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LiSyM: Liver Systems Medicine 2
LiSyM-Krebs - Systemmedizinisches Forschungsnetz zur Früherkennung und Prävention von Leberkrebs2
Project
LiSyM network2
LiSyM-Krebs Partnering2
LiSyM Pillar I: Early Metabolic Injury (LiSyM-EMI)1
LiSyM Pillar IV: Liver Function Diagnostics (LiSyM-LiFuDi)1
Multi-Scale Models for Personalized Liver Function Tests (LiSyM-MM-PLF)1
LiSyM PALs1
Institution
Humboldt-Universität zu Berlin - Institute for Theoretical Biology (ITB)1
Humboldt-Universität zu Berlin - Institute of Biology1
Location
Germany2
Expertise
FBA2
Tool
FBA2
Immunohistochemistry9
confocal microscopy7
Mathematical Modelling6
Cell and tissue culture6
Molecular Biology5
qPCR5
Isolation and cultivation of mouse hepatocyte5
Metabolomics4
Mouse surgery4
Python3
rtPCR3
Computational and theoretical biology2
Cytometry and fluorescent microscopy2
Isolation purification and separation2
SBML2
Partial differential equations2
Databases2
Copasi2
Cytoscape2
kinetic modelling2
SED-ML2
Stability analysis2
Bifurcation analysis2
Multiscale simulation2
live cell imaging2
image analysis2
RNA analysis2
Computer Graphics2
Computer Simulations2
Dynamic modeling/dMod2
Biochemistry and protein analysis1
Genetic analysis1
Proteomics1
Virology1
Model organisms1
ODE1
Algebraic equations1
Java1
Workflows1
PCR1
Microarray analysis1
R1
Ruby on Rails1
Intravital imaging1
Ontologies1
Molecular Dynamics Simulations1
Javascript1
SEEK1
openBis1
Protege1
JWS online RightFiled1
Mitochondrial disorders1
Milliplex analysis1
Laser scan microscopy1
Morpheus1
Liver resection1
3D reconstruction1
in vivo 2-photon imaging1
Animal facility1
pharmacokinetics1
Qt1
PDEs1
Physiologically-based pharmacokinetic modelling1
Parameter estimation1
Data2Dynamics/d2d1
Parameter identifiability - Profile likelihood1
Cell Isolation1
Digital Pathology1
AI1
Mouse experiments in vivo1
Isolation of primary cells (hepatocytes and non-parenchymal cells)1
Groovy1
Ruby1
Docker1
BERT1
Llama1
QuPath1
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Projects: LiSyM PALs, Multi-Scale Models for Personalized Liver Function Tests (LiSyM-MM-PLF), LiSyM Pillar IV: Liver Function Diagnostics (LiSyM-LiFuDi), LiSyM network, LiSyM-Krebs Partnering
Institutions: Humboldt-Universität zu Berlin - Institute for Theoretical Biology (ITB)

We are investigating liver metabolism and function with the help of computational models and methods.
Group Leader Dr. Matthias König
Institute for Theoretical Biology Humboldt-University Berlin Philippstraße 13, 10115 Berlin, Germany phone +49 30 2093-98435 koenigmx@hu-berlin.de https://www.livermetabolism.com
The König group works on computational modeling, data science, data management, bioinformatics methods and machine learning on ...