Identification of key processes leading to non-alcoholic fatty liver disease (NAFLD) and its progression to non-alcoholic steato-hepatitis (NASH): Based on the finding within the Virtual Liver Network that the Hedgehog signalling pathway is a core player in the regulation of liver lipid metabolism, this project aims to characterize and model the central role of Hedgehog signalling during the transition from benign steatosis to NAFLD and NASH using patient data and large data sets from various

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