SEEK ID: https://seek.lisym.org/people/27
Location: Germany
ORCID: https://orcid.org/0000-0003-0195-9603
Joined: 3rd May 2017
Expertise: Not specified
Tools: Not specified
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Liver Systems Medicine : striving to develop non-invasive methods for diagnosing and treating NAFLD by combining mathematical modeling and biological research. LiSyM, is a multidisciplinary research network, in which molecular and cell biologists, clinical researchers, pharmacologists and experts in mathematical modeling examine the liver in its entirety. LiSyM research focuses on the metabolic liver disease non-alcoholic fatty liver disease (NAFLD), which includes non-alcoholic steatohepatitis ...
Projects: LiSyM Core Infrastructure and Management (LiSyM-PD), LiSyM Pillar I: Early Metabolic Injury (LiSyM-EMI), LiSyM Pillar II: Chronic Liver Disease Progression (LiSyM-DP), LiSyM Pillar III: Regeneration and Repair in Acute-on-Chronic Liver Failure (LiSyM-ACLF), LiSyM Pillar IV: Liver Function Diagnostics (LiSyM-LiFuDi), Model Guided Pharmacotherapy In Chronic Liver Disease (LiSyM-MGP), Molecular Steatosis - Imaging & Modeling (LiSyM-MSIM), The Hedgehog Signalling Pathway (LiSyM-JGMMS), Multi-Scale Models for Personalized Liver Function Tests (LiSyM-MM-PLF), LiSyM PALs, Project Management PTJ, LiSyM network, LiSyM Scientific Leadership Team (LiSyM-LT)
Web page: https://www.lisym.org/
This comprises the whole LiSyM network
Programme: LiSyM: Liver Systems Medicine
Public web page: http://www.lisym.org
Start date: 1st Jan 2016
Organisms: Rattus norvegicus, Rattus rattus, Mus musculus, Homo sapiens
In one in five people with NAFLD, the functioning liver cells, the hepatocytes, are replaced by connective tissue. Eventually this fibrosis becomes irreversible. In this state the liver is like a ‘scar that never heals’. Through it, the liver loses many of its vital functions. LiSyM-Pillar II wants to know more about which factors promote fibrosis and the conditions under which fibrosis becomes irreversible How can fibrosis be diagnosed as early as possible? Researchers in the pillar are also ...
Programme: LiSyM: Liver Systems Medicine
Public web page: http://www.lisym.org/our-work/pillar-research
Start date: 1st Jan 2016
Organisms: Mus musculus, Rattus rattus, Rattus norvegicus, Homo sapiens
Video for SBMC 2018 poster
Creator: Lars Ole Schwen
Submitter: Lars Ole Schwen
Investigations: No Investigations
Studies: No Studies
Assays: No Assays
Abstract (Expand)
Authors: A. Homeyer, S. Hammad, L. O. Schwen, U. Dahmen, H. Hofener, Y. Gao, S. Dooley, A. Schenk
Date Published: 20th Sep 2018
Publication Type: Not specified
PubMed ID: 30231920
Citation: Diagn Pathol. 2018 Sep 20;13(1):76. doi: 10.1186/s13000-018-0753-5.
Abstract (Expand)
Authors: Arne Schenk, Ahmed Ghallab, Ute Hofmann, Reham Hassan, Michael Schwarz, Andreas Schuppert, Lars Ole Schwen, Albert Braeuning, Donato Teutonico, Jan G. Hengstler, Lars Kuepfer
Date Published: 1st Dec 2017
Publication Type: Not specified
DOI: 10.1038/s41598-017-04574-z
Citation: Sci Rep 7(1) : 275
Abstract
Authors: Arne Schenk, Ahmed Ghallab, Ute Hofmann, Reham Hassan, Michael Schwarz, Andreas Schuppert, Lars Ole Schwen, Albert Braeuning, Donato Teutonico, Jan G. Hengstler, Lars Kuepfer
Date Published: 1st Dec 2017
Publication Type: Not specified
DOI: 10.1038/s41598-017-04574-z
Citation: Sci Rep 7(1) : 275
Abstract (Expand)
Authors: Lars Ole Schwen, Lars Kuepfer, Tobias Preusser
Date Published: 29th Nov 2017
Publication Type: Not specified
DOI: 10.1016/j.ddmod.2017.09.002
Citation:
Abstract (Expand)
Authors: Bruno Christ, Uta Dahmen, Karl-Heinz Herrmann, Matthias König, Jürgen R. Reichenbach, Tim Ricken, Jana Schleicher, Lars Ole Schwen, Sebastian Vlaic, Navina Waschinsky
Date Published: 14th Nov 2017
Publication Type: Not specified
Citation: Front. Physiol. 8 : 83
Poster presented at Hünfeld Retreat 2018
Creators: André Homeyer, Seddik Hammad, Lars Ole Schwen, Steven Dooley, Andrea Schenk, Uta Dahmen, Henning Höfener, Yan Gao
Submitter: Lars Ole Schwen
Presentation at 20. Chirurgische Forschungstage, Minisymposium Systembiologie der (Fett-)Leber und Implikationen für chirurgische Forschung, Magdeburg 2016
Creator: Lars Ole Schwen
Submitter: Lars Ole Schwen
Poster at SBMC 2018
Creators: Lars Ole Schwen, Lars Kuepfer, Ahmed Ghallab, Jan Hengstler, Tobias Preusser, Raymond Reif
Submitter: Lars Ole Schwen