Web page: https://itb.biologie.hu-berlin.de/
City: 10115 Berlin
Philippstr. 13, Haus 4
We are investigating liver metabolism and function with the help of computational models and methods.
Read more about the LiSyM junior group at: https://www.livermetabolism.com
Junior Group Leader
Dr. Matthias König
Institute for Theoretical Biology
Invalidenstraße 110, 10115 Berlin, Germany
phone +49 30 2093-98435
The liver is the central metabolic organ of our body playing a crucial role in the clearance of drugs, xenobiotics and numerous
Former postdoc in the Theoretical Biophysics group headed by Edda Klipp at Humboldt-Universität zu Berlin and member of the LiSyM network, I am now an independent Group Leader at the Technical University of Munich focusing on developing an advanced bioinformatics toolbox for analyzing, integrating, and mining of various omics data in the context of precision medicine as well as molecular disease and patient subtyping.
Projects: LiSyM-Krebs Partneringhttps://orcid.org/0000-0003-2217-1655
Interested in modelling metabolism, predicting metabolic phenotypes and dynamic transitions in metabolism. Also using partially and incompletely characterized models (probabilistic predictions).
This generic project is intended to be a forum for all LiSyM partner and external stakeholders interested in participating in the BMBF initiative LiSyM-Krebs.
Organisms: Not specified
Disorders of the liver show up through changes in blood tests. These blood tests indicate markers for events taking place in the liver. Usually studies of liver tissue cannot be performed: as liver samples would need to be obtained through a liver biopsy, and this procedure is not without risk, therefore these samples are usually unavailable. Complex metabolism models based on existing and new scientific data can simulate changes in the liver caused by disease. They often reveal unknown relationships
Programme: LiSyM: Liver Systems Medicine
Start date: 1st Jan 2016
Organisms: Homo sapiens
One of the tasks of the healthy liver is to store fat. Yet, at some stage, too much fat makes the liver sick. One critical time point occurs when a healthy fatty liver becomes inflamed and progresses to steatohepatitis, or NASH.
LiSyM-Pillar I will identify what events lead to this transition. Does it occur in all parts of the liver? Which molecules indicate that it is taking place? Can the degeneration be stopped or undone - and if so, how?
Dr. Matthias König (Humboldt University, Berlin) models the human liver on the computer. His simulations show the extent of individual differences in liver function and the external factors influencing it. König has shown that smoking falsifies the result of an important liver test (LiMAx). With his models, drug doses can be calculated so that they can be administered in doses that do not harm the liver.