Morpheus model of spatio-temporal Smo regulation in response to Hh signaling Version 2
The model is adapted from A.P. Kupinski, I. Raabe, M. Michel, D. Ail, L. Brusch, T. Weidemann, C. Bökel (2013) Phosphorylation of the Smo tail is controlled by membrane localization and is dispensable for clustering, J. Cell Sci., 126, 20, 4684-4697 https://doi.org/10.1242/jcs.128926
The model format is MorpheusML that can readily be loaded and run in Morpheus: https://morpheus.gitlab.io
SEEK ID: https://seek.lisym.org/models/3?version=2
1 item is associated with this Model:-
endocytosis_and_signaling_Morpheus.xml (XML document - 5.47 KB)
Organism: Not specified
Model type: Ordinary differential equations (ODE)
Model format: MorpheusML
Execution or visualisation environment: Morpheus
Model image: No image specified
Export PNG
Creators and Submitter
Views: 2135 Downloads: 979
Created: 21st Jul 2017 at 16:58
Last updated: 4th Dec 2020 at 22:56
Last used: 21st Apr 2021 at 19:16
AttributionsNone
Related items
https://orcid.org/0000-0003-0137-5106
One of the tasks of the healthy liver is to store fat. Yet, at some stage, too much fat makes the liver sick. One critical time point occurs when a healthy fatty liver becomes inflamed and progresses to steatohepatitis, or NASH.
LiSyM-Pillar I will identify what events lead to this transition. Does it occur in all parts of the liver? Which molecules indicate that it is taking place? Can the degeneration be stopped or undone - and if so, how?
Programme: LiSyM: Liver Systems Medicine
Public web page: http://www.lisym.org/our-work/pillar-research/zones-of-the-liver
Start date: 1st Jan 2016
