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Seddik Hammad13
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LiSyM Pillar II: Chronic Liver Disease Progression (LiSyM-DP)13
LiSyM network10
LiSyM Pillar III: Regeneration and Repair in Acute-on-Chronic Liver Failure (LiSyM-ACLF)4
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LiSyM: Liver Systems Medicine 13
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Seddik Hammad13
Steven Dooley4
Dirk Drasdo4
Tim Johann4
Ahmed Ghallab3
Lars Ole Schwen3
Jieling Zhao3
Stefan Höhme2
Christian Holland2
Jan Hengstler2
Martin Golebiewski1
Viktor Makarenko1
Lars Kuepfer1
Daniel Lill1
André Homeyer1
Andrea Schenk1
Tobias Preusser1
Ayham Zaza1
Jens Timmer1
Ursula Klingmüller1
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Poster presented at Hünfeld Retreat 2018
Creators: André Homeyer, Seddik Hammad, Lars Ole Schwen, Steven Dooley, Andrea Schenk, Uta Dahmen, Henning Höfener, Yan Gao
Submitter: Lars Ole Schwen
The transforming growth factor (TGF)-β has been identified as a master regulator of liver fibrogenesis. Thus, targeting TGF-β1 pathway might modulate chronic liver disease (CLD) development and/or progression in murine model. Galunisertib (Ly2157299), already in clinical studies phase II, is an oral small molecule targeting TGF-β type I receptor (ALK-5).
Creators: Seddik Hammad, Julia Werle
Submitter: Seddik Hammad
