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A frequent misinterpretation in current research on liver fibrosis: the vessel in the center of CCl4-induced pseudolobules is a portal vein.
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Carbon tetrachloride-induced liver injury is a thoroughly studied model for regeneration and fibrosis in rodents. Nevertheless, its pattern of liver fibrosis is frequently misinterpreted as portal type. To clarify this, we show that collagen type IV+ "streets" and alpha-SMA+ cells accumulate pericentrally and extend to neighbouring central areas of the liver lobule, forming a 'pseudolobule'. Blood vessels in the center of such pseudolobules are portal veins as indicated by the presence of bile duct cells (CK19+) and the absence of pericentral hepatocytes (glutamine synthetase+). It is critical to correctly describe this pattern of fibrosis, particulary for metabolic zonation studies.
SEEK ID: https://seek.lisym.org/publications/36
PubMed ID: 28825120
Projects: LiSyM Pillar II: Chronic Liver Disease Progression (LiSyM-DP), LiSyM Pillar III: Regeneration and Repair in Acute-on-Chronic Liver Fail..., LiSyM network
Publication type: Not specified
Journal: Arch Toxicol
Citation: Arch Toxicol. 2017 Aug 19. doi: 10.1007/s00204-017-2040-8.
Date Published: 22nd Aug 2017
Registered Mode: Not specified
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Views: 4031
Created: 23rd Aug 2017 at 11:21
Last updated: 8th Mar 2024 at 07:44
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