Morpheus model of spatio-temporal Smo regulation in response to Hh signaling Version 1
The model is adapted from A.P. Kupinski, I. Raabe, M. Michel, D. Ail, L. Brusch, T. Weidemann, C. Bökel (2013) Phosphorylation of the Smo tail is controlled by membrane localization and is dispensable for clustering, J. Cell Sci., 126, 20, 4684-4697 doi: 10.1242/jcs.128926
The model format is MorpheusML that can readily be loaded and run in Morpheus: https://imc.zih.tu-dresden.de//wiki/morpheus
SEEK ID: https://seek.lisym.org/models/3?version=1
1 item is associated with this Model:-
endocytosis_and_signaling_Morpheus.xml (XML document - 4 KB)
Organism: Not specified
Model type: Ordinary differential equations (ODE)
Model format: MorpheusML
Execution or visualisation environment: Morpheus
Model image: No image specified
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Contributor and Creators
Views: 1228 Downloads: 902
Created: 21st Jul 2017 at 16:58
Last updated: 24th Nov 2017 at 14:33
Last used: 19th Sep 2019 at 12:45
AttributionsNone
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https://orcid.org/0000-0003-0137-5106
Non-alcoholic fatty liver disease (NAFLD) is the most common chronic liver disease worldwide. LiSyM-EMI looks into the transition from steatosis to non-alcoholic steatohepatitis (NASH) as the disease-defining moment in NAFLD. A systems analysis of these early disease events will be performed to elucidate the molecular mechanisms that trigger disease establishment.
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