Lysyl Oxidases as Targets for Cancer Therapy and Diagnostic Imaging

        The understanding of the contribution of the tumour microenvironment to cancer progression and metastasis, in particular the interplay between tumour cells, fibroblasts and the extracellular matrix has grown tremendously over the last years. Lysyl oxidases are increasingly recognised as key players in this context, in addition to their function as drivers of fibrotic diseases. These insights have considerably stimulated drug discovery efforts towards lysyl oxidases as targets over the last decade. This review article summarises the biochemical and structural properties of theses enzymes. Their involvement in tumour progression and metastasis is highlighted from a biochemical point of view, taking into consideration both the extracellular and intracellular action of lysyl oxidases. More recently reported inhibitor compounds are discussed with an emphasis on their discovery, structure‐activity relationships and the results of their biological characterisation. Molecular probes developed for imaging of lysyl oxidase activity are reviewed from the perspective of their detection principles, performance and biomedical applications.


DOI: 10.1002/cmdc.202300331

Projects: DEEP-HCC network

Publication type: Journal

Journal: ChemMedChem

Citation: ChemMedChem 18(18),e202300331

Date Published: 15th Sep 2023

Registered Mode: by DOI

Authors: Reik Löser, Manuela Kuchar, Robert Wodtke, Christin Neuber, Birgit Belter, Klaus Kopka, Lakshmi Santhanam, Jens Pietzsch

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Löser, R., Kuchar, M., Wodtke, R., Neuber, C., Belter, B., Kopka, K., Santhanam, L., & Pietzsch, J. (2023). Lysyl Oxidases as Targets for Cancer Therapy and Diagnostic Imaging. In ChemMedChem (Vol. 18, Issue 18). Wiley.

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Created: 4th Oct 2023 at 08:45

Last updated: 4th Oct 2023 at 08:45

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