Leibniz-Institut für Arbeitsforschung (IfADo)

This comprises the whole LiSyM network

The incidence of this life-threatening acute-on-chronic liver failure (ACLF) is increasing, and early detection and cure are urgent clinical needs. Pillar III applies a Systems Medicine approach to identify the critical mechanisms of acute-on-chronic liver failure (ACLF) and to foster liver regeneration and repair.

Chronic liver diseases (CLD) progression leads to cirrhosis, often cancer, and ultimately to organ failure and death. Because of the complexity of this scenario, a Systems Medicine approach is chosen to develop strategies to better characterize progression and resolution of fibrosis. Pillar II aims to define key molecular mechanisms and structural changes in tissue architecture during the progression of CLD by visualizing and quantifying at a cellular level, tissue and organ scale.

Lipid droplet accumulation is the primary cellular phenotype that is interpreted as fat deposition at organ level in steatosis. The goal of this project is to establish a model that bridges molecular lipogenic stimuli with compromised liver functions.
Approach:
– Functional imaging of hepatic transport mechanisms
– Systems modeling of lipid droplet formation

Approach:
– Systems modeling of hepatic metabolism in liver diseases
– Control mechanisms of liver regeneration