Web page: https://itb.biologie.hu-berlin.de/
City: 10115 Berlin
Philippstr. 13, Haus 4
We are investigating liver metabolism and function with the help of computational models and methods.
Read more about the LiSyM junior group at: www.livermetabolism.com
Junior Group Leader
Dr. Matthias König
Institute for Theoretical Biology
Invalidenstraße 43, 10117 Berlin, Germany
phone +49 30 2093-8450
The liver is the central metabolic organ of our body playing a crucial role in the clearance of drugs, xenobiotics and numerous metabolites
Non-alcoholic fatty liver disease (NAFLD) is the most common chronic liver disease worldwide. LiSyM-EMI looks into the transition from steatosis to non-alcoholic steatohepatitis (NASH) as the disease-defining moment in NAFLD. A systems analysis of these early disease events will be performed to elucidate the molecular mechanisms that trigger disease establishment.
Data (breath tests scores, imaging data from MRE, histopathological characterization and proteomics data of liver biopsies) will be acquired from two different groups of patients to be used in computer-assisted diagnostic tools for early detection and comprehensive evaluation of altered liver functions.
Public web page: Not specified
Organisms: Not specified