created>
</rdf:Description>
</rdf:RDF>
</COPASI>
</annotation>
</parameter>
<parameter constant="false" id="SOCS3mRNA_log10" metaid="COPASI49" name="SOCS3mRNA_log10" value="0.0338256939533103">
<annotation>
<COPASI xmlns="http://www.copasi.org/static/sbml">
<rdf:RDF xmlns:dcterms="http://purl.org/dc/terms/" xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#">
<rdf:Description rdf:about="#COPASI49">
<dcterms:created>
<rdf:Description>
<dcterms:W3CDTF>2020-08-17T14:07:22Z</dcterms:W3CDTF>
</rdf:Description>
</dcterms:created>
</rdf:Description>
</rdf:RDF>
</COPASI>
</annotation>
</parameter>
</listOfParameters>
<listOfRules>
<assignmentRule variable="IRF2_mRNA_log10">
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<log/>
<logbase>
<cn type="integer"> 10 </cn>
</logbase>
<ci> IRF2mRNA </ci>
</apply>
</math>
</assignmentRule>
<assignmentRule variable="IRF9_mRNA_log10">
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<log/>
<logbase>
<cn type="integer"> 10 </cn>
</logbase>
<ci> IRF9mRNA </ci>
</apply>
</math>
</assignmentRule>
<assignmentRule variable="STAT1mRNA_log10">
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<log/>
<logbase>
<cn type="integer"> 10 </cn>
</logbase>
<ci> STAT1mRNA </ci>
</apply>
</math>
</assignmentRule>
<assignmentRule variable="STAT2mRNA_log10">
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<log/>
<logbase>
<cn type="integer"> 10 </cn>
</logbase>
<ci> STAT2mRNA </ci>
</apply>
</math>
</assignmentRule>
<assignmentRule variable="USP18mRNA_log10">
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<log/>
<logbase>
<cn type="integer"> 10 </cn>
</logbase>
<ci> USP18mRNA </ci>
</apply>
</math>
</assignmentRule>
<assignmentRule variable="SOCS1mRNA_log10">
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<log/>
<logbase>
<cn type="integer"> 10 </cn>
</logbase>
<ci> SOCS1mRNA </ci>
</apply>
</math>
</assignmentRule>
<assignmentRule variable="SOCS3mRNA_log10">
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<log/>
<logbase>
<cn type="integer"> 10 </cn>
</logbase>
<ci> SOCS3mRNA </ci>
</apply>
</math>
</assignmentRule>
</listOfRules>
<listOfReactions>
<reaction id="Receptor_production" metaid="COPASI50" name="Receptor production" reversible="false">
<annotation>
<rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:dc="http://purl.org/dc/elements/1.1/" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/">
<rdf:Description rdf:about="#COPASI50">
<bqmodel:isInstanceOf>
<rdf:Bag>
<rdf:li rdf:resource="http://identifiers.org/sbo/SBO:0000393"/>
</rdf:Bag>
</bqmodel:isInstanceOf>
</rdf:Description>
</rdf:RDF>
<COPASI xmlns="http://www.copasi.org/static/sbml">
<rdf:RDF xmlns:bqmodel="http://biomodels.net/model-qualifiers/" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#">
<rdf:Description rdf:about="#COPASI50">
<bqmodel:isInstanceOf rdf:resource="urn:miriam:sbo:SBO:0000393"/>
<dcterms:created>
<rdf:Description>
<dcterms:W3CDTF>2019-04-15T14:20:15Z</dcterms:W3CDTF>
</rdf:Description>
</dcterms:created>
</rdf:Description>
</rdf:RDF>
</COPASI>
</annotation>
<listOfProducts>
<speciesReference species="Rec" stoichiometry="1"/>
</listOfProducts>
<kineticLaw>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<times/>
<ci> compartment </ci>
<apply>
<ci> Constant_flux__irreversible </ci>
<ci> v </ci>
</apply>
</apply>
</math>
<listOfParameters>
<parameter id="v" name="v" value="16.98"/>
</listOfParameters>
</kineticLaw>
</reaction>
<reaction id="Receptor_degradation_basal" metaid="COPASI51" name="Receptor degradation basal" reversible="false">
<annotation>
<rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:dc="http://purl.org/dc/elements/1.1/" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/">
<rdf:Description rdf:about="#COPASI51">
<bqbiol:isVersionOf>
<rdf:Bag>
<rdf:li rdf:resource="http://identifiers.org/go/GO:0032801"/>
</rdf:Bag>
</bqbiol:isVersionOf>
</rdf:Description>
</rdf:RDF>
<COPASI xmlns="http://www.copasi.org/static/sbml">
<rdf:RDF xmlns:CopasiMT="http://www.copasi.org/RDF/MiriamTerms#" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#">
<rdf:Description rdf:about="#COPASI51">
<dcterms:created>
<rdf:Description>
<dcterms:W3CDTF>2019-04-15T14:23:40Z</dcterms:W3CDTF>
</rdf:Description>
</dcterms:created>
<CopasiMT:isVersionOf rdf:resource="urn:miriam:go:GO:0032801"/>
</rdf:Description>
</rdf:RDF>
</COPASI>
</annotation>
<listOfReactants>
<speciesReference species="Rec" stoichiometry="1"/>
</listOfReactants>
<kineticLaw>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<times/>
<ci> compartment </ci>
<ci> k1 </ci>
<ci> Rec </ci>
</apply>
</math>
<listOfParameters>
<parameter id="k1" name="k1" value="2.06E-5"/>
</listOfParameters>
</kineticLaw>
</reaction>
<reaction id="Receptor_degradation_by_SOCS1" metaid="COPASI52" name="Receptor degradation by SOCS1" reversible="false">
<annotation>
<rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:dc="http://purl.org/dc/elements/1.1/" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/">
<rdf:Description rdf:about="#COPASI52">
<bqbiol:isVersionOf>
<rdf:Bag>
<rdf:li rdf:resource="http://identifiers.org/go/GO:0032801"/>
</rdf:Bag>
</bqbiol:isVersionOf>
</rdf:Description>
</rdf:RDF>
<COPASI xmlns="http://www.copasi.org/static/sbml">
<rdf:RDF xmlns:CopasiMT="http://www.copasi.org/RDF/MiriamTerms#" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#">
<rdf:Description rdf:about="#COPASI52">
<dcterms:created>
<rdf:Description>
<dcterms:W3CDTF>2019-04-15T14:27:17Z</dcterms:W3CDTF>
</rdf:Description>
</dcterms:created>
<CopasiMT:isVersionOf rdf:resource="urn:miriam:go:GO:0032801"/>
</rdf:Description>
</rdf:RDF>
</COPASI>
</annotation>
<listOfReactants>
<speciesReference species="Rec" stoichiometry="1"/>
</listOfReactants>
<listOfModifiers>
<modifierSpeciesReference species="SOCS1"/>
</listOfModifiers>
<kineticLaw>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<times/>
<ci> compartment </ci>
<apply>
<ci> Receptor_degradation_by_SOCS1_1 </ci>
<ci> Rec </ci>
<ci> SOCS1 </ci>
<ci> degRecBySOCS </ci>
</apply>
</apply>
</math>
<listOfParameters>
<parameter id="degRecBySOCS" name="degRecBySOCS" value="0.01028"/>
</listOfParameters>
</kineticLaw>
</reaction>
<reaction id="Active_receptor_complex_formation" metaid="COPASI53" name="Active receptor complex formation" reversible="false">
<annotation>
<rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:dc="http://purl.org/dc/elements/1.1/" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/">
<rdf:Description rdf:about="#COPASI53">
<bqbiol:hasProperty>
<rdf:Bag>
<rdf:li rdf:resource="http://identifiers.org/go/GO:0043235"/>
</rdf:Bag>
</bqbiol:hasProperty>
</rdf:Description>
</rdf:RDF>
<COPASI xmlns="http://www.copasi.org/static/sbml">
<rdf:RDF xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#">
<rdf:Description rdf:about="#COPASI53">
<bqbiol:hasProperty rdf:resource="urn:miriam:go:GO:0043235"/>
<dcterms:created>
<rdf:Description>
<dcterms:W3CDTF>2019-04-15T16:31:54Z</dcterms:W3CDTF>
</rdf:Description>
</dcterms:created>
</rdf:Description>
</rdf:RDF>
</COPASI>
</annotation>
<listOfReactants>
<speciesReference species="IFN" stoichiometry="1"/>
<speciesReference species="Rec" stoichiometry="1"/>
</listOfReactants>
<listOfProducts>
<speciesReference species="aRecIFN" stoichiometry="1"/>
</listOfProducts>
<listOfModifiers>
<modifierSpeciesReference species="SOCS1"/>
<modifierSpeciesReference species="USP18"/>
<modifierSpeciesReference species="SOCS3"/>
</listOfModifiers>
<kineticLaw>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<times/>
<ci> compartment </ci>
<apply>
<ci> Active_receptor_complex_formation_1 </ci>
<ci> BindIFN </ci>
<ci> IFN </ci>
<ci> Rec </ci>
<ci> SOCS1 </ci>
<ci> SOCS3 </ci>
<ci> USP18 </ci>
<ci> kinhBySOCS </ci>
<ci> kinhByUSP18 </ci>
</apply>
</apply>
</math>
<listOfParameters>
<parameter id="BindIFN" name="BindIFN" value="0.0593"/>
<parameter id="kinhBySOCS" name="kinhBySOCS" value="889.4"/>
<parameter id="kinhByUSP18" name="kinhByUSP18" value="0.0001364"/>
</listOfParameters>
</kineticLaw>
</reaction>
<reaction id="Active_receptor_complex_degradation_basal" metaid="COPASI54" name="Active receptor complex degradation basal" reversible="false">
<annotation>
<rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:dc="http://purl.org/dc/elements/1.1/" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/">
<rdf:Description rdf:about="#COPASI54">
<bqbiol:hasProperty>
<rdf:Bag>
<rdf:li rdf:resource="http://identifiers.org/sbo/SBO:0000179"/>
</rdf:Bag>
</bqbiol:hasProperty>
</rdf:Description>
</rdf:RDF>
<COPASI xmlns="http://www.copasi.org/static/sbml">
<rdf:RDF xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#">
<rdf:Description rdf:about="#COPASI54">
<bqbiol:hasProperty rdf:resource="urn:miriam:sbo:SBO:0000179"/>
<dcterms:created>
<rdf:Description>
<dcterms:W3CDTF>2019-04-15T19:44:50Z</dcterms:W3CDTF>
</rdf:Description>
</dcterms:created>
</rdf:Description>
</rdf:RDF>
</COPASI>
</annotation>
<listOfReactants>
<speciesReference species="aRecIFN" stoichiometry="1"/>
</listOfReactants>
<kineticLaw>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<times/>
<ci> compartment </ci>
<ci> k1 </ci>
<ci> aRecIFN </ci>
</apply>
</math>
<listOfParameters>
<parameter id="k1" name="k1" value="19840"/>
</listOfParameters>
</kineticLaw>
</reaction>
<reaction id="Active_receptor_complex_degradation_by_SOCS1" metaid="COPASI55" name="Active receptor complex degradation by SOCS1" reversible="false">
<annotation>
<rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:dc="http://purl.org/dc/elements/1.1/" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/">
<rdf:Description rdf:about="#COPASI55">
<bqbiol:hasProperty>
<rdf:Bag>
<rdf:li rdf:resource="http://identifiers.org/sbo/SBO:0000179"/>
</rdf:Bag>
</bqbiol:hasProperty>
</rdf:Description>
</rdf:RDF>
<COPASI xmlns="http://www.copasi.org/static/sbml">
<rdf:RDF xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#">
<rdf:Description rdf:about="#COPASI55">
<bqbiol:hasProperty rdf:resource="urn:miriam:sbo:SBO:0000179"/>
<dcterms:created>
<rdf:Description>
<dcterms:W3CDTF>2019-04-15T19:45:04Z</dcterms:W3CDTF>
</rdf:Description>
</dcterms:created>
</rdf:Description>
</rdf:RDF>
</COPASI>
</annotation>
<listOfReactants>
<speciesReference species="aRecIFN" stoichiometry="1"/>
</listOfReactants>
<listOfModifiers>
<modifierSpeciesReference species="SOCS1"/>
</listOfModifiers>
<kineticLaw>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<times/>
<ci> compartment </ci>
<apply>
<ci> Active_receptor_complex_degradation_by_SOCS1_1 </ci>
<ci> SOCS1 </ci>
<ci> aRecIFN </ci>
<ci> degaRecIFNBySOCS </ci>
</apply>
</apply>
</math>
<listOfParameters>
<parameter id="degaRecIFNBySOCS" name="degaRecIFNBySOCS" value="0.8837"/>
</listOfParameters>
</kineticLaw>
</reaction>
<reaction id="Active_receptor_complex_degradation_by_USP18" metaid="COPASI56" name="Active receptor complex degradation by USP18" reversible="false">
<annotation>
<rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:dc="http://purl.org/dc/elements/1.1/" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/">
<rdf:Description rdf:about="#COPASI56">
<bqbiol:hasProperty>
<rdf:Bag>
<rdf:li rdf:resource="http://identifiers.org/sbo/SBO:0000179"/>
</rdf:Bag>
</bqbiol:hasProperty>
</rdf:Description>
</rdf:RDF>
<COPASI xmlns="http://www.copasi.org/static/sbml">
<rdf:RDF xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#">
<rdf:Description rdf:about="#COPASI56">
<bqbiol:hasProperty rdf:resource="urn:miriam:sbo:SBO:0000179"/>
<dcterms:created>
<rdf:Description>
<dcterms:W3CDTF>2019-04-15T19:45:18Z</dcterms:W3CDTF>
</rdf:Description>
</dcterms:created>
</rdf:Description>
</rdf:RDF>
</COPASI>
</annotation>
<listOfReactants>
<speciesReference species="aRecIFN" stoichiometry="1"/>
</listOfReactants>
<listOfModifiers>
<modifierSpeciesReference species="USP18"/>
</listOfModifiers>
<kineticLaw>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<times/>
<ci> compartment </ci>
<apply>
<ci> Active_receptor_complex_degradation_by_USP18_1 </ci>
<ci> USP18 </ci>
<ci> aRecIFN </ci>
<ci> degByUSP18 </ci>
</apply>
</apply>
</math>
<listOfParameters>
<parameter id="degByUSP18" name="degByUSP18" value="0.01644"/>
</listOfParameters>
</kineticLaw>
</reaction>
<reaction id="Active_receptor_complex_degradation_by_USP18_and_SOCS1__synergy" metaid="COPASI57" name="Active receptor complex degradation by USP18 and SOCS1 (synergy)" reversible="false">
<annotation>
<rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:dc="http://purl.org/dc/elements/1.1/" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/">
<rdf:Description rdf:about="#COPASI57">
<bqbiol:hasProperty>
<rdf:Bag>
<rdf:li rdf:resource="http://identifiers.org/sbo/SBO:0000179"/>
</rdf:Bag>
</bqbiol:hasProperty>
</rdf:Description>
</rdf:RDF>
<COPASI xmlns="http://www.copasi.org/static/sbml">
<rdf:RDF xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#">
<rdf:Description rdf:about="#COPASI57">
<bqbiol:hasProperty rdf:resource="urn:miriam:sbo:SBO:0000179"/>
<dcterms:created>
<rdf:Description>
<dcterms:W3CDTF>2019-04-15T19:45:28Z</dcterms:W3CDTF>
</rdf:Description>
</dcterms:created>
</rdf:Description>
</rdf:RDF>
</COPASI>
</annotation>
<listOfReactants>
<speciesReference species="aRecIFN" stoichiometry="1"/>
</listOfReactants>
<listOfModifiers>
<modifierSpeciesReference species="SOCS1"/>
<modifierSpeciesReference species="USP18"/>
</listOfModifiers>
<kineticLaw>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<times/>
<ci> compartment </ci>
<apply>
<ci> Active_receptor_complex_degradation_by_USP18_and_SOCS1__synergy__1 </ci>
<ci> SOCS1 </ci>
<ci> USP18 </ci>
<ci> aRecIFN </ci>
<ci> degBySOCSandUSP18 </ci>
</apply>
</apply>
</math>
<listOfParameters>
<parameter id="degBySOCSandUSP18" name="degBySOCSandUSP18" value="27.82"/>
</listOfParameters>
</kineticLaw>
</reaction>
<reaction id="USP18_degradation" metaid="COPASI58" name="USP18 degradation" reversible="false">
<annotation>
<rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:dc="http://purl.org/dc/elements/1.1/" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/">
<rdf:Description rdf:about="#COPASI58">
<bqbiol:isVersionOf>
<rdf:Bag>
<rdf:li rdf:resource="http://identifiers.org/sbo/SBO:0000179"/>
</rdf:Bag>
</bqbiol:isVersionOf>
</rdf:Description>
</rdf:RDF>
<COPASI xmlns="http://www.copasi.org/static/sbml">
<rdf:RDF xmlns:CopasiMT="http://www.copasi.org/RDF/MiriamTerms#" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#">
<rdf:Description rdf:about="#COPASI58">
<dcterms:created>
<rdf:Description>
<dcterms:W3CDTF>2019-04-15T19:17:06Z</dcterms:W3CDTF>
</rdf:Description>
</dcterms:created>
<CopasiMT:isVersionOf rdf:resource="urn:miriam:sbo:SBO:0000179"/>
</rdf:Description>
</rdf:RDF>
</COPASI>
</annotation>
<listOfReactants>
<speciesReference species="USP18" stoichiometry="1"/>
</listOfReactants>
<kineticLaw>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<times/>
<ci> compartment </ci>
<ci> k1 </ci>
<ci> USP18 </ci>
</apply>
</math>
<listOfParameters>
<parameter id="k1" name="k1" value="0.6719"/>
</listOfParameters>
</kineticLaw>
</reaction>
<reaction id="Heterodimer_complex_formation" metaid="COPASI59" name="Heterodimer complex formation" reversible="false">
<annotation>
<rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:dc="http://purl.org/dc/elements/1.1/" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/">
<rdf:Description rdf:about="#COPASI59">
<bqbiol:hasProperty>
<rdf:Bag>
<rdf:li rdf:resource="http://identifiers.org/sbo/SBO:0000609"/>
</rdf:Bag>
</bqbiol:hasProperty>
<bqbiol:hasProperty>
<rdf:Bag>
<rdf:li rdf:resource="http://identifiers.org/sbo/SBO:0000526"/>
</rdf:Bag>
</bqbiol:hasProperty>
</rdf:Description>
</rdf:RDF>
<COPASI xmlns="http://www.copasi.org/static/sbml">
<rdf:RDF xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#">
<rdf:Description rdf:about="#COPASI59">
<bqbiol:hasProperty rdf:resource="urn:miriam:sbo:SBO:0000526"/>
<bqbiol:hasProperty rdf:resource="urn:miriam:sbo:SBO:0000609"/>
<dcterms:created>
<rdf:Description>
<dcterms:W3CDTF>2019-04-15T19:01:23Z</dcterms:W3CDTF>
</rdf:Description>
</dcterms:created>
</rdf:Description>
</rdf:RDF>
</COPASI>
</annotation>
<listOfReactants>
<speciesReference species="STAT1c" stoichiometry="1"/>
<speciesReference species="STAT2c" stoichiometry="1"/>
</listOfReactants>
<listOfProducts>
<speciesReference species="pSTAT1pSTAT2c" stoichiometry="1"/>
</listOfProducts>
<listOfModifiers>
<modifierSpeciesReference species="aRecIFN"/>
</listOfModifiers>
<kineticLaw>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<times/>
<ci> compartment </ci>
<apply>
<ci> Heterodimer_complex_formation_1 </ci>
<ci> ComplFormSTAT1STAT2c </ci>
<ci> STAT1c </ci>
<ci> STAT2c </ci>
<ci> aRecIFN </ci>
</apply>
</apply>
</math>
<listOfParameters>
<parameter id="ComplFormSTAT1STAT2c" name="ComplFormSTAT1STAT2c" value="0.001112"/>
</listOfParameters>
</kineticLaw>
</reaction>
<reaction id="Heterodimer_translocation_to_nucleus" metaid="COPASI60" name="Heterodimer translocation to nucleus" reversible="false">
<annotation>
<rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:dc="http://purl.org/dc/elements/1.1/" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/">
<rdf:Description rdf:about="#COPASI60">
<bqbiol:isVersionOf>
<rdf:Bag>
<rdf:li rdf:resource="http://identifiers.org/ncit/C28506"/>
</rdf:Bag>
</bqbiol:isVersionOf>
</rdf:Description>
</rdf:RDF>
<COPASI xmlns="http://www.copasi.org/static/sbml">
<rdf:RDF xmlns:CopasiMT="http://www.copasi.org/RDF/MiriamTerms#" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#">
<rdf:Description rdf:about="#COPASI60">
<dcterms:created>
<rdf:Description>
<dcterms:W3CDTF>2019-04-15T19:01:48Z</dcterms:W3CDTF>
</rdf:Description>
</dcterms:created>
<CopasiMT:isVersionOf rdf:resource="urn:miriam:ncit:C28506"/>
</rdf:Description>
</rdf:RDF>
</COPASI>
</annotation>
<listOfReactants>
<speciesReference species="pSTAT1pSTAT2c" stoichiometry="1"/>
</listOfReactants>
<listOfProducts>
<speciesReference species="pSTAT1pSTAT2n" stoichiometry="1"/>
</listOfProducts>
<kineticLaw>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<times/>
<ci> compartment </ci>
<ci> k1 </ci>
<ci> pSTAT1pSTAT2c </ci>
</apply>
</math>
<listOfParameters>
<parameter id="k1" name="k1" value="0.1855"/>
</listOfParameters>
</kineticLaw>
</reaction>
<reaction id="Heterodimer_decay" metaid="COPASI61" name="Heterodimer decay" reversible="false">
<annotation>
<rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:dc="http://purl.org/dc/elements/1.1/" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/">
<rdf:Description rdf:about="#COPASI61">
<bqbiol:isVersionOf>
<rdf:Bag>
<rdf:li rdf:resource="http://identifiers.org/ncit/C75947"/>
</rdf:Bag>
</bqbiol:isVersionOf>
</rdf:Description>
</rdf:RDF>
<COPASI xmlns="http://www.copasi.org/static/sbml">
<rdf:RDF xmlns:CopasiMT="http://www.copasi.org/RDF/MiriamTerms#" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#">
<rdf:Description rdf:about="#COPASI61">
<dcterms:created>
<rdf:Description>
<dcterms:W3CDTF>2019-04-15T19:01:33Z</dcterms:W3CDTF>
</rdf:Description>
</dcterms:created>
<CopasiMT:isVersionOf rdf:resource="urn:miriam:ncit:C75947"/>
</rdf:Description>
</rdf:RDF>
</COPASI>
</annotation>
<listOfReactants>
<speciesReference species="pSTAT1pSTAT2n" stoichiometry="1"/>
</listOfReactants>
<listOfProducts>
<speciesReference species="STAT1n" stoichiometry="1"/>
<speciesReference species="STAT2n" stoichiometry="1"/>
</listOfProducts>
<kineticLaw>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<times/>
<ci> compartment </ci>
<ci> k1 </ci>
<ci> pSTAT1pSTAT2n </ci>
</apply>
</math>
<listOfParameters>
<parameter id="k1" name="k1" value="1.187"/>
</listOfParameters>
</kineticLaw>
</reaction>
<reaction id="ISGF3_complex_formation" metaid="COPASI62" name="ISGF3 complex formation" reversible="false">
<annotation>
<rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:dc="http://purl.org/dc/elements/1.1/" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/">
<rdf:Description rdf:about="#COPASI62">
<bqbiol:hasProperty>
<rdf:Bag>
<rdf:li rdf:resource="http://identifiers.org/sbo/SBO:0000526"/>
</rdf:Bag>
</bqbiol:hasProperty>
</rdf:Description>
</rdf:RDF>
<COPASI xmlns="http://www.copasi.org/static/sbml">
<rdf:RDF xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#">
<rdf:Description rdf:about="#COPASI62">
<bqbiol:hasProperty rdf:resource="urn:miriam:sbo:SBO:0000526"/>
<dcterms:created>
<rdf:Description>
<dcterms:W3CDTF>2019-04-15T19:05:14Z</dcterms:W3CDTF>
</rdf:Description>
</dcterms:created>
</rdf:Description>
</rdf:RDF>
</COPASI>
</annotation>
<listOfReactants>
<speciesReference species="pSTAT1pSTAT2c" stoichiometry="1"/>
<speciesReference species="IRF9c" stoichiometry="1"/>
</listOfReactants>
<listOfProducts>
<speciesReference species="ISGF3c" stoichiometry="1"/>
</listOfProducts>
<kineticLaw>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<times/>
<ci> compartment </ci>
<ci> k1 </ci>
<ci> pSTAT1pSTAT2c </ci>
<ci> IRF9c </ci>
</apply>
</math>
<listOfParameters>
<parameter id="k1" name="k1" value="0.008975"/>
</listOfParameters>
</kineticLaw>
</reaction>
<reaction id="ISGF3_translocation_to_nucleus" metaid="COPASI63" name="ISGF3 translocation to nucleus" reversible="false">
<annotation>
<rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:dc="http://purl.org/dc/elements/1.1/" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/">
<rdf:Description rdf:about="#COPASI63">
<bqbiol:isVersionOf>
<rdf:Bag>
<rdf:li rdf:resource="http://identifiers.org/ncit/C28506"/>
</rdf:Bag>
</bqbiol:isVersionOf>
</rdf:Description>
</rdf:RDF>
<COPASI xmlns="http://www.copasi.org/static/sbml">
<rdf:RDF xmlns:CopasiMT="http://www.copasi.org/RDF/MiriamTerms#" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#">
<rdf:Description rdf:about="#COPASI63">
<dcterms:created>
<rdf:Description>
<dcterms:W3CDTF>2019-04-15T19:05:57Z</dcterms:W3CDTF>
</rdf:Description>
</dcterms:created>
<CopasiMT:isVersionOf rdf:resource="urn:miriam:ncit:C28506"/>
</rdf:Description>
</rdf:RDF>
</COPASI>
</annotation>
<listOfReactants>
<speciesReference species="ISGF3c" stoichiometry="1"/>
</listOfReactants>
<listOfProducts>
<speciesReference species="ISGF3n" stoichiometry="1"/>
</listOfProducts>
<kineticLaw>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<times/>
<ci> compartment </ci>
<ci> k1 </ci>
<ci> ISGF3c </ci>
</apply>
</math>
<listOfParameters>
<parameter id="k1" name="k1" value="0.8636"/>
</listOfParameters>
</kineticLaw>
</reaction>
<reaction id="ISGF3_decay" metaid="COPASI64" name="ISGF3 decay" reversible="false">
<annotation>
<rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:dc="http://purl.org/dc/elements/1.1/" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/">
<rdf:Description rdf:about="#COPASI64">
<bqbiol:isVersionOf>
<rdf:Bag>
<rdf:li rdf:resource="http://identifiers.org/ncit/C75947"/>
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</bqbiol:isVersionOf>
</rdf:Description>
</rdf:RDF>
<COPASI xmlns="http://www.copasi.org/static/sbml">
<rdf:RDF xmlns:CopasiMT="http://www.copasi.org/RDF/MiriamTerms#" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#">
<rdf:Description rdf:about="#COPASI64">
<dcterms:created>
<rdf:Description>
<dcterms:W3CDTF>2019-04-15T19:05:38Z</dcterms:W3CDTF>
</rdf:Description>
</dcterms:created>
<CopasiMT:isVersionOf rdf:resource="urn:miriam:ncit:C75947"/>
</rdf:Description>
</rdf:RDF>
</COPASI>
</annotation>
<listOfReactants>
<speciesReference species="ISGF3n" stoichiometry="1"/>
</listOfReactants>
<listOfProducts>
<speciesReference species="STAT1n" stoichiometry="1"/>
<speciesReference species="STAT2n" stoichiometry="1"/>
<speciesReference species="IRF9n" stoichiometry="1"/>
</listOfProducts>
<kineticLaw>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<times/>
<ci> compartment </ci>
<ci> k1 </ci>
<ci> ISGF3n </ci>
</apply>
</math>
<listOfParameters>
<parameter id="k1" name="k1" value="3.407"/>
</listOfParameters>
</kineticLaw>
</reaction>
<reaction id="Homodimer_complex_formation" metaid="COPASI65" name="Homodimer complex formation" reversible="false">
<annotation>
<rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:dc="http://purl.org/dc/elements/1.1/" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/">
<rdf:Description rdf:about="#COPASI65">
<bqbiol:hasProperty>
<rdf:Bag>
<rdf:li rdf:resource="http://identifiers.org/sbo/SBO:0000526"/>
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</bqbiol:hasProperty>
<bqbiol:hasProperty>
<rdf:Bag>
<rdf:li rdf:resource="http://identifiers.org/sbo/SBO:0000608"/>
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</bqbiol:hasProperty>
</rdf:Description>
</rdf:RDF>
<COPASI xmlns="http://www.copasi.org/static/sbml">
<rdf:RDF xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#">
<rdf:Description rdf:about="#COPASI65">
<bqbiol:hasProperty rdf:resource="urn:miriam:sbo:SBO:0000526"/>
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<dcterms:created>
<rdf:Description>
<dcterms:W3CDTF>2019-04-15T19:02:00Z</dcterms:W3CDTF>
</rdf:Description>
</dcterms:created>
</rdf:Description>
</rdf:RDF>
</COPASI>
</annotation>
<listOfReactants>
<speciesReference species="STAT1c" stoichiometry="2"/>
</listOfReactants>
<listOfProducts>
<speciesReference species="pSTAT1dimc" stoichiometry="1"/>
</listOfProducts>
<listOfModifiers>
<modifierSpeciesReference species="aRecIFN"/>
</listOfModifiers>
<kineticLaw>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<times/>
<ci> compartment </ci>
<apply>
<ci> Homodimer_complex_formation_1 </ci>
<ci> ComplFormSTAT1dimc </ci>
<ci> STAT1c </ci>
<ci> aRecIFN </ci>
</apply>
</apply>
</math>
<listOfParameters>
<parameter id="ComplFormSTAT1dimc" name="ComplFormSTAT1dimc" value="7.12E-6"/>
</listOfParameters>
</kineticLaw>
</reaction>
<reaction id="Homodimer_translocation_to_nucleus" metaid="COPASI66" name="Homodimer translocation to nucleus" reversible="false">
<annotation>
<rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:dc="http://purl.org/dc/elements/1.1/" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/">
<rdf:Description rdf:about="#COPASI66">
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<rdf:li rdf:resource="http://identifiers.org/ncit/C28506"/>
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</bqbiol:isVersionOf>
</rdf:Description>
</rdf:RDF>
<COPASI xmlns="http://www.copasi.org/static/sbml">
<rdf:RDF xmlns:CopasiMT="http://www.copasi.org/RDF/MiriamTerms#" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#">
<rdf:Description rdf:about="#COPASI66">
<dcterms:created>
<rdf:Description>
<dcterms:W3CDTF>2019-04-15T19:02:28Z</dcterms:W3CDTF>
</rdf:Description>
</dcterms:created>
<CopasiMT:isVersionOf rdf:resource="urn:miriam:ncit:C28506"/>
</rdf:Description>
</rdf:RDF>
</COPASI>
</annotation>
<listOfReactants>
<speciesReference species="pSTAT1dimc" stoichiometry="1"/>
</listOfReactants>
<listOfProducts>
<speciesReference species="pSTAT1dimn" stoichiometry="1"/>
</listOfProducts>
<kineticLaw>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<times/>
<ci> compartment </ci>
<ci> k1 </ci>
<ci> pSTAT1dimc </ci>
</apply>
</math>
<listOfParameters>
<parameter id="k1" name="k1" value="4.296"/>
</listOfParameters>
</kineticLaw>
</reaction>
<reaction id="Homodimer_decay" metaid="COPASI67" name="Homodimer decay" reversible="false">
<annotation>
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<rdf:Description rdf:about="#COPASI67">
<bqbiol:isVersionOf>
<rdf:Bag>
<rdf:li rdf:resource="http://identifiers.org/ncit/C75947"/>
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</bqbiol:isVersionOf>
</rdf:Description>
</rdf:RDF>
<COPASI xmlns="http://www.copasi.org/static/sbml">
<rdf:RDF xmlns:CopasiMT="http://www.copasi.org/RDF/MiriamTerms#" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#">
<rdf:Description rdf:about="#COPASI67">
<dcterms:created>
<rdf:Description>
<dcterms:W3CDTF>2019-04-15T19:02:19Z</dcterms:W3CDTF>
</rdf:Description>
</dcterms:created>
<CopasiMT:isVersionOf rdf:resource="urn:miriam:ncit:C75947"/>
</rdf:Description>
</rdf:RDF>
</COPASI>
</annotation>
<listOfReactants>
<speciesReference species="pSTAT1dimn" stoichiometry="1"/>
</listOfReactants>
<listOfProducts>
<speciesReference species="STAT1n" stoichiometry="2"/>
</listOfProducts>
<kineticLaw>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<times/>
<ci> compartment </ci>
<ci> k1 </ci>
<ci> pSTAT1dimn </ci>
</apply>
</math>
<listOfParameters>
<parameter id="k1" name="k1" value="10.53"/>
</listOfParameters>
</kineticLaw>
</reaction>
<reaction id="OccGAS_ISREbs_formation_by_ISGF3" metaid="COPASI68" name="OccGAS_ISREbs formation by ISGF3" reversible="false">
<annotation>
<rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:dc="http://purl.org/dc/elements/1.1/" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/">
<rdf:Description rdf:about="#COPASI68">
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<rdf:Bag>
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</bqbiol:isVersionOf>
</rdf:Description>
</rdf:RDF>
<COPASI xmlns="http://www.copasi.org/static/sbml">
<rdf:RDF xmlns:CopasiMT="http://www.copasi.org/RDF/MiriamTerms#" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#">
<rdf:Description rdf:about="#COPASI68">
<dcterms:created>
<rdf:Description>
<dcterms:W3CDTF>2019-04-15T19:08:54Z</dcterms:W3CDTF>
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<CopasiMT:isVersionOf rdf:resource="urn:miriam:go:GO:0001046"/>
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</annotation>
<listOfProducts>
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</listOfProducts>
<listOfModifiers>
<modifierSpeciesReference species="ISGF3n"/>
</listOfModifiers>
<kineticLaw>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<times/>
<ci> compartment </ci>
<apply>
<ci> OccGAS_ISREbs_formation_by_ISGF3_1 </ci>
<ci> ISGF3n </ci>
<ci> genOccGAS_ISREbsByISGF3n </ci>
</apply>
</apply>
</math>
<listOfParameters>
<parameter id="genOccGAS_ISREbsByISGF3n" name="genOccGAS_ISREbsByISGF3n" value="0.0003583"/>
</listOfParameters>
</kineticLaw>
</reaction>
<reaction id="OccGAS_ISREbs_formation_by_heterodimer" metaid="COPASI69" name="OccGAS_ISREbs formation by heterodimer" reversible="false">
<annotation>
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<rdf:Description rdf:about="#COPASI69">
<bqbiol:isVersionOf>
<rdf:Bag>
<rdf:li rdf:resource="http://identifiers.org/go/GO:0001046"/>
</rdf:Bag>
</bqbiol:isVersionOf>
<bqbiol:hasProperty>
<rdf:Bag>
<rdf:li rdf:resource="http://identifiers.org/sbo/SBO:0000609"/>
</rdf:Bag>
</bqbiol:hasProperty>
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<COPASI xmlns="http://www.copasi.org/static/sbml">
<rdf:RDF xmlns:CopasiMT="http://www.copasi.org/RDF/MiriamTerms#" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#">
<rdf:Description rdf:about="#COPASI69">
<bqbiol:hasProperty rdf:resource="urn:miriam:sbo:SBO:0000609"/>
<dcterms:created>
<rdf:Description>
<dcterms:W3CDTF>2019-04-15T19:08:34Z</dcterms:W3CDTF>
</rdf:Description>
</dcterms:created>
<CopasiMT:isVersionOf rdf:resource="urn:miriam:go:GO:0001046"/>
</rdf:Description>
</rdf:RDF>
</COPASI>
</annotation>
<listOfProducts>
<speciesReference species="OccGAS_ISREbs" stoichiometry="1"/>
</listOfProducts>
<listOfModifiers>
<modifierSpeciesReference species="pSTAT1pSTAT2n"/>
</listOfModifiers>
<kineticLaw>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<times/>
<ci> compartment </ci>
<apply>
<ci> OccGAS_ISREbs_formation_by_heterodimer_0 </ci>
<ci> genOccGAS_ISREbsBySTAT1STAT2n </ci>
<ci> pSTAT1pSTAT2n </ci>
</apply>
</apply>
</math>
<listOfParameters>
<parameter id="genOccGAS_ISREbsBySTAT1STAT2n" name="genOccGAS_ISREbsBySTAT1STAT2n" value="0.0002972"/>
</listOfParameters>
</kineticLaw>
</reaction>
<reaction id="OccGAS_ISREbs_decay" metaid="COPASI70" name="OccGAS_ISREbs decay" reversible="false">
<annotation>
<rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:dc="http://purl.org/dc/elements/1.1/" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/">
<rdf:Description rdf:about="#COPASI70">
<bqbiol:isVersionOf>
<rdf:Bag>
<rdf:li rdf:resource="http://identifiers.org/ncit/C75947"/>
</rdf:Bag>
</bqbiol:isVersionOf>
</rdf:Description>
</rdf:RDF>
<COPASI xmlns="http://www.copasi.org/static/sbml">
<rdf:RDF xmlns:CopasiMT="http://www.copasi.org/RDF/MiriamTerms#" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#">
<rdf:Description rdf:about="#COPASI70">
<dcterms:created>
<rdf:Description>
<dcterms:W3CDTF>2019-04-15T19:08:22Z</dcterms:W3CDTF>
</rdf:Description>
</dcterms:created>
<CopasiMT:isVersionOf rdf:resource="urn:miriam:ncit:C75947"/>
</rdf:Description>
</rdf:RDF>
</COPASI>
</annotation>
<listOfReactants>
<speciesReference species="OccGAS_ISREbs" stoichiometry="1"/>
</listOfReactants>
<kineticLaw>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<times/>
<ci> compartment </ci>
<ci> k1 </ci>
<ci> OccGAS_ISREbs </ci>
</apply>
</math>
<listOfParameters>
<parameter id="k1" name="k1" value="0.5519"/>
</listOfParameters>
</kineticLaw>
</reaction>
<reaction id="Occupy_GAS_binding_site" metaid="COPASI71" name="Occupy GAS binding site" reversible="false">
<annotation>
<rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:dc="http://purl.org/dc/elements/1.1/" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/">
<rdf:Description rdf:about="#COPASI71">
<bqbiol:isVersionOf>
<rdf:Bag>
<rdf:li rdf:resource="http://identifiers.org/go/GO:0001047"/>
</rdf:Bag>
</bqbiol:isVersionOf>
</rdf:Description>
</rdf:RDF>
<COPASI xmlns="http://www.copasi.org/static/sbml">
<rdf:RDF xmlns:CopasiMT="http://www.copasi.org/RDF/MiriamTerms#" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#">
<rdf:Description rdf:about="#COPASI71">
<dcterms:created>
<rdf:Description>
<dcterms:W3CDTF>2019-04-15T19:09:19Z</dcterms:W3CDTF>
</rdf:Description>
</dcterms:created>
<CopasiMT:isVersionOf rdf:resource="urn:miriam:go:GO:0001047"/>
</rdf:Description>
</rdf:RDF>
</COPASI>
</annotation>
<listOfProducts>
<speciesReference species="OccGASbs" stoichiometry="1"/>
</listOfProducts>
<listOfModifiers>
<modifierSpeciesReference species="pSTAT1dimn"/>
</listOfModifiers>
<kineticLaw>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<times/>
<ci> compartment </ci>
<apply>
<ci> Occupy_GAS_binding_site_0 </ci>
<ci> genOccGASbsBySTAT1dimn </ci>
<ci> pSTAT1dimn </ci>
</apply>
</apply>
</math>
<listOfParameters>
<parameter id="genOccGASbsBySTAT1dimn" name="genOccGASbsBySTAT1dimn" value="1395"/>
</listOfParameters>
</kineticLaw>
</reaction>
<reaction id="OccGASbs_0" metaid="COPASI72" name="OccGASbs" reversible="false">
<annotation>
<rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:dc="http://purl.org/dc/elements/1.1/" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/">
<rdf:Description rdf:about="#COPASI72">
<bqbiol:hasProperty>
<rdf:Bag>
<rdf:li rdf:resource="http://identifiers.org/go/GO:0001046"/>
</rdf:Bag>
</bqbiol:hasProperty>
</rdf:Description>
</rdf:RDF>
<COPASI xmlns="http://www.copasi.org/static/sbml">
<rdf:RDF xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#">
<rdf:Description rdf:about="#COPASI72">
<bqbiol:hasProperty rdf:resource="urn:miriam:go:GO:0001046"/>
<dcterms:created>
<rdf:Description>
<dcterms:W3CDTF>2019-04-15T19:08:12Z</dcterms:W3CDTF>
</rdf:Description>
</dcterms:created>
</rdf:Description>
</rdf:RDF>
</COPASI>
</annotation>
<listOfReactants>
<speciesReference species="OccGASbs" stoichiometry="1"/>
</listOfReactants>
<kineticLaw>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<times/>
<ci> compartment </ci>
<ci> k1 </ci>
<ci> OccGASbs </ci>
</apply>
</math>
<listOfParameters>
<parameter id="k1" name="k1" value="1395"/>
</listOfParameters>
</kineticLaw>
</reaction>
<reaction id="STAT1_degradation" metaid="COPASI73" name="STAT1 degradation" reversible="false">
<annotation>
<rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:dc="http://purl.org/dc/elements/1.1/" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/">
<rdf:Description rdf:about="#COPASI73">
<bqbiol:isVersionOf>
<rdf:Bag>
<rdf:li rdf:resource="http://identifiers.org/sbo/SBO:0000179"/>
</rdf:Bag>
</bqbiol:isVersionOf>
</rdf:Description>
</rdf:RDF>
<COPASI xmlns="http://www.copasi.org/static/sbml">
<rdf:RDF xmlns:CopasiMT="http://www.copasi.org/RDF/MiriamTerms#" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#">
<rdf:Description rdf:about="#COPASI73">
<dcterms:created>
<rdf:Description>
<dcterms:W3CDTF>2019-04-15T19:13:42Z</dcterms:W3CDTF>
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</dcterms:created>
<CopasiMT:isVersionOf rdf:resource="urn:miriam:sbo:SBO:0000179"/>
</rdf:Description>
</rdf:RDF>
</COPASI>
</annotation>
<listOfReactants>
<speciesReference species="STAT1c" stoichiometry="1"/>
</listOfReactants>
<kineticLaw>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<times/>
<ci> compartment </ci>
<ci> k1 </ci>
<ci> STAT1c </ci>
</apply>
</math>
<listOfParameters>
<parameter id="k1" name="k1" value="0.4996"/>
</listOfParameters>
</kineticLaw>
</reaction>
<reaction id="STAT1_translocation_to_cytoplasm" metaid="COPASI74" name="STAT1 translocation to cytoplasm" reversible="false">
<annotation>
<rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:dc="http://purl.org/dc/elements/1.1/" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/">
<rdf:Description rdf:about="#COPASI74">
<bqbiol:isVersionOf>
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<rdf:li rdf:resource="http://identifiers.org/sbo/SBO:0000185"/>
</rdf:Bag>
</bqbiol:isVersionOf>
</rdf:Description>
</rdf:RDF>
<COPASI xmlns="http://www.copasi.org/static/sbml">
<rdf:RDF xmlns:CopasiMT="http://www.copasi.org/RDF/MiriamTerms#" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#">
<rdf:Description rdf:about="#COPASI74">
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<rdf:Description>
<dcterms:W3CDTF>2019-04-15T19:14:10Z</dcterms:W3CDTF>
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<CopasiMT:isVersionOf rdf:resource="urn:miriam:sbo:SBO:0000185"/>
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</rdf:RDF>
</COPASI>
</annotation>
<listOfReactants>
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</listOfReactants>
<listOfProducts>
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</listOfProducts>
<kineticLaw>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<times/>
<ci> compartment </ci>
<ci> k1 </ci>
<ci> STAT1n </ci>
</apply>
</math>
<listOfParameters>
<parameter id="k1" name="k1" value="0.9702"/>
</listOfParameters>
</kineticLaw>
</reaction>
<reaction id="STAT1_translocation_to_nucleus" metaid="COPASI75" name="STAT1 translocation to nucleus" reversible="false">
<annotation>
<rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:dc="http://purl.org/dc/elements/1.1/" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/">
<rdf:Description rdf:about="#COPASI75">
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</bqbiol:isVersionOf>
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<COPASI xmlns="http://www.copasi.org/static/sbml">
<rdf:RDF xmlns:CopasiMT="http://www.copasi.org/RDF/MiriamTerms#" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#">
<rdf:Description rdf:about="#COPASI75">
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</annotation>
<listOfReactants>
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<listOfProducts>
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<kineticLaw>
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<apply>
<times/>
<ci> compartment </ci>
<ci> k1 </ci>
<ci> STAT1c </ci>
</apply>
</math>
<listOfParameters>
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</listOfParameters>
</kineticLaw>
</reaction>
<reaction id="STAT2_degradation" metaid="COPASI76" name="STAT2 degradation" reversible="false">
<annotation>
<rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:dc="http://purl.org/dc/elements/1.1/" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/">
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</bqbiol:isVersionOf>
</rdf:Description>
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<COPASI xmlns="http://www.copasi.org/static/sbml">
<rdf:RDF xmlns:CopasiMT="http://www.copasi.org/RDF/MiriamTerms#" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#">
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</dcterms:created>
<CopasiMT:isVersionOf rdf:resource="urn:miriam:sbo:SBO:0000179"/>
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</rdf:RDF>
</COPASI>
</annotation>
<listOfReactants>
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<kineticLaw>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<times/>
<ci> compartment </ci>
<ci> k1 </ci>
<ci> STAT2c </ci>
</apply>
</math>
<listOfParameters>
<parameter id="k1" name="k1" value="0.1468"/>
</listOfParameters>
</kineticLaw>
</reaction>
<reaction id="STAT2_translocation_to_cytoplasm" metaid="COPASI77" name="STAT2 translocation to cytoplasm" reversible="false">
<annotation>
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<rdf:Description rdf:about="#COPASI77">
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</bqbiol:isVersionOf>
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</rdf:RDF>
<COPASI xmlns="http://www.copasi.org/static/sbml">
<rdf:RDF xmlns:CopasiMT="http://www.copasi.org/RDF/MiriamTerms#" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#">
<rdf:Description rdf:about="#COPASI77">
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</dcterms:created>
<CopasiMT:isVersionOf rdf:resource="urn:miriam:sbo:SBO:0000185"/>
</rdf:Description>
</rdf:RDF>
</COPASI>
</annotation>
<listOfReactants>
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</listOfReactants>
<listOfProducts>
<speciesReference species="STAT2c" stoichiometry="1"/>
</listOfProducts>
<kineticLaw>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<times/>
<ci> compartment </ci>
<ci> k1 </ci>
<ci> STAT2n </ci>
</apply>
</math>
<listOfParameters>
<parameter id="k1" name="k1" value="1.81"/>
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</kineticLaw>
</reaction>
<reaction id="STAT2_translocation_to_nucleus" metaid="COPASI78" name="STAT2 translocation to nucleus" reversible="false">
<annotation>
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<rdf:Description rdf:about="#COPASI78">
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<kineticLaw>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<times/>
<ci> compartment </ci>
<apply>
<ci> STAT2mRNA_production_by_ISRE_1 </ci>
<ci> OccGAS_ISREbs </ci>
<ci> synthSTAT2mRNA </ci>
</apply>
</apply>
</math>
<listOfParameters>
<parameter id="synthSTAT2mRNA" name="synthSTAT2mRNA" value="1.561"/>
</listOfParameters>
</kineticLaw>
</reaction>
<reaction id="STAT2mRNA_decay" metaid="COPASI90" name="STAT2mRNA decay" reversible="false">
<annotation>
<rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:dc="http://purl.org/dc/elements/1.1/" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/">
<rdf:Description rdf:about="#COPASI90">
<bqbiol:isVersionOf>
<rdf:Bag>
<rdf:li rdf:resource="http://identifiers.org/ncit/C75947"/>
</rdf:Bag>
</bqbiol:isVersionOf>
</rdf:Description>
</rdf:RDF>
<COPASI xmlns="http://www.copasi.org/static/sbml">
<rdf:RDF xmlns:CopasiMT="http://www.copasi.org/RDF/MiriamTerms#" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#">
<rdf:Description rdf:about="#COPASI90">
<dcterms:created>
<rdf:Description>
<dcterms:W3CDTF>2019-04-15T19:16:16Z</dcterms:W3CDTF>
</rdf:Description>
</dcterms:created>
<CopasiMT:isVersionOf rdf:resource="urn:miriam:ncit:C75947"/>
</rdf:Description>
</rdf:RDF>
</COPASI>
</annotation>
<listOfReactants>
<speciesReference species="STAT2mRNA" stoichiometry="1"/>
</listOfReactants>
<kineticLaw>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<times/>
<ci> compartment </ci>
<ci> k1 </ci>
<ci> STAT2mRNA </ci>
</apply>
</math>
<listOfParameters>
<parameter id="k1" name="k1" value="0.2446"/>
</listOfParameters>
</kineticLaw>
</reaction>
<reaction id="IRF9mRNA_basal_production" metaid="COPASI91" name="IRF9mRNA basal production" reversible="false">
<annotation>
<rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:dc="http://purl.org/dc/elements/1.1/" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/">
<rdf:Description rdf:about="#COPASI91">
<bqbiol:isVersionOf>
<rdf:Bag>
<rdf:li rdf:resource="http://identifiers.org/sbo/SBO:0000393"/>
</rdf:Bag>
</bqbiol:isVersionOf>
</rdf:Description>
</rdf:RDF>
<COPASI xmlns="http://www.copasi.org/static/sbml">
<rdf:RDF xmlns:CopasiMT="http://www.copasi.org/RDF/MiriamTerms#" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#">
<rdf:Description rdf:about="#COPASI91">
<dcterms:created>
<rdf:Description>
<dcterms:W3CDTF>2019-04-15T19:04:35Z</dcterms:W3CDTF>
</rdf:Description>
</dcterms:created>
<CopasiMT:isVersionOf rdf:resource="urn:miriam:sbo:SBO:0000393"/>
</rdf:Description>
</rdf:RDF>
</COPASI>
</annotation>
<listOfProducts>
<speciesReference species="IRF9mRNA" stoichiometry="1"/>
</listOfProducts>
<kineticLaw>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<times/>
<ci> compartment </ci>
<apply>
<ci> Constant_flux__irreversible </ci>
<ci> v </ci>
</apply>
</apply>
</math>
<listOfParameters>
<parameter id="v" name="v" value="0.3605"/>
</listOfParameters>
</kineticLaw>
</reaction>
<reaction id="IRF9mRNA_production_by_ISRE" metaid="COPASI92" name="IRF9mRNA production by ISRE" reversible="false">
<annotation>
<rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:dc="http://purl.org/dc/elements/1.1/" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/">
<rdf:Description rdf:about="#COPASI92">
<bqbiol:isVersionOf>
<rdf:Bag>
<rdf:li rdf:resource="http://identifiers.org/sbo/SBO:0000183"/>
</rdf:Bag>
</bqbiol:isVersionOf>
</rdf:Description>
</rdf:RDF>
<COPASI xmlns="http://www.copasi.org/static/sbml">
<rdf:RDF xmlns:CopasiMT="http://www.copasi.org/RDF/MiriamTerms#" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#">
<rdf:Description rdf:about="#COPASI92">
<dcterms:created>
<rdf:Description>
<dcterms:W3CDTF>2019-04-15T19:05:01Z</dcterms:W3CDTF>
</rdf:Description>
</dcterms:created>
<CopasiMT:isVersionOf rdf:resource="urn:miriam:sbo:SBO:0000183"/>
</rdf:Description>
</rdf:RDF>
</COPASI>
</annotation>
<listOfProducts>
<speciesReference species="IRF9mRNA" stoichiometry="1"/>
</listOfProducts>
<listOfModifiers>
<modifierSpeciesReference species="OccGAS_ISREbs"/>
</listOfModifiers>
<kineticLaw>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<times/>
<ci> compartment </ci>
<apply>
<ci> IRF9mRNA_production_by_ISRE_1 </ci>
<ci> OccGAS_ISREbs </ci>
<ci> kmIRF9 </ci>
<ci> synthIRF9mRNA </ci>
</apply>
</apply>
</math>
<listOfParameters>
<parameter id="kmIRF9" name="kmIRF9" value="0.121"/>
<parameter id="synthIRF9mRNA" name="synthIRF9mRNA" value="18.62"/>
</listOfParameters>
</kineticLaw>
</reaction>
<reaction id="IRF9mRNA_decay" metaid="COPASI93" name="IRF9mRNA decay" reversible="false">
<annotation>
<rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:dc="http://purl.org/dc/elements/1.1/" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/">
<rdf:Description rdf:about="#COPASI93">
<bqbiol:isVersionOf>
<rdf:Bag>
<rdf:li rdf:resource="http://identifiers.org/ncit/C75947"/>
</rdf:Bag>
</bqbiol:isVersionOf>
</rdf:Description>
</rdf:RDF>
<COPASI xmlns="http://www.copasi.org/static/sbml">
<rdf:RDF xmlns:CopasiMT="http://www.copasi.org/RDF/MiriamTerms#" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#">
<rdf:Description rdf:about="#COPASI93">
<dcterms:created>
<rdf:Description>
<dcterms:W3CDTF>2019-04-15T19:04:46Z</dcterms:W3CDTF>
</rdf:Description>
</dcterms:created>
<CopasiMT:isVersionOf rdf:resource="urn:miriam:ncit:C75947"/>
</rdf:Description>
</rdf:RDF>
</COPASI>
</annotation>
<listOfReactants>
<speciesReference species="IRF9mRNA" stoichiometry="1"/>
</listOfReactants>
<kineticLaw>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<times/>
<ci> compartment </ci>
<ci> k1 </ci>
<ci> IRF9mRNA </ci>
</apply>
</math>
<listOfParameters>
<parameter id="k1" name="k1" value="0.4189"/>
</listOfParameters>
</kineticLaw>
</reaction>
<reaction id="IRF2mRNA_basal_production" metaid="COPASI94" name="IRF2mRNA basal production" reversible="false">
<annotation>
<rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:dc="http://purl.org/dc/elements/1.1/" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/">
<rdf:Description rdf:about="#COPASI94">
<bqbiol:isVersionOf>
<rdf:Bag>
<rdf:li rdf:resource="http://identifiers.org/sbo/SBO:0000183"/>
</rdf:Bag>
</bqbiol:isVersionOf>
</rdf:Description>
</rdf:RDF>
<COPASI xmlns="http://www.copasi.org/static/sbml">
<rdf:RDF xmlns:CopasiMT="http://www.copasi.org/RDF/MiriamTerms#" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#">
<rdf:Description rdf:about="#COPASI94">
<dcterms:created>
<rdf:Description>
<dcterms:W3CDTF>2019-04-15T19:03:07Z</dcterms:W3CDTF>
</rdf:Description>
</dcterms:created>
<CopasiMT:isVersionOf rdf:resource="urn:miriam:sbo:SBO:0000183"/>
</rdf:Description>
</rdf:RDF>
</COPASI>
</annotation>
<listOfProducts>
<speciesReference species="IRF2mRNA" stoichiometry="1"/>
</listOfProducts>
<kineticLaw>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<times/>
<ci> compartment </ci>
<apply>
<ci> Constant_flux__irreversible </ci>
<ci> v </ci>
</apply>
</apply>
</math>
<listOfParameters>
<parameter id="v" name="v" value="0.9833"/>
</listOfParameters>
</kineticLaw>
</reaction>
<reaction id="IRF2mRNA_production_by_ISRE" metaid="COPASI95" name="IRF2mRNA production by ISRE" reversible="false">
<annotation>
<rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:dc="http://purl.org/dc/elements/1.1/" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/">
<rdf:Description rdf:about="#COPASI95">
<bqbiol:isVersionOf>
<rdf:Bag>
<rdf:li rdf:resource="http://identifiers.org/sbo/SBO:0000183"/>
</rdf:Bag>
</bqbiol:isVersionOf>
</rdf:Description>
</rdf:RDF>
<COPASI xmlns="http://www.copasi.org/static/sbml">
<rdf:RDF xmlns:CopasiMT="http://www.copasi.org/RDF/MiriamTerms#" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#">
<rdf:Description rdf:about="#COPASI95">
<dcterms:created>
<rdf:Description>
<dcterms:W3CDTF>2019-04-15T19:03:19Z</dcterms:W3CDTF>
</rdf:Description>
</dcterms:created>
<CopasiMT:isVersionOf rdf:resource="urn:miriam:sbo:SBO:0000183"/>
</rdf:Description>
</rdf:RDF>
</COPASI>
</annotation>
<listOfProducts>
<speciesReference species="IRF2mRNA" stoichiometry="1"/>
</listOfProducts>
<listOfModifiers>
<modifierSpeciesReference species="OccGAS_ISREbs"/>
</listOfModifiers>
<kineticLaw>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<times/>
<ci> compartment </ci>
<apply>
<ci> IRF2mRNA_production_by_ISRE_1 </ci>
<ci> OccGAS_ISREbs </ci>
<ci> synthIRF2mRNA </ci>
</apply>
</apply>
</math>
<listOfParameters>
<parameter id="synthIRF2mRNA" name="synthIRF2mRNA" value="0.6775"/>
</listOfParameters>
</kineticLaw>
</reaction>
<reaction id="IRF2_translation_and_mRNA_decay" metaid="COPASI96" name="IRF2 translation and mRNA decay" reversible="false">
<annotation>
<rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:dc="http://purl.org/dc/elements/1.1/" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/">
<rdf:Description rdf:about="#COPASI96">
<bqbiol:isVersionOf>
<rdf:Bag>
<rdf:li rdf:resource="http://identifiers.org/sbo/SBO:0000184"/>
</rdf:Bag>
</bqbiol:isVersionOf>
<bqbiol:isVersionOf>
<rdf:Bag>
<rdf:li rdf:resource="http://identifiers.org/ncit/C75947"/>
</rdf:Bag>
</bqbiol:isVersionOf>
</rdf:Description>
</rdf:RDF>
<COPASI xmlns="http://www.copasi.org/static/sbml">
<rdf:RDF xmlns:CopasiMT="http://www.copasi.org/RDF/MiriamTerms#" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#">
<rdf:Description rdf:about="#COPASI96">
<dcterms:created>
<rdf:Description>
<dcterms:W3CDTF>2019-04-15T19:02:53Z</dcterms:W3CDTF>
</rdf:Description>
</dcterms:created>
<CopasiMT:isVersionOf rdf:resource="urn:miriam:ncit:C75947"/>
<CopasiMT:isVersionOf rdf:resource="urn:miriam:sbo:SBO:0000184"/>
</rdf:Description>
</rdf:RDF>
</COPASI>
</annotation>
<listOfReactants>
<speciesReference species="IRF2mRNA" stoichiometry="1"/>
</listOfReactants>
<listOfProducts>
<speciesReference species="IRF2" stoichiometry="1"/>
</listOfProducts>
<kineticLaw>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<times/>
<ci> compartment </ci>
<ci> k1 </ci>
<ci> IRF2mRNA </ci>
</apply>
</math>
<listOfParameters>
<parameter id="k1" name="k1" value="1.062"/>
</listOfParameters>
</kineticLaw>
</reaction>
<reaction id="USP18mRNA_basal_production" metaid="COPASI97" name="USP18mRNA basal production" reversible="false">
<annotation>
<rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:dc="http://purl.org/dc/elements/1.1/" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/">
<rdf:Description rdf:about="#COPASI97">
<bqbiol:isVersionOf>
<rdf:Bag>
<rdf:li rdf:resource="http://identifiers.org/sbo/SBO:0000183"/>
</rdf:Bag>
</bqbiol:isVersionOf>
</rdf:Description>
</rdf:RDF>
<COPASI xmlns="http://www.copasi.org/static/sbml">
<rdf:RDF xmlns:CopasiMT="http://www.copasi.org/RDF/MiriamTerms#" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#">
<rdf:Description rdf:about="#COPASI97">
<dcterms:created>
<rdf:Description>
<dcterms:W3CDTF>2019-04-15T19:17:21Z</dcterms:W3CDTF>
</rdf:Description>
</dcterms:created>
<CopasiMT:isVersionOf rdf:resource="urn:miriam:sbo:SBO:0000183"/>
</rdf:Description>
</rdf:RDF>
</COPASI>
</annotation>
<listOfProducts>
<speciesReference species="USP18mRNA" stoichiometry="1"/>
</listOfProducts>
<kineticLaw>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<times/>
<ci> compartment </ci>
<apply>
<ci> Constant_flux__irreversible </ci>
<ci> v </ci>
</apply>
</apply>
</math>
<listOfParameters>
<parameter id="v" name="v" value="0.06442"/>
</listOfParameters>
</kineticLaw>
</reaction>
<reaction id="USP18mRNA_production_by_ISRE" metaid="COPASI98" name="USP18mRNA production by ISRE" reversible="false">
<annotation>
<rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:dc="http://purl.org/dc/elements/1.1/" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/">
<rdf:Description rdf:about="#COPASI98">
<bqbiol:isVersionOf>
<rdf:Bag>
<rdf:li rdf:resource="http://identifiers.org/sbo/SBO:0000183"/>
</rdf:Bag>
</bqbiol:isVersionOf>
</rdf:Description>
</rdf:RDF>
<COPASI xmlns="http://www.copasi.org/static/sbml">
<rdf:RDF xmlns:CopasiMT="http://www.copasi.org/RDF/MiriamTerms#" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#">
<rdf:Description rdf:about="#COPASI98">
<dcterms:created>
<rdf:Description>
<dcterms:W3CDTF>2019-04-15T19:17:57Z</dcterms:W3CDTF>
</rdf:Description>
</dcterms:created>
<CopasiMT:isVersionOf rdf:resource="urn:miriam:sbo:SBO:0000183"/>
</rdf:Description>
</rdf:RDF>
</COPASI>
</annotation>
<listOfProducts>
<speciesReference species="USP18mRNA" stoichiometry="1"/>
</listOfProducts>
<listOfModifiers>
<modifierSpeciesReference species="OccGAS_ISREbs"/>
</listOfModifiers>
<kineticLaw>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<times/>
<ci> compartment </ci>
<apply>
<ci> USP18mRNA_production_by_ISRE_1 </ci>
<ci> OccGAS_ISREbs </ci>
<ci> synthUSP18mRNA </ci>
</apply>
</apply>
</math>
<listOfParameters>
<parameter id="synthUSP18mRNA" name="synthUSP18mRNA" value="2.784"/>
</listOfParameters>
</kineticLaw>
</reaction>
<reaction id="USP18mRNA_decay" metaid="COPASI99" name="USP18mRNA decay" reversible="false">
<annotation>
<rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:dc="http://purl.org/dc/elements/1.1/" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/">
<rdf:Description rdf:about="#COPASI99">
<bqbiol:isVersionOf>
<rdf:Bag>
<rdf:li rdf:resource="http://identifiers.org/ncit/C75947"/>
</rdf:Bag>
</bqbiol:isVersionOf>
</rdf:Description>
</rdf:RDF>
<COPASI xmlns="http://www.copasi.org/static/sbml">
<rdf:RDF xmlns:CopasiMT="http://www.copasi.org/RDF/MiriamTerms#" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#">
<rdf:Description rdf:about="#COPASI99">
<dcterms:created>
<rdf:Description>
<dcterms:W3CDTF>2019-04-15T19:17:45Z</dcterms:W3CDTF>
</rdf:Description>
</dcterms:created>
<CopasiMT:isVersionOf rdf:resource="urn:miriam:ncit:C75947"/>
</rdf:Description>
</rdf:RDF>
</COPASI>
</annotation>
<listOfReactants>
<speciesReference species="USP18mRNA" stoichiometry="1"/>
</listOfReactants>
<kineticLaw>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<times/>
<ci> compartment </ci>
<ci> k1 </ci>
<ci> USP18mRNA </ci>
</apply>
</math>
<listOfParameters>
<parameter id="k1" name="k1" value="0.09103"/>
</listOfParameters>
</kineticLaw>
</reaction>
<reaction id="SOCS1mRNA_basal_production" metaid="COPASI100" name="SOCS1mRNA basal production" reversible="false">
<annotation>
<rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:dc="http://purl.org/dc/elements/1.1/" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/">
<rdf:Description rdf:about="#COPASI100">
<bqbiol:isVersionOf>
<rdf:Bag>
<rdf:li rdf:resource="http://identifiers.org/sbo/SBO:0000393"/>
</rdf:Bag>
</bqbiol:isVersionOf>
</rdf:Description>
</rdf:RDF>
<COPASI xmlns="http://www.copasi.org/static/sbml">
<rdf:RDF xmlns:CopasiMT="http://www.copasi.org/RDF/MiriamTerms#" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#">
<rdf:Description rdf:about="#COPASI100">
<dcterms:created>
<rdf:Description>
<dcterms:W3CDTF>2019-04-15T19:11:38Z</dcterms:W3CDTF>
</rdf:Description>
</dcterms:created>
<CopasiMT:isVersionOf rdf:resource="urn:miriam:sbo:SBO:0000393"/>
</rdf:Description>
</rdf:RDF>
</COPASI>
</annotation>
<listOfProducts>
<speciesReference species="SOCS1mRNA" stoichiometry="1"/>
</listOfProducts>
<kineticLaw>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<times/>
<ci> compartment </ci>
<apply>
<ci> Constant_flux__irreversible </ci>
<ci> v </ci>
</apply>
</apply>
</math>
<listOfParameters>
<parameter id="v" name="v" value="1.301"/>
</listOfParameters>
</kineticLaw>
</reaction>
<reaction id="SOCS1mRNA_production_by_ISRE" metaid="COPASI101" name="SOCS1mRNA production by ISRE" reversible="false">
<annotation>
<rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:dc="http://purl.org/dc/elements/1.1/" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/">
<rdf:Description rdf:about="#COPASI101">
<bqbiol:isVersionOf>
<rdf:Bag>
<rdf:li rdf:resource="http://identifiers.org/sbo/SBO:0000183"/>
</rdf:Bag>
</bqbiol:isVersionOf>
</rdf:Description>
</rdf:RDF>
<COPASI xmlns="http://www.copasi.org/static/sbml">
<rdf:RDF xmlns:CopasiMT="http://www.copasi.org/RDF/MiriamTerms#" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#">
<rdf:Description rdf:about="#COPASI101">
<dcterms:created>
<rdf:Description>
<dcterms:W3CDTF>2019-04-15T19:12:07Z</dcterms:W3CDTF>
</rdf:Description>
</dcterms:created>
<CopasiMT:isVersionOf rdf:resource="urn:miriam:sbo:SBO:0000183"/>
</rdf:Description>
</rdf:RDF>
</COPASI>
</annotation>
<listOfProducts>
<speciesReference species="SOCS1mRNA" stoichiometry="1"/>
</listOfProducts>
<listOfModifiers>
<modifierSpeciesReference species="OccGAS_ISREbs"/>
</listOfModifiers>
<kineticLaw>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<times/>
<ci> compartment </ci>
<apply>
<ci> SOCS1mRNA_production_by_ISRE_1 </ci>
<ci> OccGAS_ISREbs </ci>
<ci> synthSOCS1mRNA </ci>
</apply>
</apply>
</math>
<listOfParameters>
<parameter id="synthSOCS1mRNA" name="synthSOCS1mRNA" value="8.848"/>
</listOfParameters>
</kineticLaw>
</reaction>
<reaction id="SOCS1mRNA_decay" metaid="COPASI102" name="SOCS1mRNA decay" reversible="false">
<annotation>
<rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:dc="http://purl.org/dc/elements/1.1/" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/">
<rdf:Description rdf:about="#COPASI102">
<bqbiol:isVersionOf>
<rdf:Bag>
<rdf:li rdf:resource="http://identifiers.org/ncit/C75947"/>
</rdf:Bag>
</bqbiol:isVersionOf>
</rdf:Description>
</rdf:RDF>
<COPASI xmlns="http://www.copasi.org/static/sbml">
<rdf:RDF xmlns:CopasiMT="http://www.copasi.org/RDF/MiriamTerms#" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#">
<rdf:Description rdf:about="#COPASI102">
<dcterms:created>
<rdf:Description>
<dcterms:W3CDTF>2019-04-15T19:11:37Z</dcterms:W3CDTF>
</rdf:Description>
</dcterms:created>
<CopasiMT:isVersionOf rdf:resource="urn:miriam:ncit:C75947"/>
</rdf:Description>
</rdf:RDF>
</COPASI>
</annotation>
<listOfReactants>
<speciesReference species="SOCS1mRNA" stoichiometry="1"/>
</listOfReactants>
<listOfModifiers>
<modifierSpeciesReference species="IRF2"/>
</listOfModifiers>
<kineticLaw>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<times/>
<ci> compartment </ci>
<apply>
<ci> SOCS1mRNA_decay_1 </ci>
<ci> IRF2 </ci>
<ci> SOCS1mRNA </ci>
<ci> hlSOCS1mRNA </ci>
</apply>
</apply>
</math>
<listOfParameters>
<parameter id="hlSOCS1mRNA" name="hlSOCS1mRNA" value="0.5644"/>
</listOfParameters>
</kineticLaw>
</reaction>
<reaction id="SOCS3mRNA_basal_production" metaid="COPASI103" name="SOCS3mRNA basal production" reversible="false">
<annotation>
<rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:dc="http://purl.org/dc/elements/1.1/" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/">
<rdf:Description rdf:about="#COPASI103">
<bqbiol:isVersionOf>
<rdf:Bag>
<rdf:li rdf:resource="http://identifiers.org/sbo/SBO:0000393"/>
</rdf:Bag>
</bqbiol:isVersionOf>
</rdf:Description>
</rdf:RDF>
<COPASI xmlns="http://www.copasi.org/static/sbml">
<rdf:RDF xmlns:CopasiMT="http://www.copasi.org/RDF/MiriamTerms#" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#">
<rdf:Description rdf:about="#COPASI103">
<dcterms:created>
<rdf:Description>
<dcterms:W3CDTF>2019-04-15T19:10:00Z</dcterms:W3CDTF>
</rdf:Description>
</dcterms:created>
<CopasiMT:isVersionOf rdf:resource="urn:miriam:sbo:SBO:0000393"/>
</rdf:Description>
</rdf:RDF>
</COPASI>
</annotation>
<listOfProducts>
<speciesReference species="SOCS3mRNA" stoichiometry="1"/>
</listOfProducts>
<kineticLaw>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<times/>
<ci> compartment </ci>
<apply>
<ci> Constant_flux__irreversible </ci>
<ci> v </ci>
</apply>
</apply>
</math>
<listOfParameters>
<parameter id="v" name="v" value="1.257"/>
</listOfParameters>
</kineticLaw>
</reaction>
<reaction id="SOCS3mRNA_production_by_ISRE" metaid="COPASI104" name="SOCS3mRNA production by ISRE" reversible="false">
<annotation>
<rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:dc="http://purl.org/dc/elements/1.1/" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/">
<rdf:Description rdf:about="#COPASI104">
<bqbiol:isVersionOf>
<rdf:Bag>
<rdf:li rdf:resource="http://identifiers.org/sbo/SBO:0000183"/>
</rdf:Bag>
</bqbiol:isVersionOf>
</rdf:Description>
</rdf:RDF>
<COPASI xmlns="http://www.copasi.org/static/sbml">
<rdf:RDF xmlns:CopasiMT="http://www.copasi.org/RDF/MiriamTerms#" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#">
<rdf:Description rdf:about="#COPASI104">
<dcterms:created>
<rdf:Description>
<dcterms:W3CDTF>2019-04-15T19:13:10Z</dcterms:W3CDTF>
</rdf:Description>
</dcterms:created>
<CopasiMT:isVersionOf rdf:resource="urn:miriam:sbo:SBO:0000183"/>
</rdf:Description>
</rdf:RDF>
</COPASI>
</annotation>
<listOfProducts>
<speciesReference species="SOCS3mRNA" stoichiometry="1"/>
</listOfProducts>
<listOfModifiers>
<modifierSpeciesReference species="OccGASbs"/>
</listOfModifiers>
<kineticLaw>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<times/>
<ci> compartment </ci>
<apply>
<ci> SOCS3mRNA_production_by_ISRE_1 </ci>
<ci> OccGASbs </ci>
<ci> synthSOCS3mRNA </ci>
</apply>
</apply>
</math>
<listOfParameters>
<parameter id="synthSOCS3mRNA" name="synthSOCS3mRNA" value="0.01205"/>
</listOfParameters>
</kineticLaw>
</reaction>
<reaction id="SOCS3mRNA_decay" metaid="COPASI105" name="SOCS3mRNA decay" reversible="false">
<annotation>
<rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:dc="http://purl.org/dc/elements/1.1/" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/">
<rdf:Description rdf:about="#COPASI105">
<bqbiol:isVersionOf>
<rdf:Bag>
<rdf:li rdf:resource="http://identifiers.org/ncit/C75947"/>
</rdf:Bag>
</bqbiol:isVersionOf>
</rdf:Description>
</rdf:RDF>
<COPASI xmlns="http://www.copasi.org/static/sbml">
<rdf:RDF xmlns:CopasiMT="http://www.copasi.org/RDF/MiriamTerms#" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#">
<rdf:Description rdf:about="#COPASI105">
<dcterms:created>
<rdf:Description>
<dcterms:W3CDTF>2019-04-15T19:12:52Z</dcterms:W3CDTF>
</rdf:Description>
</dcterms:created>
<CopasiMT:isVersionOf rdf:resource="urn:miriam:ncit:C75947"/>
</rdf:Description>
</rdf:RDF>
</COPASI>
</annotation>
<listOfReactants>
<speciesReference species="SOCS3mRNA" stoichiometry="1"/>
</listOfReactants>
<kineticLaw>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<times/>
<ci> compartment </ci>
<ci> k1 </ci>
<ci> SOCS3mRNA </ci>
</apply>
</math>
<listOfParameters>
<parameter id="k1" name="k1" value="1.163"/>
</listOfParameters>
</kineticLaw>
</reaction>
<reaction id="IRF2_degradation" metaid="COPASI106" name="IRF2 degradation" reversible="false">
<annotation>
<rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:dc="http://purl.org/dc/elements/1.1/" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/">
<rdf:Description rdf:about="#COPASI106">
<bqbiol:isVersionOf>
<rdf:Bag>
<rdf:li rdf:resource="http://identifiers.org/sbo/SBO:0000179"/>
</rdf:Bag>
</bqbiol:isVersionOf>
</rdf:Description>
</rdf:RDF>
<COPASI xmlns="http://www.copasi.org/static/sbml">
<rdf:RDF xmlns:CopasiMT="http://www.copasi.org/RDF/MiriamTerms#" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#">
<rdf:Description rdf:about="#COPASI106">
<dcterms:created>
<rdf:Description>
<dcterms:W3CDTF>2019-04-15T19:02:36Z</dcterms:W3CDTF>
</rdf:Description>
</dcterms:created>
<CopasiMT:isVersionOf rdf:resource="urn:miriam:sbo:SBO:0000179"/>
</rdf:Description>
</rdf:RDF>
</COPASI>
</annotation>
<listOfReactants>
<speciesReference species="IRF2" stoichiometry="1"/>
</listOfReactants>
<kineticLaw>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<times/>
<ci> compartment </ci>
<ci> k1 </ci>
<ci> IRF2 </ci>
</apply>
</math>
<listOfParameters>
<parameter id="k1" name="k1" value="0.552"/>
</listOfParameters>
</kineticLaw>
</reaction>
<reaction id="Linear_chain_for_time_delay_in_STAT1_translation" metaid="COPASI107" name="Linear chain for time delay in STAT1 translation" reversible="false">
<annotation>
<rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:dc="http://purl.org/dc/elements/1.1/" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/">
<rdf:Description rdf:about="#COPASI107">
<bqbiol:isVersionOf>
<rdf:Bag>
<rdf:li rdf:resource="http://identifiers.org/sbo/SBO:0000184"/>
</rdf:Bag>
</bqbiol:isVersionOf>
</rdf:Description>
</rdf:RDF>
<COPASI xmlns="http://www.copasi.org/static/sbml">
<rdf:RDF xmlns:CopasiMT="http://www.copasi.org/RDF/MiriamTerms#" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#">
<rdf:Description rdf:about="#COPASI107">
<dcterms:created>
<rdf:Description>
<dcterms:W3CDTF>2019-04-15T19:07:24Z</dcterms:W3CDTF>
</rdf:Description>
</dcterms:created>
<CopasiMT:isVersionOf rdf:resource="urn:miriam:sbo:SBO:0000184"/>
</rdf:Description>
</rdf:RDF>
</COPASI>
</annotation>
<listOfProducts>
<speciesReference species="STAT1_LC_1" stoichiometry="1"/>
</listOfProducts>
<listOfModifiers>
<modifierSpeciesReference species="STAT1mRNA"/>
</listOfModifiers>
<kineticLaw>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<times/>
<ci> compartment </ci>
<apply>
<ci> Linear_chain_for_time_delay_in_STAT1_translation_1 </ci>
<ci> STAT1mRNA </ci>
<ci> kmsynthSTAT1 </ci>
<ci> synthSTAT1 </ci>
</apply>
</apply>
</math>
<listOfParameters>
<parameter id="kmsynthSTAT1" name="kmsynthSTAT1" value="5.373"/>
<parameter id="synthSTAT1" name="synthSTAT1" value="1533000"/>
</listOfParameters>
</kineticLaw>
</reaction>
<reaction id="STAT1_chain_step_1" metaid="COPASI108" name="STAT1 chain step 1" reversible="false">
<annotation>
<rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:dc="http://purl.org/dc/elements/1.1/" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/">
<rdf:Description rdf:about="#COPASI108">
<bqbiol:isVersionOf>
<rdf:Bag>
<rdf:li rdf:resource="http://identifiers.org/omit/0011435"/>
</rdf:Bag>
</bqbiol:isVersionOf>
</rdf:Description>
</rdf:RDF>
<COPASI xmlns="http://www.copasi.org/static/sbml">
<rdf:RDF xmlns:CopasiMT="http://www.copasi.org/RDF/MiriamTerms#" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#">
<rdf:Description rdf:about="#COPASI108">
<dcterms:created>
<rdf:Description>
<dcterms:W3CDTF>2019-04-15T19:13:24Z</dcterms:W3CDTF>
</rdf:Description>
</dcterms:created>
<CopasiMT:isVersionOf rdf:resource="urn:miriam:omit:0011435"/>
</rdf:Description>
</rdf:RDF>
</COPASI>
</annotation>
<listOfReactants>
<speciesReference species="STAT1_LC_1" stoichiometry="1"/>
</listOfReactants>
<listOfProducts>
<speciesReference species="STAT1_LC_2" stoichiometry="1"/>
</listOfProducts>
<kineticLaw>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<times/>
<ci> compartment </ci>
<ci> k1 </ci>
<ci> STAT1_LC_1 </ci>
</apply>
</math>
<listOfParameters>
<parameter id="k1" name="k1" value="0.5275"/>
</listOfParameters>
</kineticLaw>
</reaction>
<reaction id="STAT1_chain_step_2" metaid="COPASI109" name="STAT1 chain step 2" reversible="false">
<annotation>
<rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:dc="http://purl.org/dc/elements/1.1/" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/">
<rdf:Description rdf:about="#COPASI109">
<bqbiol:isVersionOf>
<rdf:Bag>
<rdf:li rdf:resource="http://identifiers.org/omit/0011435"/>
</rdf:Bag>
</bqbiol:isVersionOf>
</rdf:Description>
</rdf:RDF>
<COPASI xmlns="http://www.copasi.org/static/sbml">
<rdf:RDF xmlns:CopasiMT="http://www.copasi.org/RDF/MiriamTerms#" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#">
<rdf:Description rdf:about="#COPASI109">
<dcterms:created>
<rdf:Description>
<dcterms:W3CDTF>2019-04-15T19:13:33Z</dcterms:W3CDTF>
</rdf:Description>
</dcterms:created>
<CopasiMT:isVersionOf rdf:resource="urn:miriam:omit:0011435"/>
</rdf:Description>
</rdf:RDF>
</COPASI>
</annotation>
<listOfReactants>
<speciesReference species="STAT1_LC_2" stoichiometry="1"/>
</listOfReactants>
<listOfProducts>
<speciesReference species="STAT1_LC_3" stoichiometry="1"/>
</listOfProducts>
<kineticLaw>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<times/>
<ci> compartment </ci>
<ci> k1 </ci>
<ci> STAT1_LC_2 </ci>
</apply>
</math>
<listOfParameters>
<parameter id="k1" name="k1" value="0.5275"/>
</listOfParameters>
</kineticLaw>
</reaction>
<reaction id="STAT1_chain_step3" metaid="COPASI110" name="STAT1 chain step3" reversible="false">
<annotation>
<rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:dc="http://purl.org/dc/elements/1.1/" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/">
<rdf:Description rdf:about="#COPASI110">
<bqbiol:isVersionOf>
<rdf:Bag>
<rdf:li rdf:resource="http://identifiers.org/omit/0011435"/>
</rdf:Bag>
</bqbiol:isVersionOf>
</rdf:Description>
</rdf:RDF>
<COPASI xmlns="http://www.copasi.org/static/sbml">
<rdf:RDF xmlns:CopasiMT="http://www.copasi.org/RDF/MiriamTerms#" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#">
<rdf:Description rdf:about="#COPASI110">
<dcterms:created>
<rdf:Description>
<dcterms:W3CDTF>2019-04-15T19:13:43Z</dcterms:W3CDTF>
</rdf:Description>
</dcterms:created>
<CopasiMT:isVersionOf rdf:resource="urn:miriam:omit:0011435"/>
</rdf:Description>
</rdf:RDF>
</COPASI>
</annotation>
<listOfReactants>
<speciesReference species="STAT1_LC_3" stoichiometry="1"/>
</listOfReactants>
<listOfProducts>
<speciesReference species="STAT1c" stoichiometry="1"/>
</listOfProducts>
<kineticLaw>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<times/>
<ci> compartment </ci>
<ci> k1 </ci>
<ci> STAT1_LC_3 </ci>
</apply>
</math>
<listOfParameters>
<parameter id="k1" name="k1" value="0.5275"/>
</listOfParameters>
</kineticLaw>
</reaction>
<reaction id="Linear_chain_for_time_delay_in_STAT2_translation" metaid="COPASI111" name="Linear chain for time delay in STAT2 translation" reversible="false">
<annotation>
<rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:dc="http://purl.org/dc/elements/1.1/" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/">
<rdf:Description rdf:about="#COPASI111">
<bqbiol:isVersionOf>
<rdf:Bag>
<rdf:li rdf:resource="http://identifiers.org/sbo/SBO:0000184"/>
</rdf:Bag>
</bqbiol:isVersionOf>
</rdf:Description>
</rdf:RDF>
<COPASI xmlns="http://www.copasi.org/static/sbml">
<rdf:RDF xmlns:CopasiMT="http://www.copasi.org/RDF/MiriamTerms#" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#">
<rdf:Description rdf:about="#COPASI111">
<dcterms:created>
<rdf:Description>
<dcterms:W3CDTF>2019-04-15T19:07:41Z</dcterms:W3CDTF>
</rdf:Description>
</dcterms:created>
<CopasiMT:isVersionOf rdf:resource="urn:miriam:sbo:SBO:0000184"/>
</rdf:Description>
</rdf:RDF>
</COPASI>
</annotation>
<listOfProducts>
<speciesReference species="STAT2_LC_1" stoichiometry="1"/>
</listOfProducts>
<listOfModifiers>
<modifierSpeciesReference species="STAT2mRNA"/>
</listOfModifiers>
<kineticLaw>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<times/>
<ci> compartment </ci>
<apply>
<ci> Linear_chain_for_time_delay_in_STAT2_translation_1 </ci>
<ci> STAT2mRNA </ci>
<ci> synthSTAT2 </ci>
</apply>
</apply>
</math>
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</math>
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</math>
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<reaction id="Linear_chain_for_time_delay_in_SOCS1_translation" metaid="COPASI123" name="Linear chain for time delay in SOCS1 translation" reversible="false">
<annotation>
<rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:dc="http://purl.org/dc/elements/1.1/" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/">
<rdf:Description rdf:about="#COPASI123">
<bqbiol:isVersionOf>
<rdf:Bag>
<rdf:li rdf:resource="http://identifiers.org/sbo/SBO:0000184"/>
</rdf:Bag>
</bqbiol:isVersionOf>
</rdf:Description>
</rdf:RDF>
<COPASI xmlns="http://www.copasi.org/static/sbml">
<rdf:RDF xmlns:CopasiMT="http://www.copasi.org/RDF/MiriamTerms#" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#">
<rdf:Description rdf:about="#COPASI123">
<dcterms:created>
<rdf:Description>
<dcterms:W3CDTF>2019-04-15T19:06:36Z</dcterms:W3CDTF>
</rdf:Description>
</dcterms:created>
<CopasiMT:isVersionOf rdf:resource="urn:miriam:sbo:SBO:0000184"/>
</rdf:Description>
</rdf:RDF>
</COPASI>
</annotation>
<listOfProducts>
<speciesReference species="SOCS1_LC_1" stoichiometry="1"/>
</listOfProducts>
<listOfModifiers>
<modifierSpeciesReference species="SOCS1mRNA"/>
</listOfModifiers>
<kineticLaw>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<times/>
<ci> compartment </ci>
<apply>
<ci> Linear_chain_for_time_delay_in_SOCS1_translation_1 </ci>
<ci> SOCS1mRNA </ci>
<ci> synthSOCS1 </ci>
</apply>
</apply>
</math>
<listOfParameters>
<parameter id="synthSOCS1" name="synthSOCS1" value="0.9029"/>
</listOfParameters>
</kineticLaw>
</reaction>
<reaction id="SOCS1_chain_step_1" metaid="COPASI124" name="SOCS1 chain step 1" reversible="false">
<annotation>
<rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:dc="http://purl.org/dc/elements/1.1/" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/">
<rdf:Description rdf:about="#COPASI124">
<bqbiol:hasProperty>
<rdf:Bag>
<rdf:li rdf:resource="http://identifiers.org/omit/0011435"/>
</rdf:Bag>
</bqbiol:hasProperty>
</rdf:Description>
</rdf:RDF>
<COPASI xmlns="http://www.copasi.org/static/sbml">
<rdf:RDF xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#">
<rdf:Description rdf:about="#COPASI124">
<bqbiol:hasProperty rdf:resource="urn:miriam:omit:0011435"/>
<dcterms:created>
<rdf:Description>
<dcterms:W3CDTF>2019-04-15T19:11:12Z</dcterms:W3CDTF>
</rdf:Description>
</dcterms:created>
</rdf:Description>
</rdf:RDF>
</COPASI>
</annotation>
<listOfReactants>
<speciesReference species="SOCS1_LC_1" stoichiometry="1"/>
</listOfReactants>
<listOfProducts>
<speciesReference species="SOCS1" stoichiometry="1"/>
</listOfProducts>
<kineticLaw>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<times/>
<ci> compartment </ci>
<ci> k1 </ci>
<ci> SOCS1_LC_1 </ci>
</apply>
</math>
<listOfParameters>
<parameter id="k1" name="k1" value="0.9029"/>
</listOfParameters>
</kineticLaw>
</reaction>
</listOfReactions>
</model>
</sbml>