Models
What is a Model?Filters
Query
Created At
Updated At
Submitter
Ursula Klingmüller1
Programme
LiSyM: Liver Systems Medicine 1
Creator
Ursula Klingmüller1
Lutz Brusch9
Michael Kücken4
Jens Timmer3
Diego Jahn2
Viktor Makarenko1
Lorenza D'Alessandro1
Daniel Lill1
Daniel Seehofer1
More...
Model type
Ordinary differential equations (ODE)1
Model format
SBML1
Recommended environment
Copasi1
Modelling analysis type
Model Analysis Type1
ODE model describes dynamics of IFNalpha-induced signaling in Huh7.5 cells for a time scale up to 32 hours after stimulation with IFNalpha. The model consists of an IFN receptor model, formation/degradation and cytoplasmic/nuclear shuttling of STAT1-homodimers, STAT1-STAT2-heterodimers and STAT1-STAT2-IRF9 (ISGF3) complexes. On top, formation of feedback proteins STAT1, STAT2, IRF9, USP18, SOCS1, SOCS3 and IRF2 and corresponding influences on IFNalpha signaling dynamics was incorporated. The model ...
Creators: Jens Timmer, Ursula Klingmüller, Daniel Seehofer, Marcus Rosenblatt, Krishna Kumar Tiwari, Frédérique Kok
Submitter: Olga Krebs
Model type: Ordinary differential equations (ODE)
Model format: SBML
Environment: Copasi
Download
