The LiSyM Seek

48 items tagged with 'pharmacokinetics'.

Matthias König

We are investigating liver metabolism and function with the help of computational models and methods. Read more about the LiSyM junior group at: https://www.livermetabolism.com

Junior Group Leader Dr. Matthias König

Institute for Theoretical Biology Humboldt-University Berlin Invalidenstraße 110, 10115 Berlin, Germany phone +49 30 2093-98435 konigmatt@googlemail.com

The liver is the central metabolic organ of our body playing a crucial role in the clearance of drugs, xenobiotics and numerous ...

Projects: LiSyM-Krebs Partnering

Institutions: Fraunhofer Institute for Cell Therapy and Immunology - Branch Bioanalytics and Bioprocesses (IZI_BB)

Expertise: Organ-On-Chip

Tools: microfluidics, pharmacokinetics, Cell and tissue culture, Isolation and cultivation of mouse hepatocyte

Projects: LiSyM Pillar I: Early Metabolic Injury (LiSyM-EMI), LiSyM network, LiSyM-Krebs Partnering

Institutions: Dr. Margarete Fischer-Bosch-Institut für Klinische Pharmakologie

https://orcid.org/0000-0003-0823-9027

Tools: Metabolomics, pharmacokinetics

Digitized pharmacokinetics data (Jeppesen1996)

Multi-Scale Models for Personalized Liver Function Tests (LiSyM-MM-PLF)

Data digitized from publication.

Jeppesen1996 Description

Submitter: Matthias König

Assay type: Experimental Assay Type

Technology type: Technology Type

Investigation: Caffeine investigation

Study: PKDB Caffeine Study

Organisms: Homo sapiens

SOPs: No SOPs

Data files: CSV (Jeppesen1996), PNG (Jeppesen1996)

Snapshots: No snapshots

Created: 3rd May 2019 at 09:46, Last updated: 20th Jul 2021 at 14:37

Digitized pharmacokinetics data (Magnusson2008)

Multi-Scale Models for Personalized Liver Function Tests (LiSyM-MM-PLF)

Data digitized from publication.

Magnusson2008 Description

Submitter: Matthias König

Assay type: Experimental Assay Type

Technology type: Technology Type

Investigation: Caffeine investigation

Study: PKDB Caffeine Study

Organisms: Homo sapiens

SOPs: No SOPs

Data files: CSV (Magnusson2008), PNG (Magnusson2008)

Snapshots: No snapshots

Created: 3rd May 2019 at 09:46, Last updated: 20th Jul 2021 at 14:37

Digitized pharmacokinetics data (Kaplan1997)

Multi-Scale Models for Personalized Liver Function Tests (LiSyM-MM-PLF)

Data digitized from publication.

Kaplan1997 Description

Submitter: Matthias König

Assay type: Experimental Assay Type

Technology type: Technology Type

Investigation: Caffeine investigation

Study: PKDB Caffeine Study

Organisms: Homo sapiens

SOPs: No SOPs

Data files: CSV (Kaplan1997), PNG (Kaplan1997)

Snapshots: No snapshots

Created: 3rd May 2019 at 09:46, Last updated: 20th Jul 2021 at 14:37

Digitized pharmacokinetics data (Tanaka2014)

Multi-Scale Models for Personalized Liver Function Tests (LiSyM-MM-PLF)

Data digitized from publication.

Tanaka2014 Description

Submitter: Matthias König

Assay type: Experimental Assay Type

Technology type: Technology Type

Investigation: Caffeine investigation

Study: PKDB Caffeine Study

Organisms: Homo sapiens

SOPs: No SOPs

Data files: CSV (Tanaka2014), PNG (Tanaka2014)

Snapshots: No snapshots

Created: 3rd May 2019 at 09:46, Last updated: 20th Jul 2021 at 14:37

Digitized pharmacokinetics data (Blanchard1983a)

Multi-Scale Models for Personalized Liver Function Tests (LiSyM-MM-PLF)

Data digitized from publication.

Blanchard1983a Description

Submitter: Matthias König

Assay type: Experimental Assay Type

Technology type: Technology Type

Investigation: Caffeine investigation

Study: PKDB Caffeine Study

Organisms: Homo sapiens

SOPs: No SOPs

Data files: CSV (Blanchard1983a), PNG (Blanchard1983a)

Snapshots: No snapshots

Created: 3rd May 2019 at 09:46, Last updated: 20th Jul 2021 at 14:37

Digitized pharmacokinetics data (Healy1991)

Multi-Scale Models for Personalized Liver Function Tests (LiSyM-MM-PLF)

Data digitized from publication.

Healy1991 Description

Submitter: Matthias König

Assay type: Experimental Assay Type

Technology type: Technology Type

Investigation: Caffeine investigation

Study: PKDB Caffeine Study

Organisms: Homo sapiens

SOPs: No SOPs

Data files: CSV (Healy1991), PNG (Healy1991)

Snapshots: No snapshots

Created: 3rd May 2019 at 09:46, Last updated: 20th Jul 2021 at 14:37

Digitized pharmacokinetics data (Haller2002)

Multi-Scale Models for Personalized Liver Function Tests (LiSyM-MM-PLF)

Data digitized from publication.

Haller2002 Description

Submitter: Matthias König

Assay type: Experimental Assay Type

Technology type: Technology Type

Investigation: Caffeine investigation

Study: PKDB Caffeine Study

Organisms: Homo sapiens

SOPs: No SOPs

Data files: CSV (Haller2002), PNG (Haller2002)

Snapshots: No snapshots

Created: 3rd May 2019 at 09:46, Last updated: 20th Jul 2021 at 14:37

Digitized pharmacokinetics data (Kakuda2014)

Multi-Scale Models for Personalized Liver Function Tests (LiSyM-MM-PLF)

Data digitized from publication.

Kakuda2014 Description

Submitter: Matthias König

Assay type: Experimental Assay Type

Technology type: Technology Type

Investigation: Caffeine investigation

Study: PKDB Caffeine Study

Organisms: Homo sapiens

SOPs: No SOPs

Data files: CSV (Kakuda2014), PNG (Kakuda2014)

Snapshots: No snapshots

Created: 3rd May 2019 at 09:46, Last updated: 20th Jul 2021 at 14:37

Digitized pharmacokinetics data (Oh2012)

Multi-Scale Models for Personalized Liver Function Tests (LiSyM-MM-PLF)

Data digitized from publication.

Oh2012 Description

Submitter: Matthias König

Assay type: Experimental Assay Type

Technology type: Technology Type

Investigation: Caffeine investigation

Study: PKDB Caffeine Study

Organisms: Homo sapiens

SOPs: No SOPs

Data files: CSV (Oh2012), PNG (Oh2012)

Snapshots: No snapshots

Created: 3rd May 2019 at 09:46, Last updated: 20th Jul 2021 at 14:37

Digitized pharmacokinetics data (Amchin1999)

Multi-Scale Models for Personalized Liver Function Tests (LiSyM-MM-PLF)

Data digitized from publication.

Amchin1999 Description

Submitter: Matthias König

Assay type: Experimental Assay Type

Technology type: Technology Type

Investigation: Caffeine investigation

Study: PKDB Caffeine Study

Organisms: Homo sapiens

SOPs: No SOPs

Data files: CSV (Amchin1999), PNG (Amchin1999)

Snapshots: No snapshots

Created: 3rd May 2019 at 09:46, Last updated: 20th Jul 2021 at 14:37

Digitized pharmacokinetics data (Perera2011)

Multi-Scale Models for Personalized Liver Function Tests (LiSyM-MM-PLF)

Data digitized from publication.

Perera2011 Description

Submitter: Matthias König

Assay type: Experimental Assay Type

Technology type: Technology Type

Investigation: Caffeine investigation

Study: PKDB Caffeine Study

Organisms: Homo sapiens

SOPs: No SOPs

Data files: CSV (Perera2011), PNG (Perera2011)

Snapshots: No snapshots

Created: 3rd May 2019 at 09:46, Last updated: 20th Jul 2021 at 14:37

Digitized pharmacokinetics data (Akinyinka2000)

Multi-Scale Models for Personalized Liver Function Tests (LiSyM-MM-PLF)

Data digitized from publication.

Akinyinka2000 Description

Submitter: Matthias König

Assay type: Experimental Assay Type

Technology type: Technology Type

Investigation: Caffeine investigation

Study: PKDB Caffeine Study

Organisms: Homo sapiens

SOPs: No SOPs

Data files: CSV (Akinyinka2000), PNG (Akinyinka2000)

Snapshots: No snapshots

Created: 3rd May 2019 at 09:46, Last updated: 20th Jul 2021 at 14:37

Digitized pharmacokinetics data (Spigset1999a)

Multi-Scale Models for Personalized Liver Function Tests (LiSyM-MM-PLF)

Data digitized from publication.

Spigset1999a Description

Submitter: Matthias König

Assay type: Experimental Assay Type

Technology type: Technology Type

Investigation: Caffeine investigation

Study: PKDB Caffeine Study

Organisms: Homo sapiens

SOPs: No SOPs

Data files: CSV (Spigset1999a), PNG (Spigset1999a)

Snapshots: No snapshots

Created: 3rd May 2019 at 09:46, Last updated: 20th Jul 2021 at 14:37

Digitized pharmacokinetics data (Hetzler1990)

Multi-Scale Models for Personalized Liver Function Tests (LiSyM-MM-PLF)

Data digitized from publication.

Hetzler1990 Description

Submitter: Matthias König

Assay type: Experimental Assay Type

Technology type: Technology Type

Investigation: Caffeine investigation

Study: PKDB Caffeine Study

Organisms: Homo sapiens

SOPs: No SOPs

Data files: CSV (Hetzler1990), PNG (Hetzler1990)

Snapshots: No snapshots

Created: 3rd May 2019 at 09:46, Last updated: 20th Jul 2021 at 14:37

PNG (Jeppesen1996)

Multi-Scale Models for Personalized Liver Function Tests (LiSyM-MM-PLF)

Digitized pharmacokinetics data.

Creator: Matthias König

Submitter: Matthias König

Investigations: Caffeine investigation

Studies: PKDB Caffeine Study

Assays: Digitized pharmacokinetics data (Jeppesen1996)

Download

Created: 3rd May 2019 at 09:48, Last updated: 3rd May 2019 at 09:48

PNG (Magnusson2008)

Multi-Scale Models for Personalized Liver Function Tests (LiSyM-MM-PLF)

Digitized pharmacokinetics data.

Creator: Matthias König

Submitter: Matthias König

Investigations: Caffeine investigation

Studies: PKDB Caffeine Study

Assays: Digitized pharmacokinetics data (Magnusson2008)

Download

Created: 3rd May 2019 at 09:48, Last updated: 3rd May 2019 at 09:48

PNG (Kaplan1997)

Multi-Scale Models for Personalized Liver Function Tests (LiSyM-MM-PLF)

Digitized pharmacokinetics data.

Creator: Matthias König

Submitter: Matthias König

Investigations: Caffeine investigation

Studies: PKDB Caffeine Study

Assays: Digitized pharmacokinetics data (Kaplan1997)

Download

Created: 3rd May 2019 at 09:48, Last updated: 3rd May 2019 at 09:48

PNG (Tanaka2014)

Multi-Scale Models for Personalized Liver Function Tests (LiSyM-MM-PLF)

Digitized pharmacokinetics data.

Creator: Matthias König

Submitter: Matthias König

Investigations: Caffeine investigation

Studies: PKDB Caffeine Study

Assays: Digitized pharmacokinetics data (Tanaka2014)

Download

Created: 3rd May 2019 at 09:47, Last updated: 3rd May 2019 at 09:47

PNG (Blanchard1983a)

Multi-Scale Models for Personalized Liver Function Tests (LiSyM-MM-PLF)

Digitized pharmacokinetics data.

Creator: Matthias König

Submitter: Matthias König

Investigations: Caffeine investigation

Studies: PKDB Caffeine Study

Assays: Digitized pharmacokinetics data (Blanchard1983a)

Download

Created: 3rd May 2019 at 09:47, Last updated: 3rd May 2019 at 09:47

PNG (Healy1991)

Multi-Scale Models for Personalized Liver Function Tests (LiSyM-MM-PLF)

Digitized pharmacokinetics data.

Creator: Matthias König

Submitter: Matthias König

Investigations: Caffeine investigation

Studies: PKDB Caffeine Study

Assays: Digitized pharmacokinetics data (Healy1991)

Download

Created: 3rd May 2019 at 09:47, Last updated: 3rd May 2019 at 09:47

PNG (Haller2002)

Multi-Scale Models for Personalized Liver Function Tests (LiSyM-MM-PLF)

Digitized pharmacokinetics data.

Creator: Matthias König

Submitter: Matthias König

Investigations: Caffeine investigation

Studies: PKDB Caffeine Study

Assays: Digitized pharmacokinetics data (Haller2002)

Download

Created: 3rd May 2019 at 09:47, Last updated: 3rd May 2019 at 09:47

PNG (Kakuda2014)

Multi-Scale Models for Personalized Liver Function Tests (LiSyM-MM-PLF)

Digitized pharmacokinetics data.

Creator: Matthias König

Submitter: Matthias König

Investigations: Caffeine investigation

Studies: PKDB Caffeine Study

Assays: Digitized pharmacokinetics data (Kakuda2014)

Download

Created: 3rd May 2019 at 09:47, Last updated: 3rd May 2019 at 09:47

Multi-Scale Models for Personalized Liver Function Tests (LiSyM-MM-PLF)

Digitized pharmacokinetics data.

Creator: Matthias König

Submitter: Matthias König

Investigations: Caffeine investigation

Studies: PKDB Caffeine Study

Assays: Digitized pharmacokinetics data (Oh2012)

Download

Created: 3rd May 2019 at 09:47, Last updated: 3rd May 2019 at 09:47

PNG (Amchin1999)

Multi-Scale Models for Personalized Liver Function Tests (LiSyM-MM-PLF)

Digitized pharmacokinetics data.

Creator: Matthias König

Submitter: Matthias König

Investigations: Caffeine investigation

Studies: PKDB Caffeine Study

Assays: Digitized pharmacokinetics data (Amchin1999)

Download

Created: 3rd May 2019 at 09:47, Last updated: 3rd May 2019 at 09:47

PNG (Perera2011)

Multi-Scale Models for Personalized Liver Function Tests (LiSyM-MM-PLF)

Digitized pharmacokinetics data.

Creator: Matthias König

Submitter: Matthias König

Investigations: Caffeine investigation

Studies: PKDB Caffeine Study

Assays: Digitized pharmacokinetics data (Perera2011)

Download

Created: 3rd May 2019 at 09:47, Last updated: 3rd May 2019 at 09:47

PNG (Akinyinka2000)

Multi-Scale Models for Personalized Liver Function Tests (LiSyM-MM-PLF)

Digitized pharmacokinetics data.

Creator: Matthias König

Submitter: Matthias König

Investigations: Caffeine investigation

Studies: PKDB Caffeine Study

Assays: Digitized pharmacokinetics data (Akinyinka2000)

Download

Created: 3rd May 2019 at 09:47, Last updated: 3rd May 2019 at 09:47

PNG (Spigset1999a)

Multi-Scale Models for Personalized Liver Function Tests (LiSyM-MM-PLF)

Digitized pharmacokinetics data.

Creator: Matthias König

Submitter: Matthias König

Investigations: Caffeine investigation

Studies: PKDB Caffeine Study

Assays: Digitized pharmacokinetics data (Spigset1999a)

Download

Created: 3rd May 2019 at 09:47, Last updated: 3rd May 2019 at 09:47

PNG (Hetzler1990)

Multi-Scale Models for Personalized Liver Function Tests (LiSyM-MM-PLF)

Digitized pharmacokinetics data.

Creator: Matthias König

Submitter: Matthias König

Investigations: Caffeine investigation

Studies: PKDB Caffeine Study

Assays: Digitized pharmacokinetics data (Hetzler1990)

Download

Created: 3rd May 2019 at 09:47, Last updated: 3rd May 2019 at 09:47

CSV (Jeppesen1996)

Multi-Scale Models for Personalized Liver Function Tests (LiSyM-MM-PLF)

Digitized pharmacokinetics data.

Creator: Matthias König

Submitter: Matthias König

Investigations: Caffeine investigation

Studies: PKDB Caffeine Study

Assays: Digitized pharmacokinetics data (Jeppesen1996)

Download

Created: 3rd May 2019 at 09:47, Last updated: 3rd May 2019 at 09:47

CSV (Magnusson2008)

Multi-Scale Models for Personalized Liver Function Tests (LiSyM-MM-PLF)

Digitized pharmacokinetics data.

Creator: Matthias König

Submitter: Matthias König

Investigations: Caffeine investigation

Studies: PKDB Caffeine Study

Assays: Digitized pharmacokinetics data (Magnusson2008)

Download

Created: 3rd May 2019 at 09:47, Last updated: 3rd May 2019 at 09:47

CSV (Kaplan1997)

Multi-Scale Models for Personalized Liver Function Tests (LiSyM-MM-PLF)

Digitized pharmacokinetics data.

Creator: Matthias König

Submitter: Matthias König

Investigations: Caffeine investigation

Studies: PKDB Caffeine Study

Assays: Digitized pharmacokinetics data (Kaplan1997)

Download

Created: 3rd May 2019 at 09:47, Last updated: 3rd May 2019 at 09:47

CSV (Tanaka2014)

Multi-Scale Models for Personalized Liver Function Tests (LiSyM-MM-PLF)

Digitized pharmacokinetics data.

Creator: Matthias König

Submitter: Matthias König

Investigations: Caffeine investigation

Studies: PKDB Caffeine Study

Assays: Digitized pharmacokinetics data (Tanaka2014)

Download

Created: 3rd May 2019 at 09:47, Last updated: 3rd May 2019 at 09:47

CSV (Blanchard1983a)

Multi-Scale Models for Personalized Liver Function Tests (LiSyM-MM-PLF)

Digitized pharmacokinetics data.

Creator: Matthias König

Submitter: Matthias König

Investigations: Caffeine investigation

Studies: PKDB Caffeine Study

Assays: Digitized pharmacokinetics data (Blanchard1983a)

Download

Created: 3rd May 2019 at 09:47, Last updated: 3rd May 2019 at 09:47

CSV (Healy1991)

Multi-Scale Models for Personalized Liver Function Tests (LiSyM-MM-PLF)

Digitized pharmacokinetics data.

Creator: Matthias König

Submitter: Matthias König

Investigations: Caffeine investigation

Studies: PKDB Caffeine Study

Assays: Digitized pharmacokinetics data (Healy1991)

Download

Created: 3rd May 2019 at 09:46, Last updated: 3rd May 2019 at 09:47

CSV (Haller2002)

Multi-Scale Models for Personalized Liver Function Tests (LiSyM-MM-PLF)

Digitized pharmacokinetics data.

Creator: Matthias König

Submitter: Matthias König

Investigations: Caffeine investigation

Studies: PKDB Caffeine Study

Assays: Digitized pharmacokinetics data (Haller2002)

Download

Created: 3rd May 2019 at 09:46, Last updated: 3rd May 2019 at 09:46

CSV (Kakuda2014)

Multi-Scale Models for Personalized Liver Function Tests (LiSyM-MM-PLF)

Digitized pharmacokinetics data.

Creator: Matthias König

Submitter: Matthias König

Investigations: Caffeine investigation

Studies: PKDB Caffeine Study

Assays: Digitized pharmacokinetics data (Kakuda2014)

Download

Created: 3rd May 2019 at 09:46, Last updated: 3rd May 2019 at 09:46

Multi-Scale Models for Personalized Liver Function Tests (LiSyM-MM-PLF)

Digitized pharmacokinetics data.

Creator: Matthias König

Submitter: Matthias König

Investigations: Caffeine investigation

Studies: PKDB Caffeine Study

Assays: Digitized pharmacokinetics data (Oh2012)

Download

Created: 3rd May 2019 at 09:46, Last updated: 3rd May 2019 at 09:46

CSV (Amchin1999)

Multi-Scale Models for Personalized Liver Function Tests (LiSyM-MM-PLF)

Digitized pharmacokinetics data.

Creator: Matthias König

Submitter: Matthias König

Investigations: Caffeine investigation

Studies: PKDB Caffeine Study

Assays: Digitized pharmacokinetics data (Amchin1999)

Download

Created: 3rd May 2019 at 09:46, Last updated: 3rd May 2019 at 09:46

CSV (Perera2011)

Multi-Scale Models for Personalized Liver Function Tests (LiSyM-MM-PLF)

Digitized pharmacokinetics data.

Creator: Matthias König

Submitter: Matthias König

Investigations: Caffeine investigation

Studies: PKDB Caffeine Study

Assays: Digitized pharmacokinetics data (Perera2011)

Download

Created: 3rd May 2019 at 09:46, Last updated: 3rd May 2019 at 09:46

CSV (Akinyinka2000)

Multi-Scale Models for Personalized Liver Function Tests (LiSyM-MM-PLF)

Digitized pharmacokinetics data.

Creator: Matthias König

Submitter: Matthias König

Investigations: Caffeine investigation

Studies: PKDB Caffeine Study

Assays: Digitized pharmacokinetics data (Akinyinka2000)

Download

Created: 3rd May 2019 at 09:46, Last updated: 3rd May 2019 at 09:46

CSV (Spigset1999a)

Multi-Scale Models for Personalized Liver Function Tests (LiSyM-MM-PLF)

Digitized pharmacokinetics data.

Creator: Matthias König

Submitter: Matthias König

Investigations: Caffeine investigation

Studies: PKDB Caffeine Study

Assays: Digitized pharmacokinetics data (Spigset1999a)

Download

Created: 3rd May 2019 at 09:46, Last updated: 3rd May 2019 at 09:46

CSV (Hetzler1990)

Multi-Scale Models for Personalized Liver Function Tests (LiSyM-MM-PLF)

Digitized pharmacokinetics data.

Creator: Matthias König

Submitter: Matthias König

Investigations: Caffeine investigation

Studies: PKDB Caffeine Study

Assays: Digitized pharmacokinetics data (Hetzler1990)

Download

Created: 3rd May 2019 at 09:46, Last updated: 3rd May 2019 at 09:46

PK-DB: pharmacokinetics database for individualized and stratified computational modeling.

Multi-Scale Models for Personalized Liver Function Tests (LiSyM-MM-PLF)

Abstract (Expand)

A multitude of pharmacokinetics studies have been published. However, due to the lack of an open database, pharmacokinetics data, as well as the corresponding meta-information, have been difficult to …

Authors: J. Grzegorzewski, J. Brandhorst, K. Green, D. Eleftheriadou, Y. Duport, F. Barthorscht, A. Koller, D. Y. J. Ke, S. De Angelis, M. Konig

Date Published: 5th Nov 2020

Publication Type: Journal

PubMed ID: 33151297

Citation: Nucleic Acids Res. 2020 Nov 5. pii: 5957165. doi: 10.1093/nar/gkaa990.

Created: 18th Dec 2020 at 18:53

Integration of Representative Sinusoids into a Physiologically Based Whole-Body Model for a Detailed Description of Biliary Transport

LiSyM Pillar II: Chronic Liver Disease Progression (LiSyM-DP)

(Show All)

Poster at SBMC 2018

Creators: Lars Ole Schwen, Lars Kuepfer, Ahmed Ghallab, Jan Hengstler, Tobias Preusser, Raymond Reif

Submitter: Lars Ole Schwen

Download

Created: 29th Jun 2018 at 09:17, Last updated: 4th Jul 2018 at 09:00

LiSyM Midterm Evaluation Poster 7 - Schwab/Hofmann

LiSyM Pillar I: Early Metabolic Injury (LiSyM-EMI)

No description specified

Creators: Ute Hofmann, Matthias Schwab

Submitter: Ute Hofmann

Created: 30th Apr 2018 at 14:21, Last updated: 30th Apr 2018 at 14:34

(v.1.11.1)

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