Projects: LiSyM Pillar I: Early Metabolic Injury (LiSyM-EMI), LiSyM network, LiSyM-Krebs Partnering
Institutions: Humboldt-Universität zu Berlin - Institute for Theoretical Biology (ITB), Technical University Munich - Klinikum rechts der Isar
Former postdoc in the Theoretical Biophysics group headed by Edda Klipp at Humboldt-Universität zu Berlin and member of the LiSyM network, I am now an independent Group Leader at the Technical University of Munich focusing on developing an advanced bioinformatics toolbox for analyzing, integrating, and mining of various omics data in the context of precision medicine as well as molecular disease and patient subtyping.
Projects: LiSyM Pillar II: Chronic Liver Disease Progression (LiSyM-DP), LiSyM Pillar III: Regeneration and Repair in Acute-on-Chronic Liver Failure (LiSyM-ACLF), LiSyM network
Institutions: Universitätsklinikum Düsseldorf - Klinik für Gastroenterologie, Hepatologie und Infektiologiehttps://orcid.org/0000-0003-0103-1856
Expertise: Biochemistry, Hepatocytes, Inflammation, Liver injury and regeneration, MAP kinases, Macrophages, Jak/STAT pathway, RNA stability, Molecular Biology, wet lab, non parenchymal cells
Tools: Milliplex analysis, qPCR, Molecular Biology, Laser scan microscopy, Immunohistochemistry, Cell and tissue culture, confocal microscopy, Mouse surgery, RNA analysis, rtPCR, Cytometry and fluorescent microscopy, Mouse experiments in vivo, Isolation of primary cells (hepatocytes and non-parenchymal cells)
I received my diploma in biology in 2001 from the Heinrich-Heine-University in Duesseldorf and the Dr. rer. nat. (Ph.D.) degree in 2006 from the University of Hohenheim in Germany. The practical part of my Ph.D. thesis had been realized at the clinic for gastroenterology, hepatology and infectiology at the university hospital in Duesseldorf. After my Ph.D. I focussed my studies on MAP-kinase-regulated cytokine/chemokine expression in response to bacterial or viral pathogens with a main issue on ...
Projects: LiSyM Core Infrastructure and Management (LiSyM-PD), LiSyM Pillar I: Early Metabolic Injury (LiSyM-EMI), LiSyM Pillar II: Chronic Liver Disease Progression (LiSyM-DP), LiSyM Pillar III: Regeneration and Repair in Acute-on-Chronic Liver Failure (LiSyM-ACLF), LiSyM Pillar IV: Liver Function Diagnostics (LiSyM-LiFuDi), Model Guided Pharmacotherapy In Chronic Liver Disease (LiSyM-MGP), Molecular Steatosis - Imaging & Modeling (LiSyM-MSIM), The Hedgehog Signalling Pathway (LiSyM-JGMMS), Multi-Scale Models for Personalized Liver Function Tests (LiSyM-MM-PLF), LiSyM PALs, LiSyM network, LiSyM-Krebs Partnering
Institutions: HITS gGmbHhttps://orcid.org/0000-0002-8683-7084
Expertise: Data Management, Databases, Biochemistry, Bioinformatics, Systems Biology, Standards
Tools: kinetic modelling, Databases, Mathematical Modelling, Ontologies, Workflows
Data management and standardization expert for systems biology and systems medicine, responsible for the data management user requirements and user contacts within the German LiSyM network (Liver Systems Medicine: http://lisym.org/) and associated to the FAIRDOM team. Involved in different standardization initiatives and committees, i.e. COMBINE (http://co.mbine.org), ISO/TC 276 Biotechnology (https://www.iso.org/committee/4514241.html), European COST action CHARME (http://www.cost-charme.eu) and ...